Drug Discovery@nature.com 22 August 2014

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TABLE OF CONTENTS 22 August 2014 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement EXCLUSIVE DEALS: Lab equipment and services Learn more and save on the latest lab equipment you need! Before you buy, VISIT MARKETPLACE      News Top Massive schizophrenia genomics study offers new drug directions doi:10.1038/nrd4411 But much more basic research on disease pathways is needed to entice more pharmaceutical companies back to the field. Full Text NIH chief keeps hopes afloat doi:10.1038/nature.2014.15723 Director Francis Collins discusses the changing landscape of biomedical research. Full Text Cancer centers zero in on exceptional responders doi:10.1038/nbt0814-703 Cancer patients who make remarkable recoveries will be studied systematically in two large-scale translational oncology initiatives now underway at the Memorial Sloan-Kettering Cancer Center in New York and the US National Cancer Institute. Full Text Group seeks standardization for what clinical trials must measure doi:10.1038/nm0814-798 In many areas of medicine, studies select what they measure in isolation, making it impossible to directly compare their results and leading to redundancies in research. Full Text Analysis Top Navigating the new road in psychiatry doi:10.1038/scibx.2014.913 The lack of predictive animal models for neuropsychiatric diseases is arguably the biggest single factor stifling early drug development in the field. To address this, stakeholders will need to abandon traditional models, build on emerging genetic findings and capitalize on new capabilities in stem cell technology, imaging and computational modeling. Full Text Antithrombotic drugs market doi:10.1038/nrd4365 This article investigates the antithrombotic drug pipeline and the changing landscape of the antithrombotics market. Full Text Research Highlights Top Anticancer drugs: Horizons broaden for PI3Kδ inhibitors doi:10.1038/nrd4399 Inhibitors of the p110δ isoform of PI3K could have therapeutic potential in a broad range of cancers. Full Text Analgesia: Anti-itch and anti-ouch antibody doi:10.1038/nrd4396 An antibody that targets sodium channel Nav1.7 could be useful for treating inflammatory or neuropathic pain, as well as itch-related disorders. Full Text Vaccines: HIV vaccine failure due to induction of immune suppressors? doi:10.1038/nrd4398 New findings show that vaccines can potentially induce suppressor cells and thereby dampen any specific immune responses. Full Text Research & Reviews Top Phenotypic screening in cancer drug discovery — past, present and future doi:10.1038/nrd4366 Moffat and colleagues investigate the contribution of phenotypic assays in anticancer drug development, and discuss technical and biological advances that could empower phenotypic drug discovery in oncology. Full Text Semaphorins and plexins as therapeutic targets doi:10.1038/nrd4337 Worzfeld and Offermanns summarize the pathological roles of semaphorins and plexins in cancer, bone diseases, immuno-inflammatory diseases and spinal cord injury, and discuss emerging strategies to therapeutically target these molecules. Full Text Therapeutic targeting of microRNAs: current status and future challenges doi:10.1038/nrd4359 Li and Rana discuss strategies in the design of micro RNA-targeting oligonucleotides with increased efficacy and improved in vivo delivery characteristics, and highlight some of the challenges ahead in the clinical development of these therapeutics. Full Text Drug Discovery JOBS of the week Head of Drug and RNAi Screening Platform UCLA Professorship (W2) "Phospholipids in Drug Development" Friedrich Schiller University Jena Senior Assistant in Drug Delivery Vehicle / Particle Synthesis ETH Zurich Drug Discovery Scientist (IMI) University of Dundee Faculty Positions (Drug Discovery and Experimental Therapeutics) University of Hawaii Cancer Center More Science jobs from Drug Discovery EVENT Diabetic Kidney Disease: Drug Discovery and Clinical Development Challenges 09.12.14 New York, USA More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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