Nature Reviews Cancer contents September 2014 Volume 14 Number 9 pp575-641

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TABLE OF CONTENTS
September 2014 Volume 14 Number 9
Impact Factor 37.912 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: The impact of the endoplasmic reticulum protein-folding environment Miao Wang & Randal J. Kaufman
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Nature Outlook Assessing Science Australia and New Zealand might be neighbours, but their programmes of research assessment are very different. Focusing on the tools and methods used to measure the quality and impact of science in Australia and New Zealand should inform similar debates throughout the scientific world.  Access the Outlook free online for six months.
RESEARCH HIGHLIGHTS Top Tumorigenesis: FBP1 is suppressed in kidney tumours p575 | doi:10.1038/nrc3810 Li et al. find that fructose-1,6-bisphosphatase 1 (FBP1) levels are uniformly reduced in clear cell renal cell carcinoma (ccRCC), identifying a new mechanism of metabolic reprogramming in this cancer type. PDF Therapy: Using CTCs to test drug sensitivity p576 | doi:10.1038/nrc3799 Yu et al. show that circulating tumour cells derived from patients with metastatic breast cancer can be used to track tumour evolution and can also be grown in culture to test for drug sensitivities. PDF Cachexia: Running on empty p576 | doi:10.1038/nrc3801 Two papers have identified some of the pathways leading to important early changes in white adipose tissue that contribute to cachexia. PDF Hepatocellular carcinoma: Gender differences p578 | doi:10.1038/nrc3808 Hartwell et al. show that the oestrogen-responsive pituitary hormone prolactin might cause some of the gender bias in hepatocellular carcinoma (HCC) development, and therapeutic activation of prolactin signalling might reduce HCC risk. PDF RNA dynamics: Destabilizing mRNAs promotes metastasis p578 | doi:10.1038/nrc3809 Goodarzi et al. highlight the regulation of RNA stability as a crucial mechanism in breast cancer metastasis. PDF Microenvironment: HSF1, the troublemaker next door p579 | doi:10.1038/nrc3807 Heat shock factor 1 (HSF1) in stromal cells promotes both reprogramming of cancer cell gene expression and activation of a transcriptional programme in stromal cells that potentiates malignancy in neighbouring tumour cells. PDF IN BRIEF Radiotherapy: FLASHing tumours | Metastasis: Regulating brain metastasis | Tumour suppressors: p53 and cellular plasticity | Proteomics: Connecting genotypes to phenotypes PDF Cancer JOBS of the week Postdoctoral Fellow in Cancer Genetics / Genomics University of Pennsylvania Postdoctoral Fellow - Breast Cancer Research Albert Einstein College of Medicine in New York Cancer Biologist Wake Forest Baptist Medical Center Postdoctoral Position in Hypoxia Signaling and Cancer-Initiating Cells ETH Zurich Post-Docs in Cell Death Signaling & Cancer Goethe-Universität Frankfurt am Main More Science jobs from Cancer EVENT Development of Cancer Medicines 27.11.14 London, UK More science events from
Erratum: Molecular detection to improve surgery Gemma K. Alderton p579 | doi:10.1038/nrc3804 Full Text | PDF
REVIEWS		Top
The impact of the endoplasmic reticulum protein-folding environment on cancer development Miao Wang & Randal J. Kaufman p581 | doi:10.1038/nrc3800 The unfolded protein response (UPR) is an important pro-survival pathway that is often activated in tumour cells owing to endoplasmic reticulum stress that is caused by both intrinsic and extrinsic factors. Wang and Kaufman discuss the mechanisms of UPR activation in tumour cells, the importance of this pathway to cancer development and targeting strategies for therapeutic intervention. Abstract | Full Text | PDF | Supplementary information
FAK in cancer: mechanistic findings and clinical applications Florian J. Sulzmaier, Christine Jean & David D. Schlaepfer p598 | doi:10.1038/nrc3792 Focal adhesion kinase (FAK) can promote tumour growth and metastasis through various kinase-dependent and kinase-independent pathways. This Review discusses the roles of FAK in tumour cells and cells of the microenvironment, as well as the progress that is being made in the clinical development of FAK inhibitors. Abstract | Full Text | PDF
Mechanisms of disseminated cancer cell dormancy: an awakening field Maria Soledad Sosa, Paloma Bragado & Julio A. Aguirre-Ghiso p611 | doi:10.1038/nrc3793 Disseminated tumour cells that survive treatment may become dormant and their 'awakening' may be the source of metastases. This Review discusses the mechanisms and factors that regulate tumour dormancy, including the extracellular and stromal microenvironments, autophagy and epigenetics. The authors also discuss how this information could be used therapeutically for metastatic disease. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Challenges in circulating tumour cell research Catherine Alix-Panabieres & Klaus Pantel p623 | doi:10.1038/nrc3686 Circulating tumour cells (CTCs) are the subject of many published papers, but the diversity of assays used for their analysis can be daunting. This Opinion article discusses issues regarding the detection and characterization of CTCs, and poses the major outstanding questions in this field. Abstract | Full Text | PDF
OPINION Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression Cassandra L. Buchheit, Kelsey J. Weigel & Zachary T. Schafer p632 | doi:10.1038/nrc3789 In this Opinion article, Buchheit et al. describe the cellular changes that regulate cell viability when cells become detached from the ECM. In particular, they discuss how cancer cells take advantage of these specific processes and how better understanding them will be instrumental in designing therapeutic strategies that aim to eliminate ECM-detached metastatic cells. Abstract | Full Text | PDF
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