The EMBO Journal - Table of Contents alert Volume 31 Issue 15

TABLE OF CONTENTS 01 August 2012 | Volume 31, Issue 15 Editorial Have you seen? Articles Corrigendum Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Editorial Top Evolution and revolution at The EMBO Journal On its 30th anniversary, executive editors of The EMBO Journal reflect on change and progress. The EMBO Journal (2012), 31, 3231 - 3233; 10.1038/emboj.2012.208 Full text | PDF Published online: 01 August 2012 Have you seen? Top Divorce of obligatory partners in pain: disruption of GABAB receptor heterodimers in neuralgia The team of Marc Landry provides support for a novel mechanism by which GABAB receptor heterodimers are disrupted and inactivated at the cell surface under pathological conditions. Dietmar Benke and Hanns Ulrich Zeilhofer The EMBO Journal (2012), 31, 3234 - 3236; 10.1038/emboj.2012.174 Abstract | Full text | PDF Published online: 26 June 2012 Silent decision: HP1 protein escorts heterochromatic RNAs to their destiny A recent study published in Molecular Cell reports on a heterochromatin-specific checkpoint that captures and primes heterochromatic RNAs for degradation. The authors propose HP1Swi6 to facilitate this by competitive binding to mRNA transcripts respective histone tails. Jie Ren and Robert A Martienssen The EMBO Journal (2012), 31, 3237 - 3238; 10.1038/emboj.2012.172 Abstract | Full text | PDF | Related article Published online: 15 June 2012 Articles Top Impairment of GABAB receptor dimer by endogenous 14-3-3ζ in chronic pain conditions 14-3-3ζ expression is upregulated in a rat model of chronic pain where it dissociates GABAB heterodimers and impairs GABAB signalling to modulate pain sensation. Sophie Laffray, Rabia Bouali-Benazzouz, Marie-Amélie Papon, Alexandre Favereaux, Yang Jiang, Tina Holm, Corentin Spriet, Pascal Desbarats, Pascal Fossat, Yves Le Feuvre, Marion Decossas, Laurent Héliot, Ulo Langel, Frédéric Nagy and Marc Landry The EMBO Journal (2012), 31, 3239 - 3251; 10.1038/emboj.2012.161 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 June 2012 ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation The GTPase Arf6 and its exchange factor EFA6A promote internalization of the Ig-like molecule TLN in hippocampal neurons leading to the maturation of filopodia into dendritic spines, important for synapse formation. Tim Raemaekers, Aleksandar Peric, Pieter Baatsen, Ragna Sannerud, Ilse Declerck, Veerle Baert, Christine Michiels and Wim Annaert The EMBO Journal (2012), 31, 3252 - 3269; 10.1038/emboj.2012.182 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 July 2012 Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release Regulated exocytosis of synaptic vesicles is triggered by a local increase in calcium levels, relieving a block in the assembly of the membrane fusion machinery. Based on a reconstituted system, this study characterizes the roles of complexin and synaptotagmin 1 in arresting and synchronizing fusion. Jörg Malsam, Daniel Parisotto, Tanmay A M Bharat, Andrea Scheutzow, Jean Michel Krause, John A G Briggs and Thomas H Söllner The EMBO Journal (2012), 31, 3270 - 3281; 10.1038/emboj.2012.164 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 June 2012 BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER Sec61, the protein-conducting channel of the endoplasmic reticulum, also mediates calcium efflux. The chaperone BiP binds to a luminal loop of Sec61 to inhibit calcium leakage and to link channel gating to protein homeostasis in the endoplasmic reticulum. Nico Schäuble, Sven Lang, Martin Jung, Sabine Cappel, Stefan Schorr, Özlem Ulucan, Johannes Linxweiler, Johanna Dudek, Robert Blum, Volkhard Helms, Adrienne W Paton, James C Paton, Adolfo Cavalié and Richard Zimmermann The EMBO Journal (2012), 31, 3282 - 3296; 10.1038/emboj.2012.189 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 July 2012 Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains The two-pore domain potassium channel K2P2.1 (TREK-1) responds to extracellular and intracellular stimuli, including pH and temperature. This study elucidates how the intracellular sensor element relays metabolic and thermal stimuli to the extracellular C-type gating element. Sviatoslav N Bagriantsev, Kimberly A Clark and Daniel L Minor Jr The EMBO Journal (2012), 31, 3297 - 3308; 10.1038/emboj.2012.171 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 June 2012 The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development This paper reveals the contribution of the F-BAR-domain protein Nostrin towards vascular development and angiogenesis by virtue of its interactions with the FGFR1, Rac1 and SOS. Igor Kovacevic, Jiong Hu, Ann Siehoff-Icking, Nils Opitz, Aliesha Griffin, Andrew C Perkins, Alan L Munn, Werner Müller-Esterl, Rüdiger Popp, Ingrid Fleming, Benno Jungblut, Meike Hoffmeister and Stefanie Oess The EMBO Journal (2012), 31, 3309 - 3322; 10.1038/emboj.2012.176 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 29 June 2012 The cis-regulatory code of Hox function in Drosophila Hox transcription factors have similar in-vitro DNA-binding specificity but regulate different target genes. Differences in Hox cis-regulatory element composition, inter-motif distance and motif-pair association define cell type-specific regulation of Hox target genes. Sebastian Sorge, Nati Ha, Maria Polychronidou, Jana Friedrich, Daniela Bezdan, Petra Kaspar, Martin H Schaefer, Stephan Ossowski, Stefan R Henz, Juliane Mundorf, Jenny Rätzer, Fani Papagiannouli and Ingrid Lohmann The EMBO Journal (2012), 31, 3323 - 3333; 10.1038/emboj.2012.179 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 July 2012 The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins Muscle atrophy is associated with and dependent on expression of the ubiquitin-dependent protein segregase p97/VCP, which may aid extraction and degradation of myofibrillar proteins. Rosanna Piccirillo and Alfred L Goldberg The EMBO Journal (2012), 31, 3334 - 3350; 10.1038/emboj.2012.178 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 July 2012 Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C The WD40 protein Cdc20 activates the ubiquitin ligase APC/C during mitosis. CDK phosphorylation inhibits Cdc20 binding to APC/C and requires specific reversal by phosphatases, paralleling the control of the related activator Cdh1 in later stages of mitosis. Helene Labit, Kazuyuki Fujimitsu, N Sumru Bayin, Tohru Takaki, Julian Gannon and Hiroyuki Yamano The EMBO Journal (2012), 31, 3351 - 3362; 10.1038/emboj.2012.168 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 June 2012 Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state The related tyrosine kinases Syk and Zap-70 are key signalling proteins downstream of antigen receptors. A knock-in strategy reveals that the two kinases differentially affect BCR signalling, leading to aberrant B cell section and increased risk of autoimmune disease. Sebastian Königsberger, Jan Prodöhl, David Stegner, Vanessa Weis, Martin Andreas, Martin Stehling, Theresa Schumacher, Ruben Böhmer, Ina Thielmann, Judith M M van Eeuwijk, Bernhard Nieswandt and Friedemann Kiefer The EMBO Journal (2012), 31, 3363 - 3374; 10.1038/emboj.2012.169 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 June 2012 Corrigendum Top Drugging Wnt signalling in cancer Paul Polakis The EMBO Journal (2012), 31, 3375; 10.1038/emboj.2012.196 Full text | PDF Published online: 01 August 2012 Advertisement Follow EMBO on Twitter for as-it-happens access to news, comments and articles.Make Twitter a place to share information and network with others interested in the life sciences. http://twitter.com/#!/EMBOcomm   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. 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