Scientific Reports Biology Table of Contents e-alert: 23 December 2014

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23 December 2014      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Biological Sciences               The bacterial flagellar protein export apparatus processively transports flagellar proteins even with extremely infrequent ATP hydrolysis ▶     Tohru Minamino, Yusuke V. Morimoto, Miki Kinoshita et al.     For self-assembly of the bacterial flagellum, a specific protein export apparatus utilizes ATP and proton motive force (PMF) as the energy source to transport component proteins …             An engineered genetic selection for ternary protein complexes inspired by a natural three-component hitchhiker mechanism ▶     Hyeon-Cheol Lee, Alyse D. Portnoff, Mark A. Rocco et al.     The bacterial twin-arginine translocation (Tat) pathway is well known to translocate correctly folded monomeric and dimeric proteins across the tightly sealed cytoplasmic …             In-vivo RGB marking and multicolour single-cell tracking in the adult brain ▶     Diego Gomez-Nicola, Kristoffer Riecken, Boris Fehse et al.     In neuroscience it is a technical challenge to identify and follow the temporal and spatial distribution of cells as they differentiate. We hypothesised that RGB marking, the …             Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans ▶     Xiangyang Chen, Fei Xu, Chengming Zhu et al.     The CRISPR RNA-guided Cas9 nuclease gene-targeting system has been successfully used for genome editing in a variety of organisms. Here, we report the use of dual sgRNA-guided …             Inherent directionality explains the lack of feedback loops in empirical networks ▶     Virginia Domínguez-García, Simone Pigolotti, Miguel A. Muñoz     We explore the hypothesis that the relative abundance of feedback loops in many empirical complex networks is severely reduced owing to the presence of an inherent global …             Highly sensitive colorimetric detection of 17β-estradiol using split DNA aptamers immobilized on unmodified gold nanoparticles ▶     Jinchuan Liu, Wenhui Bai, Shucao Niu et al.     Gold nanoparticle (AuNP) based colorimetric aptasensor have been developed for many analytes recently largely because of the ease of detection, high sensitivity, and potential …             CORRIGENDUM: Escherichia coli ribose binding protein based bioreporters revisited ▶     Artur Reimer, Sharon Yagur-Kroll, Shimshon Belkin et al.                 Stimulus similarity determines the prevalence of behavioral laterality in a visual discrimination task for mice ▶     Mario Treviño     Animal choices depend on direct sensory information, but also on the dynamic changes in the magnitude of reward. In visual discrimination tasks, the emergence of lateral biases …             Interleukin-17 inhibits Adult Hippocampal Neurogenesis ▶     Qiang Liu, Wei Xin, Ping He et al.     Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under …             ERRATUM: Bright-White Beetle Scales Optimise Multiple Scattering of Light ▶     Matteo Burresi, Lorenzo Cortese, Lorenzo Pattelli et al.                 Modulation properties of factors released by bone marrow stromal cells on activated microglia: an in vitro study ▶     Dasa Cizkova, Stéphanie Devaux, Françoise Le Marrec-Croq et al.     In the present paper we develop a new non-cell based (cell-free) therapeutic approach applied to BV2 microglial cells and spinal cord derived primary microglia (PM) using …             A Fluorescence-Quenching Platform based on Biomineralized Hydroxyapatite from Natural Seashell and Applied to Cancer Cell Detection ▶     Ying Zhang, Wei Liu, Craig E. Banks et al.     As a typical biomineral, hydroxyapatite (HAp) is widely applied in bone implants and other related fields. However, the inherent nature of HAp can potentially be altered through …             Controlling Networks of Nonlinearly-Coupled Nodes using Response Surfaces ▶     Jason Shulman, Franck Malatino, Alexander Mo et al.     Control of complex processes is a major goal of network analyses. Most approaches to control nonlinearly coupled systems require the network topology and/or network dynamics. Un…             Greater temporal changes of sediment microbial community than its waterborne counterpart in Tengchong hot springs, Yunnan Province, China ▶     Shang Wang, Hailiang Dong, Weiguo Hou et al.     Temporal variation in geochemistry can cause changes in microbial community structure and diversity. Here we studied temporal changes of microbial communities in Tengchong hot …             Entropy, complexity, and Markov diagrams for random walk cancer models ▶     Paul K. Newton, Jeremy Mason, Brian Hurt et al.     