Nature Immunology Contents: May 2012 Volume 13 pp 421 - 518

Advertisement Cell Symposia Human Immunity August 19 - 21, 2012 Sheraton Lisboa, Lisbon, Portugal Keynote Speaker: James Allison, Memorial Sloan-Kettering Cancer Center, USA Submit your abstract before April 27, 2012 for consideration in our poster program and register before June 1, 2012 to save €100! TABLE OF CONTENTS May 2012 Volume 13, Issue 5 Correspondence Commentary News and Views Research Highlights Review Articles Resources Advertisement Free Sample: New Brilliant Violet™ 421 Reagents Add a brilliant new dimension to your multicolor panels with Brilliant Violet™ 421 from BD Biosciences. Request a free sample of this new violet-excitable dye with significantly improved brightness over other dyes offered for the violet laser and get the high-sensitivity fluorescence needed to better resolve dim populations. bdbiosciences.com/go/brilliant Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Reviews Cancer & Nature Reviews Immunology FOCUS ON TUMOUR IMMUNOLOGY & IMMUNOTHERAPY Access the Focus online for FREE until end of September 2012: www.nature.com/reviews/focus/tumourimmunology Produced with support from Boehringer Ingelheim   Correspondence Top The Else Kröner-Fresenius Immunology Award pp421 - 422 Susanne Schultz-Hector and Stefan HE Kaufmann doi:10.1038/ni.2285 Full Text | PDF Commentary Top Lessons learned from HIV-1 vaccine trials: new priorities and directions pp423 - 427 Andrew J McMichael and Barton F Haynes doi:10.1038/ni.2264 Abstract | Full Text | PDF News and Views Top For gut's sake: NLRC4 inflammasomes distinguish friend from foe pp429 - 431 Bernardo S Franklin and Eicke Latz doi:10.1038/ni.2289 In the gut, cells of the immune system must tolerate commensal bacteria but also detect pathogens. To achieve this, intestinal phagocytes are hyporesponsive to Toll-like receptor stimulants released from commensals, but can detect invasion of pathogens via the intracellular NLRC4 inflammasome. Full Text | PDF See also: Article by Franchi et al. Thymic signatures of tailored peripheral functions pp431 - 433 Marc Bonneville doi:10.1038/ni.2287 Gene profiling by the Immunological Genome Project consortium has identified distinct transcriptional programs that determine the migratory and functional fates of emerging γδ thymocytes. Full Text | PDF See also: Resource by Narayan et al. Restraining IL-17: Del-1 deals the blow pp433 - 435 Shabaana A Khader doi:10.1038/ni.2290 Interleukin-17 (IL-17) induces the recruitment of neutrophils to sites of inflammation. In a model of periodontitis, Del-1 is now described to be an inhibitor of IL-17 expression that suppresses the recruitment of neutrophils and the associated inflammation-mediated pathology. Full Text | PDF See also: Article by Eskan et al. Lipids-Я-Us: peroxisome generation of iNKT ligands pp435 - 436 Randy R Brutkiewicz and Alexander L Dent doi:10.1038/ni.2288 The identification of the natural lipids that select invariant natural killer T cells (iNKT cells) in vivo has been somewhat elusive and controversial. A new study shows that ether-bonded phospholipids, generated mainly in peroxisomes, are responsible for the development of a major subpopulation of iNKT cells. Full Text | PDF See also: Article by Facciotti et al. Immunology JOBS of the week Postdoctoral Fellow in Integrative Immunobiology NIH, NIAID, Laboratory of Immunology Graduate Student National Institutes of Health, NIAID, Laboratory of Immunology Postdoctoral Fellow or Graduate Student National Institutes of Health, NIAID, Laboratory of Immunology Postdoctoral Fellow in Cancer Immunology Medical University of South Carolina Ph.D. Scholarship in Immunology and Transplantation in Nantes UMRS 1064 More Science jobs from Immunology EVENT Cell Symposia: Human Immunity 19th Aug - 21st Aug 2012 Lisbon, Portugal More science events from Research Highlights Top No depot for alum | STING scaffold | Suppression by Helicobacter | Stealthy silencing | The hygiene hypothesis | Thymus dialogs Review Top Protein tyrosine phosphatases in lymphocyte activation and autoimmunity pp439 - 447 Inmoo Rhee and Andre Veillette doi:10.1038/ni.2246 Abstract | Full Text | PDF Articles Top NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense pp449 - 456 Luigi Franchi, Nobuhiko Kamada, Yuumi Nakamura, Aaron Burberry, Peter Kuffa, Shiho Suzuki, Michael H Shaw, Yun-Gi Kim and Gabriel Núñez doi:10.1038/ni.2263 Discriminating between pathogens and commensals is a major dilemma faced by the immune system. Nunez et al. demonstrate that the