Clinical Pharmacology and Therapeutics - Table of Contents alert Volume 92 Issue 1

TABLE OF CONTENTS Volume 92, Issue 1 (July 2012) In this issue In This Issue Editorial News & Views Perspectives Clinical Trial State of the Art Research Discovery & Development Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Now accepting submissions Open Access - Peer Review - Renowned International Editorial Board A new online open access journal in the pharmacometrics and systems pharmacology space.   In This Issue Top In This Issue Clin Pharmacol Ther 2012 92: 1-2; 10.1038/clpt.2012.76 Full Text Editorial Top Models of Physiology and Physiologically Based Models in Clinical Pharmacology A J Atkinson, Jr and B P Smith Clin Pharmacol Ther 2012 92: 3-6; 10.1038/clpt.2012.67 Abstract | Full Text News & Views Top Highlights Clin Pharmacol Ther 2012 92: 8-9; 10.1038/clpt.2012.75 Full Text ASCPT News Clin Pharmacol Ther 2012 92: 10-13; 10.1038/clpt.2012.71 Full Text BOOKS Principles of Pharmacogenetics and Pharmacogenomics Reviewed by  J R Kelsoe Clin Pharmacol Ther 2012 92: 14-15; 10.1038/clpt.2012.70 Full Text Perspectives Top OPINION Best Practice in the Use of Physiologically Based Pharmacokinetic Modeling and Simulation to Address Clinical Pharmacology Regulatory Questions P Zhao, M Rowland and S-M Huang Clin Pharmacol Ther 2012 92: 17-20; 10.1038/clpt.2012.68 Abstract | Full Text Clinical Trial Top Impact of the β1-Adrenoceptor Arg389Gly Polymorphism on Heart-Rate Responses to Bisoprolol and Carvedilol in Heart-Failure Patients T Rau, H-D Düngen, F Edelmann, F Waagstein, M Lainščak, S Dimković, S Apostolović, A N Nešković, W Haverkamp, G Gelbrich and T Eschenhagen Clin Pharmacol Ther 2012 92: 21-28; advance online publication, May 23, 2012; 10.1038/clpt.2012.18 Abstract | Full Text A Multiple-Ascending-Dose Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Novel GPR40 Agonist, TAK-875, in Subjects With Type 2 Diabetes E Leifke, H Naik, J Wu, P Viswanathan, D DeManno, M Kipnes and M Vakilynejad Clin Pharmacol Ther 2012 92: 29-39; advance online publication, June 6, 2012; 10.1038/clpt.2012.43 Abstract | Full Text State of the Art Top Physiologically Based Pharmacokinetic (PBPK) Modeling in Children J S Barrett, O Della Casa Alberighi, S Läer and B Meibohm Clin Pharmacol Ther 2012 92: 40-49; advance online publication, June 6, 2012; 10.1038/clpt.2012.64 Abstract | Full Text Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology A Rostami-Hodjegan Clin Pharmacol Ther 2012 92: 50-61; advance online publication, May 30, 2012; 10.1038/clpt.2012.65 Abstract | Full Text Research Top REPORTS Effects of CYP Induction by Rifampicin on Tamoxifen Exposure L Binkhorst, T van Gelder, W J Loos, F E de Jongh, P Hamberg, I M Ghobadi Moghaddam-Helmantel, E de Jonge, A Jager, C Seynaeve, R H N van Schaik, J Verweij and R H J Mathijssen Clin Pharmacol Ther 2012 92: 62-67; advance online publication, May 23, 2012; 10.1038/clpt.2011.372 Abstract | Full Text Carboxylesterase 1 Polymorphism Impairs Oseltamivir Bioactivation in Humans E K Tarkiainen, J T Backman, M Neuvonen, P J Neuvonen, M Schwab and M Niemi Clin Pharmacol Ther 2012 92: 68-71; advance online publication, May 16, 2012; 10.1038/clpt.2012.13 Abstract | Full