Nature Reviews Cancer contents March 2012 Volume 12 Number 3 pp 151-226

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TABLE OF CONTENTS
March 2012 Volume 12 Number 3		Advertisement
Impact Factor 37.178 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Genomic instability in cancer  Featured article: The insulin and insulin-like growth factor receptor family in neoplasia: an update Michael Pollak	Apoptosis Detection: A streamlined approach. New BD FACSuite™ software on the BD FACSVerse™ flow cytometry system provides predefined research assays matched with reagent kits, making it easy to achieve reproducible, consistent results. Download a free application note on apoptosis detection and see the exciting innovations behind the new BD FACSVerse. bdbiosciences.com/go/verse
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RESEARCH HIGHLIGHTS Top Metastasis: Navigating uncharted territory p151 | doi:10.1038/nrc3229 Two papers published in Cell expand our knowledge and raise new questions about how metastasis occurs in pancreatic cancer. PDF Genomic instability: Shattered details p152 | doi:10.1038/nrc3228 Two new studies provide mechanistic insights into the phenomenon of chromothripsis in cancer. PDF Microenvironment: Enforced compliance p152 | doi:10.1038/nrc3240 In order to proliferate, cells with oncogenic mutations might first need to escape the restrictions of the epithelial environment. PDF Leukaemia: Targeting menin p154 | doi:10.1038/nrc3231 Inhibitors that target the interaction between menin and MLL could be useful for the treatment of acute lymphocytic leukaemia. PDF Angiogenesis: Scheduled delivery p154 | doi:10.1038/nrc3232 Data from patients with non-small-cell lung cancer (NSCLC) indicate that angiogenesis inhibitors may not increase the delivery of chemotherapy. PDF Morphology: Oncogenic morphs of p53 p155 | doi:10.1038/nrc3230 Prives and colleagues show that two p53 mutants exhibit oncogenic functions such that they increase the expression of the mevalonate pathway, which causes altered morphology of mammary acini. PDF Epigenetics: Histone modification at the gene level p156 | doi:10.1038/nrc3233 Two new studies identify mutations in histone variants in high-grade paediatric gliomas PDF Metastasis: Leaky effect p157 | doi:10.1038/nrc3227 Data that support a link between pericyte loss and metastasis have been published in Cancer Cell. PDF IN BRIEF Metabolism: Context-specific metabolism | Alternative splicing: Dose-dependent splicing | Hypoxia: Scaffolding the regulation of hypoxia | Therapeutics: Passed down to the next generation | Tumour heterogeneity: All mixed up | Therapeutic resistance: Rational combination PDF Cancer JOBS of the week postdoc fellow or junior faculty position Ohio State University Medical Center Postdoctoral Fellow in Cancer Research European Bioinformatics Institute (EBI) Postdoctoral Fellow in Immunology Univ of Texas M. D. Anderson Cancer Center Post-Doctoral (WW) - Target Identification and Drug Discovery - Immunobiology and Cancer Research Program (W Wang) Oklahoma Medical Research Foundation (OMRF) Postdoctoral Fellow Mount Sinai School of Medicine More Science jobs from Cancer EVENT Stromal-epithelial interactions in breast cancer development and progression 15.-18.04.12 Manchester, UK More science events from
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REVIEWS		Top
The insulin and insulin-like growth factor receptor family in neoplasia: an update Michael Pollak p159 | doi:10.1038/nrc3215 This Review reflects on the recent disappointing initial results from Phase III trials of insulin-like growth factor I receptor (IGF1R)-specific antibodies for cancer treatment, and discusses the next steps in targeting insulin and IGFI signalling in cancer therapy. Abstract | Full Text | PDF
Epithelial stem cells, wound healing and cancer Esther N. Arwert, Esther Hoste & Fiona M. Watt p170 | doi:10.1038/nrc3217 There are many connections between wound healing and tumorigenesis. Using the epidermis as an example, this Review discusses these connections and how stem cells affect these two processes. Abstract | Full Text | PDF
The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention Jeffrey M. Peters, Yatrik M. Shah & Frank J. Gonzalez p181 | doi:10.1038/nrc3214 Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that are involved in regulating glucose and lipid homeostasis, inflammation, proliferation and differentiation. This Review discusses the roles of PPARs in cancer and focuses on PPARβ/δ and the controversies yet to be resolved. Abstract | Full Text | PDF
The nuclear envelope environment and its cancer connections Kin-Hoe Chow, Rachel E. Factor & Katharine S. Ullman p196 | doi:10.1038/nrc3219 Aberrant nuclear morphology is already used as a diagnostic criterion for cancer, but why is the nucleus deformed in cancer cells? This Review discusses how components of the nuclear envelope and the adjoining lamina are deregulated in cancer cells and the consequences of this change in cell morphology. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity Melody A. Swartz & Amanda W. Lund p210 | doi:10.1038/nrc3186 Tumours often engage the lymphatic system to invade and metastasize. This Opinion article proposes that increased interstitial and lymphatic flow in the tumour microenvironment, and the resulting mechanical changes to the tumour stroma, may strongly alter host immunity to the tumour. Abstract | Full Text | PDF
OPINION Article series: Genomic instability in cancer RB: mitotic implications of a tumour suppressor Amity L. Manning & Nicholas J. Dyson p220 | doi:10.1038/nrc3216 The RB family is usually associated with the regulation of the G1/S transition and cell cycle entry. Recent data have shown a role for the RB family in regulating S phase and mitosis, which has implications for the genomic stability of tumour cells in which the RB family is inactivated. Abstract | Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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