EMBO Reports - Table of Contents alert Volume 13 Issue 8, pp 661-764

TABLE OF CONTENTS August 2012 | Volume 13, Issue 8 Upfront Science & Society Reviews Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement New in EMBO reports: Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells Emma Sandilands, Bryan Serrels, Simon Wilkinson & Margaret C Frame This paper reveals Src to be a general mediator of FAK-binding kinase degradation under adhesion stress, thus enabling cancer cell survival. EMBO reports advance online publication: 26 June, 2012   Upfront Top Editorial Vaster, hotter, grainier In a light-hearted preview of the Olympics, Howy asks which countries would win the medals if molecular biology was included as an official event. Howy Jacobs EMBO reports (2012), 13, 661; 10.1038/embor.2012.94 Full text | PDF Published online: 01 August 2012 Subject Categories: Societal Issues & Politics Hot off the Press Elucidating the temporal order of silencing Three recent studies, one published in this issue of EMBO reports, show that miRNA-mediated translational inhibition of mRNA targets precedes mRNA deadenylation and decay. Elisa Izaurralde EMBO reports (2012), 13, 662 - 663; 10.1038/embor.2012.91 Full text | PDF Published online: 22 June 2012 Subject Categories: RNA Meeting Point A half-century after the molecular clock: new dimensions of molecular evolution The EMBO Workshop on ‘Evolution in the Time of Genomics’ took place in May 2012. The meeting focused on phenomena that are not part of the traditional narrative of molecular evolution and which might signal a paradigm shift in the field. Eugene V Koonin EMBO reports (2012), 13, 664 - 666; 10.1038/embor.2012.103 Abstract | Full text | PDF Published online: 13 July 2012 Subject Categories: Molecular Evolution Lipids as organizers of cell membranes The 105th Boehringer Ingelheim Fonds International Titisee Conference ‘Lipids as Organizers of Cell Membranes’ gathered cell biologists and biophysicists to discuss the interplay between lipids and proteins in biological membranes, with an emphasis on how technological advances could help fill the gap in our understanding of the lipid part of the membrane. Benoît Kornmann and Aurélien Roux EMBO reports (2012), 13, 667 - 669; 10.1038/embor.2012.104 Abstract | Full text | PDF Published online: 13 July 2012 Subject Categories: Cellular Metabolism | Membranes & Transport | Signal Transduction The young and happy marriage of membrane traffic and cell polarity The ESF–EMBO Meeting on ‘Cell polarity and Membrane Traffic’ took place in April 2012. It brought together scientists from two once very separate fields and highlighted the emerging interdependence between them. Barry J Thompson, Franck Perez and Thomas Vaccari EMBO reports (2012), 13, 670 - 672; 10.1038/embor.2012.98 Abstract | Full text | PDF Published online: 10 July 2012 Subject Categories: Membranes & Transport | Cell & Tissue Architecture Science & Society Top Measuring the societal impact of research The global financial crisis has changed how nations and agencies prioritize research investment. There has been a push towards science with expected benefits for society, yet devising reliable tools to predict and measure the social impact of research remains a major challenge. Lutz Bornmann EMBO reports (2012), 13, 673 - 676; 10.1038/embor.2012.99 Full text | PDF Published online: 10 July 2012 Subject Categories: Science Policy & Funding | Societal Issues & Politics The 'atom-splitting' moment of synthetic biology Synthetic biology and nuclear physics share many commonalities in terms of public perception and funding. Synthetic biologists could learn valuable lessons from the history of the atomic bomb and nuclear power. Alex J Valentine, Aleysia Kleinert and Jerome Verdier EMBO reports (2012), 13, 677 - 679; 10.1038/embor.2012.95 Full text | PDF Published online: 03 July 2012 Subject Categories: Philosophy & History of Science | Societal Issues & Politics Where next for antibiotics? The prevalence of drug resistance in major pathogenic bacteria is an increasingly severe public health problem. In addition to looking for new antibiotics, researchers are focusing on the immune system and the nature of pathogenicity itself to devise new strategies for fighting infectious disease. Philip Hunter EMBO reports (2012), 13, 680 - 683; 10.1038/embor.2012.101 Full text | PDF Published online: 06 July 2012 Subject Categories: Health & Disease | Technology, Development & Applications Reviews Top Innate immune signalling at the intestinal epithelium in homeostasis and disease The intestinal epithelium actively contributes to mucosal health and defense. This review analyses specific epithelial cell functions within the diverse cellular composition of the mucosal tissue, in the presence of the complex and dynamic gut microbiota. Johanna Pott and Mathias Hornef EMBO reports (2012), 13, 684 - 