The EMBO Journal Table of Contents for 2 July 2015; Vol. 34, No. 13

2 July 2015 | Volume 34, Number 13 Submit Table of Contents Obituary Have you seen? Articles Volume 34, Number 13 Obituary Alan Hall (1952–2015), an Englishman in New York Annette Self and Sandrine Etienne‐Manneville Published online 18.06.2015 Have you seen? Departure gate of acidic Ca2+ confirmed The generation of a new knockout mouse model highlights the role for TPC1/2 channels in NAADP‐dependent Ca2+ release from lysosomes. Thomas J Jentsch, Maja B Hoegg‐Beiler, and Janis Vogt Published online 28.05.2015 Simply the right time to turn on insulin Recent work identifies precise induction of NEUROG3 expression in pancreatic progenitor cells as a crucial checkpoint for generating functional human beta cells. Francesca M Spagnoli Published online 13.05.2015 Articles Expression of Ca2+‐permeable two‐pore channels rescues NAADP signalling in TPC‐deficient cells By presenting a new double‐knockout mouse model this study demonstrates that two‐pore channels (TPCs) are responsible for NAADP‐dependent Ca2+ release from endo‐lysosomes. Margarida Ruas, Lianne C Davis, Cheng‐Chang Chen, Anthony J Morgan, Kai‐Ting Chuang, Timothy F Walseth, Christian Grimm, Clive Garnham, Trevor Powell, Nick Platt, Frances M Platt, Martin Biel, Christian Wahl‐Schott, John Parrington, and Antony Galione Published online 14.04.2015 Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro Focusing on developmental mechanisms, the results of this study further accelerate successful differentiation of human ESCs into functional pancreatic beta cells. Holger A Russ, Audrey V Parent, Jennifer J Ringler, Thomas G Hennings, Gopika G Nair, Mayya Shveygert, Tingxia Guo, Sapna Puri, Leena Haataja, Vincenzo Cirulli, Robert Blelloch, Greg L Szot, Peter Arvan, and Matthias Hebrok Published online 23.04.2015 Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2 The amino acid transporter Lat1 increases cellular S‐adenosylmethionine concentrations and thereby EZH2 activity, and this dictates the differentiation state of cancer cells and tumour growth. Stephen G Dann, Michael Ryskin, Anthony M Barsotti, Jonathon Golas, Celine Shi, Miriam Miranda, Christine Hosselet, Luanna Lemon, Judy Lucas, Maha Karnoub, Fang Wang, Jeremy S Myers, Scott J Garza, Maximillian T Follettie, Kenneth G Geles, Anke Klippel, Robert A Rollins, and Valeria R Fantin Published online 15.05.2015 A NAD‐dependent glutamate dehydrogenase coordinates metabolism with cell division in Caulobacter crescentus GdhZ and KidO are complementary negative regulators of FtsZ that connect metabolic conditions to cell division in Caulobacter crescentus. GdhZ is an inhibitor of FtsZ polymerization while KidO prevents FtsZ filament bundling in response to nutrient availability. François Beaufay, Jérôme Coppine, Aurélie Mayard, Géraldine Laloux, Xavier De Bolle, and Régis Hallez Published online 07.05.2015 TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms Uridylation of miRNA precursors can either stimulate processing or trigger RNA degradation. This study shows how RNA overhang structure and the mode of TUTase binding facilitate differential uridylation of specific precursor types. Boseon Kim, Minju Ha, Luuk Loeff, Hyeshik Chang, Dhirendra K Simanshu, Sisi Li, Mohamed Fareh, Dinshaw J Patel, Chirlmin Joo, and V Narry Kim Published online 15.05.2015 Cerebral nitric oxide represses choroid plexus NFκB‐dependent gateway activity for leukocyte trafficking Neurodegenerative disorders are associated with excessive nitric oxide (NO) production. New findings show here that NO represses leukocyte trafficking to the CNS via inhibition of the NFκB/p65 signaling pathway. Kuti Baruch, Alexander Kertser, Ziv Porat, and Michal Schwartz Published online 04.05.2015 Okazaki fragment maturation involves α‐segment error editing by the mammalian FEN1/MutSα functional complex The key role of proofreading‐deficient DNA polymerase α in initiating Okazaki fragment synthesis requires mismatch removal by a dedicated DNA repair process involving mammalian flap endonuclease. Songbai Liu, Guojun Lu, Shafat Ali, Wenpeng Liu, Li Zheng, Huifang Dai, Hongzhi Li, Hong Xu, Yuejin Hua, Yajing Zhou, Janice Ortega, Guo‐Min Li, Thomas A Kunkel, and Binghui Shen Published online 28.04.2015   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.