Nature contents: 02 October 2014

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Volume 514 Number 7520      nature •Visit Nature homepage •Subscribe to Nature •View Table of Contents The science that matters. Every week.               Quickly Identify Disease-Causing Variants. HGMD® Professional is the most widely used reference on inherited disease mutations. Quickly access detailed reports without time consuming literature searches and verify whether an observed mutation is novel or has been previously described. Doing high-throughput mapping for NGS variant analysis? Learn to prioritize mutations using BIOBASE's companion tool - Genome Trax™. Try it now!       Jump to the content that matters to you View Table of Contents ▶ ▼ News & Comment   ▼ Biological Sciences   ▼ Health Sciences   ▼ Physical Sciences   ▼ Earth & Environmental Sciences   ▼ Careers & Jobs       This week's highlights     Biological Sciences More Biological sciences ▼   Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp   This study shows that ZMapp, the optimized cocktail of three monoclonal antibodies that has been pressed into clinical use in response to the current Ebola virus disease epidemic, was able to rescue all of 18 Rhesus macaques when treatment was initiated up to five days post-infection. All three controls had died by day eight.       Physical Sciences More Physical sciences ▼   Structure and evolution of the lunar Procellarum region as revealed by GRAIL gravity data   Clues about the origin of the Moon's Procellarum – a large region previously interpreted to be an ancient impact basin – are provided in an analysis of data from NASA's GRAIL mission. Analysis of gravity anomalies suggests that surface features, previously interpreted as remnants of an impact basin rim, are instead the remains of the magma plumbing system for much of the volcanism in this region. The pattern of structures is strikingly similar to the structures seen on Saturn’s moon Enceladus, which may have experienced a similar geodynamic history.       Earth & Environmental Sciences More Earth & Environmental sciences ▼   Prevalence of viscoelastic relaxation after the 2011 Tohoku-oki earthquake   This paper presents revised estimates of the afterslip following the 2011 Tohoku-oki earthquake. Based on seafloor GPS observations made immediately after the earthquake, Tianhaozhe Sun et al. obtain clear evidence for the dominant role of viscoelastic relaxation in short-term postseismic deformation, rather than elastic afterslip on the fault as is commonly assumed. They conclude that models which erroneously assume an elastic Earth substantially overestimate afterslip downdip of the rupture zone, and underestimate afterslip updip.                 Podcast & Video     In this week's podcast: the bugs that call our skin their home, excessive water use in Asia, and what's made crazy shapes on the surface of the Moon?         News & Comment Read daily news coverage▶ ▲top               THIS WEEK           Editorials                   Retraction challenges ▶     Cleaning up the literature can be difficult.             Warming up ▶     Prospects for international agreement on combating climate change look brighter.             BRAIN gain ▶     A mixture of focus and innovation is the way forward for big neuroscience.             World View                   Water politics must adapt to a warming world ▶     As rainfall patterns shift, technological and legislative changes are needed to address water shortages, says Moshe Alamaro.             Seven Days                   Seven days: 26 September–2 October ▶     The week in science: Japanese volcano erupts, India's Mars mission enters orbit, and Obama orders massive expansion of marine reserve.             NEWS IN FOCUS           Fast genetic sequencing saves newborn lives ▶     Infants with mysterious conditions stand to benefit — but technique raises ethical questions.             Biopiracy ban stirs red-tape fears ▶     Critics worry Nagoya Protocol will hamper disease monitoring.             Ebola outbreak shuts down malaria-control efforts ▶     Public-health experts fear that one epidemic may fuel another in West Africa.             Tibetan plateau gets wired up for monsoon prediction ▶     Largest and highest plateau in the world has outsized impact on climate.             Forensic chemistry could stop African plant thieves ▶     Isotope analysis could help in the rush to save South Africa's cycads from extinction.             Astronomy data bounty spurs debate over access ▶     Small institutions fear exclusion from Large Synoptic Survey Telescope's benefits.             