Molecular Systems Biology - New articles published 28 August 2012

Latest Articles 28th August 2012   Featured article Reports   Web feeds About Open access Advertisement Systems Biology Toolset Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega Fabian Sievers, Desmond G Higgins and colleagues ¦ doi:10.1038/msb.2011.75 A framework for mapping, visualisation and automatic model creation of signal-transduction networks Carl-Fredrik Tiger, Markus Krantz and colleagues ¦ doi:10.1038/msb.2012.12 INDI: a computational framework for inferring drug interactions and their associated recommendations Assaf Gottlieb, Roded Sharan and colleagues ¦ doi:10.1038/msb.2012.26     Featured Articles Inferring transcriptional and microRNA-mediated regulatory programs in glioblastoma Integration of expression, copy number, methylation, and regulatory sequence information identifies miRNAs and transcription factors that drive the global expression changes associated with different glioblastoma subtypes. Manu Setty, Karim Helmy, Aly A Khan, Joachim Silber, Aaron Arvey, Frank Neezen, Phaedra Agius, Jason T Huse, Eric C Holland & Christina S Leslie Molecular Systems Biology :605; doi:10.1038/msb.2012.37; published 28 August 2012 Full Text | PDF | Supp. Inf. | Review Process Systems-based analysis of Arabidopsis leaf growth reveals adaptation to water deficit Deep profiling of the transcriptome and proteome during leaf development reveals unexpected responses to water deficit, as well as a surprising lack of protein-level fluctuations during the day-night cycle, despite clear changes at the transcript level. Katja Baerenfaller, Catherine Massonnet, Sean Walsh, Sacha Baginsky, Peter Bühlmann, Lars Hennig, Matthias Hirsch-Hoffmann, Katharine A Howell, Sabine Kahlau, Amandine Radziejwoski, Doris Russenberger, Dorothea Rutishauser, Ian Small, Daniel Stekhoven, Ronan Sulpice, Julia Svozil, Nathalie Wuyts, Mark Stitt, Pierre Hilson, Christine Granier & Wilhelm Gruissem Molecular Systems Biology :606; doi:10.1038/msb.2012.39; published 28 August 2012 Full Text | PDF | Supp. Inf. | Review Process Report Dynamics of protein noise can distinguish between alternate sources of gene-expression variability Intrinsic noise in gene expression stems from two major sources: promoter fluctuations and lowcopy mRNA fluctuations. A new method allows these sources to be distinguished using transient changes in protein variance without the need for involved single molecule mRNA assays, and reveals that promoter fluctuations drive variability in HIV-1 gene expression. Abhyudai Singh, Brandon S Razooky, Roy D Dar & Leor S Weinberger Molecular Systems Biology :607; doi:10.1038/msb.2012.38; published 28 August 2012 Full Text | PDF | Supp. Inf. | Review Process

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