Nature Communications - 03 October 2018

Weekly Content Alert Nature Communications is fully open access. Read more. 03 October 2018  Latest content: Comments Articles Correspondence Author Corrections Publisher Corrections Journal homepage Recommend to library Web feed   Advertisement Nature Index 2018 Rising Stars  Creative minds drive the scientific enterprise. This supplement profiles up-and-coming researchers in the natural sciences who have achieved excellence in the Nature Index, and have demonstrated the passion, ambition and resilience to rise even higher in the competitive world of academia.  Read the full supplement      Latest Comments     Bacterial dynamin-like proteins reveal mechanism for membrane fusion OPEN Marc Bramkamp 28 September 2018 | doi: 10.1038/s41467-018-06559-6 Bacteria  Structural biology  Cancer cells with trapped nuclei cut their way through the extracellular matrix OPEN Emmanuel Dornier & Jim C. Norman 27 September 2018 | doi: 10.1038/s41467-018-06351-6 Breast cancer  Cancer  Cancer microenvironment  Cell adhesion  Cell biology      Latest Articles View all Articles     An ultra-low thiourea catalyzed strain-release glycosylation and a multicatalytic diversification strategy OPEN Chunfa Xu & Charles C. J. Loh Non-covalent glycosyl donor activation often requires high organocatalyst loadings. Here, the authors demonstrate that strain-release glycosylations can take place at very low thiourea catalyst loadings. In addition, the authors developed a one-pot multicatalytic strategy that can diversify glycosides rapidly. 03 October 2018 | doi: 10.1038/s41467-018-06329-4 Carbohydrate chemistry  Diversity-oriented synthesis  Synthetic chemistry methodology  Organocatalysis  Combined impacts of deforestation and wildlife trade on tropical biodiversity are severely underestimated OPEN William S. Symes, David P. Edwards, Jukka Miettinen, Frank E. Rheindt & L. Roman Carrasco Disentangling multiple drivers of species declines can be difficult yet is critical to species conservation. Here, the authors parse the relative contributions of deforestation and trapping to declines of native birds in Southeast Asia, finding that the extinction risk of trapped species may be underestimated. 03 October 2018 | doi: 10.1038/s41467-018-06579-2 Biodiversity  Conservation biology  Tropical ecology  Cloning of the wheat Yr15 resistance gene sheds light on the plant tandem kinase-pseudokinase family OPEN Valentina Klymiuk, Elitsur Yaniv, Lin Huang, Dina Raats, Andrii Fatiukha, Shisheng Chen, Lihua Feng, Zeev Frenkel, Tamar Krugman, Gabriel Lidzbarsky, Wei Chang, Marko J. Jääskeläinen, Christian Schudoma, Lars Paulin, Pia Laine, Harbans Bariana, Hanan Sela, Kamran Saleem, Chris Khadgi Sørensen, Mogens S. Hovmøller et al. Yellow rust fungus severely limits global wheat production and breeding of durable resistance is challenging. Here Klymiuk et al. isolate the broad-spectrum Yr15 resistance gene from wild emmer wheat and show that it is a member of a distinct tandem kinase-pseudokinase family of plant proteins. 03 October 2018 | doi: 10.1038/s41467-018-06138-9 Biotic  Evolutionary biology  Plant breeding  Bi-directional cell-pericellular matrix interactions direct stem cell fate OPEN Silvia A. Ferreira, Meghna S. Motwani, Peter A. Faull, Alexis J. Seymour, Tracy T. L. Yu, Marjan Enayati, Dheraj K. Taheem, Christoph Salzlechner, Tabasom Haghighi, Ewa M. Kania, Oommen P. Oommen, Tarek Ahmed, Sandra Loaiza, Katarzyna Parzych, Francesco Dazzi, Oommen P. Varghese, Frederic Festy, Agamemnon E. Grigoriadis, Holger W. Auner, Ambrosius P. Snijders et al. 3D hydrogels have provided information on the physical requirements of stem cell fate, but the contribution of interactions with the pericellular environment are under-explored. Here the authors show that pericellular matrix secreted by