698; 10.1038/embor.2012.96 Abstract | Full text | PDF Published online: 17 July 2012 Subject Categories: Immunology Dendritic spines: from structure to in vivo function Dendritic spines receive inputs from excitatory axons, but questions about their function remain. This review tackles our understanding of their structural and biochemical properties, and the imaging methods that allow spine activity to be studied in living tissue. These new results shed light on the development, integration properties and plasticity of dendritic spines. Nathalie L Rochefort and Arthur Konnerth EMBO reports (2012), 13, 699 - 708; 10.1038/embor.2012.102 Abstract | Full text | PDF Published online: 13 July 2012 Subject Categories: Neuroscience Scientific Reports Top Intracellular single molecule microscopy reveals two kinetically distinct pathways for microRNA assembly This study reports a new method—iSHiRLOC—that allows an unprecedented resolution in the visualization of functional small RNAs. Its use has revealed the existence of both a time-dependent and an mRNA-dependent pathway for miRNA assembly. Sethuramasundaram Pitchiaya, John R Androsavich and Nils G Walter EMBO reports (2012), 13, 709 - 715; 10.1038/embor.2012.85 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 June 2012 Subject Categories: RNA Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells Kinetic analysis of the effect of miRNAs on target mRNA reporters over time reveals that translational repression precedes mRNA deadenylation and decay. Julien Béthune, Caroline G Artus-Revel and Witold Filipowicz EMBO reports (2012), 13, 716 - 723; 10.1038/embor.2012.82 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 June 2012 Subject Categories: RNA Tankyrase 1 regulates centrosome function by controlling CPAP stability Centrosomal P4.1-associated protein (CPAP) degradation and function is shown to be controlled by the poly(ADP-ribose) polymerase tankyrase 1. CPAP PARsylation precisely precedes its degradation in G1, limiting centriole elongation and ensuring proper centrosome function. Mi Kyung Kim, Charles Dudognon and Susan Smith EMBO reports (2012), 13, 724 - 732; 10.1038/embor.2012.86 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 June 2012 Subject Categories: Cell Cycle | Proteins Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells Ret is shown to be a Src-dependent autophagy substrate upon defective FAK signalling, when Src is known to induce its own autophagic degradation. Thus, Src is a general mediator of FAK-binding kinase degradation under adhesion stress, enabling cancer cell survival. Emma Sandilands, Bryan Serrels, Simon Wilkinson and Margaret C Frame EMBO reports (2012), 13, 733 - 740; 10.1038/embor.2012.92 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 June 2012 Subject Categories: Signal Transduction | Membranes & Transport | Molecular Biology of Disease Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3 Mono-nucleated myoblasts fuse to form multi-nucleated myotubes. After the fusion, the myoblast nucleus moves towards the centre of the myotube. This movement is driven by microtubules and dynein, and is regulated by Cdc42, Par6 and Par3. Bruno Cadot, Vincent Gache, Elena Vasyutina, Sestina Falcone, Carmen Birchmeier and Edgar R Gomes EMBO reports (2012), 13, 741 - 749; 10.1038/embor.2012.89 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 June 2012 Subject Categories: Cell & Tissue Architecture Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling A direct interaction between Kindlin-2, active β-catenin and Tcf4 is shown. This transcriptional complex is required for Kindlin-2-induced tumour cell invasion. Yu Yu, Junzhou Wu, Yunling Wang, Ting Zhao, Bo Ma, Yuqing Liu, Weigang Fang, Wei-Guo Zhu and Hongquan Zhang EMBO reports (2012), 13, 750 - 758; 10.1038/embor.2012.88 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 15 June 2012 Subject Categories: Chromatin & Transcription | Cell & Tissue Architecture Loss of fused in sarcoma (FUS) promotes pathological Tau splicing Tau mRNA is identified as a splicing target of FUS in mouse brain. FUS silencing leads to inclusion of Tau exons 3 and 10, and phenocopies Tau loss-of-function, providing new insights into the generation of the neurodegenerative diseases ALS and FTLD. Denise Orozco, Sabina Tahirovic, Kristin Rentzsch, Benjamin M Schwenk, Christian Haass and Dieter Edbauer EMBO reports (2012), 13, 759 - 764; 10.1038/embor.2012.90 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 June 2012 Subject Categories: RNA | Neuroscience | Molecular Biology of Disease Advertisement Follow EMBO on Facebook for access to news, comments and articles make it a place to share information with others interested in the life sciences. https://www.facebook.com/EMBO.excellence.in.life.sciences   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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