Nature Reviews Immunology Contents January 2015 Volume 15 Number 1 pp 1-65

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TABLE OF CONTENTS
January 2015 Volume 15 Number 1
Impact Factor 33.836 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Dendritic cell metabolism Edward J. Pearce & Bart Everts
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RESEARCH HIGHLIGHTS Top Microbiota: Gut bacteria cross malaria p1 | doi:10.1038/nri3796 Bacteria in the gut that cross-react with malarial parasites can induce the production of protective natural antibodies. PDF Inflammasome: Inflammatory target of antiretroviral drugs p2 | doi:10.1038/nri3791 Nucleoside reverse transcriptase inhibitors target P2X7-dependent inflammasome activation to mediate anti-inflammatory effects. PDF Macrophages: Capturing HIV-infected T cells p2 | doi:10.1038/nri3794 Macrophages capture HIV-1-infected CD4+ T cells, which results in robust macrophage infection. PDF T cells: Flexibility in humans p3 | doi:10.1038/nri3797 Human memory CD4+ T cells primed in vivo by pathogens or vaccines are highly heterogeneous. PDF Microbiota: A viral understudy for commensal bacteria p4 | doi:10.1038/nri3788 An enteric RNA virus can substitute for commensal bacteria and support immune maturation and intestinal homeostasis. PDF Inflammasome: Stiffening up defences against Salmonella p4 | doi:10.1038/nri3798 NLRC4 activation by Salmonella alters cytoskeletal dynamics to reduce intracellular bacterial burden. PDF Tumour immunology: Checkpoint parley p5 | doi:10.1038/nri3792 Seven new studies advance our understanding of immune checkpoint blockade and highlight an approach for developing personalized cancer vaccines. PDF Immunology JOBS of the week Master of Medical Sciences Degree in Immunology Harvard Medical School Multiple Postdoc Openings in Particle Tracking, Immunology, Microbiome, Vaccines University of North Carolina at Chapel Hill Postdoctoral Scientist in Immuno-metabolism University of North Carolina at Chapel Hill Graduate Student Sanquin Research Postdoctoral Fellow University of Cincinnati More Science jobs from Immunology EVENT Immunology of Diabetes Society 14th International Congress 12.04.15 Munich, Germany More science events from
REVIEWS		Top
Epigenetic control of myeloid cell differentiation, identity and function Damiana Álvarez-Errico, Roser Vento-Tormo, Michael Sieweke & Esteban Ballestar p7 | doi:10.1038/nri3777 In this Review, the authors describe the key epigenetic events that are associated with the differentiation and function of cells of the myeloid lineage, with a particular emphasis on monocytes and macrophages. They detail the epigenetic enzymes that control these events and discuss emerging data that show the importance of epigenetic regulation for 'memory-like' behaviour in innate immune cells. Abstract | Full Text | PDF
Dendritic cell metabolism Edward J. Pearce & Bart Everts p18 | doi:10.1038/nri3771 This Review describes how key metabolic processes are differentially regulated in dendritic cells (DCs), both during their development and during their participation in active immune responses. The authors discuss the importance of these changes in cellular metabolism for DC function and also explain how both intracellular and extracellular metabolites shape DC biology. Abstract | Full Text | PDF
Periodontitis: from microbial immune subversion to systemic inflammation George Hajishengallis p30 | doi:10.1038/nri3785 Periodontitis has been linked to systemic inflammatory conditions such as rheumatoid arthritis. In this Review, the author summarizes these links and discusses the mechanisms of microbial immune subversion that tip the balance from homeostasis to disease at oral or distant sites. Abstract | Full Text | PDF
Clinical blockade of PD1 and LAG3 — potential mechanisms of action Linh T. Nguyen & Pamela S. Ohashi p45 | doi:10.1038/nri3790 Here, two receptors that inhibit T cell functions — programmed cell death protein 1 (PD1) and lymphocyte activation gene 3 protein (LAG3) — are reviewed. Their mechanisms of action are discussed in the context of clinical blockade for cancer therapy and potential biomarkers of the efficacy of therapeutic blockade are proposed. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Type 2 inflammation in asthma — present in most, absent in many John V. Fahy p57 | doi:10.1038/nri3786 The discovery that patients with asthma can be dichotomized according to levels of type 2 inflammation, and hence their response to inhibitors of this pathway, promises to enhance our understanding of pathogenic mechanisms and personalized therapies. Abstract | Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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