Nature Reviews Immunology Contents February 2015 Volume 15 Number 2 pp 67-129

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TABLE OF CONTENTS
February 2015 Volume 15 Number 2
Impact Factor 33.836 *	In this issue Research Highlights Reviews Also this month  Featured article: Type I interferons in infectious disease Finlay McNab, Katrin Mayer-Barber, Alan Sher, Andreas Wack & Anne O'Garra
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Innate Immune Memory (18-20 March 2015)  Wellcome Trust Genome Campus, Hinxton, Cambridge, UK This new meeting will discuss how the innate immune system is activated and regulated and how it can be harnessed to develop new therapies to treat inflammatory diseases, infection and cancer. Abstract/Bursary Deadline: 30 Jan. Registration Deadline: 18 Feb.
RESEARCH HIGHLIGHTS Top Immunometabolism: ILC2s skew the fat p67 | doi:10.1038/nri3805 Group 2 innate lymphoid cells promote beiging of adipose tissue and protect against obesity. PDF Cell death: Silencing the immune response of apoptotic cells p68 | doi:10.1038/nri3808 Mitochondrial DNA released during apoptosis triggers a type I interferon response that is held in check by the apoptotic caspases. PDF Infection: Double skin protection p68 | doi:10.1038/nri3811 Skin immunity can be promoted by bacterial skin commensals that induce distinct CD8+ T cell responses and by adipocytes that produce antimicrobial peptides. PDF Antiviral immunity: Dual attack by RIG-I p70 | doi:10.1038/nri3810 RIG-I induces a type III interferon response during hepatitis B virus infection and also directly interferes with viral replication. PDF T cells: Endogenous agonists for orphan RORγ p70 | doi:10.1038/nri3812 Sterol metabolism drives T helper 17 cell differentiation. PDF Regulatory T cells: The PTEN stabilizer p71 | doi:10.1038/nri3809 PTEN maintains regulatory T cell lineage stability and immune homeostasis. PDF IN BRIEF Immunometabolism: Macrophages and smaller ages | Infection: The cost of targeting helminths | Inflammation: Dopamine blocks inflammasome activation PDF Immunology JOBS of the week Research Scientists / Postdoctoral Scientists / Associate Scientists 1Globe Health Institute PhD Position in Plant-Microbe Interactions, Small Regulatory RNAs Ludwig-Maximilians-Universität (LMU) in Munich Postdoctoral Research Fellow John Wayne Cancer Institute at Providence Saint John's Health Center Senior Scientist University of California - Davis Postdoctoral Associate Univeristy of Minnesota More Science jobs from Immunology EVENT Nutritional Immunology: Role in Health and Disease 26.07.15 Lisbon, Portugal More science events from
REVIEWS		Top
Immune cell promotion of metastasis Takanori Kitamura, Bin-Zhi Qian & Jeffrey W. Pollard p73 | doi:10.1038/nri3789 In addition to avoiding immune attack in the primary tumour, metastatic cancer cells can harness suppressive immune cells to help promote and protect them from immune surveillance as they travel from the primary tumour site, through blood or lymphatic vessels, to the metastatic site. Thus, targeting pro-metastatic immune cells may offer new therapeutic strategies for treating the major cause of death from cancer — metastatic disease. Abstract | Full Text | PDF
Type I interferons in infectious disease Finlay McNab, Katrin Mayer-Barber, Alan Sher, Andreas Wack & Anne O'Garra p87 | doi:10.1038/nri3787 Type I interferons have multiple direct and indirect effects on immune cells during infectious diseases. For the most part, they protect the host against infection, but they can also have adverse effects on the host. The existence of complex cross-regulatory networks involving type I interferons helps to ensure host protection with minimum host damage. Abstract | Full Text | PDF
Cholesterol, inflammation and innate immunity Alan R. Tall & Laurent Yvan-Charvet p104 | doi:10.1038/nri3793 The accumulation of cholesterol in macrophages and other immune cells promotes inflammatory responses. Inflammation, in turn, reduces the normal physiological excretion of cholesterol, which amplifies the inflammatory response and promotes myelopoiesis. Here, the authors detail the mechanisms by which cholesterol accumulation affects immune signalling pathways and highlight potential therapeutic interventions that may have benefits for metabolic diseases. Abstract | Full Text | PDF
Role of innate and adaptive immune mechanisms in cardiac injury and repair Slava Epelman, Peter P. Liu & Douglas L. Mann p117 | doi:10.1038/nri3800 This Review describes the immune responses that occur in the heart, explaining how different innate and adaptive immune cell populations can have beneficial or detrimental roles during cardiac tissue injury. In particular, the authors focus on the unique macrophage subsets that are found in the heart and their roles in regenerating damaged cardiac tissue. Abstract | Full Text | PDF
Corrigendum: Type 2 inflammation in asthma — present in most, absent in many John V. Fahy p129 | doi:10.1038/nri3807 Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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