Features                   Astronomy: To catch a cosmic ray ▶     The Pierre Auger Observatory in Argentina has spent almost ten years looking for the source of ultra-high-energy cosmic rays — but to no avail. Now the observatory faces an uncertain future.             The first South Americans: Extreme living ▶     After humans arrived in South America, they quickly spread into some of its most remote corners.             COMMENT           Resources: Curb vast water use in central Asia ▶     Irrigation-intensive industries in former Soviet republics have sucked water bodies dry. Olli Varis calls for economic reform to ease environmental and social tensions.             Climate policy: Ditch the 2 °C warming goal ▶     Average global temperature is not a good indicator of planetary health. Track a range of vital signs instead, urge David G. Victor and Charles F. Kennel.             Books and Arts                   Computing history: Geeks, Inc. ▶     Jennifer Light enjoys a chronicle of the collaborations that conjured the digital realm.             Books in brief ▶     Barbara Kiser reviews five of the week's best science picks.             Genetics: The neighbourly nature of evolution ▶     Mark Pagel relishes an analysis of how natural selection riffles through life's immense genetic library.             Correspondence                   Scientific misconduct: Research integrity guidelines in Japan Masanori Wada | Preventative care: Lung-cancer screens now worth the cost Laurie Fenton-Ambrose, Ella A. Kazerooni | Society: Protect privacy of mobile data Caroline O. Buckee | Environment: Invest in renewable energy in Tibet Gang Liu, Mario Lucas | Psychosocial models: Focus on positive features of ageing Theodore D. Cosco, Carol Brayne, Blossom C. M. Stephan             Correction                   Correction ▶                 Biological Sciences ▲top             RESEARCH           Latest Online                   Evolutionary biology: Survival of the fittest group ▶     Timothy Linksvayer             Immunology: Starve a fever, feed the microbiota ▶     Seth Rakoff-Nahoum, Laurie E. Comstock             Genomics: Of monarchs and migration ▶     Richard H. Ffrench-Constant             Lung disease: Treatment by cell transplant ▶     Mary Jane Thomassen, Mani S. Kavuru             Animal behaviour: Incipient tradition in wild chimpanzees ▶     Andrew Whiten             Pulmonary macrophage transplantation therapy ▶     Takuji Suzuki, Paritha Arumugam, Takuro Sakagami et al.     This study reports the correction of pulmonary alveolar proteinosis (PAP) in Csf2rb–/– mice by a single transfer of either wild-type or gene-corrected macrophages directly to the lungs — the transplanted macrophages persisted for at least 1 year; this transplantation strategy obviated the need for myeloablation and immunosuppression and should be a feasible therapy for humans with hereditary PAP.             The genetics of monarch butterfly migration and warning colouration ▶     Shuai Zhan, Wei Zhang, Kristjan Niitepõld et al.     The monarch butterfly, well known for its spectacular annual migration across North America, is shown by genome sequencing of monarchs from around the world to have been ancestrally migratory and to have dispersed out of North America to occupy its current broad distribution; the authors also discovered signatures of selection associated with migration within loci implicated in flight muscle function, leading to greater flight efficiency.             An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons ▶     Frank M. J. Jacobs, David Greenberg, Ngan Nguyen et al.     The authors show that two primate-specific genes encoding KRAB domain containing zinc finger proteins, ZNF91 and ZNF93, have evolved during the last 25 million years to repress retrotransposon families that emerged during this time period; according to the new data KZNF gene expansion limits the activity of newly emerged retrotransposons, which subsequently mutate to evade repression.             Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma ▶     Jagan R. Muppidi, Roland Schmitz, Jesse A. Green et al.     Inactivation of the S1PR2–Gα13–ARHGEF1 signalling pathway in mice allows Akt activation and promotes dissemination of germinal centre B cells, consistent with a role of function-disrupting mutations in the systemic dissemination of diffuse large B-cell lymphoma.             Programmable RNA recognition and cleavage by CRISPR/Cas9 ▶     Mitchell R. O’Connell, Benjamin L. Oakes, Samuel H. Sternberg et al.     In the presence of a short DNA oligonucleotide containing a protospacer adjacent motif, a guide-RNA-programmed Cas9 is able to specifically bind and/or cleave single-stranded RNA—this system can be used to isolate specific endogenous RNA transcripts from a cell lysate without any tag or modification.             