Nature Reviews Neuroscience contents July 2012 Volume 13 Number 7 pp 447-514

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TABLE OF CONTENTS
July 2012 Volume 13 Number 7
Impact Factor 29.51 *	In this issue Research Highlights Reviews Perspectives Correspondence Also this month Article series: Brain ageing  Featured article: Structural plasticity upon learning: regulation and functions Pico Caroni, Flavio Donato & Dominique Muller
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RESEARCH HIGHLIGHTS Top Pain: Transplanted precursors halt neuropathic pain p447 | doi:10.1038/nrn3283 Transplanted forebrain interneuron precursors integrate into spinal cord circuits and relieve neuropathic pain symptoms. PDF Ion channels: Metabolite targets sodium channels in diabetic pain p448 | doi:10.1038/nrn3273 Diabetic patients often experience chronic pain as a complication of their condition. In this study, a metabolite produced under hyperglycaemic conditions is shown to influence the function of voltage-gated sodium channels expressed in nociceptive neurons resulting in neuropathic pain. PDF Neuroimmunology: Uncovering new roles for microRNAs and TLRs p448 | doi:10.1038/nrn3276 The microRNA let-7 can induce neurodegeneration by activating the Toll-like receptor TLR7. PDF Synaptic plasticity: ARC plays inverse tag at synapses p449 | doi:10.1038/nrn3272 ARC targets less active synapses for weakening through an interaction with inactive CaMKIIβ. PDF Traumatic brain injury: Brain trauma in military veterans p450 | doi:10.1038/nrn3277 A single exposure to a shock wave associated with a 'typical' explosive device is sufficient to induce sustained brain pathology and memory impairments as early as 2 weeks after exposure in mice. PDF Neural Development: No entry for AnkG p450 | doi:10.1038/nrn3282 A cytoskeleton in the distal part of the axon forms a boundary that spatially restricts AnkG clustering and thereby AIS assembly. PDF Sensory systems: Inverting the blues p450 | doi:10.1038/nrn3288 Two studies show that a population of amacrine cells may have a key role in mammalian blue–green colour vision. PDF IN BRIEF Sensory systems: The smell of anxiety | Neuroanatomy: Revising the phylogeny of von Economo neurons | Cognitive neuroscience: Valuing reward | Auditory system: A dangerous din? | Neural repair: Bionic rats? | Glia: Microglia eat synapses for breakfast | Sensory systems: Human olfaction is not neurogenesis-dependent | Glia: Astrocytes make synapses noisy PDF Neuroscience JOBS of the week postdoc fellow in Neuroscience (Stroke) Louisiana State University Health Sciences Center (LSUHSC) Research Associate, Stem Cell Biology / Neuroscience University of Cardiff Research Fellow in Behavioral Neuroscience / Depression Research McLean Hospital Postdoctoral Research Associate - Neuroscience Scripps Florida PhD scholarship in cognitive neuroscience Université catholique de Louvain (UCL) More Science jobs from Neuroscience EVENT Champalimaud Neuroscience Symposium 30.09.-03.10.12 Lisbon, Portugal More science events from
REVIEWS		Top
Use of next-generation sequencing and other whole-genome strategies to dissect neurological disease Jose Bras, Rita Guerreiro & John Hardy p453 | doi:10.1038/nrn3271 Recent improvements in the technology available for the analysis of genetic variability have revolutionized the study of many diseases. Hardy and colleagues illustrate how genome-wide strategies, including whole-genome and whole-exome sequencing, have been used to improve our understanding of the pathobiological mechanisms of neurological diseases Abstract | Full Text | PDF | Supplementary information
Kynurenines in the mammalian brain: when physiology meets pathology Robert Schwarcz, John P. Bruno, Paul J. Muchowski & Hui-Qiu Wu p465 | doi:10.1038/nrn3257 Tryptophan metabolism along the kynurenine pathway generates several neuroactive metabolites. Schwarcz and colleagues discuss the regulation of this pathway in the normal brain and in neurological and psychiatric disorders, and consider the potential therapeutic opportunities of targeting this pathway. Abstract | Full Text | PDF
Structural plasticity upon learning: regulation and functions Pico Caroni, Flavio Donato & Dominique Muller p478 | doi:10.1038/nrn3258 Behavioural learning is accompanied by loss and gain of synapses, which is thought to be the mechanism by which circuits are altered and 'memory traces' established. Recent research, reviewed here, suggests that learning and memory events involve the rearrangement of ensembles of adjacent synapses on short stretches of dendrites. Abstract | Full Text | PDF
Article series: Brain ageing The cognitive neuroscience of ageing Cheryl Grady p491 | doi:10.1038/nrn3256 Functional MRI studies have revealed useful information about the ageing brain. In this Review, Cheryl Grady explains how correlating cognitive decline to changes in brain structure and function is hampered by the complexity of the ageing process. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Will the real multiple sclerosis please stand up? Peter K. Stys, Gerald W. Zamponi, Jan van Minnen & Jeroen J. G. Geurts p507 | doi:10.1038/nrn3275 Multiple sclerosis (MS) is generally considered to be an autoimmune, inflammatory disease. In this provocative Perspective, Stys and colleagues propose that non-inflammatory, primary progressive MS is the 'real' MS, and that inflammatory forms of the disorder reflect an aberrant immune reaction to ongoing cytodegeneration. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: Tossing the baby out with the bathwater after a brief rinse? The potential downside of dismissing food addiction based on limited data Nicole M. Avena, Ashley N. Gearhardt, Mark S. Gold, Gene-Jack Wang & Marc N. Potenza p514 | doi:10.1038/nrn3212-c1 Full Text | PDF
Correspondence: Food addiction: is there a baby in the bathwater? Hisham Ziauddeen, I. Sadaf Farooqi & Paul C. Fletcher p514 | doi:10.1038/nrn3212-c2 Full Text | PDF
Corrigendum: Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair Hosung Jung, Byung C. Yoon & Christine E. Holt p514 | doi:10.1038/nrn3274 Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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