The EMBO Journal Table of Contents for 1 October 2014; Vol. 33, No. 19

1 October 2014 | Volume 33, Number 19 Submit Table of Contents Have you seen? Review Articles Volume 33, Number 19 Have you seen? Taming the young and restless—epigenetic gene regulation in pancreas and beta‐cell precursors A new study reports genome‐wide occupancy maps of H3K27me3 during pancreatic progenitor differentiation. The functional perturbation of Ezh2 increases endocrine progenitor fate and could thus inform therapeutically relevant differentiation protocols. Holger A Russ and Matthias Hebrok Published online 25.08.2014 A near death experience: Shigella manipulates host death machinery to silence innate immunity Andree and colleagues report that an intracellular bacterial pathogen exploits apoptotic machinery to suppress host immune signaling, yet avoids cell death. Denise N Bronner and Mary XD O'Riordan Published online 01.09.2014 A tail of new lipids Dictyostelium inositol lipids have unique glycerol backbones, indicating that different lipid tails have evolved to serve specific functions. Gerald R V Hammond and Tamas Balla Published online 01.09.2014 Review A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles Damaged mitochondria are eliminated via mitophagy to prevent cell death. To preserve mitochondria, oxidized proteins can be shuttled away in mitochondrial derived vesicles that also provide a general trafficking route from mitochondria to other organelles. Ayumu Sugiura, Gian‐Luca McLelland, Edward A Fon, and Heidi M McBride Published online 08.08.2014 Articles Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification The in vivo analysis of Ezh2‐dependent H3K27me3‐dynamics during pancreatic endocrine specification could instruct optimized ES cell differentiation for future therapeutic application. Cheng‐Ran Xu, Lin‐Chen Li, Greg Donahue, Lei Ying, Yu‐Wei Zhang, Paul Gadue, and Kenneth S Zaret Published online 08.08.2014 BID‐dependent release of mitochondrial SMAC dampens XIAP‐mediated immunity against Shigella Invasive Shigella bacteria co‐opt the mitochondrial XIAP antagonist SMAC in ways that selectively decrease antibacterial inflammatory responses without triggering host cell apoptosis. Maria Andree, Jens M Seeger, Stephan Schüll, Oliver Coutelle, Diana Wagner‐Stippich, Katja Wiegmann, Claudia M Wunderlich, Kerstin Brinkmann, Pia Broxtermann, Axel Witt, Melanie Fritsch, Paola Martinelli, Harald Bielig, Tobias Lamkemeyer, Elena I Rugarli, Thomas Kaufmann, Anja Sterner‐Kock, F Thomas Wunderlich, Andreas Villunger, L Miguel Martins, Martin Krönke, Thomas A Kufer, Olaf Utermöhlen, and Hamid Kashkar Published online 23.07.2014 Dictyostelium uses ether‐linked inositol phospholipids for intracellular signalling A new mass spectrometry technique reveals that inositol phospholipids in Dictyostelium are based on a novel backbone. These plasmanyl inositides are functionally identical to the canonical diacyl glycerol configurations found in mammalian cells. Jonathan Clark, Robert R Kay, Anna Kielkowska, Izabella Niewczas, Louise Fets, David Oxley, Len R Stephens, and Phillip T Hawkins Published online 01.09.2014 Post‐transcriptional gene expression control by NANOS is up‐regulated and functionally important in pRb‐deficient cells Post‐transcriptional gene expression control by NANOS is up‐regulated and functionally important in pRb‐deficient cells. Interplay of transcriptional and posttranscriptional gene regulation explains how cells with mutations in the retinoblastoma tumor suppressor can contribute relatively normally to tissues in mice and flies. Wayne O Miles, Michael Korenjak, Lyra M Griffiths, Michael A Dyer, Paolo Provero, and Nicholas J Dyson Published online 06.08.2014 The miR‐379/miR‐410 cluster at the imprinted Dlk1‐Dio3 domain controls neonatal metabolic adaptation Maternal expression of the imprinted miRNA cluster miR‐379/miR‐410 is central for metabolic adaptation in new‐born mice, uncovering a physiological role for these miRNAs in regulating neonatal hepatic gene expression. Stéphane Labialle, Virginie Marty, Marie‐Line Bortolin‐Cavaillé, Magali Hoareau‐Osman, Jean‐Philippe Pradère, Philippe Valet, Pascal GP Martin, and Jérôme Cavaillé Published online 14.08.2014 MiR‐134‐dependent regulation of Pumilio‐2 is necessary for homeostatic synaptic depression The neuronal activity regulated miR‐134/Pum2/Plk2 pathway mediates synaptic depression in primary hippocampal neurons by inhibiting the AMPA‐type glutamate receptor GluA2. Roberto Fiore, Marek Rajman, Chrysovalandis Schwale, Silvia Bicker, Anna Antoniou, Claus Bruehl, Andreas Draguhn, and Gerhard Schratt Published online 05.08.2014 Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon This study reports first evidence for tubulin glycylation to affect the establishment and maintenance of primary cilia. Functional abrogation of tubulin glycine ligases impacts cell proliferation and tumor onset. Cecilia Rocha, Laura Papon, Wulfran Cacheux, Patricia Marques Sousa, Valeria Lascano, Olivia Tort, Tiziana Giordano, Sophie Vacher, Benedicte Lemmers, Pascale Mariani, Didier Meseure, Jan Paul Medema, Ivan Bièche, Michael Hahne, and Carsten Janke Published online 01.09.2014 The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess The fungal transcription factor HapX is involved in adaptation to both iron starvation and excess. HapX and the CCAAT‐binding complex cooperatively bind to the promoter of the vacuolar iron transporter gene and regulate its expression to control vacuolar iron storage. Fabio Gsaller, Peter Hortschansky, Sarah R Beattie, Veronika Klammer, Katja Tuppatsch, Beatrix E Lechner, Nicole Rietzschel, Ernst R Werner, Aaron A Vogan, Dawoon Chung, Ulrich Mühlenhoff, Masashi Kato, Robert A Cramer, Axel A Brakhage, and Hubertus Haas Published online 04.08.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.