 | The EMBO Journal Volume 38, Issue 18 16 September 2019 |
Editorial
Self‐correction prevents withdrawal syndrome
e70001 | First Published: 30 August 2019
EMBO Press has enhanced the toolkit for corrections to research papers by including 'withdrawal' and 'partial retraction'. The aim is to encourage self‐correction.
News & Views
Photoreceptor signaling: when COP1 meets VPs
e102962 | First Published: 21 August 2019
A new study reveals a unified mechanism of transcription factor activation by structurally diverse photoreceptors during plant photomorphogenesis.
Review
DNA damage kinase signaling: checkpoint and repair at 30 years
e101801 | First Published: 08 August 2019
Smolka et al revisit the seminal Hartwell & Weinert concept of cell‐cycle ordering by checkpoint controls, particularly summarizing our current understanding of kinase networks and their direct roles in damage responses and DNA repair.
Articles
Open Access Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs
e102140 | First Published: 15 July 2019
Light activation increases affinity of various photoreceptors for the E3 ligase COP1, resulting in protection of light‐regulated transcription factors from COP1‐mediated degradation.
Open Access Molecular pathways of senescence regulate placental structure and function
e100849 | First Published: 19 August 2019
Compromised cellular senescence in the multinucleated syncytiotrophoblast layer is associated with pathophysiology of intrauterine growth restriction during pregnancy in mice and humans.
Open Access Hyperoxidation of mitochondrial peroxiredoxin limits H2O2‐induced cell death in yeast
e101552 | First Published: 07 August 2019
H2O2‐mediated oxidation of the mitochondrial glutathione pool by peroxiredoxin Prx1 is a key determinant of peroxide‐induced cell death in yeast.
Interplay between the bacterial protein deacetylase CobB and the second messenger c‐di‐GMP
e100948 | First Published: 16 August 2019
A negative feedback loop between c‐di‐GMP production and the Escherichia coli Sir2‐family deacetylase CobB modulates biogenesis of acetyl‐CoA.
Open Access Diverse roles of TssA‐like proteins in the assembly of bacterial type VI secretion systems
e100825 | First Published: 12 August 2019
Comparative analysis of TssA/TagA subunits of the Type VI secretion system reveals three functional classes with distinct roles in sheath dynamics.
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity
e102075 | First Published: 07 August 2019
The TRAF3 interacting protein 3, TRAF3IP3, promotes RIG‐I‐MAVS signaling to stimulate type I interferon production and protection against RNA virus infection.
C/EBPα mediates the growth inhibitory effect of progestins on breast cancer cells
e101426 | First Published: 02 August 2019
C/EBPα acts as a tumor suppressor in hormone‐dependent breast cancer by facilitating chromatin accessibility and progesterone receptor loading at key cell cycle genes.
Resources
Open Access The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification
e101220 | First Published: 12 August 2019
Comprehensive interaction mapping of the KRAB domain zinc finger transcription factor family shows conservation of their function in KAP1 binding and identifies novel binding partners of the most ancient members.
A single‐cell transcriptome atlas of the adult human retina
e100811 | First Published: 22 August 2019
A comprehensive analysis of the human retinal transcriptome at a single‐cell level defines gene expression profiles of all major retinal cell types.
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