| | | | | | Advertisement | | Nature Outlook Addiction Breaking the bonds of dependency. Access the Outlook and accompanying video free online.
Produced with support from the National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse and Reckitt Benckiser Pharmaceuticals Inc., a subsidiary of Indivior PLC | | | | | | | Nature Communications - now fully open access
All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website.
Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | Latest Articles | View all Articles | | | PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine OPEN | | Shu-Yun Kuo, Chia-Lin Wu, Min-Yen Hsieh, Chen-Ta Lin, Rong-Kun Wen, Lien-Cheng Chen, Yu-Hui Chen, Yhu-Wei Yu, Horng-Dar Wang, Yi-Ju Su, Chun-Ju Lin, Cian-Yi Yang, Hsien-Yu Guan, Pei-Yu Wang, Tsuo-Hung Lan and Tsai-Feng Fu | | We currently lack a detailed understanding of the neurobiological basis for the decline of male sexual desire with age. Here the authors demonstrate that restoring impaired dopaminergic signalling in a specific cluster of neurons in the Drosophila brain increases sexual behaviour in ageing male flies. | | 30 June 2015 | doi: 10.1038/ncomms8490 | | Biological Sciences Neuroscience | Early emergence of Yersinia pestis as a severe respiratory pathogen OPEN | | Daniel L. Zimbler, Jay A. Schroeder, Justin L. Eddy and Wyndham W. Lathem | | Yersinia pestis, which evolved from a gastrointestinal pathogen, causes pneumonic and bubonic plague. Here Zimbler et al. show that the gain of a single protein enabled Y. pestis to first cause pneumonic plague, and one amino-acid change in the same protein then allowed the bacteria to efficiently cause bubonic plague. | | 30 June 2015 | doi: 10.1038/ncomms8487 | | Biological Sciences Evolution Microbiology | Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment OPEN | | Yael R. Nobel, Laura M. Cox, Francis F. Kirigin, Nicholas A. Bokulich, Shingo Yamanishi, Isabel Teitler, Jennifer Chung, Jiho Sohn, Cecily M. Barber, David S. Goldfarb, Kartik Raju, Sahar Abubucker, Yanjiao Zhou, Victoria E. Ruiz, Huilin Li, Makedonka Mitreva, Alexander V. Alekseyenko, George M. Weinstock, Erica Sodergren and Martin J. Blaser et al. | | The potential recovery of the human gut microbiota after an antibiotic treatment, and its effects on our health, are poorly understood. Here, the authors use a mouse model mimicking paediatric antibiotic use to shed new light into these processes. | | 30 June 2015 | doi: 10.1038/ncomms8486 | | Biological Sciences Ecology Microbiology | Variable Holocene deformation above a shallow subduction zone extremely close to the trench OPEN | | Kaustubh Thirumalai, Frederick W. Taylor, Chuan-Chou Shen, Luc L. Lavier, Cliff Frohlich, Laura M. Wallace, Chung-Che Wu, Hailong Sun and Alison K. Papabatu | | Information regarding tectonic motion from before instrumental records can be found from palaeoshorelines and the reconstruction of sea level from observations. Here, the authors study corals uplifted by past earthquakes near the Solomon Islands and assess the Holocene deformation that took place there. | | 30 June 2015 | doi: 10.1038/ncomms8607 | | Earth Sciences Geology and geophysics | Supramolecular amplification of amyloid self-assembly by iodination OPEN | | Arianna Bertolani, Lisa Pirrie, Loic Stefan, Nikolay Houbenov, Johannes S. Haataja, Luca Catalano, Giancarlo Terraneo, Gabriele Giancane, Ludovico Valli, Roberto Milani, Olli Ikkala, Giuseppe Resnati and Pierangelo Metrangolo | | Amyloid assemblies lie at the heart of many physiological functions, as well as being the cause of numerous diseases. Here, the authors subtly modify wild-type pentapeptides with halides, and discover that the new halogen bonding interactions have a remarkable influence on