human bone marrow stromal cells (hMSC) embedded in a HA-based hydrogel contribute to hMSC fate. 03 October 2018 | doi: 10.1038/s41467-018-06183-4 Biomaterials – cells  Stem-cell differentiation  Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis OPEN Chiharu Kimura-Yoshida, Kyoko Mochida, Masa-aki Nakaya, Takeomi Mizutani & Isao Matsuo The transcription factor Grhl3 is known to play a role in the nucleus during epidermal differentiation. Here, the authors report that Grhl3 is also cytoplasmic and membrane-localized, increasing mechanical stiffness by upregulating actomyosin networks. 03 October 2018 | doi: 10.1038/s41467-018-06171-8 Cell signalling  Morphogenesis  Turning a native or corroded Mg alloy surface into an anti-corrosion coating in excited CO2 OPEN Yuecun Wang, Boyu Liu, Xin'ai Zhao, Xionghu Zhang, Yucong Miao, Nan Yang, Bo Yang, Liqiang Zhang, Wenjun Kuang, Ju Li, Evan Ma & Zhiwei Shan Magnesium alloys usually have poor corrosion resistance, which inhibits their use in the automotive and biomedical industries. Here, the authors use an environmental TEM to carbonate the natural corrosion products at the surface of magnesium alloys and form a compact and protective surface layer. 03 October 2018 | doi: 10.1038/s41467-018-06433-5 Corrosion  Metals and alloys  Surfaces, interfaces and thin films  High-content ductile coherent nanoprecipitates achieve ultrastrong high-entropy alloys OPEN Yao-Jian Liang, Linjing Wang, Yuren Wen, Baoyuan Cheng, Qinli Wu, Tangqing Cao, Qian Xiao, Yunfei Xue, Gang Sha, Yandong Wang, Yang Ren, Xiaoyan Li, Lu Wang, Fuchi Wang & Hongnian Cai High entropy alloys usually emphasize equiatomic compositions, which restrict the compositions available to induce strengthening via precipitation. Here the authors use spinodal decomposition in a five-element alloy to obtain high content nanophases and the highest tensile strength reported to date. 03 October 2018 | doi: 10.1038/s41467-018-06600-8 Mechanical properties  Metals and alloys  Reconfigurable MEMS Fano metasurfaces with multiple-input–output states for logic operations at terahertz frequencies OPEN Manukumara Manjappa, Prakash Pitchappa, Navab Singh, Nan Wang, Nikolay I. Zheludev, Chengkuo Lee & Ranjan Singh Here, the authors demonstrate excitation and active tuning of sharp Fano resonances in a MEMS reconfigurable metasurface possessing multiple-input-output states. They realize XOR, XNOR, NOT and NAND logic gate operations by using two independently controllable electrical inputs and an optical readout using terahertz beam. 03 October 2018 | doi: 10.1038/s41467-018-06360-5 Metamaterials  Photonic devices  Terahertz optics  Coherently driven microcavity-polaritons and the question of superfluidity OPEN R. T. Juggins, J. Keeling & M. H. Szymańska Driven-dissipative microcavity polariton experiments find superfluid-like behaviour but the intuition developed from equilibrium systems cannot be straightforwardly applied. Juggins et al. show coherently-driven polaritons are not superfluid and earlier observations instead arise from a distinct rigid state. 03 October 2018 | doi: 10.1038/s41467-018-06436-2 Polaritons  Quantum fluids and solids  Enhanced voltage generation through electrolyte flow on liquid-filled surfaces OPEN B. Fan, A. Bhattacharya & P. R. Bandaru Superhydrophobic surfaces are expected to increase streaming potential, but are hindered by the presence of air. Here the authors enhance streaming potential by flowing high-dielectric salt water over liquid-filled surfaces infiltrated with low-dielectric liquid, harnessing electric slip and surface charge. 