Nature Communications - 28 August 2012

Weekly Content Alert 28 August 2012 Featured image: Direnberger et al. study the anatomy, physiology and behavior of transgenic mice expressing the calcium indicator TN-XXL. Latest content: Articles Journal homepage Recommend to library Web feed   Advertisement Nurture your career with the new-look Naturejobs As the world's largest dedicated jobs boards for the scientific community, Naturejobs is the ideal resource to build your career. Our new and improved functionality enables you to search, save and apply for jobs quickly and easily. Search over 10,000 vacancies to find exactly the right job for you at: www.naturejobs.com     Latest Articles View all Articles     Imaging enzyme-triggered self-assembly of small molecules inside live cells Yuan Gao, Junfeng Shi, Dan Yuan and Bing Xu Supramolecular interactions allow some small molecules to self-assemble into nanofibres and hydrogels in aqueous environments. Gao et al. report a hydrogelator that forms fluorescent nanofibres within cells, leading to the visualization of their self-assembly at the endoplasmic reticulum. 28 Aug | Nat Commun 3:1033 doi:10.1038/ncomms2040 (2012) Chemical sciences Chemical biology  Nanotechnology  Abstract | Full Text | PDF (1,131 kB) | Supplementary Information Active learning framework with iterative clustering for bioimage classification OPEN Natsumaro Kutsuna, Takumi Higaki, Sachihiro Matsunaga, Tomoshi Otsuki, Masayuki Yamaguchi, Hirofumi Fujii and Seiichiro Hasezawa Semi-automated imaging systems help with the task of classifying large numbers of biological images. This study presents a novel framework—CARTA—with an active learning algorithm combined with a genetic algorithm, whose applications include the classification of magnetic resonance imaging of cancer cells. 28 Aug | Nat Commun 3:1032 doi:10.1038/ncomms2030 (2012) Biological sciences Bioinformatics  Abstract | Full Text | PDF (2,011 kB) | Supplementary Information Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model Stephan Direnberger, Marsilius Mues, Vincenzo Micale, Carsten T. Wotjak, Steffen Dietzel, Michael Schubert, Andreas Scharr, Sami Hassan, Christian Wahl-Schott, Martin Biel, Gurumoorthy Krishnamoorthy and Oliver Griesbeck Calcium-sensing fluorescent proteins such as TN-XXL are valuable tools for studying cellular function but, when expressed in mice, may affect animal physiology and behaviour. The authors of this paper create transgenic mice expressing TN-XXL and show that long-term expression of TN-XXL is tolerated well. 28 Aug | Nat Commun 3:1031 doi:10.1038/ncomms2035 (2012) Biological sciences Biotechnology  Genetics  Abstract | Full Text | PDF (1,200 kB) | Supplementary Information Rotational dynamics of cargos at pauses during axonal transport Yan Gu, Wei Sun, Gufeng Wang, Ksenija Jeftinija, Srdija Jeftinija and Ning Fang Vesicle trafficking in the cell is likely to involve a tug-of-war between motor proteins of opposing directionality. Gu et al. use high-speed single-particle tracking in neurons to uncover rotation of paused cargo vesicles, providing insight into the changing forces as the vesicles change direction. 28 Aug | Nat Commun 3:1030 doi:10.1038/ncomms2037 (2012) Biological sciences Biophysics  Cell biology Abstract | Full Text | PDF (715 kB) | Supplementary Information Optical detection of a single rare-earth ion in a crystal OPEN R. Kolesov, K. Xia, R. Reuter, R. Stöhr, A. Zappe, J. Meijer, P.R. Hemmer and J. Wrachtrup The optical transitions that occur in rare-earth-doped crystals offer promise for quantum information storage and processing. Kolesov et al. report the optical detection of a single praseodymium ion residing in a crystal host by using an excited-state absorption process to enhance its fluorescence yield. 28 Aug | Nat Commun 3:1029 doi:10.1038/ncomms2034 (2012) Physical sciences Materials science  Optical physics  Abstract | Full Text | PDF (1,004 kB) | Supplementary Information Direct dynamic imaging of non-adiabatic spin torque effects S.D. Pollard, L. Huang, K.S. Buchanan, D.A. Arena and Y. Zhu The torque contributions exerted by spin-polarized currents on magnetic structures are not fully understood due to the difficulty in discerning their relative weight. Pollard et al. propose a novel method to directly determine the value of the competing spin transfer torques by in-situ Lorentz microscopy. 28 Aug | Nat Commun 3:1028 doi:10.1038/ncomms2025 (2012) Physical sciences Materials science  Abstract | Full Text | PDF (1,261 kB) | Supplementary Information Exploiting multimode waveguides for pure fibre-based imaging OPEN Tomáš Čižmár and Kishan Dholakia Fibre-based technologies provide miniaturization, flexibility and the capability to access hard to reach areas. Čižmár and Dholakia exploit disorder in multimode fibres to enable a variety of imaging modalities, including bright- and dark-field microscopy and fluorescent imaging, using a single waveguide. 