their physical properties. | | 30 June 2015 | doi: 10.1038/ncomms8574 | | Chemical Sciences Chemical biology Materials science Organic chemistry | In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging OPEN | | Zhenhua Hu, Yawei Qu, Kun Wang, Xiaojun Zhang, Jiali Zha, Tianming Song, Chengpeng Bao, Haixiao Liu, Zhongliang Wang, Jing Wang, Zhongyu Liu, Haifeng Liu and Jie Tian | | Insufficient imaging sensitivity can make it challenging to assess early stage tumour lesions in vivo. Here, the authors present the radiopharmaceutical-excited fluorescence imaging technique that can detect tumour lesions less than 2 mm in size in living mice. | | 30 June 2015 | doi: 10.1038/ncomms8560 | | Biological Sciences Medical research Nanotechnology | Atomic species identification at the (101) anatase surface by simultaneous scanning tunnelling and atomic force microscopy OPEN | | Oleksandr Stetsovych, Milica Todorović, Tomoko K. Shimizu, César Moreno, James William Ryan, Carmen Pérez León, Keisuke Sagisaka, Emilio Palomares, Vladimír Matolín, Daisuke Fujita, Ruben Perez and Oscar Custance | | Anatase is a pivotal material in devices for energy-harvesting applications and catalysis. Here, Stetsovych et al. demonstrate the potential of simultaneously combining atomic force microscopy and scanning tunnelling microscopy to identify the atomic species populating the (101) surface of anatase. | | 29 June 2015 | doi: 10.1038/ncomms8265 | | Physical Sciences Condensed matter Materials science | Sprite streamer initiation from natural mesospheric structures | | Ningyu Liu, Joseph R. Dwyer, Hans C. Stenbaek-Nielsen and Matthew G. McHarg | | Sprites, electrical discharges in the upper atmosphere, are thought to be triggered by inhomogeneities. Here the authors present numerical models and propose that mesospheric structures created by atmospheric gravity waves can initiate sprite streamers, and also provide observations supporting this theory. | | 29 June 2015 | doi: 10.1038/ncomms8540 | | Earth Sciences Atmospheric science | Pliocene cooling enhanced by flow of low-salinity Bering Sea water to the Arctic Ocean OPEN | | Keiji Horikawa, Ellen E. Martin, Chandranath Basak, Jonaotaro Onodera, Osamu Seki, Tatsuhiko Sakamoto, Minoru Ikehara, Saburo Sakai and Kimitaka Kawamura | | Late Pliocene cooling led to the glaciation of the Northern Hemisphere, yet its trigger remains unclear. Here, the authors present neodymium and lead isotope records from the Bering Sea, and propose that the introduction of low-salinity water into the Arctic Ocean preconditioned Pliocene cooling. | | 29 June 2015 | doi: 10.1038/ncomms8587 | | Earth Sciences Climate science Oceanography | Cidea improves the metabolic profile through expansion of adipose tissue | | Gustavo Abreu-Vieira, Alexander W. Fischer, Charlotte Mattsson, Jasper M.A. de Jong, Irina G. Shabalina, Mikael Rydén, Jurga Laurencikiene, Peter Arner, Barbara Cannon, Jan Nedergaard and Natasa Petrovic | | Unlike rodents, humans produce the protein Cidea in white adipose tissue, where it associates with lipid droplets. Here the authors generate mice that express human Cidea in fat tissues to show Cidea exerts beneficial metabolic effects by regulating the expansion of visceral fat in response to a high-fat diet. | | 29 June 2015 | doi: 10.1038/ncomms8433 | | Biological Sciences Medical research | Extreme ultraviolet imaging of three-dimensional magnetic reconnection in a solar eruption OPEN | | J. Q. Sun, X. Cheng, M. D. Ding, Y. Guo, E. R. Priest, C. E. Parnell, S. J. Edwards, J. Zhang, P. F. Chen and C. Fang | | Magnetic reconnection is a fundamental energy release process taking place in various astrophysical environments, but it is difficult to observe it directly. Here, the authors provide