EMBO reports Table of Contents for October 2014; Vol. 15, No. 10

October 2014 | Volume 15, Number 10 Submit Table of Contents Editorial Science & Society Reviews Scientific Reports Corrigendum Volume 15, Number 10 Editorial Safe European home I have a dream…. that one day top‐quality science will be practised all over the world. Howy Jacobs Published online 01.10.2014 Science & Society Finding planets and life among the stars: For the first time in history, mankind has the tools to look for other planets and whether these might host life Are we alone in the universe? For the first time in its history, humankind has the tools to look for potentially habitable planets and discern whether they too have evolved life. Margaret C Turnbull Published online 17.09.2014 From challenges to perspectives: Reflections of young scientists on the current state of academic research The imbalance between the growing number of PhD graduates and the stagnating number of research positions damages science and scientists alike. With the world facing serious challenges in climate and health, governments need to redress the balance to create a solid research base. Kevin Titeca, Liesbeth Aerts, Michiel Krols, Lana Vandersarren, Özden Akay, Şule Yılmaz, Nevena Hristozova, and Michal Janiak Published online 12.09.2014 The Babylonian benefit: Neurological research shows that being bilingual enhances mental performance and may protect from Alzheimer's disease Speaking two languages has a positive effect on cognition and might even delay the onset of neurodegenerative diseases. Researchers are just beginning to unravel the neurological underpinnings of this bilingual advantage. Katrin Weigmann Published online 09.09.2014 The genetics of human migrations: Our ancestors migration out of Africa has left traces in our genomes that explain how they adapted to new environments Genomics is unraveling the migratory history of modern humans. Knowledge about how they adapted to new environments and pathogens has implications for human health today and may also help to counter the toxic notion of “races”. Philip Hunter Published online 12.09.2014 Reviews Cellular and molecular basis of decision‐making People think to be in control of their decisions. Recent research identifying molecular and cellular mechanisms that underlie decision‐making behaviour in model organisms suggests that it goes beyond the control of reason. Nilay Yapici, Manuel Zimmer, and Ana I Domingos Published online 19.09.2014 Cholesterol in brain disease: sometimes determinant and frequently implicated Cholesterol is well known to be essential for normal brain and neuron function. This review discusses how defects in cholesterol metabolism might contribute to neurological syndromes, either as a cause or a consequence of these serious illnesses. Mauricio G Martín, Frank Pfrieger, and Carlos G Dotti Published online 15.09.2014 Scientific Reports Autophagy‐related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex This study shows that Atg5 promotes astrocyte differentiation during embryonic brain development through autophagic degradation of SOCS2 and activation of the JAK2‐STAT3 pathway. Shukun Wang, Baoguo Li, Huimin Qiao, Xiaohui Lv, Qingli Liang, Zixiao Shi, Wenlong Xia, Fen Ji, and Jianwei Jiao Published online 15.09.2014 Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion This study shows that both p53 and p21WAF1 bind to Slug and cooperate to promote the Mdm2‐dependent degradation of Slug, thus suppressing cell invasion. Jongdoo Kim, Seunghee Bae, Sungkwan An, Jong Kuk Park, Eun Mi Kim, Sang‐Gu Hwang, Wun‐Jae Kim, and Hong‐Duck Um Published online 20.08.2014 Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes This study provides guidelines and protocols for the accurate quantification of the specific contribution of UCP1 to thermogenesis in brown and brite/beige adipocytes. Yongguo Li, Tobias Fromme, Sabine Schweizer, Theresa Schöttl, and Martin Klingenspor Published online 18.08.2014 Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo Variously tethered ubiquitins, expressed as linear histone‐ubiquitin fusions, can substitute for native H2BK123ub in the crosstalk to H3 methylation and in the DNA damage response. This reveals a remarkable plasticity in H2Bub signaling in vivo. Hanneke Vlaming, Tibor van Welsem, Erik L de Graaf, David Ontoso, AF Maarten Altelaar, Pedro A San‐Segundo, Albert JR Heck, and Fred van Leeuwen Published online 20.08.2014 The crystal structure of the phosphatidylinositol 4‐kinase IIα The crystal structure of PI4K IIα reveals its membrane binding mode and highlights a membrane‐oriented hydrophobic pocket as a potential allosteric regulatory site. Adriana Baumlova, Dominika Chalupska, Bartosz Róźycki, Marko Jovic, Eva Wisniewski, Martin Klima, Anna Dubankova, Daniel P Kloer, Radim Nencka, Tamas Balla, and Evzen Boura Published online 28.08.2014 Tel1ATM dictates the replication timing of short yeast telomeres This study shows that the Tel1ATM checkpoint kinase is required in S phase for the early firing of origins of DNA replication located near short telomeres. The data indicate that Tel1ATM controls the timing of telomerase recruitment to short telomeres. Carol Cooley, Anoushka Davé, Mansi Garg, and Alessandro Bianchi Published online 13.08.2014 Corrigendum CATP is a critical component of the Neurospora circadian clock by regulating the nucleosome occupancy rhythm at the frequency locus Joonseok Cha, Mian Zhou, and Yi Liu Published online 01.10.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.