Nature Reviews Molecular Cell Biology contents October 2011 Volume 12 Number 10 pp621-686

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TABLE OF CONTENTS
October 2011 Volume 12 Number 10		Advertisement
Impact Factor 38.65 * Subscribe to Nature Reviews Molecular Cell Biology Recommend to your library	In this issue Research Highlights Reviews Perspectives Also this month Article series: Post-translational modifications Article series: 10-year anniversary Poster: From teratomas to embryonic stem cells: discovering pluripotency  Featured article: Dynamic niches in the origination and differentiation of haematopoietic stem cells Leo D. Wang & Amy J. Wagers	See the Light. Make the Switch. Stop Cloning! The LightSwitch Luciferase Assay System provides everything you need for reporter assays: pre-cloned human promoters and 3'UTRs in luciferase reporter vectors plus optimized luciferase reagents to measure promoter induction and miRNA target validation. Visit SwitchGear Genomics and explore our genome-wide collections and validated pathway sets.
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From the editors p621 | doi:10.1038/nrm3201 PDF
RESEARCH HIGHLIGHTS Top Cell cycle: The division belt p622 | doi:10.1038/nrm3194 Chromosomes align into an equatorial ring prior to bi-orientation. PDF Chromatin: Stress inhibits replication through JNK1 signalling p623 | doi:10.1038/nrm3193 Stress-induced phosphorylation of CDT1 by JNK1 prevents HBO1 recruitment to inhibit replication. PDF STRUCTURE WATCH Deconstructing dynamin | Tuning CaMKII p623 | doi:10.1038/nrm3203 PDF Telomeres: Fusing with RNF8 p624 | doi:10.1038/nrm3186 RNF8 promotes the fusion of uncapped telomeres through ubiquitylation. PDF Cell division: Repo-Man's extra exit strategy p624 | doi:10.1038/nrm3197 Repo-Man has a role in both chromatin remodelling and nuclear envelope reformation. PDF Cell death: Linking metabolism to apoptotic sensitivity p625 | doi:10.1038/nrm3195 BCL-XL suppresses acetyl CoA production to protect cells against apoptosis. PDF Cell division: CENPA's tail rules the centromere p626 | doi:10.1038/nrm3196 An in vitro system shows the C-terminal tail of CENPA is sufficient for centromere assembly. PDF IN BRIEF Cell signalling | Plant cell biology | Cell signalling p626 | doi:10.1038/nrm3202 PDF Cell death: Phagocytes whet their appetite p627 | doi:10.1038/nrm3192 Mitochondrial membrane potential regulates a cell's phagocytic ability. PDF Membrane dynamics: ER marks the spot p627 | doi:10.1038/nrm3200 ER contact with mitochondria positions mitochondrial constriction and fission. PDF Molecular Cell Biology JOBS of the week Immunology Faculty Position Memorial Sloan-Kettering Cancer Center New York, US Group Leader in Structural Biology Beatson Institute for Cancer Research Glasgow, GB Chair The University of Western Ontario CA GU / Renal Disease Scientist Connecticut Children's Medical Center Hartford, US Tenure-Track Faculty Members Carnegie Mellon University Pittsburgh, US More Science jobs from Molecular Cell Biology EVENT Cell Signaling Networks 2011 22.-27.10.11 Yucatan, Mexico More science events from
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REVIEWS		Top
Article series: Post-translational modifications Deciphering arginine methylation: Tudor tells the tale Chen Chen, Timothy J. Nott, Jing Jin & Tony Pawson p629 | doi:10.1038/nrm3185 The ability of methylarginine sites to serve as binding motifs for Tudor proteins, and the functional significance of this, is now becoming clear. Tudor proteins are thought to interact with methylated PIWI proteins and regulate the PIWI-interacting RNA pathway in the germ line. Abstract | Full Text | PDF | Supplementary information
Dynamic niches in the origination and differentiation of haematopoietic stem cells Leo D. Wang & Amy J. Wagers p643 | doi:10.1038/nrm3184 Haematopoietic stem cell function is tightly controlled to maintain haematopoietic homeostasis, in part by specialized cells and factors that constitute the haematopoietic 'niche'. Recent discoveries have engendered a new appreciation for the dynamic nature of the niche, identifying novel cellular and acellular niche components and uncovering fluctuations in their importance over time. Abstract | Full Text | PDF
Article series: 10-year anniversary Proteins on the move: insights gained from fluorescent protein technologies Atsushi Miyawaki p656 | doi:10.1038/nrm3199 In the past 10 years, great progress has been made in the development of fluorescent proteins, including green fluorescent protein (GFP) and GFP-like proteins. Using these proteins together with a range of techniques has furthered our understanding of protein movement and protein–protein interactions. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
VIEWPOINT Article series: 10-year anniversary A decade of molecular cell biology: achievements and challenges Asifa Akhtar, Elaine Fuchs, Tim Mitchison, Reuben J. Shaw, Daniel St Johnston, Andreas Strasser, Susan Taylor, Claire Walczak & Marino Zerial p669 | doi:10.1038/nrm3187 Researchers from across the field consider the new concepts that have emerged during the past decade of molecular cell biology research, and the key challenges still to be met. Abstract | Full Text | PDF
OPINION Insights into autotaxin: how to produce and present a lipid mediator Wouter H. Moolenaar & Anastassis Perrakis p674 | doi:10.1038/nrm3188 The phosphodiesterase autotaxin (ATX) produces the lipid mediator lysophosphatidic acid (LPA) to regulate diverse processes, including cell migration and proliferation. Studies of the structure of ATX may shed new light on how ATX recognizes its substrates and associates with the cell surface to promote specificity in LPA signalling. Abstract | Full Text | PDF
TIMELINE Discovering pluripotency: 30 years of mouse embryonic stem cells Martin Evans p680 | doi:10.1038/nrm3190 This year marks the thirtieth anniversary since embryonic stem (ES) cells were first isolated from mouse blastocysts. In this Timeline, one of the scientists to isolate mouse ES cells in 1981 gives a personal account of the ideas that led to, and followed, this milestone. Abstract | Full Text | PDF
Erratum: The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation Allan M. Weissman, Nitzan Shabek & Aaron Ciechanover p686 | doi:10.1038/nrm3191 Full Text | PDF
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Nature Reviews Molecular Cell Biology FOCUS ON MORPHOGENESIS Cells in a developing organism reorganize to allow tissues and organs to take their shape through morphogenesis. In this focus issue, specially commissioned articles highlight how our cell biological understanding of morphogenesis is gaining new ground and consider the implications for tissue homeostasis and disease. Read the Focus online: www.nature.com/nrm/focus/morphogenesis
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