evidence of three-dimensional magnetic reconnection in a solar eruption using combined perspectives of two spacecraft. | | 26 June 2015 | doi: 10.1038/ncomms8598 | | Physical Sciences Astronomy | Structure and gating of the nuclear pore complex OPEN | | Matthias Eibauer, Mauro Pellanda, Yagmur Turgay, Anna Dubrovsky, Annik Wild and Ohad Medalia | | Nuclear pore complexes (NPCs) are large macromolecular assemblies that mediate the exchange of molecules between the nucleus and cytoplasm. Here the authors present a ∼20 Å cryo-EM structure of the X. laevis NPC in different states of transport to propose a model for the architecture of the NPC’s molecular gate within its central channel. | | 26 June 2015 | doi: 10.1038/ncomms8532 | | Biological Sciences Biophysics Cell biology Molecular biology | Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones OPEN | | Patrick Pausch, Ujjwala Singh, Yasar Luqman Ahmed, Benjamin Pillet, Guillaume Murat, Florian Altegoer, Gunter Stier, Matthias Thoms, Ed Hurt, Irmgard Sinning, Gert Bange and Dieter Kressler | | The synthesis of ribosomes requires the orderly assembly of many proteins and large RNA molecules, a process that involves several assembly factors. Here the authors show that dedicated chaperones capture the N termini of specific nascent ribosomal proteins to promote folding and assembly into maturing ribosomes. | | 26 June 2015 | doi: 10.1038/ncomms8494 | | Biological Sciences Biochemistry Biophysics | Glycan complexity dictates microbial resource allocation in the large intestine OPEN | | Artur Rogowski, Jonathon A. Briggs, Jennifer C. Mortimer, Theodora Tryfona, Nicolas Terrapon, Elisabeth C. Lowe, Arnaud Baslé, Carl Morland, Alison M. Day, Hongjun Zheng, Theresa E. Rogers, Paul Thompson, Alastair R. Hawkins, Madhav P. Yadav, Bernard Henrissat, Eric C. Martens, Paul Dupree, Harry J. Gilbert and David N. Bolam | | The human gut microbiota helps us to degrade complex dietary carbohydrates such as xylan and, in turn, the carbohydrate breakdown products control the structure of the microbiota. Here the authors characterize the xylan-degrading apparatus of a key member of the gut microbiota, Bacteroides ovatus. | | 26 June 2015 | doi: 10.1038/ncomms8481 | | Biological Sciences Biochemistry Microbiology | Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells OPEN | | Mélanie Chabaud, Mélina L. Heuzé, Marine Bretou, Pablo Vargas, Paolo Maiuri, Paola Solanes, Mathieu Maurin, Emmanuel Terriac, Maël Le Berre, Danielle Lankar, Tristan Piolot, Robert S. Adelstein, Yingfan Zhang, Michael Sixt, Jordan Jacobelli, Olivier Bénichou, Raphaël Voituriez, Matthieu Piel and Ana-Maria Lennon-Duménil | | Dendritic cells alternate between fast and slow migratory behaviours, however in the absence of a component of the antigen processing machinery, migration is uniform and fast. Chabaud et al. now show that slow migration results from the relocalisation of myosin II to the cell front where it promotes antigen capture. | | 25 June 2015 | doi: 10.1038/ncomms8526 | | Biological Sciences Cell biology | Lucilia cuprina genome unlocks parasitic fly biology to underpin future interventions OPEN | | Clare A. Anstead, Pasi K. Korhonen, Neil D. Young, Ross S. Hall, Aaron R. Jex, Shwetha C. Murali, Daniel S.T. Hughes, Siu F. Lee, Trent Perry, Andreas J. Stroehlein, Brendan R.E. Ansell, Bert Breugelmans, Andreas Hofmann, Jiaxin Qu, Shannon Dugan, Sandra L. Lee, Hsu Chao, Huyen Dinh, Yi Han, Harsha V. Doddapaneni et al. | | Lucilia cuprina is a parasitic blowfly of major economic importance worldwide that feeds on the tissues of animals such as sheep. Here, the authors sequence the genome of L. cuprina and provide insights into the fly’s molecular biology, interactions with the host animal and