Nature Reviews Immunology Contents September 2014 Volume 14 Number 9 pp 579-646

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TABLE OF CONTENTS
September 2014 Volume 14 Number 9
Impact Factor 33.836 *	In this issue Research Highlights Reviews Analysis Perspectives Also this month  Featured article: The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing Sarah L. Gaffen, Renu Jain, Abhishek V. Garg & Daniel J. Cua
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RESEARCH HIGHLIGHTS Top Regulatory T cells: Alarmin(g) control p579 | doi:10.1038/nri3733 In response to intestinal tissue damage, the alarmin interleukin-33 enhances local regulatory T cell responses. PDF Inflammasomes: Ubiquitin lines up for inflammasome activity p580 | doi:10.1038/nri3730 Linear ubiquitylation of the adaptor protein ASC regulates interleukin-1β production by the NLRP3 inflammasome. PDF Mucosal immunology: Eosinophils get the party started p580 | doi:10.1038/nri3731 Eosinophils initiate T helper 2 cell responses in the small intestine by promoting dendritic cell activation. PDF Regulatory T cells: A message of peace p581 | doi:10.1038/nri3729 Regulatory T cells suppress effector T cells by releasing exosomes that contain microRNAs. PDF Mucosal immunology: Killing time in the lungs p582 | doi:10.1038/nri3732 Pulmonary epithelial cells drive rhythmic neutrophil recruitment by secreting chemokines in a clock-dependent manner. PDF Inflammasomes: New LPS receptors discovered p582 | doi:10.1038/nri3736 A new study identifies inflammatory caspases as the cytoplasmic LPS receptors that trigger non-canonical inflammasome activation. PDF Pattern recognition receptors: Curbing gut inflammation p583 | doi:10.1038/nri3735 NOD2 restricts small intestinal inflammation by controlling the overgrowth of commensal bacteria. PDF Immunology JOBS of the week Post doctoral position in cellular Immunology University of Southern California Postdoctoral Associate in Immunology Virginia Tech Professor (W3) in "Cell Biology and Immunology" University of Stuttgart More Science jobs from Immunology EVENT IMMUNOLOGY 2015 AAI Annual Meeting 08.05.15 New Orleans, USA More science events from
REVIEWS		Top
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing Sarah L. Gaffen, Renu Jain, Abhishek V. Garg & Daniel J. Cua p585 | doi:10.1038/nri3707 T helper 17 (TH17) cells promote protective immune responses against infection, particularly at barrier sites, but they can also have pathogenic roles in inflammatory diseases. In this Review, the authors describe the factors that control the development and maintenance of TH17 cells, and discuss their diverse functions in both health and disease. Abstract | Full Text | PDF | Supplementary information
A long-awaited merger of the pathways mediating host defence and programmed cell death J. Magarian Blander p601 | doi:10.1038/nri3720 There is a growing appreciation of how the host inflammatory response is intricately entwined with the various forms of programmed cell death. This Review discusses the signalling mechanisms that link these processes, with a particular focus on how the key mediators of cell death, such as the caspases, are integrated into innate signalling modules. Abstract | Full Text | PDF | Supplementary information
ANALYSIS		Top
Phenotypic models of T cell activation Melissa Lever, Philip K. Maini, P. Anton van der Merwe & Omer Dushek p619 | doi:10.1038/nri3728 There is currently no single model that fits the wealth of experimental data that relate T cell activation to T cell receptor-peptide-MHC binding parameters. Here, the authors analyse and reformulate the published models, and suggest that a kinetic proofreading model that involves limited T cell receptor signalling provides the best fit. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Interactions between innate and adaptive lymphocytes Georg Gasteiger & Alexander Y. Rudensky p631 | doi:10.1038/nri3726 Recent evidence indicates that adaptive T cell-mediated immune responses can regulate innate lymphocytes (natural killer cells and innate lymphoid cells) in an interleukin-2-dependent manner. The authors propose a model in which adaptive T cells function as peripheral antigen-specific sensors that recruit and activate innate lymphocytes to amplify and coordinate local immune responses. Abstract | Full Text | PDF
OPINION Natural killer T cells: drivers or passengers in preventing human disease? Stuart P. Berzins & David S. Ritchie p640 | doi:10.1038/nri3725 Natural killer T (NKT) cell defects have been implicated in several diseases such as autoimmunity, asthma and cancer, but will targeting them really be of clinical benefit? Here, the authors investigate this question and conclude that more careful studies are needed before the true clinical potential of NKT cell-targeted therapies can be determined. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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