Dietary modulation of the microbiome affects autoinflammatory disease ▶     John R. Lukens, Prajwal Gurung, Peter Vogel et al.     Pstpip2-mutant mice fed a high-fat diet are protected against inflammatory bone disease and bone erosion; this protection is associated with reductions in intestinal Prevotella levels and pro-IL-1β expression, and is dependent on the deletion of both caspases 1 and 8.             Site-specific group selection drives locally adapted group compositions ▶     Jonathan N. Pruitt, Charles J. Goodnight     Here, colonies of social spiders are used to investigate the evolution of a group-level trait, the ratio of individuals with the ‘docile’ versus ‘aggressive’ phenotype in a colony; experimental colonies were generated with varying ratios and established in the wild, revealing group-level selection.             Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection ▶     Mark W. Pellegrino, Amrita M. Nargund, Natalia V. Kirienko et al.     A link between an intracellular stress response, bacterial infection and triggering of the innate immune response is shown in Caenorhabditis elegans; exposure to the pathogen Pseudomonas aeruginosa caused activation of the transcription factor ATFS-1 and innate immunity that is regulated by the mitochondrial unfolded protein response.             Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness ▶     Joseph M. Pickard, Corinne F. Maurice, Melissa A. Kinnebrew et al.     Systemic exposure to Toll-like receptor (TLR) ligands during sickness is shown to induce fucosylation of the small intestine in mice; some of the fucose is shed into the intestinal lumen, where it provides nourishment for the microbiota.             The complete structure of the large subunit of the mammalian mitochondrial ribosome ▶     Basil J. Greber, Daniel Boehringer, Marc Leibundgut et al.     The structure of the 39S large mitoribosome subunit is solved by cryo-electron microscopy at an impressive 3.4 Å resolution, revealing the location of 50 ribosomal proteins, the peptidyl transferase centre, the tRNAs within this active site, and the nascent peptide chain within the exit tunnel.             Articles and Letters                   Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp ▶     Xiangguo Qiu, Gary Wong, Jonathan Audet et al.     A new treatment, containing an optimized cocktail of three monoclonal antibodies against Ebola virus, provided full protection and disease reversal in rhesus monkeys when given under conditions in which controls succumbed by day 8; this new therapy may be a good candidate for treating Ebola virus infection in human patients.             Molecular basis of adaptation to high soil boron in wheat landraces and elite cultivars ▶     Margaret Pallotta, Thorsten Schnurbusch, Julie Hayes et al.     Adaptation of wheat to environments where growth is limited by boron toxicity has resulted from multiple genomic changes and selection for functionally diverse alleles.             Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity ▶     Andriy Marusyk, Doris P. Tabassum, Philipp M. Altrock et al.     To investigate the role of sub-clonal tumour heterogeneity in cancer progression, a mouse xenograft model was used which revealed that tumour growth can be driven by a minor cell subpopulation by a non-cell-autonomous mechanism, although this minor subpopulation can be outcompeted by faster proliferating competitors.             Biogeography and individuality shape function in the human skin metagenome ▶     Julia Oh, Allyson L. Byrd, Clay Deming et al.     Previous work has shown that human skin is home to a rich and varied microbiota; here a metagenomic approach for samples from physiologically diverse body sites illuminates that the skin microbiota, including bacterial, fungal and viral members, is shaped by the local biogeography and yet marked by strong individuality.             Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche ▶     John R. B. Perry, Felix Day, Cathy E. Elks et al.     Here 106 genomic loci associated with age at menarche, a marker of puberty timing in females, are identified; these loci show enrichment for genes involved in nuclear hormone receptor function, body mass index, and rare disorders of puberty, and for genes located in imprinted regions, with parent-of-origin specific effects at several loci.             The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function ▶     Diogo Fonseca-Pereira, Sílvia Arroz-Madeira, Mariana Rodrigues-Campos et al.     