insecticide resistance. | | 25 June 2015 | doi: 10.1038/ncomms8344 | | Biological Sciences Genetics | IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells | | Aoi Akitsu, Harumichi Ishigame, Shigeru Kakuta, Soo-hyun Chung, Satoshi Ikeda, Kenji Shimizu, Sachiko Kubo, Yang Liu, Masayuki Umemura, Goro Matsuzaki, Yasunobu Yoshikai, Shinobu Saijo and Yoichiro Iwakura | | Control of γδ T-cell activation remains incompletely understood. Here the authors show that during autoimmune arthritis development αβ CD4+ T cells recruit a subset of IL-17-producing γδ T cells to the joints, and that both components are essential to cause pathology in a mouse model of the disease. | | 25 June 2015 | doi: 10.1038/ncomms8464 | | Biological Sciences Immunology | IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection OPEN | | Stanley Adoro, Juan R. Cubillos-Ruiz, Xi Chen, Maud Deruaz, Vladimir D. Vrbanac, Minkyung Song, Suna Park, Thomas T. Murooka, Timothy E. Dudek, Andrew D. Luster, Andrew M. Tager, Hendrik Streeck, Brittany Bowman, Bruce D. Walker, Douglas S. Kwon, Vanja Lazarevic and Laurie H. Glimcher | | HIV-infected patients who maintain undetectable virus levels possess elevated plasma concentrations of IL-21. Here, Adoro et al. show that IL-21 inhibits early viral infection in humanized mice and suppresses HIV-1 replication in vitro by upregulating a microRNA via the regulatory protein STAT3. | | 25 June 2015 | doi: 10.1038/ncomms8562 | | Biological Sciences Immunology Microbiology Virology | Nanoscale memristive radiofrequency switches | | Shuang Pi, Mohammad Ghadiri-Sadrabadi, Joseph C. Bardin and Qiangfei Xia | | Radiofrequency switches based on micro-electromechanical systems or phase-change materials are large and require high voltages. Here, the authors demonstrate a nanoscale radiofrequency switch based on a memristive device with actuation voltages as low as 0.4 V and a typical cutoff frequency of 35 THz. | | 25 June 2015 | doi: 10.1038/ncomms8519 | | Physical Sciences Applied physics | Caenorhabditis elegans is a useful model for anthelmintic discovery OPEN | | Andrew R. Burns, Genna M. Luciani, Gabriel Musso, Rachel Bagg, May Yeo, Yuqian Zhang, Luckshika Rajendran, John Glavin, Robert Hunter, Elizabeth Redman, Susan Stasiuk, Michael Schertzberg, G. Angus McQuibban, Conor R. Caffrey, Sean R. Cutler, Mike Tyers, Guri Giaever, Corey Nislow, Andy G. Fraser, Calum A. MacRae et al. | | Screening for new anthelmintic compounds that are active against parasitic nematodes is costly and labour intensive. Here, the authors use the non-parasitic nematode Caenorhabditis elegans to identify 30 anthelmintic lead compounds in an effective and cost-efficient manner. | | 25 June 2015 | doi: 10.1038/ncomms8485 | | Biological Sciences Chemical biology Genetics Medicinal chemistry | Nanoscale control of phonon excitations in graphene OPEN | | Hyo Won Kim, Wonhee Ko, JiYeon Ku, Insu Jeon, Donggyu Kim, Hyeokshin Kwon, Youngtek Oh, Seunghwa Ryu, Young Kuk, Sung Woo Hwang and Hwansoo Suh | | A fundamental understanding of electron–phonon interactions in graphene is crucial to developing graphene-based electronic and photonic devices. Here, the authors control the properties of phonons in graphene by tuning the interaction strength between graphene and an underlying platinum substrate. | | 25 June 2015 | doi: 10.1038/ncomms8528 | | Physical Sciences Condensed matter Nanotechnology | Superstatistical analysis and modelling of heterogeneous random walks OPEN | | Claus Metzner, Christoph Mark, Julian Steinwachs, Lena Lautscham, Franz Stadler and Ben Fabry | | Conventional methods to quantify the migratory behaviour of cells assume that underlying parameters are constant. Mark et al. apply a superstatistical approach to extract