Scientific Reports Biology Table of Contents e-alert: 18 November 2014

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18 November 2014      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion ▶     Toshiyuki Ishiba, Makoto Nagahara, Tsuyoshi Nakagawa et al.     The ability of cancer cells to metastasize is dependent on the interactions between their cell-surface molecules and the microenvironment. However, the tumor microenvironment, …             High-throughput formation of lipid bilayer membrane arrays with an asymmetric lipid composition ▶     Rikiya Watanabe, Naoki Soga, Tomoko Yamanaka et al.     We present a micro-device in which more than 10,000 asymmetric lipid bilayer membranes are formed at a time on micro-chamber arrays. The arrayed asymmetric lipid bilayers, where …             A genetic variant of miR-148a binding site in the SCRN1 3′-UTR is associated with susceptibility and prognosis of gastric cancer ▶     Peng Song, Haixia Zhu, Dong Zhang et al.     Single nucleotide polymorphisms (SNPs) in the 3′-untranslated regions targeted by putative mircoRNA can change its binding strength, affecting the susceptibility and prognosis of …             Multifunctional Core/Shell Nanoparticles Cross-linked Polyetherimide-folic Acid as Efficient Notch-1 siRNA Carrier for Targeted Killing of Breast Cancer ▶     Hong Yang, Ying Li, Tingting Li et al.     In gene therapy, how genetic therapeutics can be efficiently and safely delivered into target tissues/cells remains a major obstacle to overcome. To address this issue, …             Turion morphological responses to water nutrient concentrations and plant density in the submerged macrophyte Potamogeton crispus ▶     Chang Qian, Wenhua You, Dong Xie et al.     Asexual propagules are the dominant means of propagation in most submerged macrophytes. To improve the understanding of how water nutrient concentrations and population density …             Experimental and Theoretical Approaches for the Surface Interaction between Copper and Activated Sludge Microorganisms at Molecular Scale ▶     Hong-Wei Luo, Jie-Jie Chen, Guo-Ping Sheng et al.     Interactions between metals and activated sludge microorganisms substantially affect the speciation, immobilization, transport, and bioavailability of trace heavy metals in …             Shorter telomere length in peripheral blood leukocytes is associated with childhood autism ▶     Zongchang Li, Jinsong Tang, Hong Li et al.     Telomeres are protective chromosomal structures that play a key role in preserving genomic stability. Epidemiologic studies have shown that the abnormal telomere length in …             Ventricular hypertrophy blocked delayed anesthetic cardioprotection in rats by alteration of iNOS/COX-2 signaling ▶     Leilei Ma, Feijuan Kong, Hongwei Ge et al.     The aim of the current study was to determine whether ventricular hypertrophy affects the delayed isoflurane preconditioning against myocardial ischemia-reperfusion (IR) injury. …             Endometrial cells sense and react to tissue damage during infection of the bovine endometrium via interleukin 1 ▶     Laura L. Healy, James G. Cronin, I. Martin Sheldon     Cells generate inflammatory responses to bacteria when pattern recognition receptors bind pathogen-associated molecules such as lipopolysaccharide. Cells may also respond to …             Trimeric HIV Env provides epitope occlusion mediated by hypervariable loops ▶     Carlos G. Moscoso, Li Xing, Jinwen Hui et al.     Hypervariable loops of HIV-1 Env protein gp120 are speculated to play roles in the conformational transition of Env to the receptor binding-induced metastable state. Structural …             SEPP1 gene variants and abdominal aortic aneurysm: gene association in relation to metabolic risk factors and peripheral arterial disease coexistence ▶     Ewa Strauss, Grzegorz Oszkinis, Ryszard Staniszewski     An inadequate selenium level is supposed to be a risk factor for cardiovascular diseases. However little is known about variation of the genes encoding selenium-containing …             Specific deficiency of Plzf paralog, Zbtb20, in Sertoli cells does not affect spermatogenesis and fertility in mice ▶     Xiaohua Jiang, Huan Zhang, Shi Yin et al.     Ztbt20 is a POK family transcription factor and primarily functions through its conserved C2H2 Krüppel type zinc finger and BTB/POZ domains. The present study was designed to …             Structural Insight into the Central Element Assembly of the Synaptonemal Complex ▶     Jing Lu, Yanling Gu, Jianrong Feng et al.     The key step in meiosis is synaptonemal complex formation, which mediates homologous chromosome alignment and synapsis. False pairing between homologous chromosomes produces …             Rapid Measurement of Molecular Transport and Interaction inside Living Cells Using Single Plane Illumination ▶     Per Niklas Hedde, Milka Stakic, Enrico Gratton     The ability to measure biomolecular dynamics within cells and tissues is very important to understand fundamental physiological processes including cell adhesion, signalling, …             Splicing mutation analysis reveals previously unrecognized pathways in lymph node-invasive breast cancer ▶     Stephanie N. Dorman, Coby Viner, Peter K. Rogan     Somatic mutations reported in large-scale breast cancer (BC) sequencing studies primarily consist of protein coding mutations. mRNA splicing mutation analyses have been limited …             Penguins significantly increased phosphine formation and phosphorus contribution in maritime Antarctic soils ▶     Renbin Zhu, Qing Wang, Wei Ding et al.     