Laboratory Investigation - Table of Contents alert Volume 96 Issue 2

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TABLE OF CONTENTS Volume 96, Issue 2 (February 2016) In this issue Inside the USCAP Journals Pathobiology in Focus Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Inside the USCAP Journals Top Inside the USCAP Journals 2016 96: 114-115; 10.1038/labinvest.2015.165 Full Text Pathobiology in Focus Top The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies This review focuses on recent progress in understanding WNT/β-catenin signaling in physiology, stem cell proliferation and differentiation as well as several types of cancer. The review also discusses both the therapeutic opportunities and problems of targeting Wnt/β-catenin, and highlights issues regarding Wnt signaling which need to be addressed. Ke Yang, Xin Wang, Hongmei Zhang, Zhongliang Wang, Guoxin Nan, Yasha Li, Fugui Zhang, Maryam K Mohammed, Rex C Haydon, Hue H Luu, Yang Bi and Tong-Chuan He 2016 96: 116-136; advance online publication, November 30, 2015; 10.1038/labinvest.2015.144 Abstract | Full Text WNT signaling in glioblastoma and therapeutic opportunities In this review, the authors demonstrate that WNT signaling affects proliferation, invasion and therapeutic resistance in glioblastoma. Evidence of crosstalk with other signaling pathways is described which emphasize the central importance of WNT signaling. Targeting WNT signaling is a possible therapeutic approach for glioblastoma. Yeri Lee, Jin-Ku Lee, Sun Hee Ahn, Jeongwu Lee and Do-Hyun Nam 2016 96: 137-150; advance online publication, December 7, 2015; 10.1038/labinvest.2015.140 Abstract | Full Text Canonical Wnt signaling in systemic sclerosis This review comprehensively describes the pivotal role of Wnt/β-catenin in systemic sclerosis. The emerging story of this fibrotic disease which affects not only the skin but the gastrointestinal system, lungs and heart, is the relationship of TGF-b with increased Wnt/β-catenin signaling and the amelioration of fibrosis with Dkk-1. Both translational implications and the limitations of prolonged Wnt/β-catenin inhibition are discussed. Christina Bergmann and Jörg H W Distler 2016 96: 151-155; advance online publication, January 11, 2016; 10.1038/labinvest.2015.154 Abstract | Full Text Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword This review summarizes the expression, intracellular modification, and secretion of Wnt family proteins and their regulation in a variety of kidney diseases. It also explores current understanding of the potential mechanisms by which transient Wnt/β-catenin activation regulates adaptive responses of the kidney after acute kidney injury, and discusses how sustained activation of this signaling triggers maladaptive responses and causes destructive outcomes. Dong Zhou, Roderick J Tan, Haiyan Fu and Youhua Liu 2016 96: 156-167; advance online publication, December 21, 2015; 10.1038/labinvest.2015.153 Abstract | Full Text UM206, a selective Frizzled antagonist, attenuates adverse remodeling after myocardial infarction in swine Inhibition of Wnt/Frizzled signaling with UM206 reduces m infarct mass and limits left ventricular dilation in a translational swine model of myocardial infarction (MI). These findings imply that modulating Wnt/Frizzled signaling is beneficial for post-MI wound healing and adverse remodeling. UM206-therapy may provide a novel adjunctive therapy for MI treatment. André Uitterdijk, Kevin CM Hermans, Daphne PM de Wijs-Meijler, Evangelos P Daskalopoulos, Irwin K Reiss, Dirk J Duncker, W Matthijs Blankesteijn and Daphne Merkus 2016 96: 168-176; advance online publication, December 14, 2015; 10.1038/labinvest.2015.139 Abstract | Full Text Take the Wnt out of the inflammatory sails: modulatory effects of Wnt in airway diseases Wnt pathways are known to be involved in embryogenesis, as well as lung and cancer development. Recent research has identified a role for Wnt pathways in immune regulation. This review summarizes current understanding of the role and function of different Wnt pathways for allergic airway disease and chronic obstructive pulmonary disease. Sebastian Reuter, Hendrik Beckert and Christian Taube 2016 96: 177-185; advance online publication, November 23, 2015; 10.1038/labinvest.2015.143 Abstract | Full Text Wnt signaling in cartilage development and diseases: lessons from animal studies This review focuses on Wnt signaling in cartilage development and skeletal disorders involving cartilage. It describes the essential roles of cartilage in formation, growth and function of long bones; Wnt signaling in growth plate cartilage during long bone development and growth; and Wnt signaling