Nature Reviews Immunology Contents October 2011 Volume 11 Number 10 pp 633-711

Advertisement
The New BD FACSVerse™. Simply Brilliant. Engineered from the ground up, the new BD FACSVerse™ system offers remarkable performance, flexibility, and ease of operation. What's really exciting is what's behind it. Explore the innovations in virtually every aspect of the system and software that redefine what's possible in multicolor flow cytometry instrumentation. bdbiosciences.com/go/verse
TABLE OF CONTENTS
October 2011 Volume 11 Number 10
Impact Factor 35.196 * Subscribe to Nature Reviews Immunology Recommend to your library	In this issue Comment Research Highlights Reviews Perspectives Also this month  Featured article: Highlights of 10 years of immunology in Nature Reviews Immunology Ruslan Medzhitov, Ethan M. Shevach, Giorgio Trinchieri, Andrew L. Mellor, David H. Munn, Siamon Gordon, Peter Libby, Göran K. Hansson, Ken Shortman, Chen Dong, Dmitry Gabrilovich, Leona Gabryšová, Ashleigh Howes & Anne O'Garra
Advertisement
Nature Reviews Immunology Poster on Dendritic cells: controllers of adaptive immunity This free poster provides an overview of the key roles dendritic cells have in initiating protective adaptive immunity to pathogens and in promoting tolerogenic immune responses that contribute to tissue homeostasis. Download this poster for FREE Produced with support from Biolegend
In this issue p633 | doi:10.1038/nri3077 Full Text
Editorial: Turning 10 p635 | doi:10.1038/nri3072 Abstract | Full Text | PDF
Comment: The gut microbiota: challenging immunology Navkiran Gill & B. Brett Finlay p636 | doi:10.1038/nri3061 Differences in the gut microbiota can influence immunity, not just at mucosal sites but also at more distal sites. But what are the implications for immunology research? Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Immunotherapy: Leukadherins get a grip on inflammation p638 | doi:10.1038/nri3079 New drugs promoting integrin activation stop inflammatory cells from moving on. PDF Phagocytosis: Phagocytes whet their appetite p639 | doi:10.1038/nri3078 Mitochondrial membrane potential regulates a cell's phagocytic ability. PDF IN BRIEF Infection | T cells | Innate immunity p639 | doi:10.1038/nri3082 PDF Cytokines: Structuring the type I IFN response p640 | doi:10.1038/nri3067 Binding affinity determines the biological activities of type I interferons. PDF IN THE NEWS Virus-hunter gatherers p640 | doi:10.1038/nri3080 PDF Tumour immunology: Neutrophils fight back in the final round p640 | doi:10.1038/nri3081 Neutrophil activation in the pre-metastatic niche can inhibit tumour cell seeding. PDF IN BRIEF Viral immunity | Vaccines | Signalling p641 | doi:10.1038/nri3083 PDF B cells: WASP stings autoreactive B cells p642 | doi:10.1038/nri3074 Hyperresponsive WASP-deficient B cells depend on T cells to mediate autoimmunity. PDF Natural killer T cells: Worth holding on to p642 | doi:10.1038/nri3075 Invariant NKT cells recognize glycoproteins from Streptococcus species and promote immunity to these bacteria. PDF Allergy: Peaceful death ends pain p643 | doi:10.1038/nri3076 Tolerogenic DCs kill effector CD8+ T cells and inhibit allergic reactions in the skin. PDF Trafficking: Tracking immune cells on the lymph node map p644 | doi:10.1038/nri3068 Combining intralymphatic microinjection with imaging technologies helps to trace DC and T cell routes in the lymph nodes. PDF Inflammasome: NAIPs: pathogen-sensing proteins p644 | doi:10.1038/nri3069 NAIP family members mediate NLRC4 inflammasome activation in response to distinct bacterial ligands. PDF Immunology JOBS of the week Post Doctoral Fellow Pain Signaling University of Illinois Urbana Champaign, IL, USA Urbana, US Junior Faculty Position in Nomis Center for Immunobiology and Microbial Pathogenesis Salk Institute for Biological Studies La Jolla, US Immunology Faculty Position Memorial Sloan-Kettering Cancer Center New York, US GU / Renal Disease Scientist Connecticut Children's Medical Center Hartford, US Junior Faculty Position in Nomis Center for Immunobiology and Microbial Pathogenesis Salk Institute for Biological Studies La Jolla, US More Science jobs from Immunology EVENT 2nd International Conference on Immune Tolerance 23.-25.10.11 Amsterdam, Netherlands More science events from
REVIEWS		Top
NK cell development, homeostasis and function: parallels with CD8+ T cells Joseph C. Sun & Lewis L. Lanier p645 | doi:10.1038/nri3044 Natural killer (NK) cells are traditionally considered to be innate immune players. In this Review, J. C. Sun and L. L. Lanier summarize the principles of NK cell development, homeostasis and function, and draw parallels between NK cell and CD8+ T cell biology. From a fascinating discussion it appears that the borders between innate and adaptive immunity are not as well defined as previously thought. Abstract | Full Text | PDF
Organ-specific features of natural killer cells Fu-Dong Shi, Hans-Gustaf Ljunggren, Antonio La Cava & Luc Van Kaer p658 | doi:10.1038/nri3065 Each tissue in our body contains a unique microenvironment that can differentially shape immune reactivity. In this Review article, Shi et al. describe how organ-specific factors influence natural killer cell homing and phenotype, and discuss the local molecular and cellular interactions that determine the protective or pathogenic functions of natural killer cells in the different tissues. Abstract | Full Text | PDF
New insights into the T cell synapse from single molecule techniques Michael L. Dustin & David Depoil p672 | doi:10.1038/nri3066 Unexpected and controversial results regarding the functional organization of the T cell synapse have been obtained from the single molecule imaging techniques that have recently become available. Abstract | Full Text | PDF
Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response Katherine Y. King & Margaret A. Goodell p685 | doi:10.1038/nri3062 Haematopoietic stem cells are a rare, self-renewing population that give rise to all cells of the immune system. In this Review, the authors describe how the haematopoietic stem cell compartment is shaped by infection and inflammation, and discuss the therapeutic implications of this. Abstract | Full Text | PDF
PERSPECTIVES		Top
VIEWPOINT Highlights of 10 years of immunology in Nature Reviews Immunology Ruslan Medzhitov, Ethan M. Shevach, Giorgio Trinchieri, Andrew L. Mellor, David H. Munn, Siamon Gordon, Peter Libby, Göran K. Hansson, Ken Shortman, Chen Dong, Dmitry Gabrilovich, Leona Gabryšová, Ashleigh Howes & Anne O'Garra p693 | doi:10.1038/nri3063 The authors of some of our most popular Reviews look back on a decade of immunology. Abstract | Full Text | PDF
OPINION The parallel lives of angiogenesis and immunosuppression: cancer and other tales Gregory T. Motz & George Coukos p702 | doi:10.1038/nri3064 This article discusses the evidence in support of the simultaneous activation of angiogenesis and immunosuppression in a homeostatic tissue repair programme and proposes that these normal biological processes are co-opted by tumours to enhance tumour growth. Abstract | Full Text | PDF
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2010 Journal Citation Report (Thomson Reuters, 2011)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.