Most studies on phosphorus cycle in the natural environment focused on phosphates, with limited data available for the reduced phosphine (PH3). In this paper, matrix-bound …             Effects of Tet-mediated Oxidation Products of 5-Methylcytosine on DNA Transcription in vitro and in Mammalian Cells ▶     Changjun You, Debin Ji, Xiaoxia Dai et al.     5-methylcytosine (5-mC) is a well-characterized epigenetic regulator in mammals. Recent studies showed that Ten-eleven translocation (Tet) proteins can catalyze the stepwise …             Salivary biomarkers indicate obstructive sleep apnea patients with cardiovascular diseases ▶     Hui Zheng, Ruoxuan Li, Jieni Zhang et al.     Although obstructive sleep apnea (OSA) patients are at high risk of developing cardiovascular disease (CVD), only a small proportion is currently diagnosed. To explore and …             Disruption of polyubiquitin gene Ubb causes dysregulation of neural stem cell differentiation with premature gliogenesis ▶     Han-Wook Ryu, Chul-Woo Park, Kwon-Yul Ryu     Disruption of polyubiquitin gene Ubb leads to early-onset reactive gliosis and adult-onset hypothalamic neurodegeneration in mice. However, it remains unknown why reduced levels …             Customized patterned substrates for highly versatile correlative light-scanning electron microscopy ▶     Lorena Benedetti, Elisa Sogne, Simona Rodighiero et al.     Correlative light electron microscopy (CLEM) combines the advantages of light and electron microscopy, thus making it possible to follow dynamic events in living cells at …             Increased systolic blood pressure reactivity to acute stress is related with better self-reported health ▶     Bradley J. Wright, Shaun O'Brien, Agnes Hazi et al.     The stress reactivity hypothesis posits that the magnitude of cardiovascular reactions to acute stress tasks is related with future blood pressure status, heart hypertrophy, and …             Acoustic and foraging behavior of a Baird's beaked whale, Berardius bairdii, exposed to simulated sonar ▶     A. K. Stimpert, S. L. DeRuiter, B. L. Southall et al.     Beaked whales are hypothesized to be particularly sensitive to anthropogenic noise, based on previous strandings and limited experimental and observational data. However, few …             Genetic and epidemiological insights into the emergence of peste des petits ruminants virus (PPRV) across Asia and Africa ▶     Abinash Padhi, Li Ma     Small ruminants are important components in the livelihood of millions of households in many parts of the world. The spread of the highly contagious peste des petits ruminants …             A reduction in reactive oxygen species contributes to dihydromyricetin-induced apoptosis in human hepatocellular carcinoma cells ▶     Bin Lin, Xiaoyu Tan, Jian Liang et al.     Reactive oxygen species (ROS) and cellular oxidant stress are considered inducers of carcinogenesis. However, the association of ROS with cancer is both complex and, at times, …             The choice of reference genes for assessing gene expression in sugarcane under salinity and drought stresses ▶     Jinlong Guo, Hui Ling, Qibin Wu et al.     Sugarcane (Saccharum spp. hybrids) is a world-wide cash crop for sugar and biofuel in tropical and subtropical regions and suffers serious losses in cane yield and sugar content …             Cotton-based Diagnostic Devices ▶     Shang-Chi Lin, Min-Yen Hsu, Chen-Meng Kuan et al.     A good diagnostic procedure avoids wasting medical resources, is easy to use, resists contamination, and provides accurate information quickly to allow for rapid follow-up …             Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy ▶     Konstantin P. Tamarov, Liubov A. Osminkina, Sergey V. Zinovyev et al.     Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively …             A Computer Model of Insect Traps in a Landscape ▶     Nicholas C. Manoukis, Brian Hall, Scott M. Geib     Attractant-based trap networks are important elements of invasive insect detection, pest control, and basic research programs. We present a landscape-level, spatially explicit …             RhoA and Membrane Fluidity Mediates the Spatially Polarized Src/FAK Activation in Response to Shear Stress ▶     Bo Liu, Shaoying Lu, Ying-li Hu et al.     While Src plays crucial roles in shear stress-induced cellular processes, little is known on the spatiotemporal pattern of high shear stress (HSS)-induced Src activation. HSS …             Breastfeeding experience differentially impacts recognition of happiness and anger in mothers ▶     Kathleen M. Krol, Sunjeev K. Kamboj, H. Valerie Curran et al.     Breastfeeding is a dynamic biological and social process based on hormonal regulation involving oxytocin. While there is much work on the role of breastfeeding in infant …             Uncoupling of microbial community structure and function in decomposing litter across beech forest ecosystems in Central Europe ▶     Witoon Purahong, Michael Schloter, Marek J. Pecyna et al.     The widespread paradigm in ecology that community structure determines function has recently been challenged by the high complexity of microbial communities. Here, we investigate …             Further Improvements to Linear Mixed Models for Genome-Wide Association Studies ▶     Christian Widmer, Christoph Lippert, Omer Weissbrod et al.     