Drug Discovery@nature.com 21 December 2012

TABLE OF CONTENTS 21 December 2012 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement Nature Medicine ePOSTER ON METABOLIC SYNDROME Published originally in 2011, the 2012 version of the ePoster features a new organ -- the pancreas -- plus updates for the existing organs to reflect key advances of the past year. www.nature.com/nm/poster Sponsored by   News Top Cash injection set to revive Swiss drug site doi:10.1038/492168a One of the largest philanthropic donations in European research history could give the former Merck Serono laboratories a fresh life as a centre for bioengineering. Full Text Poor may suffer as India caps drug prices doi:10.1038/nature.2012.12046 Some consumers could end up paying more as price differences shrink. Full Text Straight talk with...Guido Rasi doi:10.1038/nm1212-1725 The executive director of the European Medicines Agency (EMA) talks about how it can achieve better safety guidance and improved transparency. Full Text Orphans' matchmaker doi:10.1038/nbt1212-1156 The London-based charity Wellcome Trust launched a new scheme to fund industry-academia collaborations in orphan and neglected diseases. Full Text Analysis Top Translating autism doi:10.1038/scibx.2012.1248 Researchers have mouse data showing a causal link between eIF4E-mediated translational dysregulation and autism-related deficits. The group also corrected the dysregulation, and the associated autistic phenotype, with a small molecule. Full Text Factors influencing non-approval of new drugs in Europe doi:10.1038/nrd3894 This analysis looked at marketing applications at the EMA for new active substances, revealing the extent to which certain underlying factors were associated with failure to be approved. Full Text Research Highlights Top Drug screening: A MuSIC-al way to identify drug pairs doi:10.1038/nrd3898 Researchers have a new method to identify synergistic drug pairs and new targets for the potential treatment of HIV. The method could be applicable to other therapeutic areas where combinations of drugs might offer improved benefits. Full Text Analgesics: Deadly snake venom for pain relief? doi:10.1038/nrd3897 Proteins from snake venom function as potent painkillers with a novel mechanism of action. They could be useful tools for dissecting pain pathways, as well as having potential therapeutic value themselves. Full Text Neurodegenerative diseases: Novel route to neuroprotection doi:10.1038/nrd3899 Compounds from a series based on P7C3 — an aminopropyl carbazole with neurogenic properties — have therapeutic effects in animal models of Parkinson's disease and amyotrophic lateral sclerosis. Full Text Research & Reviews Top Protein kinase C, an elusive therapeutic target? doi:10.1038/nrd3871 This Review looks at the efforts, challenges and opportunities for the protein kinase C family, which have been a major focus of drug discovery efforts. Full Text Tankyrase-targeted therapeutics: expanding opportunities in the PARP family doi:10.1038/nrd3868 This Review focuses on the biology of tankyrases and the discovery of tankyrase-specific inhibitors. It also considers the challenges that lie ahead for the clinical development of PARP family inhibitors in general. Full Text Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline doi:10.1038/nm.2965 New research shows that inhibition of IL-12 and IL-23 signaling reduces plaque load and improves cognitive deficits in mouse models of Alzheimer's disease. The researchers suggest that this pathway may be targeted therapeutically. Full Text Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis doi:10.1038/nbt.2434 Researchers have shown that microparticles bearing encephalitogenic peptides induce long-term T-cell tolerance in mice with relapsing experimental autoimmune encephalomyelitis, preventing the onset and modifying the course of the disease. Full Text Drug Discovery JOBS of the week Informatics Manager University of Dundee, College of Life Sciences Postdoctoral Research Fellow - Cardiovascular Genetics MERCK & COMPANY INC. Post-doctoral Fellow, Epigenomics BCCA Genome Sciences Centre Scientist I, Pharmacology Biogen Idec Research Scientist, Peptide Chemistry, Purification & Analytics Cenix BioScience Belgium bvba More Science jobs from Drug Discovery EVENT Translating Natural Products into Drugs for Alzheimer�s and Neurodegenerative Disease 06.05.12 NY, US More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Advertisement SciBX: Science-Business eXchange is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. Recommend SciBX to your library today.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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