28 Aug | Nat Commun 3:1027 doi:10.1038/ncomms2024 (2012) Physical sciences Applied physics  Optical physics Abstract | Full Text | PDF (2,212 kB) | Supplementary Information Programmable multimode quantum networks OPEN Seiji Armstrong, Jean-François Morizur, Jiri Janousek, Boris Hage, Nicolas Treps, Ping Koy Lam and Hans-A. Bachor Multi-partite entanglement is essential not only to understand large quantum ensembles but also to build useful quantum technologies. Armstrong et al. demonstrate multimode entanglement of up to eight modes using programmable virtual networks based on linear optics that can be switched in real time. 28 Aug | Nat Commun 3:1026 doi:10.1038/ncomms2033 (2012) Physical sciences Applied physics  Optical physics  Abstract | Full Text | PDF (872 kB) Hygro-responsive membranes for effective oil–water separation Arun K. Kota, Gibum Kwon, Wonjae Choi, Joseph M. Mabry and Anish Tuteja Membrane-based technologies to separate oil–water mixtures are energy-intensive, suffer from fouling or cannot separate a wide range of mixtures. Now, a new membrane is reported that is superhydrophilic and superoleophobic, and can separate a range of oil–water mixtures with high efficiency, without an external energy source. 28 Aug | Nat Commun 3:1025 doi:10.1038/ncomms2027 (2012) Chemical sciences Fluids and plasma physics  Materials science Abstract | Full Text | PDF (958 kB) | Supplementary Information Optical separation of mechanical strain from charge doping in graphene Ji Eun Lee, Gwanghyun Ahn, Jihye Shim, Young Sik Lee and Sunmin Ryu The spectral position of Raman peaks is a useful diagnostic for determining the degree of strain and excess electronic charges present in graphene. This study demonstrates that these two contributions can be separated from each other and therefore be obtained at the same time. 28 Aug | Nat Commun 3:1024 doi:10.1038/ncomms2022 (2012) Physical sciences Condensed matter  Materials science Physical chemistry Abstract | Full Text | PDF (817 kB) | Supplementary Information Charge stripe order near the surface of 12-percent doped La2–x Sr x CuO4 H.-H. Wu, M. Buchholz, C. Trabant, C.F. Chang, A.C. Komarek, F. Heigl, M.v. Zimmermann, M. Cwik, F. Nakamura, M. Braden and C. Schüßler-Langeheine Charge stripe order has been predicted to be the ground state for the parent compounds of copper oxide superconductors. Using resonant X-ray diffraction, Schüßler-Lagenheine et al. probe the surface region of 12 percent doped La2–x Sr x CuO4, and observe charge-stripe order. 28 Aug | Nat Commun 3:1023 doi:10.1038/ncomms2019 (2012) Physical sciences Condensed matter  Materials science  Abstract | Full Text | PDF (456 kB) Controlled rotation of the F1-ATPase reveals differential and continuous binding changes for ATP synthesis OPEN Kengo Adachi, Kazuhiro Oiwa, Masasuke Yoshida, Takayuki Nishizaka and Kazuhiko Kinosita , Jr Reverse rotation of the F1-ATPase results in the synthesis, rather than hydrolysis of ATP. Adachi et al. show that the molecular mechanism of ATP synthesis is the reverse of hydrolysis-driven rotation of the motor, and that ADP and ATP are discriminated by angle-dependent binding. 28 Aug | Nat Commun 3:1022 doi:10.1038/ncomms2026 (2012) Biological sciences Biophysics  Abstract | Full Text | PDF (6,566 kB) | Supplementary Information Identification of the functional binding pocket for compounds targeting small-conductance Ca2+-activated potassium channels Miao Zhang, John M. Pascal, Marcel Schumann, Roger S. Armen and Ji-Fang Zhang Small- and intermediate-conductance K+ channels are activated by calcium-bound calmodulin and modulated by small molecules. In this study, a functional binding pocket for the 1-EBIO class of modulators is described and is located at the calmodulin-channel interface. 28 Aug | Nat Commun 3:1021 doi:10.1038/ncomms2017 (2012) Biological sciences Biophysics  Chemical biology  Abstract | Full Text | PDF (1,420 kB) | Supplementary Information   Nature Communications JOBS of the week Assistant Professor - Climate Change Tufts University Technical Research Assistant Cenix BioScience Belgium bvba Senior Scientist PsiOxus Therapeutics Limited Faculty Positions in Cognitive Science and Neuroscience University of Rochester Research Assistant to join Viral Hepatitis Research Group Foundation for Liver Research Tenure Track Cell Biologist Emory University, Department of Biology Research Associate Cambridge Institute for Medical Research Early Life Traces and Evolution University of Liège, Geology Department, Belgium Postdoctoral Research Fellow in Marine Ecosystem Modelling The University of New South Wales Mitochondrial signaling - master / PhD student positions University of Göttingen, Göttingen, Germany More Science jobs from Nature Communications EVENT Understanding brain development and correcting neurological disorders 22.-26.09.12 Valescure, France More science events from   Advertisement HudsonAlpha - Natureconference on Immunogenomics October 1-2, 2012 The Jackson Center, Huntsville, AL, USA The conference will bring together four areas to shape this emerging field: scientists in genomics and genetics, immunology, bioinformatics and methodology, and clinical research. 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