Molecular Systems Biology - New articles published - 1 Jul 2015

June 2015 | Volume 11, Number 6 Submit Table of Contents Articles Reviews Volume 11, Number 6 Articles Systems‐wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation Mass spectrometry‐based quantitative analysis of B‐cell receptor (BCR) signaling provides a global view of BCR signaling and identifies novel regulatory functions of phosphorylation and ubiquitylation in this system. Shankha Satpathy, Sebastian A Wagner, Petra Beli, Rajat Gupta, Trine A Kristiansen, Dessislava Malinova, Chiara Francavilla, Pavel Tolar, Gail A Bishop, Bruce S Hostager, and Chunaram Choudhary Published online 02.06.2015 Phosphoproteome dynamics of Saccharomyces cerevisiae under heat shock and cold stress High temporal resolution profiling of the yeast phosphoproteome upon heat shock and cold stress enabled the correlation of kinetic profiles between kinases and their substrates and identified cell signaling events associated with actin organization, septin assembly and cell cycle arrest. Evgeny Kanshin, Peter Kubiniok, Yogitha Thattikota, Damien D'Amours, and Pierre Thibault Published online 03.06.2015 Single‐cell polyadenylation site mapping reveals 3′ isoform choice variability BATSeq, the first transcriptomic method to quantify polyadenylation site use in single cells, reveals that stem cells from homogeneous populations differ in their preference for 3′ mRNA isoforms. Lars Velten, Simon Anders, Aleksandra Pekowska, Aino I Järvelin, Wolfgang Huber, Vicent Pelechano, and Lars M Steinmetz Published online 03.06.2015 Systems‐level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry An RNAi screen followed by quantitative analyses of cell division timing reveals dual roles of fate determinants in temporal regulation and cell fate specification and provides a resource for analyzing the genetic control of spatiotemporal coordination during metazoan development. Vincy Wing Sze Ho, Ming‐Kin Wong, Xiaomeng An, Daogang Guan, Jiaofang Shao, Hon Chun Kaoru Ng, Xiaoliang Ren, Kan He, Jinyue Liao, Yingjin Ang, Long Chen, Xiaotai Huang, Bin Yan, Yiji Xia, Leanne Lai Hang Chan, King Lau Chow, Hong Yan, and Zhongying Zhao Published online 10.06.2015 Reviews Modeling cancer metabolism on a genome scale Cancer cells have fundamental metabolic alterations that are associated with tumorigenicity and malignancy. This review discusses our current knowledge of altered tumor metabolism and strategies to model these alterations, through the integration of omics data with genome‐scale metabolic models. Keren Yizhak, Barbara Chaneton, Eyal Gottlieb, and Eytan Ruppin Published online 30.06.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.