Nature Reviews Molecular Cell Biology contents February 2015 Volume 16 Number 2 pp 66-123

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TABLE OF CONTENTS
February 2015 Volume 16 Number 2
Impact Factor 36.458 *	In this issue Research Highlights Reviews Also this month Article series: Technologies and techniques  Featured article: In the right place at the right time: visualizing and understanding mRNA localization Adina R. Buxbaum, Gal Haimovich & Robert H. Singer
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RESEARCH HIGHLIGHTS Top RNA metabolism: Promoters drive alternative polyadenylation p66 | doi:10.1038/nrm3940 The RNA-binding protein Elav is recruited in the fruit fly to promoter regions, possibly by paused RNA polymerase II, to promote alternative polyadenylation. PDF Protein folding: Phosphorylation regulates IDP folding p66 | doi:10.1038/nrm3942 A new study shows that phosphorylation regulates the folding, and thus biological function, of the intrinsically disordered protein 4E-BP2. PDF JOURNAL CLUB Super-duper resolution imaging of mitotic microtubules p67 | doi:10.1038/nrm3937 Stephen J. Royle describes a cutting-edge study that provided definitive evidence for the first time that the kinetochore fibre is a bundle of parallel microtubules. PDF Chromatin: Drivers of nuclear organization p67 | doi:10.1038/nrm3938 Chromatin decondensation is sufficient to induce the relocation of loci from the periphery to the centre of nuclei. PDF Endocytosis: A new gateway into cells p68 | doi:10.1038/nrm3939 Two studies have determined the molecular mechanisms that underlie a specific clathrin-independent pathway for the internalization of activated surface receptors and bacterial toxins. PDF Stem cells: Human primordial germ cells in a dish p68 | doi:10.1038/nrm3945 A robust method to induce primordial germ cells from human pluripotent stem cells been developed, highlighting the importance of SOX17 in the specification of the human germline. PDF IN BRIEF Metabolism: The health benefits of hydrogen sulphide | Autophagy: p53-controlled autophagy | Nuclear organization: Targeting chromatin to the lamina PDF Molecular Cell Biology JOBS of the week Postdoctoral Position on Autophagy Regulation in Health and Disease Sabanci University Postdoctoral position in Epithelial Cell Biology and Signaling Ludwig Institute for Cancer Research (LICR) Research Associate City of Hope Postdoctoral Researcher in Cancer Biology University of Pennsylvania More Science jobs from Molecular Cell Biology EVENT More science events from
Erratum: Slowly (translate) but surely (translocate) Eytan Zlotorynski p68 | doi:10.1038/nrm3936 Full Text | PDF
REVIEWS		Top
Article series: Technologies and techniques Methodological advances: the unsung heroes of the GPCR structural revolution Eshan Ghosh, Punita Kumari, Deepika Jaiman & Arun K. Shukla p69 | doi:10.1038/nrm3933 Considerable progress has been made in the past few years in our ability to visualize the structure of G protein-coupled receptors (GPCRs) and their signalling complexes. This is due to a series of technical improvements in areas such as protein engineering, lipidic cubic phase-based crystallization and microfocus synchrotron beamlines. Abstract | Full Text | PDF | Supplementary information
Spatiotemporal regulation of the anaphase-promoting complex in mitosis Sushama Sivakumar & Gary J. Gorbsky p82 | doi:10.1038/nrm3934 The anaphase-promoting complex (also known as the cyclosome) is an E3 ubiquitin ligase that has a crucial function in the regulation of mitosis, particularly during anaphase and mitotic exit. Its activity is tightly controlled by several factors to ensure the timely degradation of key mitotic regulators and thus the proper progression of mitotic events. Abstract | Full Text | PDF
In the right place at the right time: visualizing and understanding mRNA localization Adina R. Buxbaum, Gal Haimovich & Robert H. Singer p95 | doi:10.1038/nrm3918 The subcellular localization of mRNAs enables the spatial regulation of protein translation and generates functional and structural asymmetries in cells. New imaging (and other) techniques for tracking single-mRNA dynamics have unravelled mechanisms of mRNA movements and localization patterns in various cell types. Abstract | Full Text | PDF | Supplementary information
Mechanisms of retinoic acid signalling and its roles in organ and limb development Thomas J. Cunningham & Gregg Duester p110 | doi:10.1038/nrm3932 Retinoic acid regulates transcription by interacting with nuclear retinoic acid receptors, which bind to retinoic acid response elements near target genes. Recent studies have refined our knowledge of retinoic acid function in the limb, which serves as a paradigm for understanding how it regulates other developmental processes, such as somitogenesis, neuronal differentiation and organogenesis. Abstract | Full Text | PDF
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