03 October 2018 | doi: 10.1038/s41467-018-06297-9 Devices for energy harvesting  Electrochemistry  Surface patterning  Polymerization driven monomer passage through monolayer chemical vapour deposition graphene OPEN Tao Zhang, Zhongquan Liao, Leonardo Medrano Sandonas, Arezoo Dianat, Xiaoling Liu, Peng Xiao, Ihsan Amin, Rafael Gutierrez, Tao Chen, Ehrenfried Zschech, Gianaurelio Cuniberti & Rainer Jordan Translocation of larger molecules through graphene holds potential for molecular sieving, however it is rarely observed. Here, the authors show the radical polymerization of vinyl monomers via their translocation through a single layer graphene to a monolayer initiator and additionally study the monomer-graphene interactions. 03 October 2018 | doi: 10.1038/s41467-018-06599-y Polymer characterization  Polymers  Self-assembly  Two-dimensional materials   OPEN Wolfgang Hornfeck, Raphael Kobold, Matthias Kolbe, Matthias Conrad & Dieter Herlach Elucidating the formation of quasicrystals, which have long-range orientational order but no translation periodicity, remains a challenge. Here, the authors track and geometrically describe how a decagonal nickel–zirconium seed grows into a tenfold twinned dendritic structure. 03 October 2018 | doi: 10.1038/s41467-018-06597-0 Metals and alloys  Structure of solids and liquids  Synthesis and processing  Ancient proteins from ceramic vessels at Çatalhöyük West reveal the hidden cuisine of early farmers OPEN Jessica Hendy, Andre C. Colonese, Ingmar Franz, Ricardo Fernandes, Roman Fischer, David Orton, Alexandre Lucquin, Luke Spindler, Jana Anvari, Elizabeth Stroud, Peter F. Biehl, Camilla Speller, Nicole Boivin, Meaghan Mackie, Rosa R. Jersie-Christensen, Jesper V. Olsen, Matthew J. Collins, Oliver E. Craig & Eva Rosenstock Ancient diets have been reconstructed from archaeological pottery based on lipid remains, but these can lack specificity. Here, Hendy and colleagues analyze ancient proteins from ceramic vessels up to 8000 years old to produce a more nuanced understanding of ancient food processing and diet. 03 October 2018 | doi: 10.1038/s41467-018-06335-6 Anthropology  Archaeology  Lipids  Proteins  Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder OPEN Marisa W. Friederich, Sharita Timal, Christopher A. Powell, Cristina Dallabona, Alina Kurolap, Sara Palacios-Zambrano, Drago Bratkovic, Terry G. J. Derks, David Bick, Katelijne Bouman, Kathryn C. Chatfield, Nadine Damouny-Naoum, Megan K. Dishop, Tzipora C. Falik-Zaccai, Fuad Fares, Ayalla Fedida, Ileana Ferrero, Renata C. Gallagher, Rafael Garesse, Micol Gilberti et al. Mitochondrial protein synthesis requires charging a mitochondrial tRNA with its amino acid. Here, the authors describe pathogenic variants in the GatCAB protein complex genes required for the generation of glutaminyl-mt-tRNAGln, that impairs mitochondrial translation and presents with cardiomyopathy. 03 October 2018 | doi: 10.1038/s41467-018-06250-w Cardiomyopathies  Genetics research  Medical genetics  Multienzyme complexes  Reprogramming of regulatory network using expression uncovers sex-specific gene regulation in Drosophila OPEN Yijie Wang, Dong-Yeon Cho, Hangnoh Lee, Justin Fear, Brian Oliver & Teresa M. Przytycka For many applications knowledge of context-specific gene regulatory networks (GRNs) is desirable, but their inference remains a challenge. Here, the authors introduce a method for construction of context-specific GRNs, and apply it to construct sex-specific Drosophila GRNs. 03 October 2018 | doi: 10.1038/s41467-018-06382-z Gene regulatory networks  Network topology  Rich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2 OPEN Matías A. Goldin, Evan R. Harrell, Luc Estebanez & Daniel E. Shulz Sensory tuning properties of neurons in the secondary whisker somatosensory cortex (wS2) are not well understood. Here, the authors report that wS2 neurons supralinearly integrate concurrent multi-whisker input with larger temporal windows than primary somatosensory cortex. 