The notion of entropy is used to compare the complexity associated with 12 common cancers based on metastatic tumor distribution autopsy data. We characterize power-law …             toyLIFE: a computational framework to study the multi-level organisation of the genotype-phenotype map ▶     Clemente F. Arias, Pablo Catalán, Susanna Manrubia et al.     The genotype-phenotype map is an essential object to understand organismal complexity and adaptability. However, its experimental characterisation is a daunting task. Thus, …             Absence of Predispositional Attentional Sensitivity to Angry Faces in Children with Autism Spectrum Disorders ▶     Tomoko Isomura, Hiroyasu Ito, Shino Ogawa et al.     A rapid allocation of attention towards threatening stimuli in the environment is crucial for survival. Angry facial expressions act as threatening stimuli, and capture humans' …             Environmental Surveillance for Human Astrovirus in Shandong Province, China in 2013 ▶     Nan Zhou, Xiaojuan Lin, Suting Wang et al.     Human astroviruses (HAstVs) are one of the leading viral agents of acute gastroenteritis. However, there is limited information on HAstVs in China. Here, we describe the …             Mmp1 and Mmp2 cooperatively induce Drosophila fat body cell dissociation with distinct roles ▶     Qiangqiang Jia, Yang Liu, Hanhan Liu et al.     During Drosophila metamorphosis, the single-cell layer of fat body tissues gradually dissociates into individual cells. Via a fat body-specific RNAi screen in this study, we …             MiR-223-3p targeting SEPT6 promotes the biological behavior of prostate cancer ▶     Yongbao Wei, Jinrui Yang, Lu Yi et al.     MicroRNAs (miRNAs) present frequently altered expression in urologic cancers including prostate, bladder, and kidney cancer. The altered expression of miR-223 has been reported …             The EHEC-host interactome reveals novel targets for the translocated intimin receptor ▶     Sonja Blasche, Stefan Arens, Arnaud Ceol et al.     Enterohemorrhagic E. coli (EHEC) manipulate their human host through at least 39 effector proteins which hijack host processes through direct protein-protein interactions (PPIs). …             Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer ▶     Ming Shi, Shan Wang, Yuanfei Yao et al.     Epigenetic silence in cancer frequently altered signal-transduction pathways during the early stages of tumor development. Recent progress in the field of cancer epigenetics has …             Anesthetic Diffusion Through Lipid Membranes Depends on the Protonation Rate ▶     Rosendo Pérez-Isidoro, F. J. Sierra-Valdez, J. C. Ruiz-Suárez     Hundreds of substances possess anesthetic action. However, despite decades of research and tests, a golden rule is required to reconcile the diverse hypothesis behind anesthesia. …             Cyclovirus CyCV-VN species distribution is not limited to Vietnam and extends to Africa ▶     Mutien-Marie Garigliany, Ralf Matthias Hagen, Hagen Frickmann et al.     Cycloviruses, small ssDNA viruses of the Circoviridae family, have been identified in the cerebrospinal fluid from symptomatic human patients. One of these species, …             Filming protein fibrillogenesis in real time ▶     Angelo Bella, Michael Shaw, Santanu Ray et al.     Protein fibrillogenesis is a universal tool of nano-to-micro scale construction supporting different forms of biological function. Its exploitable potential in nanoscience and …             How central are clients in sexual networks created by commercial sex? ▶     Chih-Sheng Hsieh, Jaromír Kovářík, Trevon Logan     Sex workers are traditionally considered important vectors of transmission of sexually transmitted infections (STI). The role of clients is commonly overlooked, partially due to …             Simultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity ▶     Filippa Fleetwood, Susanne Klint, Martin Hanze et al.     Angiogenesis plays an important role in cancer and ophthalmic disorders such as age-related macular degeneration and diabetic retinopathy. The vascular endothelial growth factor …             The dosage of Patz1 modulates reprogramming process ▶     Hui Ma, Jin Rong Ow, Bobby Cheng Peow Tan et al.     The acquisition of pluripotent cells can be achieved by combined overexpression of transcription factors Oct4, Klf4, Sox2 and c-Myc in somatic cells. This cellular reprogramming …             Controllability of time-delayed Boolean multiplex control networks under asynchronous stochastic update ▶     Chao Luo, Xingyuan Wang, Hong Liu     In this article, the controllability of asynchronous Boolean multiplex control networks (ABMCNs) with time delay is studied. Firstly, dynamical model of Boolean multiplex control …             Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions ▶     Jin Young Joo, Hyun Woo Choi, Min Jung Kim et al.     