time-dependent parameters of motile cells, and demonstrate an enhanced ability to distinguish between different migration strategies. | | 25 June 2015 | doi: 10.1038/ncomms8516 | | Biological Sciences Biophysics Cell biology | Silicon carbide-free graphene growth on silicon for lithium-ion battery with high volumetric energy density OPEN | | In Hyuk Son, Jong Hwan Park, Soonchul Kwon, Seongyong Park, Mark H. Rümmeli, Alicja Bachmatiuk, Hyun Jae Song, Junhwan Ku, Jang Wook Choi, Jae-man Choi, Seok-Gwang Doo and Hyuk Chang | | The volume expansion of silicon is a big problem in lithium-ion batteries with silicon anodes. Here, the authors report direct graphene growth on silicon nanoparticles, which effectively mitigates the problem, leading to excellent electrochemical performance. | | 25 June 2015 | doi: 10.1038/ncomms8393 | | Chemical Sciences Materials science | Associative memory realized by a reconfigurable memristive Hopfield neural network | | S.G. Hu, Y. Liu, Z Liu, T.P. Chen, J.J. Wang, Q. Yu, L.J. Deng, Y. Yin and Sumio Hosaka | | Memristors are passive electrical components that can act like simple memories. Here, the authors use an array of hafnium oxide memristors to create a type of artificial neural network, known as a Hopfield network, that is capable of retrieving data from partial information | | 25 June 2015 | doi: 10.1038/ncomms8522 | | Physical Sciences Applied physics | Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing | | Mukund Gupta, Bibhu Ranjan Sarangi, Joran Deschamps, Yasaman Nematbakhsh, Andrew Callan-Jones, Felix Margadant, René-Marc Mège, Chwee Teck Lim, Raphaël Voituriez and Benoît Ladoux | | Adherent cells actively probe the rigidity of their substrates. Gupta et al. show that actin cytoskeleton rheology transitions from fluid to solid with increased substrate stiffness along with an isotropic to nematic ordering, implicating the remodelling of the whole actin network in rigidity sensing. | | 25 June 2015 | doi: 10.1038/ncomms8525 | | Biological Sciences Biophysics Cell biology | Large Seebeck effect by charge-mobility engineering OPEN | | Peijie Sun, Beipei Wei, Jiahao Zhang, Jan M. Tomczak, A.M. Strydom, M. Søndergaard, Bo B. Iversen and Frank Steglich | | The Seebeck effect causes an electrical potential across a temperature gradient in a material, and is therefore useful for generating useful current from waste heat. Here, the authors show that the Seebeck effect can arise due to charge-carrier relaxation in addition to the conventional mechanism. | | 25 June 2015 | doi: 10.1038/ncomms8475 | | Physical Sciences Materials science | The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17 | | Sarah Louise Dombernowsky, Jacob Samsøe-Petersen, Camilla Hansson Petersen, Rachael Instrell, Anne-Mette Bornhardt Hedegaard, Laurel Thomas, Katelyn Mae Atkins, Sylvain Auclair, Reidar Albrechtsen, Kasper Johansen Mygind, Camilla Fröhlich, Michael Howell, Peter Parker, Gary Thomas and Marie Kveiborg | | ErbB signalling is stimulated by the release of its ligands from the cell surface through metalloproteinase-dependent cleavage. Dombernowsky et al. show that this process is controlled by the sorting protein PACS-2, which enhances ErbB ligand release by regulating trafficking of the metalloprotease ADAM17. | | 25 June 2015 | doi: 10.1038/ncomms8518 | | Biological Sciences Cell biology | Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints | | M. E. Mikucki, D. T. Fisher, J. Matsuzaki, J. J. Skitzki, N. B. Gaulin, J. B. Muhitch, A. W. Ku, J. G. Frelinger, K. Odunsi, T. F. Gajewski, A. D. Luster and S. S. Evans | | Tumours secrete many lymphocyte-attracting chemokines. Here the authors show that despite the abundance of their ligands, CCR2 and CCR5 do not mediate trafficking