03 October 2018 | doi: 10.1038/s41467-018-06585-4 Barrel cortex  Cortex  Sensory processing  Whisker system  A hierarchical anti-Hebbian network model for the formation of spatial cells in three-dimensional space OPEN Karthik Soman, Srinivasa Chakravarthy & Michael M. Yartsev Neurons in the hippocampal formation encode diverse spatial properties. Here, the authors present a hierarchical network model for 3D spatial navigation that accounts for the observed neuronal representations and predict as yet unreported cell types with planar selectivity. 02 October 2018 | doi: 10.1038/s41467-018-06441-5 Computational neuroscience  Neuroscience  Molecular architecture and regulation of BCL10-MALT1 filaments OPEN Florian Schlauderer, Thomas Seeholzer, Ambroise Desfosses, Torben Gehring, Mike Strauss, Karl-Peter Hopfner, Irina Gutsche, Daniel Krappmann & Katja Lammens The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mutagenesis studies. 02 October 2018 | doi: 10.1038/s41467-018-06573-8 Cryoelectron microscopy  NF-kappaB  Observing of the super-Planckian near-field thermal radiation between graphene sheets OPEN Jiang Yang, Wei Du, Yishu Su, Yang Fu, Shaoxiang Gong, Sailing He & Yungui Ma Though monolayer graphene has the potential to be used in near-field thermal management applications, no experimental verification has been provided to date. Here, the authors directly measure plasmon-enhanced near-field heat transfer between graphene sheets on intrinsic silicon substrates. 02 October 2018 | doi: 10.1038/s41467-018-06163-8 Nanophotonics and plasmonics  Optical properties and devices  Zebra finches identify individuals using vocal signatures unique to each call type OPEN Julie E. Elie & Frédéric E. Theunissen Individual animals have vocal signatures, but are the same signatures consistent across behavioral contexts? Here, the authors use behavioral experiments and acoustic analyses to show that zebra finches have distinct vocal signatures for different call types, such as aggression and long-distance contact. 02 October 2018 | doi: 10.1038/s41467-018-06394-9 Animal behaviour  Signal processing  Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects OPEN Sharing of whole genome sequencing (WGS) data improves study scale and power, but data from different groups are often incompatible. Here, US genome centers and NIH programs define WGS data processing standards and a flexible validation method, facilitating collaboration in human genetics research. 02 October 2018 | doi: 10.1038/s41467-018-06159-4 Data processing  Genome informatics  Sequencing  In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies OPEN Andreas H. Laustsen, Aneesh Karatt-Vellatt, Edward W. Masters, Ana Silvia Arias, Urska Pus, Cecilie Knudsen, Saioa Oscoz, Peter Slavny, Daniel T. Griffiths, Alice M. Luther, Rachael A. Leah, Majken Lindholm, Bruno Lomonte, José María Gutiérrez & John McCafferty Current anti-venoms against black mamba (Dendroaspis polylepis) bites are animal-derived and associated with several limitations. Here, Laustsen and colleagues develop an experimental recombinant anti-venom based on oligoclonal human IgG antibodies and establish its potential protective value in neutralizing dendrotoxin-mediated neurotoxicity using venom challenge in vivo models. 02 October 2018 | doi: 10.1038/s41467-018-06086-4 Antibody therapy  Applied immunology  Translational research  Computational design of chemogenetic and optogenetic split proteins OPEN Onur Dagliyan, Andrey Krokhotin, Irem Ozkan-Dagliyan, Alexander Deiters, Channing J. Der, Klaus M. Hahn & Nikolay V. Dokholyan Designing split protein approaches is time consuming and often results in high background activity due to spontaneous assembly. Here the authors present an automated approach which uses a split energy scoring function to identify optimal protein split sites and reduces spontaneous assembly. 