Several mouse pluripotent stem cell types have been established either from mouse blastocysts and epiblasts. Among these, embryonic stem cells (ESCs) are considered to represent …             Diagnostic accuracy of high resolution melting analysis for detection of KRAS mutations: a systematic review and meta-analysis ▶     Yue-Ping Liu, Hai-Yan Wu, Xiang Yang et al.     Increasing evidence points to a negative correlation between KRAS mutations and patients' responses to anti-EGFR monoclonal antibody treatment. Therefore, patients must undergo …             Aberrant methylation of the SPARC gene promoter and its clinical implication in gastric cancer ▶     Zi-Yi Chen, Jun-Ling Zhang, Hong-Xin Yao et al.     Secreted protein acidic and rich in cysteine (SPARC) gene has been shown to be epigenetically silenced in several cancers. We investigated the loss of expression and promoter …             Synthesis of Au/Graphene Oxide Composites for Selective and Sensitive Electrochemical Detection of Ascorbic Acid ▶     Jian Song, Lin Xu, Ruiqing Xing et al.     In this work, we present a novel ascorbic acid (AA) sensor applied to the detection of AA in human sera and pharmaceuticals. A series of Au nanoparticles (NPs) and graphene oxide …             Nicotine exposure and transgenerational impact: a prospective study on small regulatory microRNAs ▶     Faten A. Taki, Xiaoping Pan, Myon-Hee Lee et al.     Early developmental stages are highly sensitive to stress and it has been reported that pre-conditioning with tobacco smoking during adolescence predisposes those youngsters to …             WP1066 Sensitizes Oral Squamous Cell Carcinoma Cells to Cisplatin by Targeting STAT3/miR-21 axis ▶     Xuan Zhou, Yu Ren, Aiqin Liu et al.     Accumulating evidence reveals that activation of STAT3 and miR-21 contributes to chemoresistance in multiple tumors. We examined the expression of STAT3 and miR-21 in 43 oral …             Two-dimensional Layered MoS2 Biosensors Enable Highly Sensitive Detection of Biomolecules ▶     Joonhyung Lee, Piyush Dak, Yeonsung Lee et al.     We present a MoS2 biosensor to electrically detect prostate specific antigen (PSA) in a highly sensitive and label-free manner. Unlike previous MoS2-FET-based biosensors, the …             From cells to muropeptide structures in 24 h: Peptidoglycan mapping by UPLC-MS ▶     Daniel Kühner, Mark Stahl, Dogan D. Demircioglu et al.     Peptidoglycan (PGN) is ubiquitous in nearly all bacterial species. The PGN sacculus protects the cells against their own internal turgor making PGN one of the most important …             Evidence for acoustic communication among bottom foraging humpback whales ▶     Susan E. Parks, Dana A. Cusano, Alison K. Stimpert et al.     Humpback whales (Megaptera novaeangliae), a mysticete with a cosmopolitan distribution, demonstrate marked behavioural plasticity. Recent studies show evidence of social learning …             Protonophore properties of hyperforin are essential for its pharmacological activity ▶     Thomas S. Sell, Thabet Belkacemi, Veit Flockerzi et al.     Hyperforin is a pharmacologically active component of the medicinal plant Hypericum perforatum (St. John's wort), recommended as a treatment for a range of ailments including …             An Integrated Microfluidic Chip System for Single-Cell Secretion Profiling of Rare Circulating Tumor Cells ▶     Yuliang Deng, Yu Zhang, Shuai Sun et al.     Genetic and transcriptional profiling, as well as surface marker identification of single circulating tumor cells (CTCs) have been demonstrated. However, quantitatively profiling …             Levodopa/benserazide microsphere (LBM) prevents L-dopa induced dyskinesia by inactivation of the DR1/PKA/P-tau pathway in 6-OHDA-lesioned Parkinson's rats ▶     Cheng-long Xie, Wen-Wen Wang, Su-fang Zhang et al.     L-3, 4-dihydroxyphenylalanine (L-dopa) is the gold standard for symptomatic treatment of Parkinson's disease (PD), but long-term therapy is associated with the emergence of …             The association between abnormal microRNA-10b expression and cancer risk: a meta-analysis ▶     Yajie Lu, Jun Yao, Jiani Yu et al.     Several studies have investigated the association between abnormal microRNA-10b expression and the risk of various developing cancers, but the results are inconsistent. 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