of effector CD8 T cells into the tumour, whereas CXCR3 is essential for this process and for T-cell-based elimination of melanoma in mice. | | 25 June 2015 | doi: 10.1038/ncomms8458 | | Biological Sciences Cancer Immunology | A genome-wide association study identifies multiple loci for variation in human ear morphology OPEN | | Kaustubh Adhikari, Guillermo Reales, Andrew J. P. Smith, Esra Konka, Jutta Palmen, Mirsha Quinto-Sanchez, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Macarena Fuentes, María Pizarro, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado, Valeria Villegas et al. | | The shape of the pinna varies widely in the general human population but the genetic basis of this variation is unknown. Here Adhikari et al. conduct a genome-wide association study in Latin Americans and discover seven gene regions influencing pinna morphology, including EDAR and TBX15. | | 24 June 2015 | doi: 10.1038/ncomms8500 | | Biological Sciences Genetics | Exosomes released by keratinocytes modulate melanocyte pigmentation OPEN | | Alessandra Lo Cicero, Cédric Delevoye, Floriane Gilles-Marsens, Damarys Loew, Florent Dingli, Christelle Guéré, Nathalie André, Katell Vié, Guillaume van Niel and Graça Raposo | | The activity of melanocytes determines skin pigmentation, and is regulated by a tight dialogue with keratinocytes. Here, the authors show that exosomes released by keratinocytes have a direct effect on melanocyte function, and exosome content is dependent on skin phototype and is modulated by ultraviolet B radiation. | | 24 June 2015 | doi: 10.1038/ncomms8506 | | Biological Sciences Cell biology | Ultralow noise miniature external cavity semiconductor laser OPEN | | W. Liang, V. S. Ilchenko, D. Eliyahu, A. A. Savchenkov, A. B. Matsko, D. Seidel and L. Maleki | | Optical metrology applications require lasers with high spectral purity but on-chip devices with sub-100 Hz linewidth are yet to be realized. Here, Liang et al. present a heterogeneously integrated, chip-scale semiconductor laser with 30 Hz integral linewidth and sub-Hz instantaneous linewidth. | | 24 June 2015 | doi: 10.1038/ncomms8371 | | Physical Sciences Applied physics Optical physics | Imaging an aligned polyatomic molecule with laser-induced electron diffraction OPEN | | Michael G. Pullen, Benjamin Wolter, Anh-Thu Le, Matthias Baudisch, Michaël Hemmer, Arne Senftleben, Claus Dieter Schröter, Joachim Ullrich, Robert Moshammer, C. D. Lin and Jens Biegert | | Laser-induced electron diffraction can provide structural information on gas-phase molecules with high spatial and temporal resolution. Going beyond previous diatomic cases, Pullen et al. apply this approach to acetylene and show that it can be used to measure bond lengths for polyatomic molecules. | | 24 June 2015 | doi: 10.1038/ncomms8262 | | Physical Sciences Atomic and molecular physics Optical physics | Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children OPEN | | Heng Xu, Hui Zhang, Wenjian Yang, Rachita Yadav, Alanna C. Morrison, Maoxiang Qian, Meenakshi Devidas, Yu Liu, Virginia Perez-Andreu, Xujie Zhao, Julie M. Gastier-Foster, Philip J. Lupo, Geoff Neale, Elizabeth Raetz, Eric Larsen, W. Paul Bowman, William L. Carroll, Naomi Winick, Richard Williams, Torben Hansen et al. | | Genome-wide association studies indicate a strong genetic susceptibility to acute lymphoblastic leukaemia in children, though the effect on protein-coding genes is not fully understood. Here Xu and Zhang et al. identify a missense variant in CDKN2A which reduces tumour suppression. | | 24 June 2015 | doi: 10.1038/ncomms8553 | | Biological Sciences Cancer Genetics | Digital microfluidic immunocytochemistry in single cells OPEN | | Alphonsus H. C. Ng, M. Dean Chamberlain, Haozhong Situ, Victor