Haematopoietic stem cells are direct targets for neurotrophic factors, indicating that haematopoietic stem cells and neurons are regulated by similar signals.             A long noncoding RNA protects the heart from pathological hypertrophy ▶     Pei Han, Wei Li, Chiou-Hong Lin et al.     Here, a long noncoding RNA, termed Mhrt, is identified in the loci of myosin heavy chain (Myh) genes in mice and shown to be capable of suppressing cardiomyopathy in the animals, as well as being repressed in diseased human hearts.             DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier ▶     Margarida A. Santos, Robert B. Faryabi, Aysegul V. Ergen et al.     Histone methyl-transferase MLL4 is required for stem-cell activity and an aggressive form of acute myeloid leukaemia harbouring the MLL–AF9 oncogene.             Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy ▶     Bernardo Tavora, Louise E. Reynolds, Silvia Batista et al.     The tumour microenvironment can influence its response to anticancer therapies; here, the enzyme FAK in endothelial cells is shown to have a role in the induction of a number of cytokines during chemotherapy or irradiation, which in turn protect tumours from DNA-damaging agents.             Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast ▶     Brian M. Zid, Erin K. O’Shea     Transcription and translation are generally thought of as disconnected processes in eukaryotes; however, under starvation conditions in yeast, the promoter sequence influences not only messenger RNA levels but also several processes downstream of transcription, including the localization of mRNA within the cytoplasm and the translation rate of mRNA.             Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks ▶     Elda Cannavo, Petr Cejka     The MRX complex, required for double-strand break (DSB) repair by homologous recombination, has 3′ to 5′ exonuclease activity, but homologous recombination at a DSB uses a 3′-tailed molecule, which requires resection of the 5′ strand; here it is shown that in yeast, Sae2 nuclease promotes MRX to make an initial endonucleolytic cut on the 5′ strand that may allow MRX to digest the 5′ strand back to the end in a 3′ to 5′ fashion.             News & Views                   DNA repair: Making the cut ▶     Lorraine S. Symington             Medical research: Ebola therapy protects severely ill monkeys ▶     Thomas W. Geisbert             50 & 100 Years Ago ▶             Microbiology: An integrated view of the skin microbiome ▶     Patrick D. Schloss             Evolutionary biology: Survival of the fittest group ▶     Timothy Linksvayer             Immunology: Starve a fever, feed the microbiota ▶     Seth Rakoff-Nahoum, Laurie E. Comstock             Genomics: Of monarchs and migration ▶     Richard H. Ffrench-Constant             Lung disease: Treatment by cell transplant ▶     Mary Jane Thomassen, Mani S. Kavuru             Animal behaviour: Incipient tradition in wild chimpanzees ▶     Andrew Whiten             Brief Communications Arising                   Inhibition of demethylases by GSK-J1/J4 ▶     Bo Heinemann, Jesper Morten Nielsen, Heidi Rye Hudlebusch et al.             Kruidenier et al. reply ▶     Laurens Kruidenier, Chun-wa Chung, Zhongjun Cheng et al.             Another explanation for apparent epistasis ▶     Andrew R. Wood, Marcus A. Tuke, Mike A. Nalls et al.             Hemani et al. reply ▶     Gibran Hemani, Konstantin Shakhbazov, Harm-Jan Westra et al.             Corrigenda                   Corrigendum: Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators ▶     Daniel W. Bellott, Jennifer F. Hughes, Helen Skaletsky et al.             Corrigendum: Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells ▶     Ryan Lister, Mattia Pelizzola, Yasuyuki S. Kida et al.             Research Highlights                   Ig Nobel prizes provide fun fodder | Palaeontology: Amphibian regrew limbs long ago | Neuroscience: Paralysed rats stimulated to walk | Cancer: Vitamin D boosts cancer treatment | Ecology: Dingo destruction okay for prey | Archaeology: Stone tools not out of Africa | Physiology: Ancient roots of daily rhythm         NEWS & COMMENT           Ebola outbreak shuts down malaria-control efforts | Books in brief | Genetics: The neighbourly nature of evolution | Preventative care: Lung-cancer screens now worth the cost | Psychosocial models: Focus on positive features of ageing | BRAIN gain | Fast genetic sequencing saves newborn lives | Biopiracy ban stirs red-tape fears | Forensic chemistry could stop African plant thieves             More Biological Sciences ▶                 Nature Communications soon to be fully open access: From 20th October