Nature Reviews Cancer contents October 2011 Volume 11 Number 10 pp 687-754

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TABLE OF CONTENTS
October 2011 Volume 11 Number 10		Advertisement
Impact Factor 37.178 * Subscribe to Nature Reviews Cancer Recommend to your library	In this issue Research Highlights Review Analysis Perspectives Also this month Article series: The next 10 years  Featured article: A decade of exploring the cancer epigenome — biological and translational implications Stephen B. Baylin & Peter A. Jones	Matrigel Matrix. Cited in more than 6000 papers. BD Matrigel Matrix is certified LDEV-free, and is the most trusted and extensively published basement membrane matrix for good reason: Reliability. Try BD Matrigel Matrix or other BD recommended materials for 3D culture and save 15% on your order. BD Extracellular Matrices give you reliability, confidence and consistency. bdbiosciences.com/cellculture/ecm
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Nature Reviews Molecular Cell Biology Poster - From teratomas to embryonic stem cells: discovering pluripotency This Poster provides a timeline overview of the history of pluripotency, starting from early studies of teratocarcinomas in 1954, which preceded the isolation of mouse and human ES cells, and ending with the generation of iPS cells. In doing so, it highlights how our understanding of the pluripotent state has evolved over almost 60 years. Access the Poster FREE online! www.nature.com/nrm/posters/discoveringpluripotency Produced with support from: Abcam Plc
From the editors p687 | doi:10.1038/nrc3149 PDF
RESEARCH HIGHLIGHTS Top Epithelial to mesenchymal transition: Layers of regulation p689 | doi:10.1038/nrc3146 Two recent papers have shown that EMT can be driven by both alternative splicing and chromatin modification. PDF Cell migration: Cytokine cues p690 | doi:10.1038/nrc3141 A cytokine signalling pathway activating the kinase JAK1 generates actomyosin contractility in both tumour cells and surrounding fibroblasts to permit tumour cell migration. PDF IN THE NEWS Ancient dog with new trick? p690 | doi:10.1038/nrc3148 PDF Tumour heterogeneity: That's the theory p691 | doi:10.1038/nrc3140 A new mathematical model of phenotypic equilibrium indicates that stochastic transitions between basal, luminal and stem cell phenotypes in breast cancer influences tumour evolution. PDF Genomic instability: Aneuploidy stokes the fire p692 | doi:10.1038/nrc3142 Two new studies suggest that aneuploidy can promote genomic instability and tumorigenesis. PDF Metabolism: Haem is where the heart is p692 | doi:10.1038/nrc3145 This Nature paper shows that inhibition of haem oxygenase 1 is synthetic lethal in kidney cells lacking the tumour suppressor fumarate hydratase. PDF Therapy: Targeting MYC? You BET p693 | doi:10.1038/nrc3147 Bradner, Mitsiades and colleagues show that inhibition of BET family proteins with the small-molecule inhibitor JQ1 selectively represses the expression of MYC,and MYC and E2F1 target genes. PDF Cancer JOBS of the week Postdoctoral Research Fellow - T Cell Biology in Transplantation and Tumor Moffitt Cancer Center Tampa, US Faculty Position Structural Biology Program Sloan-Kettering Institute Sloan-Kettering Institute New York, US Postdoctoral Fellow, Cancer Biology Novartis Institute for Biomedical Research Emeryville, US PhD scholarship: Medical Bioinformatics University of Rostock Rostock, DE Product Manager, Oncology (m / f) Hays AG US More Science jobs from Cancer EVENT ABC1 Advanced Breast Cancer - First Consensus Conference 03.-05.11.11 Lisbon, Portugal More science events from
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REVIEW		Top
Perineural invasion and associated pain in pancreatic cancer Aditi A. Bapat, Galen Hostetter, Daniel D. Von Hoff & Haiyong Han p695 | doi:10.1038/nrc3131 Perineural invasion (PNI) is a prominent characteristic of pancreatic cancer that is involved in the generation of pain, and correlates with poor prognosis in most studies. This Review discusses the signalling molecules and pathways that are involved in PNI and whether knowledge of these could be used to alleviate pain and to reduce the incidence of PNI. Abstract | Full Text | PDF
ANALYSIS		Top
Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping Sunghoon Kim, Sungyong You & Daehee Hwang p708 | doi:10.1038/nrc3124 Aminoacyl-tRNA synthetases (ARSs) are assumed to be simply 'housekeeping' genes. However, mammalian ARSs interact with diverse regulatory factors both inside and outside the cell. Do these enzymes have a role in tumorigenesis? Abstract | Full Text | PDF | Supplementary information
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STR Profiling: The Easiest Way to be Sure Cell line authentication has never been quicker, more convenient, or so necessary. With 20+ years of experience performing STR profiling — more than any other provider — ATCC offers researchers the easiest and surest solution to verify the identity of their human cell lines. Using the ATCC® FTA® Sample Collection Kit, simply spot, dry and mail your sample. It's as easy as 1, 2, 3.
PERSPECTIVES		Top
OPINION Rethinking ovarian cancer: recommendations for improving outcomes Sebastian Vaughan, Jermaine I. Coward, Robert C. Bast, Jr, Andy Berchuck, Jonathan S. Berek, James D. Brenton, George Coukos, Christopher C. Crum, Ronny Drapkin, Dariush Etemadmoghadam, Michael Friedlander, Hani Gabra, Stan B. Kaye, Chris J. Lord, Ernst Lengyel, Douglas A. Levine, Iain A. McNeish, Usha Menon, Gordon B. Mills, Kenneth P. Nephew, Amit M. Oza, Anil K. Sood, Euan A. Stronach, Henning Walczak, David D. Bowtell & Frances R. Balkwill p719 | doi:10.1038/nrc3144 This Opinion article outlines nine major recommendations for improving our understanding of ovarian cancer and the outcomes of women with this group of diseases. Abstract | Full Text | PDF | Supplementary information
TIMELINE Article series: The next 10 years A decade of exploring the cancer epigenome — biological and translational implications Stephen B. Baylin & Peter A. Jones p726 | doi:10.1038/nrc3130 Epigenetic alterations are leading candidates for the development of specific markers for cancer detection, diagnosis and prognosis, as well as new targets for cancer therapy. Which of the discoveries in the past 10 years are ready for advancement? Abstract | Full Text | PDF
TIMELINE Article series: The next 10 years Unravelling the complexity of metastasis — molecular understanding and targeted therapies Nilay Sethi & Yibin Kang p735 | doi:10.1038/nrc3125 Will genomic and other systems level approaches help to overcome gaps in our understanding of metastasis? Abstract | Full Text | PDF
VIEWPOINT Article series: The next 10 years Cancer research: past, present and future Ya Cao, Ronald A. DePinho, Matthias Ernst & Karen Vousden p749 | doi:10.1038/nrc3138 Opinions on where we should progress next with cancer research are diverse. In this article, four top cancer researchers from across the globe discuss their thoughts on the current state of cancer research and what progress might be expected in the next 10 years. Abstract | Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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