Molecular Systems Biology - New articles published - 1 Sep 2014

August 2014 | Volume 10, Number 8 Submit Table of Contents Articles Perspective Articles Corrigendum Volume 10, Number 8 Articles A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration A computational analysis based on genome‐scale metabolic models shows that the extent of the Warburg effect is highly associated with cancer cell migration across different cell lines and identifies anti‐migratory targets. Keren Yizhak, Sylvia E Le Dévédec, Vasiliki Maria Rogkoti, Franziska Baenke, Vincent C de Boer, Christian Frezza, Almut Schulze, Bob van de Water, and Eytan Ruppin Published online 01.08.2014 Specificity, propagation, and memory of pericentric heterochromatin A comprehensive analysis of the epigenetic network that silences pericentric heterochromatin (PCH) transcription in mouse fibroblasts is presented. The resulting quantitative model explains the spatial extension, stability and propagation of histone modification domains. Katharina Müller‐Ott, Fabian Erdel, Anna Matveeva, Jan‐Philipp Mallm, Anne Rademacher, Matthias Hahn, Caroline Bauer, Qin Zhang, Sabine Kaltofen, Gunnar Schotta, Thomas Höfer, and Karsten Rippe Published online 18.08.2014 Perspective Emergence of robust growth laws from optimal regulation of ribosome synthesis Building upon empirical “growth laws”, this Perspective discusses mechanisms that integrate protein synthesis with amino acid flux and metabolic control to guarantee optimal growth irrespective of the nutrient environment. Matthew Scott, Stefan Klumpp, Eduard M Mateescu, and Terence Hwa Published online 22.08.2014 Articles Quantitative analysis of mammalian translation initiation sites by FACS‐seq The impact of the translation initiation site (TIS) sequence on translational efficiency is determined by FACS‐seq, combining cell sorting and high‐throughput sequencing. A quantitative model of initiation links TIS mutations with tumorigenesis and predicts translational protein isoforms. William L Noderer, Ross J Flockhart, Aparna Bhaduri, Alexander J Diaz de Arce, Jiajing Zhang, Paul A Khavari, and Clifford L Wang Published online 28.08.2014 Corrigendum Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers Jüri Reimand and Gary D Bader Published online 28.08.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.