in osteoarthritis. Yu Usami, Aruni T Gunawardena, Masahiro Iwamoto and Motomi Enomoto-Iwamoto 2016 96: 186-196; advance online publication, December 7, 2015; 10.1038/labinvest.2015.142 Abstract | Full Text Research Articles Top Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma This study investigates the role of Klotho (a gene known for its anti-aging properties) in the tumorigenesis of human hepatocellular carcinoma (HCC). The authors found that klotho can act as an inhibitor of the Wnt/β-catenin pathway in HCC in vitro and in vivo. Moreover, they also detected the serum levels of soluble klotho, and found a significant increase in these levels in HCC patients. These findings suggested that klotho may be a tumor suppressor in HCC, and a potential biomarker for the diagnosis of HCC. Xiaowei Tang, Yun Wang, Zhining Fan, Guozhong Ji, Min Wang, Jie Lin, Shu Huang and Stephen J Meltzer 2016 96: 197-205; advance online publication, August 3, 2015; 10.1038/labinvest.2015.86 Abstract | Full Text ROS-induced endothelial stress contributes to pulmonary fibrosis through pericytes and Wnt signaling Systemic bleomycin-administration is used to model pulmonary fibrosis, yet the mechanism is unknown. The aim of the study was to identify mechanisms for the development of pulmonary fibrosis following systemic bleomycin-administration. The results suggest that bleomycin induce oxidative stress in the endothelial niche, which initiates vascular repair processes involving pericytes and Wnt signaling. Annika Andersson-Sjöland, Jenny C Karlsson and Kristina Rydell-Törmänen 2016 96: 206-217; advance online publication, September 14, 2015; 10.1038/labinvest.2015.100 Abstract | Full Text WNT/β-catenin signaling regulates cigarette smoke-induced airway inflammation via the PPARδ/p38 pathway Persistent airway inflammation is a key pathophysiological process in chronic obstructive pulmonary disease. This study shows that WNT/β-catenin signaling pathway plays a protective effect on the cigarette smoke-induced airway inflammation through PPARδ/p38 MAPK pathway. This study therefore identifies a novel pathway that might rescue the airway inflammation in response to cigarette smoke exposure. Lingli Guo, Tao Wang, Yanqiu Wu, Zhicheng Yuan, Jiajia Dong, Xiao'ou Li, Jing An, Zenglin Liao, Xue Zhang, Dan Xu and Fu-Qiang Wen 2016 96: 218-229; advance online publication, August 31, 2015; 10.1038/labinvest.2015.101 Abstract | Full Text Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling This study demonstrates that the nuclear hormone receptor LXRα has an inhibitory effect on adipogenic differentiation in murine mesenchymal stem cells with active Wnt/beta-catenin signaling. These data provide important insights into the pathophysiology of obesity and obesity related consequences such as metabolic syndrome and may identify potential therapeutic targets. Kenichi Matsushita, Fulvio Morello, Zhiping Zhang, Tomoko Masuda, Shiro Iwanaga, Knut R Steffensen, Jan-Åke Gustafsson, Richard E Pratt and Victor J Dzau 2016 96: 230-238; advance online publication, November 23, 2015; 10.1038/labinvest.2015.141 Abstract | Full Text Dkk3 prevents familial dilated cardiomyopathy development through Wnt pathway This study demonstrates a new role for Dkk3 in mouse models of familial dilated cardiomyopathy development. Activation of Wnt/β-catenin is seen in the compensatory stage, as well as inhibition of the non-canonical Wnt pathway, which suggested that Dkk3 may serve as a therapeutic target for the treatment of cardiomyopathy and heart failure. Dan Lu, Dan Bao, Wei Dong, Ning Liu, Xu Zhang, Shan Gao, Wenping Ge, Xiang Gao and Lianfeng Zhang 2016 96: 239-248; advance online publication, December 7, 2015; 10.1038/labinvest.2015.145 Abstract | Full Text Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974 This study compares ascites cells from primary ovarian cancer patients after incubation with the porcupine inhibitor WNT974, carboplatin, or both drugs together. Both drugs together produced a greater reduction in ATP content than single drugs. qPCR demonstrated that R-spondin fusions were not prevalent in tumors or ascites. Higher porcupine and Wntless gene expression correlated with sensitivity to WNT974, suggesting they might serve as biomarkers for patient selection. Jonathan D Boone, Rebecca C Arend, Bobbi E Johnston, Sara J Cooper, Scott A Gilchrist, Denise K Oelschlager, William E Grizzle, Gerald McGwin, Jr, Abhishek Gangrade, J Michael Straughn, Jr and Donald J Buchsbaum 2016 96: 249-259; advance online publication, December 14, 2015; 10.1038/labinvest.2015.150 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. 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