Lee and Aaron R. Wheeler | | The ability to measure signalling responses in single cells following short pulses of stimulus would shed insight into temporal thresholds for cell activation. Here the authors introduce a microfluidic platform that allows downstream phosphorylation cascades to be observed following as little as one second of stimulus exposure. | | 24 June 2015 | doi: 10.1038/ncomms8513 | | Biological Sciences Biotechnology Cell biology | Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3 OPEN | | Seokwon Kang, Teresa Fernandes-Alnemri, Corey Rogers, Lindsey Mayes, Ying Wang, Christopher Dillon, Linda Roback, William Kaiser, Andrew Oberst, Junji Sagara, Katherine A. Fitzgerald, Douglas R. Green, Jianke Zhang, Edward S. Mocarski and Emad S. Alnemri | | Inflammasome activation requires a complex and incompletely understood network of signalling events. Here the authors characterize step-by-step contributions of TLR3, caspase-8, RIPK3 and MLKL to the activation of NLRP3 inflammasome in response to double-stranded RNA. | | 24 June 2015 | doi: 10.1038/ncomms8515 | | Biological Sciences Immunology Molecular biology | Resonant tunnelling in a quantum oxide superlattice | | Woo Seok Choi, Sang A. Lee, Jeong Ho You, Suyoun Lee and Ho Nyung Lee | | Quantum mechanical resonant tunnelling is believed to be only feasible in semiconductor-based heterostructures due to high crystalline quality required, which restricts the number of viable materials. Here, the authors demonstrate resonant tunnelling in a deliberately designed complex-oxide superlattice. | | 24 June 2015 | doi: 10.1038/ncomms8424 | | Physical Sciences Applied physics Materials science | Grb2 monomer–dimer equilibrium determines normal versus oncogenic function OPEN | | Zamal Ahmed, Zahra Timsah, Kin M. Suen, Nathan P. Cook, Gilbert R. Lee, Chi-Chuan Lin, Mihai Gagea, Angel A. Marti and John E. Ladbury | | Grb2 is an adaptor protein that can exist as a dimer that dissociates on phosphorylation of Y160. Here, the authors show that only the monomeric protein is capable of activating mitogen-activated protein kinase signal transduction and hence control oncogenic outcome. | | 24 June 2015 | doi: 10.1038/ncomms8354 | | Biological Sciences Cancer Cell biology | Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence OPEN | | Maja Sedic, Adam Skibinski, Nelson Brown, Mercedes Gallardo, Peter Mulligan, Paula Martinez, Patricia J. Keller, Eugene Glover, Andrea L. Richardson, Janet Cowan, Amanda E. Toland, Krithika Ravichandran, Harold Riethman, Stephen P. Naber, Anders M. Näär, Maria A. Blasco, Philip W. Hinds and Charlotte Kuperwasser | | BRCA1 functions in all cell types to help preserve genomic stability but oncogenesis is restricted to only a few tissues. Here Sedic et al. demonstrate a novel BRCA1 haploinsufficiency-induced senescence pathway in epithelial cells. | | 24 June 2015 | doi: 10.1038/ncomms8505 | | Biological Sciences Cancer Molecular biology | Membranes with artificial free-volume for biofuel production OPEN | | Nikos Petzetakis, Cara M. Doherty, Aaron W. Thornton, X. Chelsea Chen, Pepa Cotanda, Anita J. Hill and Nitash P. Balsara | | The free-volume of a polymer is a key parameter in its ability to permit through transport of small molecules. Here, the authors develop a way of introducing different degrees of artificial free-volume to a polymer membrane, and thus tailor its penetrability for applications including biofuel purification. | | 24 June 2015 | doi: 10.1038/ncomms8529 | | Chemical Sciences Materials science Nanotechnology | Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies | | Laura K. Pritchard, Daniel I.R. Spencer, Louise Royle, Camille Bonomelli, Gemma E. Seabright, Anna-Janina Behrens, Daniel W. Kulp, Sergey