Tuesday, September 3, 2019

Table of Contents Alert: The EMBO Journal, Vol. 38, No. 17, 02 September 2019

Creating is Understanding: Synthetic Biology Masters Complexity
Cover Image The EMBO Journal
Volume 38, Issue 17

02 September 2019


Walter Neupert (1939–2019), a pioneer of mitochondrial biogenesis and morphology
Roland Lill, Thomas Langer, Johannes M Herrmann

e103100 | First Published: 16 August 2019

News & Views

Sleep or deplete: how the choroid plexus helps to keep neural stem cells in balance
Thomas Wegleiter, Sebastian Jessberger

e103013 | First Published: 21 August 2019

New work uncovers systemic miRNA control of subventricular zone stem cells in the adult brain.

Toward a better understanding of signaling networks in plants: yeast has the power!
Guillaume Dubeaux, Julian I Schroeder

e102478 | First Published: 06 August 2019

A new study uses yeast as a reconstitution system to examine the functionality, plasticity, and efficiency of the highly complex plant abscisic acid signaling pathway.


Open Access
Microglial subtypes: diversity within the microglial community
Vassilis Stratoulias, Jose Luis Venero, Marie‐Ève Tremblay, Bertrand Joseph

e101997 | First Published: 02 August 2019

Bertrand Joseph and colleagues discuss the complexities and heterogeneity of the resident macrophage cells that play key roles in CNS immune responses, suggesting function‐based categorizations and ways for further studies.


Choroid plexus‐derived miR‐204 regulates the number of quiescent neural stem cells in the adult brain
Tjasa Lepko, Melanie Pusch, Tamara Müller, Dorothea Schulte, Janina Ehses, Michael Kiebler, Julia Hasler, Hagen B Huttner, Roosmarijn E Vandenbroucke, Charysse Vandendriessche, Miha Modic, Ana Martin‐Villalba, Sheng Zhao, Enric LLorens‐Bobadilla, Anja Schneider, Andre Fischer, Christopher T Breunig, Stefan H Stricker, Magdalena Götz, Jovica Ninkovic

e100481 | First Published: 15 July 2019

Neurogenic versus stem cell fate is controlled by long‐distance transfer of secreted miR‐204.

Open Access
Rebuilding core abscisic acid signaling pathways of Arabidopsis in yeast
Moritz Ruschhaupt, Julia Mergner, Stefanie Mucha, Michael Papacek, Isabel Doch, Stefanie V Tischer, Daniel Hemmler, David Chiasson, Kai H Edel, Jörg Kudla, Philippe Schmitt‐Kopplin, Bernhard Kuster, Erwin Grill

e101859 | First Published: 01 August 2019

Reconstitution of the abscisic acid signalling cascade in yeast provides insights into the specific contributions of the homologous pathway components.

LncRNA HAND2‐AS1 promotes liver cancer stem cell self‐renewal via BMP signaling
Yanying Wang, Pingping Zhu, Jianjun Luo, Jing Wang, Zhiwei Liu, Wei Wu, Ying Du, Buqing Ye, Dongpeng Wang, Lei He, Weizheng Ren, Jianyi Wang, Xianhui Sun, Runsheng Chen, Yong Tian, Zusen Fan

e101110 | First Published: 23 July 2019

A conserved lncRNA controls BMP signaling and liver oncogenesis by promoter recruitment of the INO80 remodeler.

Open Access
Nucleotide signaling pathway convergence in a cAMP‐sensing bacterial c‐di‐GMP phosphodiesterase
Ian T Cadby, Sarah M Basford, Ruth Nottingham, Richard Meek, Rebecca Lowry, Carey Lambert, Matthew Tridgett, Rob Till, Rashidah Ahmad, Rowena Fung, Laura Hobley, William S Hughes, Patrick J Moynihan, R Elizabeth Sockett, Andrew L Lovering

e100772 | First Published: 29 July 2019

Structural and biochemical work shows how usage of the second messenger cyclic dinucleotide c‐di‐GMP is controlled by upstream cAMP.

Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition
Mauro Siragusa, Janina Thöle, Sofia‐Iris Bibli, Bert Luck, Annemarieke E Loot, Kevin de Silva, Ilka Wittig, Juliana Heidler, Heike Stingl, Voahanginirina Randriamboavonjy, Karin Kohlstedt, Bernhard Brüne, Andreas Weigert, Beate Fisslthaler, Ingrid Fleming

e100938 | First Published: 22 July 2019

Endothelial nitric oxide synthase induces S‐nitrosation and inactivation of pyruvate kinase M2, triggering antioxidant responses in mice through the rewiring of endothelial cell metabolism.

Dual function of VGLL4 in muscle regeneration
Xue Feng, Zuoyun Wang, Fei Wang, Tiantian Lu, Jinjin Xu, Xueyan Ma, Jinhui Li, Lingli He, Wenxiang Zhang, Sheng Li, Wenjun Yang, Shu Zhang, Gaoxiang Ge, Yun Zhao, Ping Hu, Lei Zhang

e101051 | First Published: 22 July 2019

Analyses on knockout mice reveal that VGLL4 exhibits opposing effects on TEAD4 mediated transcription in different stages of muscle regeneration, thereby striking a balance between muscle stem cell proliferation and differentiation.

Divergent lncRNA MYMLR regulates MYC by eliciting DNA looping and promoter‐enhancer interaction
Taisuke Kajino, Teppei Shimamura, Shuyi Gong, Kiyoshi Yanagisawa, Lisa Ida, Masahiro Nakatochi, Sebastian Griesing, Yukako Shimada, Keiko Kano, Motoshi Suzuki, Satoru Miyano, Takashi Takahashi

e98441 | First Published: 30 July 2019

A long‐noncoding RNA transcribed in close proximity to the MYC locus is acting in cis to facilitate MYC oncogene expression in cancer cells.

Open Access
SALM1 controls synapse development by promoting F‐actin/PIP2‐dependent Neurexin clustering
Marinka Brouwer, Fatima Farzana, Frank Koopmans, Ning Chen, Jessie W Brunner, Silvia Oldani, Ka Wan Li, Jan RT van Weering, August B Smit, Ruud F Toonen, Matthijs Verhage

e101289 | First Published: 01 August 2019

The cell adhesion molecule SALM1 binds the presynaptic CASK/Mint1/Lin7b complex to promote neurexin clustering and synapse development.

Nuclear RNA export factor variant initiates piRNA‐guided co‐transcriptional silencing
Kensaku Murano, Yuka W Iwasaki, Hirotsugu Ishizu, Akane Mashiko, Aoi Shibuya, Shu Kondo, Shungo Adachi, Saori Suzuki, Kuniaki Saito, Tohru Natsume, Mikiko C Siomi, Haruhiko Siomi

e102870 | First Published: 01 August 2019

Piwi protein associated piRNA serve to repress transposable elements (TEs). Nuclear export factor Nxf2 binds the Piwi‐Panx‐ p15 complex for co‐transcriptional silencing initially via direct association with TE transcripts independently of H3K9me3 followed by heterochromatin formation.

Open Access
Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome
Dario Tejera, Dilek Mercan, Juan M Sanchez‐Caro, Mor Hanan, David Greenberg, Hermona Soreq, Eicke Latz, Douglas Golenbock, Michael T Heneka

e101064 | First Published: 30 July 2019

Microglia morphology and Aβ clearance is negatively regulated by systemic inflammation in a NLRP3‐dependent manner.

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