The EMBO Journal Table of Contents for 02 November 2018; Vol. 37, No. 21

02 November 2018 | Volume 37, Number 21 Submit Table of Contents News & Views Articles Volume 37, Number 21 News & Views The hypothalamic‐LC‐PFC axis: a new “ace” in the brain for fast‐behavioral stress response A central stress pathway involving hypothalamic, aqueductal and noradrenergic systems results in fast enhancement of cortical excitability following acute stress. Davide Pozzi and Michela Matteoli Published online 25.10.2018 Right time, right place—DNA damage and DNA replication checkpoints collectively safeguard S phase Recent studies shed new light on how two related checkpoint signaling cascades differ in the location and kinetics of their activation in budding yeast. Lorenzo Galanti and Boris Pfander Published online 04.10.2018 Articles Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress A new multimodal signaling pathway initiated by CRH neurons explains how acute stress is communicated from the hypothalamus to the cerebral cortex. Alán Alpár, Péter Zahola, János Hanics, Zsófia Hevesi, Solomiia Korchynska, Marco Benevento, Christian Pifl, Gergely Zachar, Jessica Perugini, Ilenia Severi, Patrick Leitgeb, Joanne Bakker, Andras G Miklosi, Evgenii Tretiakov, Erik Keimpema, Gloria Arque, Ramon O Tasan, Günther Sperk, Katarzyna Malenczyk, Zoltán Máté, Ferenc Erdélyi, Gábor Szabó, Gert Lubec, Miklós Palkovits, Antonio Giordano, Tomas GM Hökfelt, Roman A Romanov, Tamas L Horvath and Tibor Harkany Published online 12.09.2018 Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage Two yeast checkpoint mediators employ spatially and temporally distinct mechanisms for activating Rad53 signaling to ensure an optimal response to replication stress. Julien Bacal, María Moriel‐Carretero, Benjamin Pardo, Antoine Barthe, Sushma Sharma, Andrei Chabes, Armelle Lengronne and Philippe Pasero Published online 29.08.2018 ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival ESCRT proteins, components of the protein sorting machinery, promote repair of damaged lysosomes and vacuoles. Lysosomal repair protects cells from cell death, while vacuolar repair provides a replicative advantage to certain pathogens. Maja Radulovic, Kay O Schink, Eva M Wenzel, Viola Nähse, Antonino Bongiovanni, Frank Lafont and Harald Stenmark Published online 12.10.2018 Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy Syntaxin 17 supports PGAM5‐mediated dephosphorylation and activation of fission factor Drp1 in healthy cells by regulating PGAM5 localization. Masashi Sugo, Hana Kimura, Kohei Arasaki, Toshiki Amemiya, Naohiko Hirota, Naoshi Dohmae, Yuzuru Imai, Tsuyoshi Inoshita, Kahori Shiba‐Fukushima, Nobutaka Hattori, Jinglei Cheng, Toyoshi Fujimoto, Yuichi Wakana, Hiroki Inoue and Mitsuo Tagaya Published online 20.09.2018 Tuberous sclerosis complex is required for tumor maintenance in MYC‐driven Burkitt's lymphoma Although generally associated with tumor suppression, the mTOR regulators TSC1/2 are appropriated by the MYC oncogene to prevent mTORC1 hyperactivation that may otherwise jeopardize survival of MYC‐driven cancers. Götz Hartleben, Christine Müller, Andreas Krämer, Heiko Schimmel, Laura M Zidek, Carsten Dornblut, René Winkler, Sabrina Eichwald, Gertrud Kortman, Christian Kosan, Joost Kluiver, Iver Petersen, Anke van den Berg, Zhao‐Qi Wang and Cornelis F Calkhoven Published online 20.09.2018 Conformational dynamics of the ABC transporter McjD seen by single‐molecule FRET While static structural studies have increased our understanding of ABC transporter organization, the application of single‐molecule FRET provides a detailed view of the conformational dynamics associated with substrate export. Florence Husada, Kiran Bountra, Konstantinos Tassis, Marijn de Boer, Maria Romano, Sylvie Rebuffat, Konstantinos Beis and Thorben Cordes Published online 20.09.2018 Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation Differential Esrrb transcription factor expression instructs differentiation kinetics of mouse embryonic stem cells. Nicola Festuccia, Florian Halbritter, Andrea Corsinotti, Alessia Gagliardi, Douglas Colby, Simon R Tomlinson and Ian Chambers Published online 01.10.2018 Nonsense‐mediated mRNA decay involves two distinct Upf1‐bound complexes Distinct mechanisms for Nonsense‐Mediated mRNA Decay (NMD) have been proposed in different organisms. Proteomics‐based characterization of NMD complexes in yeast reveals the existence of two mutually exclusive complexes that may provide a universal model for NMD. Marine Dehecq, Laurence Decourty, Abdelkader Namane, Caroline Proux, Joanne Kanaan, Hervé Le Hir, Alain Jacquier and Cosmin Saveanu Published online 01.10.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.