Drug Discovery@nature.com 1 September 2014

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TABLE OF CONTENTS 1 September 2014 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement JSH Guidelines for the Management of Hypertension 2014 -just published in Hypertension Research Hypertension Research is proud to feature The Japanese Society of Hypertension Guidelines for the Management of Hypertension 2014 (JSH 2014) in conjunction with a compilation of clinical and population studies related to the treatment of hypertension.  Access the JSH2014 today!    News Top Drug saves monkeys from close relative of Ebola doi:10.1038/nature.2014.15745 Animals spared from Marburg virus even when treated three days after infection. Full Text Anti-CGRP antibodies for migraine turn industry heads doi:10.1038/nbt0814-707a Deals and ongoing trials suggest that companies have finally worked out how to effectively and safely target calcitonin gene-related peptide, which has long been considered a viable mechanism for migraine treatment. Full Text Liquid salts by-pass skin to treat infections doi:10.1038/nature.2014.15763 Ionic liquids' can disrupt microbial biofilms or penetrate outer skin layers. Full Text The global intellectual property landscape of induced pluripotent stem cell technologies doi:10.1038/nbt.2975 Will freedom to research and innovate be restricted as the induced pluripotent stem cell field advances toward the clinic, or are concerns premature within a rapidly changing ecosystem? Full Text Analysis Top Antithrombotic drugs market doi:10.1038/nrd4365 This article investigates the antithrombotic drug pipeline and the changing landscape of the antithrombotics market. Full Text Fat chance for cancer cachexia doi:10.1038/scibx.2014.941 With no drugs on the market and a pair of recent Phase III failures in cancer-associated cachexia, companies may consider targeting the cause of the wasting disease rather than its symptoms a better therapeutic strategy. Full Text Research Highlights Top Anticancer drugs: Horizons broaden for PI3Kδ inhibitors doi:10.1038/nrd4399 Inhibitors of the p110δ isoform of PI3K could have therapeutic potential in a broad range of cancers. Full Text Analgesia: Anti-itch and anti-ouch antibody doi:10.1038/nrd4396 An antibody that targets sodium channel Nav1.7 could be useful for treating inflammatory or neuropathic pain, as well as itch-related disorders. Full Text Vaccines: HIV vaccine failure due to induction of immune suppressors? doi:10.1038/nrd4398 New findings show that vaccines can potentially induce suppressor cells and thereby dampen any specific immune responses. Full Text Research & Reviews Top Phenotypic screening in cancer drug discovery — past, present and future doi:10.1038/nrd4366 Moffat and colleagues investigate the contribution of phenotypic assays in anticancer drug development, and discuss technical and biological advances that could empower phenotypic drug discovery in oncology. Full Text Semaphorins and plexins as therapeutic targets doi:10.1038/nrd4337 Worzfeld and Offermanns summarize the pathological roles of semaphorins and plexins in cancer, bone diseases, immuno-inflammatory diseases and spinal cord injury, and discuss emerging strategies to therapeutically target these molecules. Full Text Therapeutic targeting of microRNAs: current status and future challenges doi:10.1038/nrd4359 Li and Rana discuss strategies in the design of micro RNA-targeting oligonucleotides with increased efficacy and improved in vivo delivery characteristics, and highlight some of the challenges ahead in the clinical development of these therapeutics. Full Text Drug Discovery JOBS of the week Head of Drug and RNAi Screening Platform UCLA Professorship (W2) "Phospholipids in Drug Development" Friedrich Schiller University Jena Associate Scientist I, Drug Safety Evaluation Gilead Sciences Postdoctoral Fellow, Drug Addiction Research Icahn School of Medicine at Mount Sinai More Science jobs from Drug Discovery EVENT Diabetic Kidney Disease: Drug Discovery and Clinical Development Challenges 09.12.14 New York, USA More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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