Nature Reviews Immunology Contents March 2012 Volume 12 Number 3 pp 149-225

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TABLE OF CONTENTS
March 2012 Volume 12 Number 3
Impact Factor 35.196 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Beyond pattern recognition: five immune checkpoints for scaling the microbial threat J. Magarian Blander & Leif E. Sander
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RESEARCH HIGHLIGHTS Top Regulatory T cells: A question of stability and commitment p149 | doi:10.1038/nri3181 The apparent instability of TReg cells is explained by a minor population of uncommitted FOXP3+ cells. PDF Innate immunity: Quieting the inflammasome p150 | doi:10.1038/nri3171 Autophagosome formation accompanies inflammasome activation and acts to limit inflammasome activity. PDF Natural killer cells: Maturation and function of NK cells p150 | P doi:10.1038/nri3172 T-bet and EOMES control unique checkpoints in NK cell maturation, whereas NKp46 and Helios tune NK cell reactivity. PDF T cell responses: STAT5 reins in the follicular helpers p152 | doi:10.1038/nri3170 STAT5 inhibits follicular helper T cell differentiation by targeting BLIMP1. PDF T cells: Broken synapses in autoimmunity p152 | doi:10.1038/nri3176 Immune synapse formation is impaired in human self-reactive CD4+ T cell clones. PDF Metabolism and immunology: Gut microbiota influences liver disease p153 | doi:10.1038/nri3177 Changes in the gut microbiota owing to inflammasome deficiency promote chronic inflammatory liver disease. PDF Innate immunity: ADAM17 — gatekeeper of the skin barrier p154 | doi:10.1038/nri3178 The metalloproteinase ADAM17 maintains the epidermal barrier through basal Notch activation. PDF Regulatory T cells: A division of labour p154 | doi:10.1038/nri3180 Peripherally induced TReg cells prevent allergic inflammation at mucosal surfaces. PDF Neutrophils: Balancing the books p155 | doi:10.1038/nri3179 CXCR2 and CXCL5 control neutrophil homeostasis by downregulating IL-17A and G-CSF. PDF IN BRIEF Tolerance: Genetic regulation of peripheral tolerance | Technique: Visualizing γδ T cells in the epidermis | Natural killer T cells: Defining iNKT cell subpopulations | Antiviral immunity: A wake up call for antiviral T cells | Apoptosis: Stress triggers the healing process | T cell development: Inflammasome blockade keeps the thymus young PDF Immunology JOBS of the week Tenure-track Assistant or Associate Professor Albert Einstein College of Medicine PhD Positions Spemann Graduate School of Biology and Medicine (SGBM) Associate Research Scientist Columbia Center for Translational Immunology, Columbia University Medical Center Major Initiative in Virology and Immunology Imperial College London Research Assistant in Allergy and Immunology University of Southern California (USC) More Science jobs from Immunology EVENT Gene Expression and Signaling in the Immune System 24.-28.04.12 US More science events from
REVIEWS		Top
Selection of regulatory T cells in the thymus Chyi-Song Hsieh, Hyang-Mi Lee & Chan-Wang J. Lio p157 | doi:10.1038/nri3155 How are regulatory T (TReg) cells selected in the thymus? What is the role of T cell receptor specificity in the generation of self antigen-specific TReg cells? What is the involvement of thymic antigen-presenting cells in TReg cell differentiation and how is FOXP3 expression induced in developing thymocytes? Here, the authors summarize the latest findings in the field of TReg cells to provide answers to these long-standing questions. Abstract | Full Text | PDF
Accessory molecules for Toll-like receptors and their function Clarissa C. Lee, Ana M. Avalos & Hidde L. Ploegh p168 | doi:10.1038/nri3151 Toll-like receptors (TLRs) have a central role in the initiation of innate and adaptive immune responses. Recent studies have shown that various accessory molecules are required for the biosynthesis and/or activation of several TLRs. A detailed knowledge of these accessory molecules is necessary to better understand the function of TLRs in the immune system. Abstract | Full Text | PDF
The role of interleukin-2 during homeostasis and activation of the immune system Onur Boyman & Jonathan Sprent p180 | doi:10.1038/nri3156 Here, the authors discuss the biological role of interleukin-2 (IL-2) in the immune system, focusing on recent advances in our understanding of how IL-2 signals have different effects on various T cell populations and how this knowledge can be harnessed in the clinic. Abstract | Full Text | PDF
Standardizing immunophenotyping for the Human Immunology Project Holden T. Maecker, J. Philip McCoy & Robert Nussenblatt p191 | doi:10.1038/nri3158 The authors use flow cytometry of peripheral blood mononuclear cells as an example to outline the approaches to assay standardization that will be required to realize the full potential of immunophenotyping as a research tool and in the clinic. Abstract | Full Text | PDF
Living in the liver: hepatic infections Ulrike Protzer, Mala K. Maini & Percy A. Knolle p201 | doi:10.1038/nri3169 The tolerogenic properties of the liver make it an attractive site for infection by pathogens. This Review describes how most pathogens are effectively controlled by immune responses in the liver, and how some pathogens, such as hepatitis viruses and malaria-causing parasites, can establish chronic infections in the liver. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Beyond pattern recognition: five immune checkpoints for scaling the microbial threat J. Magarian Blander & Leif E. Sander p215 | doi:10.1038/nri3167 In this Opinion article, Blander and Sander examine how the immune system is able to distinguish between viable and dead, pathogenic and non-pathogenic, or invading and colonizing microorganisms. They propose five immune checkpoints that can be used to determine the relative threat of a particular microbial encounter. Abstract | Full Text | PDF
Corrigendum: Vaccines for the twenty-first century society Rino Rappuoli, Christian W. Mandl, Steven Black & Ennio De Gregorio p225 | doi:10.1038/nri3168 Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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