02 October 2018 | doi: 10.1038/s41467-018-06531-4 Chemical genetics  Computational biophysics  Optogenetics  Protein design  Synthetic biology  RIP2 filament formation is required for NOD2 dependent NF-κB signalling OPEN Erika Pellegrini, Ambroise Desfosses, Arndt Wallmann, Wiebke Manuela Schulze, Kristina Rehbein, Philippe Mas, Luca Signor, Stephanie Gaudon, Grasilda Zenkeviciute, Michael Hons, Helene Malet, Irina Gutsche, Carsten Sachse, Guy Schoehn, Hartmut Oschkinat & Stephen Cusack Binding of bacterial peptidoglycan muramyl dipeptides induces NOD2 activation and signalling via the downstream adaptor kinase RIP2. Here the authors show that RIP2 forms filaments via its CARD domain, analyse the structure of the CARD filaments and demonstrate the requirement of RIP2 polymerisation for the activation of NF-κB by NOD2. 02 October 2018 | doi: 10.1038/s41467-018-06451-3 Cryoelectron microscopy  NOD-like receptors  Solid-state NMR  X-ray crystallography  LOTUS domain protein MARF1 binds CCR4-NOT deadenylase complex to post-transcriptionally regulate gene expression in oocytes OPEN Li Zhu, Suresh K. Kandasamy, Susan E. Liao & Ryuya Fukunaga The RNA-binding protein MARF1 is required for post-transcriptional regulation of mRNAs during mouse oogenesis. Here, by analyzing a Drosophila MARF1 mutant, the authors show that MARF1 recruits CCR4-NOT deadenylase to shorten the poly-A tails of target mRNAs such as cyclin A and suppress their translation during Drosophila oogenesis. 02 October 2018 | doi: 10.1038/s41467-018-06404-w Biochemistry  Developmental biology  Genetics  RNA-binding proteins  Two-dimensional amorphous NiO as a plasmonic photocatalyst for solar H2 evolution OPEN Zhaoyong Lin, Chun Du, Bo Yan, Chengxin Wang & Guowei Yang While photocatalysis offers a means to store solar energy as chemical fuels, photocatalysts typically require crystalline structures and expensive noble-metal cocatalysts. Here, authors prepare 2D amorphous nano-nickel oxide capable of plasmonic, photodriven H2 evolution without cocatalysts. 02 October 2018 | doi: 10.1038/s41467-018-06456-y Devices for energy harvesting  Heterogeneous catalysis  Photocatalysis  Two-dimensional materials  Tailoring manganese oxide with atomic precision to increase surface site availability for oxygen reduction catalysis OPEN C. John Eom, Ding-Yuan Kuo, Carolina Adamo, Eun Ju Moon, Steve J. May, Ethan J. Crumlin, Darrell G. Schlom & Jin Suntivich Controlling structures at the atomic level provides an opportunity to design and understand catalysts. Here the authors use thin-film deposition to fabricate perovskite heterostructures in a non-equilibrium manner to assess the effects on electrocatalytic activity for oxygen reduction. 02 October 2018 | doi: 10.1038/s41467-018-06503-8 Design, synthesis and processing  Materials for energy and catalysis  Tensorial neutron tomography of three-dimensional magnetic vector fields in bulk materials OPEN A. Hilger, I. Manke, N. Kardjilov, M. Osenberg, H. Markötter & J. Banhart Mapping the distribution of magnetic fields inside bulk materials is challenging but crucial to understand and develop functional magnetic materials. Here the authors demonstrate the capability to visualize 3D vector magnetic fields inside materials using spin-polarized neutron tomography and tensorial reconstruction techniques. 02 October 2018 | doi: 10.1038/s41467-018-06593-4 Experimental nuclear physics  Imaging techniques  Magnetic properties and materials  Cdk1 inactivation induces post-anaphase-onset spindle migration and membrane protrusion required for extreme asymmetry in mouse oocytes OPEN Zhe Wei, Jessica Greaney, Chenxi Zhou & Hayden A. Homer Female meiotic divisions are asymmetric with the formation of large oocytes and small polar bodies, thought to result from cortical spindle placement before anaphase. The authors find that Cdk1 inactivation triggers F-actin dependent post-anaphase spindle migration, resulting in cortical protrusion. 