Nature Communications, will become fully open access for all new submissions. If an author has a manuscript they wish to submit to the journal via the subscription route, they must submit before 20th October. After this date all new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For any questions on the switch, open access or advice on policies and funding, visit our website, read the press release or contact our dedicated support team at openaccess@nature.com         Health Sciences ▲top             RESEARCH           Latest Online                   Lung disease: Treatment by cell transplant ▶     Mary Jane Thomassen, Mani S. Kavuru             Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma ▶     Jagan R. Muppidi, Roland Schmitz, Jesse A. Green et al.     Inactivation of the S1PR2–Gα13–ARHGEF1 signalling pathway in mice allows Akt activation and promotes dissemination of germinal centre B cells, consistent with a role of function-disrupting mutations in the systemic dissemination of diffuse large B-cell lymphoma.             Articles and Letters                   Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity ▶     Andriy Marusyk, Doris P. Tabassum, Philipp M. Altrock et al.     To investigate the role of sub-clonal tumour heterogeneity in cancer progression, a mouse xenograft model was used which revealed that tumour growth can be driven by a minor cell subpopulation by a non-cell-autonomous mechanism, although this minor subpopulation can be outcompeted by faster proliferating competitors.             A long noncoding RNA protects the heart from pathological hypertrophy ▶     Pei Han, Wei Li, Chiou-Hong Lin et al.     Here, a long noncoding RNA, termed Mhrt, is identified in the loci of myosin heavy chain (Myh) genes in mice and shown to be capable of suppressing cardiomyopathy in the animals, as well as being repressed in diseased human hearts.             DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier ▶     Margarida A. Santos, Robert B. Faryabi, Aysegul V. Ergen et al.     Histone methyl-transferase MLL4 is required for stem-cell activity and an aggressive form of acute myeloid leukaemia harbouring the MLL–AF9 oncogene.             Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy ▶     Bernardo Tavora, Louise E. Reynolds, Silvia Batista et al.     The tumour microenvironment can influence its response to anticancer therapies; here, the enzyme FAK in endothelial cells is shown to have a role in the induction of a number of cytokines during chemotherapy or irradiation, which in turn protect tumours from DNA-damaging agents.             News & Views                   Medical research: Ebola therapy protects severely ill monkeys ▶     Thomas W. Geisbert             Lung disease: Treatment by cell transplant ▶     Mary Jane Thomassen, Mani S. Kavuru             Research Highlights                   Ig Nobel prizes provide fun fodder | Cancer: Vitamin D boosts cancer treatment         NEWS & COMMENT           Preventative care: Lung-cancer screens now worth the cost             More Health Sciences ▶               Physical Sciences ▲top             RESEARCH           Articles and Letters                   HCN ice in Titan’s high-altitude southern polar cloud ▶     Remco J. de Kok, Nicholas A. Teanby, Luca Maltagliati et al.     The cloud that appeared above the south pole of Saturn’s satellite Titan in early 2012 is found to be composed of micrometre-sized particles of frozen hydrogen cyanide, indicating a dramatic cooling of Titan’s atmosphere to temperatures about 100 degrees less than predicted by atmospheric circulation models.             Experimental realization of universal geometric quantum gates with solid-state spins ▶     C. Zu, W.-B. Wang, L. He et al.     The manipulation of spins in a solid-state system — nitrogen–vacancy defects in diamond — allows the experimental realization of a universal set of geometric quantum gates using holonomies, that is, non-Abelian generalizations of the Berry phase, and offers a scalable platform with the potential for room-temperature quantum computing.             Evanescent-wave and ambient chiral sensing by signal-reversing cavity ringdown polarimetry ▶     Dimitris Sofikitis, Lykourgos Bougas, Georgios E. Katsoprinakis et al.     By passing light through a chiral sample — here vapours and solutions — in a specially designed ring cavity, the resulting chiral signals can be isolated from the achiral backgrounds and enhanced by a factor of more than 1,000, making them detectable in situations where conventional means of measurement fail.             