Nature Reviews Cancer contents January 2015 Volume 15 Number 1 pp1-64

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TABLE OF CONTENTS
January 2015 Volume 15 Number 1
Impact Factor 37.912 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting Lauren M. Thorpe, Haluk Yuzugullu & Jean J. Zhao
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RESEARCH HIGHLIGHTS Top Epigenetics: Histone methylation: it's in the numbers p1 | doi:10.1038/nrc3883 This paper finds that levels of histone H3 lysine 79 (H3K79) methylation affect the level of gene expression through the AF10–DOT1L complex, with implications for acute myeloid leukaemia therapy. PDF Therapeutics: Winning combination p2 | doi:10.1038/nrc3882 A screening platform using cell cultures derived from tumour biopsy samples identifies drug combinations that are effective in treating tumour resistance. PDF Immunotherapy: Checkpoint parley p3 | doi:10.1038/nrc3880 Seven new studies advance our understanding of immune checkpoint blockade and highlight an approach for developing personalized cancer vaccines. PDF Transcription: Super-enhanced p4 | doi:10.1038/nrc3879 Data from three recent papers suggest that alterations of super-enhancers in cancer cells can promote oncogene expression and therapeutic resistance in some cases. Proteins that promote transcription from super-enhancers might be viable therapeutic targets. PDF Metabolism: Feed a cold, starve a tumour p4 | doi:10.1038/nrc3881 Elsa Flores and colleagues have found that a pancreatic hormone, amylin, induces regression of Trp53-null tumours. PDF IN BRIEF Glioma: Targeting a histone mutant | Resistance: Different means to the same end | Metastasis: Home sweet home | Tumorigenesis: miRNAs — novel regulators in skin cancer | Therapy: Resisting combinations | Metastasis: Correlating types of motility with metastasis PDF Cancer JOBS of the week Postdoctoral Fellow in Stem Cells and Cancer Tsinghua University Postdoctoral Position in Cancer and Developmental Biology University of California - Irvine Postdoc Positions in Epigenetics and Translational Cancer Research The University of Texas Health Science Center at San Antonio Faculty Positions - Division of Cancer Predisposition St. Jude Children's Research Hospital (SJCRH) Postdoctoral Researcher in Metabolomics of Cancer Karolinska Institutet (KI) More Science jobs from Cancer EVENT Molecular Pathology Approach to Cancer 13.05.15 Amsterdan, Netherlands More science events from
REVIEWS		Top
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting Lauren M. Thorpe, Haluk Yuzugullu & Jean J. Zhao p7 | doi:10.1038/nrc3860 Hyperactivation of phosphatidylinositol 3-kinase (PI3K) signalling cascades is one of the most common events in human cancers. This Review discusses recent advances in our knowledge of the roles of distinct PI3K isoforms in normal and oncogenic signalling, and the current state and future potential of targeting this pathway in the clinic. Abstract | Full Text | PDF | Supplementary information
Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity Margaret A. Knowles & Carolyn D. Hurst p25 | doi:10.1038/nrc3817 This Review discusses recent advances in the molecular characterization of bladder cancer, which has provided insights into pathogenesis and subgroups of bladder cancers with different prognosis. Abstract | Full Text | PDF
Modelling bladder cancer in mice: opportunities and challenges Takashi Kobayashi, Tomasz B. Owczarek, James M. McKiernan & Cory Abate-Shen p42 | doi:10.1038/nrc3858 This Review surveys the available models of bladder cancer and discusses their advantages and limitations, making suggestions for their improvement. Abstract | Full Text | PDF
PERSPECTIVES		Top
TIMELINE VHL, the story of a tumour suppressor gene Lucy Gossage, Tim Eisen & Eamonn R. Maher p55 | doi:10.1038/nrc3844 The identification in 1993 of inherited mutations in the von Hippel-Lindau (VHL) gene in families with VHL disease was a seminal finding. This and subsequent discoveries have given the VHL tumour suppressor gene a central role in our understanding of the mechanisms of cellular oxygen sensing and in the pathobiology of clear-cell renal cell carcinoma. Abstract | Full Text | PDF
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