Nature Reviews Molecular Cell Biology contents January 2013 Volume 14 Number 1

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TABLE OF CONTENTS
January 2013 Volume 14 Number 1
Impact Factor 39.123 *	In this issue Research Highlights Progress Reviews Perspectives Also this month  Featured article: Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore Emily A. Foley & Tarun M. Kapoor
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RESEARCH HIGHLIGHTS Top Protein degradation: Ensuring quality at the ribosome p1 | doi:10.1038/nrm3499 The identification of a ribosome-bound complex that degrades stalled proteins. PDF Replication: Hog1 in conflict resolution p2 | doi:10.1038/nrm3491 Hog1 minimizes collisions between the transcription and replication machinery during osmostress. PDF Chromosomes: Getting the architecture right p2 | doi:10.1038/nrm3498 KIF4, condensin and topoisomerase IIα function to shape mitotic chromosomes. PDF Cell signalling: Hedgehog puts a damper on autophagy p3 | doi:10.1038/nrm3487 Hedgehog signalling regulates autophagy. PDF Small RNAs: miRNA machinery disposal p4 | doi:10.1038/nrm3493 Autophagy regulates microRNAs by degrading DICER and AGO. PDF Development: Resizing the guts p4 | doi:10.1038/nrm3501 YAP restricts the proliferation of intestinal stem cells by antagonizing WNT signals. PDF Development: G9A covers all bases p5 | doi:10.1038/nrm3497 The methyltransferase G9A represses adipogenesis by inhibiting PPARγ and promoting WNT10A expression. PDF Plant cell biology: Regulating plastid plasticity p6 | doi:10.1038/nrm3489 A crucial role for the ubiquitin-proteasome system in regulating chloroplast plasticity by controlling protein import. PDF JOURNAL CLUB The death and growth connection p6 | doi:10.1038/nrm3490 Dying cells promote the proliferation of neighboring cells and thus promote tissue growth. PDF IN BRIEF Cell signalling: How Notch gets selective | Calcium: Helping Ca2+ into mitochondria | Cytoskeleton: Determining optimal length of cilia PDF Molecular Cell Biology JOBS of the week Assistant Professor: Dept of Molecular and Cellular Biology University of Guelph Chair, Senior Lectureship / Research Fellowship and Lectureship Levels - Department of Molecular Biology & Biotechnology University of Sheffield Professor in Molecular Microbial Ecology - Emergent Infectious Diseases Aarhus University - Denmark Tenure-Track Faculty Position - Geomicrobiology Open Rank Faculty joint with the Department of Microbiology and Molecular Genetics Michigan State University More Science jobs from Molecular Cell Biology EVENT TM's 2nd world molecular & cell biology online conference 05.-08.02.13 Online More science events from
PROGRESS		Top
New insights into the regulation and cellular functions of the ARP2/3 complex Jeremy D. Rotty, Congying Wu & James E. Bear p7 | doi:10.1038/nrm3492 The ARP2/3 complex, which nucleates branched actin filament networks, is itself activated by nucleation-promoting factors (NPFs). New understanding is being gained into NPF control of ARP2/3 and the biological roles of ARP2/3 branched actin. Abstract | Full Text | PDF
REVIEWS		Top
The nuclear lamins: flexibility in function Brian Burke & Colin L. Stewart p13 | doi:10.1038/nrm3488 The nuclear A-type and B-type lamins, key components of the lamina underlying the nuclear envelope, have been linked to the regulation of several nuclear processes. However, studies in mice have questioned the essentiality of these lamins and have provided new understanding of how lamins function in different cells and tissues. Abstract | Full Text | PDF
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore Emily A. Foley & Tarun M. Kapoor p25 | doi:10.1038/nrm3494 Chromosome segregation during cell division is facilitated by the kinetochore, which attaches chromosomes to spindle microtubules and relays the microtubule-binding status to the spindle assembly checkpoint (SAC). How kinetochore-dependent processes ensure faithful chromosome segregation is coming to light, as are the essential roles of the KMN network and kinase-phosphatase signalling. Abstract | Full Text | PDF
Molecular basis of physiological heart growth: fundamental concepts and new players Marjorie Maillet, Jop H. van Berlo & Jeffery D. Molkentin p38 | doi:10.1038/nrm3495 The heart undergoes physiological hypertrophy in response to developmental signals and increased workload. The structural and molecular characteristics of physiological cardiac hypertrophy are now being elucidated, as are the endocrine effectors and associated signalling pathways that regulate it. Abstract | Full Text | PDF
PERSPECTIVES		Top
INNOVATION TALENs: a widely applicable technology for targeted genome editing J. Keith Joung & Jeffry D. Sander p49 | doi:10.1038/nrm3486 Transcription activator-like effector nucleases (TALENs) comprise a nonspecific nuclease fused to a sequence-specific DNA-binding domain. This domain can be engineered so that TALENs can target virtually any sequence. TALENs are an efficient tool to modify genes in a wide range of cell types and organisms. Abstract | Full Text | PDF | Supplementary information
OPINION Protein homeostasis: live long, won't prosper Brandon H. Toyama & Martin W. Hetzer p55 | doi:10.1038/nrm3496 An increasing number of proteins have been discovered that evade turnover and instead are maintained over a cell's lifetime. Accumulation of damage in these long-lived proteins may contribute to the ageing process. Abstract | Full Text | PDF
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