News & Views                   Solar system: Not just a storm in a teacup ▶     Caitlin A. Griffith             Astronomy: The age of the quasars ▶     Daniel Mortlock             Research Highlights                   Ig Nobel prizes provide fun fodder | Nanotechnology: Microphone made from a molecule | Astrophysics: Space ripples could pump up stars         NEWS & COMMENT           Astronomy: To catch a cosmic ray | Computing history: Geeks, Inc. | Genetics: The neighbourly nature of evolution | Astronomy data bounty spurs debate over access | Forensic chemistry could stop African plant thieves             More Physical Sciences ▶               Earth & Environmental Sciences ▲top             RESEARCH           Latest Online                   High winter ozone pollution from carbonyl photolysis in an oil and gas basin ▶     Peter M. Edwards, Steven S. Brown, James M. Roberts et al.     Data from the oil- and gas-producing basin of northeastern Utah and a box model are used to assess the photochemical reactions of nitrogen oxides and volatile organic compounds that lead to excessive atmospheric ozone pollution in winter.             Articles and Letters                   Structure and evolution of the lunar Procellarum region as revealed by GRAIL gravity data ▶     Jeffrey C. Andrews-Hanna, Jonathan Besserer, James W. Head III et al.     Gravity data show a rectangular pattern of narrow linear anomalies bordering the lunar Procellarum region that are interpreted to be the frozen remnants of lava-filled rifts and underlying feeder dykes.             Direct observations of evolving subglacial drainage beneath the Greenland Ice Sheet ▶     Lauren C. Andrews, Ginny A. Catania, Matthew J. Hoffman et al.     Simultaneous observations of moulins and boreholes in western Greenland show that water delivery to the base of the ice sheet via moulins affects short-term ice velocity fluctuations, but not late-season ice velocity decelerations.             Prevalence of viscoelastic relaxation after the 2011 Tohoku-oki earthquake ▶     Tianhaozhe Sun, Kelin Wang, Takeshi Iinuma et al.     Seafloor Global Positioning System observations immediately after the great 2011 Tohoku-oki earthquake provide unambiguous evidence for the dominant role of viscoelastic relaxation in short-term postseismic deformation, rather than just afterslip on the fault as is commonly assumed.             News & Views                   Geoscience: The plumbing of Greenland's ice ▶     Peter Nienow             Solar system: Not just a storm in a teacup ▶     Caitlin A. Griffith             Research Highlights                   Palaeoclimate: Winds favoured Pacific exploration         NEWS & COMMENT           The first South Americans: Extreme living | Resources: Curb vast water use in central Asia | Climate policy: Ditch the 2 °C warming goal | Tibetan plateau gets wired up for monsoon prediction | Environment: Invest in renewable energy in Tibet | Water politics must adapt to a warming world | Forensic chemistry could stop African plant thieves             More Earth & Environmental Sciences ▶               Special - Toolbox ▲top               Toolbox: Scientific writing: the online cooperative ▶     Collaborative browser-based tools aim to change the way researchers write and publish their papers.                 A picture of health n a series of four films reporter Lorna Stewart travels to the German island of Lindau to meet 600 of science’s brightest young minds and 37 rock stars – Nobel laureates. Watch the full series of films including this week’s release The long goodbye with Hans Rosling and Oliver Smithies. nature.com/lindau/2014  Supported by Mars, Incorporated and published weeky from Sep 24th - Oct 15th          Careers & Jobs ▲top               At the bench: The right mix ▶     Staffing a lab is fraught with complexity, so new team leaders can learn a lot from the experience of others.                   Turning point: Juan David Ramírez ▶     Colombian virologist leverages fellowship to fight infectious diseases in Latin America             Careers related news & comment                   Books in brief Barbara Kiser | Scientific misconduct: Research integrity guidelines in Japan Masanori Wada | Retraction challenges | Seven days: 26 September–2 October | Astronomy data bounty spurs debate over access Mark Zastrow               naturejobs.com Science jobs of the week       Research Associate / Fellow     The University of Nottingham            PhD fellowship     Imperial College London            Two Post doctoral researchers     The Sainsbury Laboratory (TSL)            Nutrition Scientist     Nestlé Research Center (NRC)          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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