Nature Reviews Genetics Contents December 2014 Volume 15 Number 12 pp 777-845

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TABLE OF CONTENTS
December 2014 Volume 15 Number 12		Advertisement
Impact Factor 39.794 *	In this issue Research Highlights Reviews Analysis Also this month Article series: Applications of next-generation sequencing  Featured article: Unravelling the genomic targets of small molecules using high-throughput sequencing Raphaël Rodriguez & Kyle M. Miller	RNAI in C. Elegans exclusively available at Source BioScience. The total collection of 19,762 bacterial strains designed for genome wide study of gene function in C.elegans. The supplemental library and individual chromosome sets (I, II, III, IV, V and X) are also available to order. Order Today: Contact us now sales@sourcebioscience.com
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nature.com webcasts Nature Publishing Group presents a custom webcast on: Complementing the genome: Epigenome wide studies to advance Wednesday, December 3, 2014 8AM PST, 11AM EST, 4PM GMT, 5PM CET  Register for the webcast and live Q and A session. Sponsored by: Life Technologies, a Thermo Fisher Scientific Brand
RESEARCH HIGHLIGHTS Top Human genetics: Dissecting deleterious mutation complexity p777 | doi:10.1038/nrg3852 PDF Genetic screens: CRISPR screening from both ways p778 | doi:10.1038/nrg3850 PDF Evolution: Evidence of group selection shown in social spiders p778 | doi:10.1038/nrg3851 PDF Disease genomics: Triaging risk variants in the non-coding genome p779 | doi:10.1038/nrg3862 PDF Genome organization: 3D genome architecture — of loops and globules p780 | doi:10.1038/nrg3858 PDF Synthetic biology: Just add water — programmable in vitro diagnostics p780 | doi:10.1038/nrg3860 PDF Circadian genetics: Timing is everything p780 | doi:10.1038/nrg3864 PDF IN BRIEF Technology: Stop-and-go acrobatics through nanopores | Disease genetics: Zebrafish models ultra-rare X-linked disease | Microbial genetics: Selective killing using programmable Cas9 | Plant genomics: High-throughput phenotyping of rice growth traits | Model organisms: Host determinants of Ebola virus pathogenicity | Chromosome biology: A high-quality mouse Y chromosome sequence | Disease genetics: New insights into the genetic architecture of ASDs PDF Genetics JOBS of the week Postdoctoral Fellow in Statistical and Computational Genomics University of Chicago Postdoctoral fellow in computational biology and cancer genomics Albert Einstein College of Medicine of Yeshiva University (AECOM) Postdoctoral Fellow in Cancer Genomics Dana-Farber Cancer Institute and Harvard School of Public Health PhD Studentship The University of Sheffield Director Max Planck Institute for Plant Breeding Research More Science jobs from Genetics EVENT Malaria Experimental Genetics 15.03.15 Bangkok, Thailand More science events from
REVIEWS		Top
Article series: Applications of next-generation sequencing Unravelling the genomic targets of small molecules using high-throughput sequencing Raphaël Rodriguez & Kyle M. Miller p783 | doi:10.1038/nrg3796 Various small molecules, including numerous anticancer agents, act by targeting DNA or protein components of chromatin. This Review describes how various complementary technologies use high-throughput sequencing to delineate drug responses, from identifying the genomic binding sites of drugs or their targets, to the ensuing changes to chromatin states and gene expression. These insights should facilitate the rational use of these therapies. Abstract | Full Text | PDF
Microbial genome-enabled insights into plant-microorganism interactions David S. Guttman, Alice C. McHardy & Paul Schulze-Lefert p797 | doi:10.1038/nrg3748 Various bacterial and eukaryotic microorganisms engage in interactions with plant hosts, ranging from co-evolutionary arms races between phytopathogens and their hosts to the beneficial effects of mutualistic microorganisms. This Review discusses how next-generation sequencing of microbial isolates and environmental samples has provided insights into the mechanisms and genome-wide evolution of pathogenesis in phytopathogens, as well as a more global understanding of plant-associated microbial communities. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing High-resolution digital profiling of the epigenome Gabriel E. Zentner & Steven Henikoff p814 | doi:10.1038/nrg3798 The resolution of epigenomic profiling has been vastly augmented with the adoption of new approaches to interrogate varied features of the epigenome. This Review describes these techniques and outlines the ways in which these genome-wide tools can be used to examine the epigenome. Abstract | Full Text | PDF
ANALYSIS		Top
A census of human RNA-binding proteins Stefanie Gerstberger, Markus Hafner & Thomas Tuschl p829 | doi:10.1038/nrg3813 Analyses of post-transcriptional gene regulation and the protein factors involved have been substantially driven forward by technological advances such as next-generation sequencing and modern protein mass spectrometry. This Analysis provides a census of 1,542 manually curated RNA-binding proteins, for which the authors have investigated interactions with different classes of RNA, evolutionary conservation, abundance and tissue-specific expression. Abstract | Full Text | PDF | Supplementary information
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Nature Collections  RNA SEQUENCING QUALITY CONTROL (SEQC) Articles from Nature Biotechnology, Nature Communications and Scientific Data presents results from The RNA Sequencing Quality Control (SEQC) project. This is the second phase of a collaboration between government, academic and industry researchers as part of the MicroArray Quality Control (MAQC) consortium. Produced with support from the FDA's National Center for Toxicological Research (NCTR/FDA) and the State Key Laboratory of Genetic Engineering (SKLGE) at Fudan University.
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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