02 October 2018 | doi: 10.1038/s41467-018-06510-9 Actin  Cytokinesis  Kinases  Meiosis  Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator OPEN Sunhee Hwang, Karen Mruk, Simin Rahighi, Andrew G. Raub, Che-Hong Chen, Lisa E. Dorn, Naoki Horikoshi, Soichi Wakatsuki, James K. Chen & Daria Mochly-Rosen Glucose-6-phosphate dehydrogenase (G6PD) deficiency provides insufficient protection from oxidative stress, contributing to diverse human pathologies. Here, the authors identify a small molecule that increases the activity and/or stability of mutant G6PD and show that it reduces oxidative stress in zebrafish and hemolysis in isolated human erythrocytes. 02 October 2018 | doi: 10.1038/s41467-018-06447-z Drug discovery  Molecular medicine  Vibrational control of selective bond cleavage in dissociative chemisorption of methanol on Cu(111) OPEN Jialu Chen, Xueyao Zhou, Yaolong Zhang & Bin Jiang Dissociative chemisorption of methanol on metal surfaces is a key step for hydrogen production. Here the authors use quasi-quantized molecular dynamics simulations to alter the branching ratios for methanol dissociative chemisorption on Cu(111) via selectively exciting specific vibrational modes. 02 October 2018 | doi: 10.1038/s41467-018-06478-6 Catalysis  Computational chemistry  Reaction kinetics and dynamics  Dye-incorporated coordination polymers for direct photocatalytic trifluoromethylation of aromatics at metabolically susceptible positions OPEN Tiexin Zhang, Xiangyang Guo, Yusheng Shi, Cheng He & Chunying Duan Direct trifluoromethylation of unactivated aromatic rings at metabolically susceptible positions is highly desirable in pharmaceutical fields. Here, the authors report a new approach for direct trifluoromethylation of unactivated aromatics by incorporating thiophenes into the backbone of triphenylamine-based ligand. 02 October 2018 | doi: 10.1038/s41467-018-05919-6 Catalyst synthesis  Synthetic chemistry methodology  Photocatalysis  A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation OPEN Chao Sheng, Johannes Jungverdorben, Hendrik Wiethoff, Qiong Lin, Lea J. Flitsch, Daniela Eckert, Matthias Hebisch, Julia Fischer, Jaideep Kesavan, Beatrice Weykopf, Linda Schneider, Dominik Holtkamp, Heinz Beck, Andreas Till, Ullrich Wüllner, Michael J. Ziller, Wolfgang Wagner, Michael Peitz & Oliver Brüstle Induced neurons, but not induced pluripotent stem cell (iPSC)-derived neurons, preserve age-related traits. Here, the authors demonstrate that blood-derived induced neural stem cells (iNSCs), despite lacking a pluripotency transit, lose age-related signatures. 02 October 2018 | doi: 10.1038/s41467-018-06398-5 Ageing  Epigenetic memory  Neural stem cells  Reprogramming  Transdifferentiation  Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors OPEN Marta Roccio, Michael Perny, Megan Ealy, Hans Ruedi Widmer, Stefan Heller & Pascal Senn Hearing requires mechanosensitive hair cells in the organ of Corti, which derive from progenitors of the cochlear duct. Here the authors examine human inner ear development by studying key developmental markers and describe organoid cultures from human cochlear duct progenitors for in vitro hair cell differentiation. 02 October 2018 | doi: 10.1038/s41467-018-06334-7 Cochlea  Stem cells  Exacerbated fires in Mediterranean Europe due to anthropogenic warming projected with non-stationary climate-fire models OPEN Marco Turco, Juan José Rosa-Cánovas, Joaquín Bedia, Sonia Jerez, Juan Pedro Montávez, Maria Carmen Llasat & Antonello Provenzale A warmer and drier climate will affect wildfire activity but the climate-fire relationship could change under warming. Here the authors use models with a non-stationary climate-fire relationship to show that to avoid doubling the burned area in the coming decades we must stay below 1.5 °C Paris target. 