Menis, Stefanie A. Krumm, D. Cameron Dunlop, Daniel J. Crispin, Thomas A. Bowden, Christopher N. Scanlan, Andrew B. Ward, William R. Schief, Katie J. Doores and Max Crispin | | The glycan patch that covers the HIV-1 envelope protein gp120 can be targeted by broadly neutralizing antibodies. Here, Pritchard et al. show that structural changes in the glycans do not significantly hamper antibody recognition, supporting the glycan patch as a stable target for vaccine design. | | 24 June 2015 | doi: 10.1038/ncomms8479 | | Biological Sciences Immunology Molecular biology Virology | A scanning cavity microscope OPEN | | Matthias Mader, Jakob Reichel, Theodor W. Hänsch and David Hunger | | Fluorescence from nanoparticles enables high-resolution optical imaging, but this approach is limited to those structures that emit light. Here, the authors demonstrate a microscope that uses a cavity to enhance the measurement of the alternative optical properties of absorption and dispersion. | | 24 June 2015 | doi: 10.1038/ncomms8249 | | | Linking megathrust earthquakes to brittle deformation in a fossil accretionary complex OPEN | | Armin Dielforder, Hauke Vollstaedt, Torsten Vennemann, Alfons Berger and Marco Herwegh | | Recent megathrust earthquakes have been documented to cause large-scale stress changes, although this has not been identified in a fossil system. Here, the authors present data that establish a link between the observations at active subduction zones and the structural record preserved in ancient mountain belts. | | 24 June 2015 | doi: 10.1038/ncomms8504 | | Earth Sciences | Aging mechanisms in amorphous phase-change materials | | Jean Yves Raty, Wei Zhang, Jennifer Luckas, Chao Chen, Riccardo Mazzarello, Christophe Bichara and Matthias Wuttig | | Phase-change materials are a route to high-density data storage, but changes in their properties in time are a limiting factor. Here, the authors combine numerical simulations, photothermal deflection spectroscopy and impedance spectroscopy experiments to investigate the aging process in germanium telluride. | | 24 June 2015 | doi: 10.1038/ncomms8467 | | Physical Sciences Materials science | | | | | | | | | Latest Corrigenda | | | |
| | | Corrigendum: Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes | | Ewa Terczyńska-Dyla, Stephanie Bibert, Francois H. T. Duong, Ilona Krol, Sanne Jørgensen, Emilie Collinet, Zoltán Kutalik, Vincent Aubert, Andreas Cerny, Laurent Kaiser, Raffaele Malinverni, Alessandra Mangia, Darius Moradpour, Beat Müllhaupt, Francesco Negro, Rosanna Santoro, David Semela, Nasser Semmo, Swiss Hepatitis C Cohort Study Group, Markus H. Heim et al. | | 29 June 2015 | doi: 10.1038/ncomms8280 | | Biological Sciences Genetics Immunology Virology | | | | | Advertisement | | Nature Insight: Origin and evolution of vertebrates
Vertebrates have many special features - from large brains to unique tissues. But how they evolved from invertebrates is obscure. This Insight looks at the many theories to explain vertebrate origins, the fossil evidence, a new perspective on the origin of the head and a uniquely vertebrate feature called the neural crest.
Access the Insight online | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | | | | You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at:www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant)
For further technical assistance, please contact our registration department
For other enquiries, please contact our customer feedback department
Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA
Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston
Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS.
© 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. | | | | |
No comments:
Post a Comment