Nature Cell Biology contents: September 2014 Volume 16 Number 9, pp 823-917

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Advertisement BD LSRFortessa™ X-20 with ultraviolet laser  Expand your research capabilities by adding the ultraviolet channel to your multicolor flow cytometry studies. Special upgrade offers let you take advantage of a whole new spectrum of choice and productivity with a dedicated ultraviolet laser position and new ultraviolet excitable dyes. bdbiosciences.com/go/ultra TABLE OF CONTENTS September 2014 Volume 16, Issue 9 Turning Points News and Views Articles Letters Advertisement   Amnis® Imaging Flow Cytometers: Analyze Every Cell in Sight Amnis® imaging flow cytometers offer the power of digital fluorescence microscopy with the speed and sensitivity of flow cytometry. You can quickly collect and analyze quantitative results of highly heterogeneous samples and rare sub-populations at speeds of 5,000 cells per second, and view up to 12 images per cell — with a 60X microscope. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement As a workflow oriented provider of lab equipment, Eppendorf offers comprehensive solutions that are engineered with smart innovations to simplify or even eliminate cumbersome lab work. Good examples are our new Cell Culture Consumables. They are developed to facilitate the lab work while offering safety and convenience in handling.   Advertisement nature.com webcasts Macmillan Science Communication presents a custom webcast on: Understanding bacterial diversity through metagenomics 16S sequencing Wednesday September 24th, 2014 Time: 8AM PDT, 10AM CDT 11AM EDT, 4PM BST, 5PM CEST Register for the webcast and live Q and A session Sponsored by: Life Technologies    Turning Points Top Following your interests: The importance of good mentors   p823 Daniel J. Klionsky doi:10.1038/ncb3033 News and Views Top Hi-TEC reprogramming for organ regeneration   pp824 - 825 Bruno Di Stefano and Thomas Graf doi:10.1038/ncb3032 The induction of cell reprogramming by transcription factors into alternative cell fates opens new avenues for regenerative medicine. Thymic epithelial cells that were obtained from fibroblasts by Foxn1 overexpression support the formation of an ectopic thymus following transplantation. See also: Letter by Bredenkamp et al. An ABC of ciliogenesis   pp826 - 827 Pascal Barbry and Laure-Emmanuelle Zaragosi doi:10.1038/ncb3034 ABCC4 is a member of the ATP-binding cassette transporter family known to transport prostaglandin E2 and other molecules across cellular membranes. A mutation in ABCC4 is now shown to cause defects in ciliogenesis, revealing a role for prostaglandin signalling in regulating cilia dynamics. See also: Article by Jin et al. Articles Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development   pp829 - 840 Fabienne Lescroart, Samira Chabab, Xionghui Lin, Steffen Rulands, Catherine Paulissen et al. doi:10.1038/ncb3024 The heart arises from distinct progenitors. Blanpain and colleagues use clonal analysis to demonstrate that early prospective cardiac progenitors, marked by Mesp1 appearing at gastrulation, are already restricted to a particular lineage and heart region. Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport   pp841 - 851 Daqing Jin, Terri T. Ni, Jianjian Sun, Haiyan Wan, Jeffrey D. Amack et al. doi:10.1038/ncb3029 Zhong and colleagues report that zebrafish leakytail (Lkt) promotes ciliogenesis by exporting prostaglandin E2 to upregulate cAMP synthesis. A human orthologue of Lkt, ABCC4, is also important for ciliogenesis in human retinal pigment epithelial cells. See also: News and Views by Barbry & Zaragosi Cell Biology JOBS of the week Postdoctoral position studying Hippo pathway signaling in stem cell biology Boston University School of Medicine & Boston Medical Center Research Technician in Molecular and Cell Biology (100%) ETH Zurich Professor in Biochemistry and / or Cell Biology University of Fribourg / Switzerland and the Department of Biology Faculty Position in Developmental and Cell Biology The Stowers Institute for Medical Research Research Assistant The Ohio Stat University Medical Center More Science jobs from Cell Biology EVENT International Symposium on Fungal Stress ISFUS 25.10.14 São José dos Campos, Brazil More science events from Reconstitution of the augmin complex provides insights into its architecture and function   pp852 - 863 Kuo-Chiang Hsia, Elizabeth M. Wilson-Kubalek, Alejandro Dottore, Qi Hao, Kuang-Lei Tsai et al. doi:10.1038/ncb3030 The augmin complex is needed for centrosome-independent microtubule nucleation. Reconstitution and characterization of the human augmin complex by Kapoor and colleagues reveal its architecture and microtubule-binding properties. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1   pp864 - 875 Peijing Zhang, Yongkun Wei, Li Wang, Bisrat G. Debeb, Yuan Yuan et al. doi:10.1038/ncb3013 Ma and colleagues show that when the EMT-associated transcription factor ZEB1 is stabilized by the ATM kinase, it interacts with the ubiquitin protease USP7 to counteract CHK1 degradation and promote DNA repair in breast cancer cells. Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S   pp876 - 888 Lisa Sevenich, Robert L. Bowman, Steven D. Mason, Daniela F. Quail, Franck Rapaport et al. doi:10.1038/ncb3011 Joyce and colleagues analyse tumour–stroma interactions in distinct metastatic microenvironments, and show that cathepsin S promotes brain metastasis by cleaving the JAM-B junctional protein, allowing cancer cells to traverse the blood–brain barrier. Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state   pp889 - 901 Masayuki Shimoda, Simona Principe, Hartland W. Jackson, Valbona Luga, Hui Fang et al. doi:10.1038/ncb3021 Khokha and colleagues report that loss of the Timp family of metalloproteinases from stromal fibroblasts promotes a cancer-associated fibroblast phenotype and production of exosomes that stimulate cancer cell motility. Letters Top An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts   pp902 - 908 Nicholas Bredenkamp, Svetlana Ulyanchenko, Kathy Emma O’Neill, Nancy Ruth Manley, Harsh Jayesh Vaidya et al. doi:10.1038/ncb3023 Generation of functional T-cells for therapeutic purposes requires a thymic epithelium. Blackburn and colleagues show that FOXN1 expression in fibroblasts triggers the formation of functional thymic epithelial cells that support T-cell differentiation from haematopoietic progenitors. See also: News and Views by Di Stefano & Graf An extracellular-matrix-specific GEF–GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration   pp909 - 917 Matthew L. Kutys and Kenneth M. Yamada doi:10.1038/ncb3026 Yamada and colleagues report that the interaction of the ß-Pix guanine exchange nucleotide factor with the GTPase activating protein, srGAP1, regulates cell migration through collagen by activating Cdc42 and suppressing RhoA activity. 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