Text ARTICLES Antidepressant Use and Risk of Out-of-Hospital Cardiac Arrest: A Nationwide Case–Time–Control Study P Weeke, A Jensen, F Folke, G H Gislason, J B Olesen, C Andersson, E L Fosbøl, J K Larsen, F K Lippert, S L Nielsen, T Gerds, P K Andersen, J K Kanters, H E Poulsen, S Pehrson, L Køber and C Torp-Pedersen Clin Pharmacol Ther 2012 92: 72-79; advance online publication, May 16, 2012; 10.1038/clpt.2011.368 Abstract | Full Text Active Safety Monitoring of Newly Marketed Medications in a Distributed Data Network: Application of a Semi-Automated Monitoring System J J Gagne, R J Glynn, J A Rassen, A M Walker, G W Daniel, G Sridhar and S Schneeweiss Clin Pharmacol Ther 2012 92: 80-86; advance online publication, May 16, 2012; 10.1038/clpt.2011.369 Abstract | Full Text Operational Implementation of Prospective Genotyping for Personalized Medicine: The Design of the Vanderbilt PREDICT Project J M Pulley, J C Denny, J F Peterson, G R Bernard, C L Vnencak-Jones, A H Ramirez, J T Delaney, E Bowton, K Brothers, K Johnson, D C Crawford, J Schildcrout, D R Masys, H H Dilks, R A Wilke, E W Clayton, E Shultz, M Laposata, J McPherson, J N Jirjis and D M Roden Clin Pharmacol Ther 2012 92: 87-95; advance online publication, May 16, 2012; 10.1038/clpt.2011.371 Abstract | Full Text UGT2B17 Genetic Polymorphisms Dramatically Affect the Pharmacokinetics of MK-7246 in Healthy Subjects in a First-in-Human Study Y-H Wang, M Trucksis, J J McElwee, P H Wong, C Maciolek, C D Thompson, T Prueksaritanont, G C Garrett, R Declercq, E Vets, K J Willson, R C Smith, J A Klappenbach, G J Opiteck, J A Tsou, C Gibson, T Laethem, P Panorchan, M Iwamoto, P M Shaw, J A Wagner and J C Harrelson Clin Pharmacol Ther 2012 92: 96-102; advance online publication, June 6, 2012; 10.1038/clpt.2012.20 Abstract | Full Text Compartment-Specific Gene Regulation of the CAR Inducer Efavirenz In Vivo H E Meyer zu Schwabedissen, S Oswald, C Bresser, A Nassif, C Modess, Z Desta, E T Ogburn, M Marinova, D Lütjohann, C Spielhagen, M Nauck, H K Kroemer and W Siegmund Clin Pharmacol Ther 2012 92: 103-111; advance online publication, May 16, 2012; 10.1038/clpt.2012.34 Abstract | Full Text Discovery & Development Top TRANSLATION The Clinical Pharmacogenomics Implementation Consortium: CPIC Guideline for SLCO1B1 and Simvastatin-Induced Myopathy R A Wilke, L B Ramsey, S G Johnson, W D Maxwell, H L McLeod, D Voora, R M Krauss, D M Roden, Q Feng, R M Cooper-DeHoff, L Gong, T E Klein, M Wadelius and M Niemi Clin Pharmacol Ther 2012 92: 112-117; advance online publication, May 23, 2012; 10.1038/clpt.2012.57 Abstract | Full Text DEVELOPMENT Quantification of Antiangiogenic and Antivascular Drug Activity by Kinetic Analysis of DCE-MRI Data G Z Ferl and R E Port Clin Pharmacol Ther 2012 92: 118-124; advance online publication, May 16, 2012; 10.1038/clpt.2012.63 Abstract | Full Text Models for Disease Progression: New Approaches and Uses D R Mould Clin Pharmacol Ther 2012 92: 125-131; advance online publication, May 23, 2012; 10.1038/clpt.2012.53 Abstract | Full Text Advertisement Ensure your access If you are unable to access the articles in thisalert, your library may not subscribe to this journal. 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