02 October 2018 | doi: 10.1038/s41467-018-06358-z Climate-change impacts  Natural hazards  Projection and prediction  Motor recruitment to the TIM23 channel's lateral gate restricts polypeptide release into the inner membrane OPEN Alexander Benjamin Schendzielorz, Piotr Bragoszewski, Nataliia Naumenko, Ridhima Gomkale, Christian Schulz, Bernard Guiard, Agnieszka Chacinska & Peter Rehling The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane. Here authors show that the import motor J-protein Pam18 controls lateral protein release into the lipid bilayer. 02 October 2018 | doi: 10.1038/s41467-018-06492-8 Biochemistry  Mitochondrial proteins  Proteins  Dereplication of microbial metabolites through database search of mass spectra OPEN Hosein Mohimani, Alexey Gurevich, Alexander Shlemov, Alla Mikheenko, Anton Korobeynikov, Liu Cao, Egor Shcherbin, Louis-Felix Nothias, Pieter C. Dorrestein & Pavel A. Pevzner New natural products can be identified via mass spectrometry by excluding all known ones from the analysis, a process called dereplication. Here, the authors extend a previously published dereplication algorithm to different classes of secondary metabolites. 02 October 2018 | doi: 10.1038/s41467-018-06082-8 Data mining  Natural products  Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape OPEN Paul Adrian Ginno, Lukas Burger, Jan Seebacher, Vytautas Iesmantavicius & Dirk Schübeler Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcription factors and preservation of the regulatory landscape. 02 October 2018 | doi: 10.1038/s41467-018-06007-5 Chromatin analysis  Epigenetics  Mitosis  Proteomics  Locally-curved geometry generates bending cracks in the African elephant skin OPEN António F. Martins, Nigel C. Bennett, Sylvie Clavel, Herman Groenewald, Sean Hensman, Stefan Hoby, Antoine Joris, Paul R. Manger & Michel C. Milinkovitch The skin of the African bush elephant features micrometer-wide channels whose function is water and mud retention for thermal regulation and protection from parasites. Here authors use microscopy and modelling to show that the channels are fractures of the animal thick and brittle skin outermost layer. 02 October 2018 | doi: 10.1038/s41467-018-06257-3 Biological physics  Zoology  Total syntheses of shizukaols A and E OPEN Jian-Li Wu, Yin-Suo Lu, Bencan Tang & Xiao-Shui Peng Shizukaols, bioactive dimers naturally occurring in the Chloranthaceae family, possess a complex polycyclic framework with more than ten contiguous stereocenters. Here the authors report the total syntheses of shizukaols A and E achieved via a modified Diels–Alder reaction mimicking the biosynthetic pathway. 02 October 2018 | doi: 10.1038/s41467-018-06245-7 Synthetic chemistry methodology  Natural product synthesis  Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors OPEN Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis H. Y. Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio-Lopes & Richard J. A. Wilson Acute bronchoconstriction is the leading cause of asthmatic sudden death following allergen exposure. The authors show that the systemic increase of LPA following inhaled allergen or bradykinin challenge activates the carotid bodies through TRPV1 and LPA-specific receptors and that systemic TRPV1 and LPA-specific receptor antagonists ameliorate acute bronchoconstriction. 02 October 2018 | doi: 10.1038/s41467-018-06189-y Asthma  Transient receptor potential channels  Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction OPEN Benjamin Steinhorn, Andrea Sorrentino, Sachin Badole, Yulia Bogdanova, Vsevolod Belousov & Thomas Michel Excessive production of reactive oxygen species (ROS) is associated with cardiac dysfunction, but the causal role of ROS remains poorly understood. Here the authors use an in vivo chemogenetic approach to develop a heart failure model in which generation of hydrogen peroxide in the heart leads to systolic heart failure without fibrotic remodeling. 