recognition of bacterial pathogen type III secretion systems by the NLRC4 inflammasome is key to this discrimination. Abstract | Full Text | PDF See also: News and Views by Franklin & Latz Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases pp457 - 464 Xiaowen Liu, Bo Ma, Asrar B Malik, Haiyang Tang, Tao Yang, Bo Sun, Gang Wang, Richard D Minshall, Yan Li, Yong Zhao, Richard D Ye and Jingsong Xu doi:10.1038/ni.2258 Neutrophils are early responders and must navigate using spatial cues to arrive at infection sites. Xu and colleagues show that the opposing activities of MAP kinases Erk and p38 govern neutrophil migration. Abstract | Full Text | PDF The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss pp465 - 473 Mehmet A Eskan, Ravi Jotwani, Toshiharu Abe, Jindrich Chmelar, Jong-Hyung Lim, Shuang Liang, Paul A Ciero, Jennifer L Krauss, Fenge Li, Martina Rauner, Lorenz C Hofbauer, Eun Young Choi, Kyoung-Jin Chung, Ahmed Hashim, Michael A Curtis, Triantafyllos Chavakis and George Hajishengallis doi:10.1038/ni.2260 Periodontitis is associated with aging and more neutrophil-mediated tissue pathology. Hajishengallis and colleagues show an inverse correlation between interleukin 17 expression and Del-1 expression in gingival tissues, with Del-1 protecting tissues from neutrophil infiltration. Abstract | Full Text | PDF See also: News and Views by Khader Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus pp474 - 480 Federica Facciotti, Gundimeda S Ramanjaneyulu, Marco Lepore, Sebastiano Sansano, Marco Cavallari, Magdalena Kistowska, Sonja Forss-Petter, Guanghui Ni, Alessia Colone, Amit Singhal, Johannes Berger, Chengfeng Xia, Lucia Mori and Gennaro De Libero doi:10.1038/ni.2245 The identity of the self lipids presented by CD1d that select iNKT cells is controversial. De Libero and colleagues identify ether-bonded self lipids generated by the peroxisome enzyme GNPAT can select developing iNKT cells in the thymus. Abstract | Full Text | PDF See also: News and Views by Brutkiewicz & Dent Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells pp481 - 490 Jae-Hoon Chang, Yichuan Xiao, Hongbo Hu, Jin Jin, Jiayi Yu, Xiaofei Zhou, Xuefeng Wu, Howard M Johnson, Shizuo Akira, Manolis Pasparakis, Xuhong Cheng and Shao-Cong Sun doi:10.1038/ni.2267 The processes that underlie maintenance of the identity of regulatory T cells are unclear. Sun and colleagues show that expression of the ubiquitin-conjugating enzyme Ubc13 by these cells is critical for this process. Abstract | Full Text | PDF The development and fate of follicular helper T cells defined by an IL-21 reporter mouse pp491 - 498 Katja Luthje, Axel Kallies, Yoko Shimohakamada, Gabrielle T Belz, Amanda Light, David M Tarlinton and Stephen L Nutt doi:10.1038/ni.2261 Follicular helper T cells provide help to cognate B cells in germinal centers to boost humoral immunity. Nutt and colleagues generate IL-21-GFP reporter mice to track the fate of follicular helper T cells. Abstract | Full Text | PDF Resources Top Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks pp499 - 510 Deepali Malhotra, Anne L Fletcher, Jillian Astarita, Veronika Lukacs-Kornek, Prakriti Tayalia, Santiago F Gonzalez, Kutlu G Elpek, Sook Kyung Chang, Konstantin Knoblich, Martin E Hemler, Michael B Brenner, Michael C Carroll, David J Mooney, Shannon J Turley and the Immunological Genome Project Consortium doi:10.1038/ni.2262 The Immunological Genome Project aims to build a comprehensive database of gene-expression and gene-regulatory networks in the mouse immune system. Here Turley and colleagues analyze the transcriptomes of lymph-node stromal cells under steady-state and inflammatory conditions. Abstract | Full Text | PDF Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes pp511 - 518 Kavitha Narayan, Katelyn E Sylvia, Nidhi Malhotra, Catherine C Yin, Gregory Martens, Therese Vallerskog, Hardy Kornfeld, Na Xiong, Nadia R Cohen, Michael B Brenner, Leslie J Berg, Joonsoo Kang and The Immunological Genome Project Consortium doi:10.1038/ni.2247 As part of the Immunogical Genome project, Kang and colleagues compare the gene-expression profiles of emergent thymocytes from adult mice that express the γδ T cell antigen receptor, segregated on the basis of the use of the γ- or δ-chain variable region, and find that the main subsets are molecularly distinct. Abstract | Full Text | PDF See also: News and Views by Bonneville Top Advertisement Emerging Microbes & Infections (EMI) - New open access journal launching in July 2012! 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