We examine improvements to the linear mixed model (LMM) that better correct for population structure and family relatedness in genome-wide association studies (GWAS). LMMs rely …             Spectroscopic approach for dynamic bioanalyte tracking with minimal concentration information ▶     Nicolas Spegazzini, Ishan Barman, Narahara Chari Dingari et al.     Vibrational spectroscopy has emerged as a promising tool for non-invasive, multiplexed measurement of blood constituents - an outstanding problem in biophotonics. Here, we …             Quantum Chemical Approach to Estimating the Thermodynamics of Metabolic Reactions ▶     Adrian Jinich, Dmitrij Rappoport, Ian Dunn et al.     Thermodynamics plays an increasingly important role in modeling and engineering metabolism. We present the first nonempirical computational method for estimating standard Gibbs …             Gender specific association of a complement component 3 polymorphism with polypoidal choroidal vasculopathy ▶     Ke Liu, Timothy Y. Y. Lai, Sylvia W. Y. Chiang et al.     Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are leading causes of irreversible blindness in developed countries. In this study, …             Comparative metabolomic and ionomic approach for abundant fishes in estuarine environments of Japan ▶     Seiji Yoshida, Yasuhiro Date, Makiko Akama et al.     Environmental metabolomics or ionomics is widely used to characterize the effects of environmental stressors on the health of aquatic organisms. However, most studies have …             PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner ▶     Fanhua Wei, Yuying Zhang, Jinlong Jian et al.     This study was aimed to determine the role and regulation of progranulin (PGRN) in the pathogenesis of inflammatory bowel diseases (IBD). Dextran sulfate sodium (DSS)−, …             From cartoon to real time MRI: in vivo monitoring of phagocyte migration in mouse brain ▶     Yuki Mori, Ting Chen, Tetsuya Fujisawa et al.     Recent studies have demonstrated that immune cells play an important role in the pathogenesis of many neurological conditions. Immune cells constantly survey the brain …             Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells ▶     Kazuaki Tokunaga, Noriko Saitoh, Ilya G. Goldberg et al.     Non-invasive evaluation of cell reprogramming by advanced image analysis is required to maintain the quality of cells intended for regenerative medicine. Here, we constructed …             Interlocking-based attachment during locomotion in the beetle Pachnoda marginata (Coleoptera, Scarabaeidae) ▶     Philipp Bußhardt, Daniel Kunze, Stanislav N. Gorb     The attachment function of tibial spurs and pretarsal claws in the beetle Pachnoda marginata (Coleoptera, Scarabaeidae) during locomotion was examined in this study. First, we …             Optimization of preservation and processing of sea anemones for microbial community analysis using molecular tools ▶     Joana Rocha, Francisco J. R. C. Coelho, Luísa Peixe et al.     For several years, knowledge on the microbiome associated with marine invertebrates was impaired by the challenges associated with the characterization of bacterial communities. …             Reduction of metastatic and angiogenic potency of malignant cancer by Eupatorium fortunei via suppression of MMP-9 activity and VEGF production ▶     Aeyung Kim, Minju Im, Nam-Hui Yim et al.     Eupatorium fortunei has long been used to treat nausea and poor appetite, and has been prescribed as a diuretic and detoxifying drug in Chinese medicine. Recent studies have …             Watching novice action degrades expert motor performance: Causation between action production and outcome prediction of observed actions by humans ▶     Tsuyoshi Ikegami, Gowrishankar Ganesh     Our social skills are critically determined by our ability to understand and appropriately respond to actions performed by others. However despite its obvious importance, the …             Rer1 and calnexin regulate endoplasmic reticulum retention of a peripheral myelin protein 22 mutant that causes type 1A Charcot-Marie-Tooth disease ▶     Taichi Hara, Yukiko Hashimoto, Tomoko Akuzawa et al.     Peripheral myelin protein 22 (PMP22) resides in the plasma membrane and is required for myelin formation in the peripheral nervous system. Many PMP22 mutants accumulate in excess …             Distinct composition of the oral indigenous microbiota in South Korean and Japanese adults ▶     Toru Takeshita, Kazuki Matsuo, Michiko Furuta et al.     A comparison of national surveys on oral health suggested that the population of South Korea has a better periodontal health status than that of Japan, despite their similar …                     • Careers & Jobs           naturejobs.com Science jobs of the week       Research Fellow     Dana-Farber Cancer Institute (DFCI)            Research Fellow     The University of Warwick            Research Associate / Senior Research Associate x 2     University College London (UCL)            Project leader position in Proteomics (m / f)     Leibniz-Institut für Analytische Wissenschaften ISAS e.V.            Research Technician     de Duve Institute            Postdoctoral Fellowship     Wayne State University            Rice Scholar Postdoctoral Program.     Rice University            Postdoctoral Research Fellow     University of Edinburgh            Group Leader Position     IMBA-Institute of Molecular Biotechnology            Medical Statistician     University of Oxford          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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