02 October 2018 | doi: 10.1038/s41467-018-06533-2 Animal disease models  Heart failure  Stress signalling  Advanced sulfide solid electrolyte by core-shell structural design OPEN Fan Wu, William Fitzhugh, Luhan Ye, Jiaxin Ning & Xin Li Sulfide electrolyte materials offer the opportunity for the development of solid-state batteries. Here the authors further improve the voltage stability of core-shell structured sulfides by modifying the microstructures, and pair the optimized electrolytes with lithium metal anode into battery devices. 02 October 2018 | doi: 10.1038/s41467-018-06123-2 Energy science and technology  Materials science  Megahertz serial crystallography OPEN Max O. Wiedorn, Dominik Oberthür, Richard Bean, Robin Schubert, Nadine Werner, Brian Abbey, Martin Aepfelbacher, Luigi Adriano, Aschkan Allahgholi, Nasser Al-Qudami, Jakob Andreasson, Steve Aplin, Salah Awel, Kartik Ayyer, Saša Bajt, Imrich Barák, Sadia Bari, Johan Bielecki, Sabine Botha, Djelloul Boukhelef et al. The new European X-Ray Free-Electron Laser (EuXFEL) is the first XFEL that generates X-ray pulses with a megahertz inter-pulse spacing. Here the authors demonstrate that high-quality and damage-free protein structures can be obtained with the currently available 1.1 MHz repetition rate pulses using lysozyme as a test case and furthermore present a β-lactamase structure. 02 October 2018 | doi: 10.1038/s41467-018-06156-7 Imaging techniques  Nanocrystallography  Multibandgap quantum dot ensembles for solar-matched infrared energy harvesting OPEN Bin Sun, Olivier Ouellette, F. Pelayo García de Arquer, Oleksandr Voznyy, Younghoon Kim, Mingyang Wei, Andrew H. Proppe, Makhsud I. Saidaminov, Jixian Xu, Mengxia Liu, Peicheng Li, James Z. Fan, Jea Woong Jo, Hairen Tan, Furui Tan, Sjoerd Hoogland, Zheng Hong Lu, Shana O. Kelley & Edward H. Sargent Efficient harvest of solar energy beyond the silicon absorption edge of 1100 nm by semiconductor solar cells remains a challenge. Here Sun et al. mix high multi-bandgap lead sulfide colloidal quantum dot ensembles to further increase both short circuit current and open circuit voltage. 01 October 2018 | doi: 10.1038/s41467-018-06342-7 Quantum dots  Solar cells  Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells OPEN Maria Montserrat Garcia Romero, Gareth McCathie, Philip Jankun & Henry Hamilton Roehl Reactive oxygen species (ROS) are required to initiate regeneration but the mechanisms regulating its production are unclear. Here, the authors show in zebrafish larval tail regeneration that ROS is released by mobilised notochord cells enables their repositioning in the damage site, assisted by secreted Hh. 01 October 2018 | doi: 10.1038/s41467-018-06460-2 Regeneration  Stem cells  Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies OPEN Vincent Madelain, Sylvain Baize, Frédéric Jacquot, Stéphanie Reynard, Alexandra Fizet, Stephane Barron, Caroline Solas, Bruno Lacarelle, Caroline Carbonnelle, France Mentré, Hervé Raoul, Xavier de Lamballerie & Jérémie Guedj Optimization of antiviral therapy can be crucial in the management of Ebola virus outbreaks. Here, Madelain et al. use an integrative mathematical model to correlate the dose and the time of treatment initiation with survival rate, enhanced immune response and viral clearance. 01 October 2018 | doi: 10.1038/s41467-018-06215-z Computational biology and bioinformatics  Diseases  Microbiology  Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma OPEN Jessica Tome-Garcia, Parsa Erfani, German Nudelman, Alexander M. Tsankov, Igor Katsyv, Rut Tejero, Bin Zhang, Martin Walsh, Roland H. Friedel, Elena Zaslavsky & