Nature Reviews Molecular Cell Biology contents January 2016 Volume 17 Number 2 pp 65-132

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TABLE OF CONTENTS
February 2016 Volume 17 Number 2
Impact Factor 37.806 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Post-translational modifications Featured article: Structure and function of ER membrane contact sites with other organelles Melissa J. Phillips & Gia K. Voeltz
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RESEARCH HIGHLIGHTS Top DNA repair: The cell cycle flavours of repair p65 | doi:10.1038/nrm.2015.24 The suppression of homologous recombination in G1 depends on BRCA1-PALB2-BRCA2 complex formation at sites of damage. In mitosis, DNA repair factors prevent the formation of DNA damage by facilitating mitotic replication. PDF Cytoskeleton: A new face of the centrosome p66 | doi:10.1038/nrm.2015.26 Centrosomes can nucleate not only microtubules but also actin filaments, in a process dependent on the actin-related protein 2/3 complex and WASH. PDF Chromosome biology: In and out through the same cohesin door p66 | doi:10.1038/nrm.2015.29 DNA enters and exits the cohesin ring by a similar two-gate mechanism. PDF Chromosomes: Complex relationships p66 | doi:10.1038/nrm.2015.30 Whole-proteome analysis of vertebrate mitotic chromosomes provides insight into the complex network of kinetochore protein interactions. PDF JOURNAL CLUB The actin seed p68 | doi:10.1038/nrm.2015.17 Rong Li tells us about the discovery of the seven-subunit actin nucleator Arp2/3 complex. PDF Non-coding RNA: Decoy pumilio for genomic stability p68 | doi:10.1038/nrm.2016.5 The sequence-specific binding by pumilio proteins of the long non-coding RNA NORAD sequesters their activity and helps to maintain genomic stability. PDF IN BRIEF DNA replication: Rif1 times replication | Stem cells: Autophagy rescues muscle ageing | Gene expression: Nuclear mRNA retention buffers expression noise PDF Molecular Cell Biology JOBS of the week Research Associate University of Glasgow Postdoc in angiogenesis and cell signaling Karolinska Institutet (KI) PhD Student (f / m) in Functional Neuroproteomics German Center for Neurodegenerative Deseases Postgraduate - Doctorate / PhD University of Fribourg Postdoctoral Fellow The University of Tennessee Health Science Center More Science jobs from
REVIEWS		Top
Structure and function of ER membrane contact sites with other organelles Melissa J. Phillips & Gia K. Voeltz p69 | doi:10.1038/nrm.2015.8 Endoplasmic reticulum (ER) is typically associated with protein biogenesis. However, recent studies suggest that it additionally synchronizes and regulates a plethora of intracellular events owing to its ability to form tight membrane associations, so-called membrane contact sites (MCSs), with other organelles. Abstract | Full Text | PDF
A-to-I editing of coding and non-coding RNAs by ADARs Kazuko Nishikura p83 | doi:10.1038/nrm.2015.4 ADAR enzymes convert adenosine to inosine (A-to-I editing) at numerous double-stranded Alu repeats in human transcripts, thereby affecting many cellular processes. Primary microRNAs (miRNAs) are also edited, and ADAR1 directly interacts with Dicer, resulting in the modulation of miRNA expression and activity and of downstream gene expression programmes during embryogenesis. Abstract | Full Text | PDF
The front and rear of collective cell migration Roberto Mayor & Sandrine Etienne-Manneville p97 | doi:10.1038/nrm.2015.14 Collective cell migration has a crucial role during morphogenesis, wound healing and tissue renewal, and it is involved in cancer spreading. Recent studies highlight the importance of intercellular communication in this process: migration is driven by leader cells at the front, and follower cells communicate between them and with the leaders to improve the efficiency of collective movement. Abstract | Full Text | PDF
Article series: Post-translational modifications Protein prenylation: unique fats make their mark on biology Mei Wang & Patrick J. Casey p110 | doi:10.1038/nrm.2015.11 Learning more about the biochemistry of protein prenylation (modification by isoprenoid lipids) and its functional effects on target CAAX proteins has provided opportunities for therapeutic intervention in a range of human diseases. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Understanding transport by the major facilitator superfamily (MFS): structures pave the way Esben M. Quistgaard, Christian Low, Fatma Guettou & Par Nordlund p123 | doi:10.1038/nrm.2015.25 Members of the major facilitator superfamily are highly conserved transmembrane proteins that transport various small molecules, including nutrients, drugs, signalling molecules and waste products, across the plasma membrane. A novel model of their functional cycle provides insights into how these important transporters operate on the molecular level. Abstract | Full Text | PDF | Supplementary information
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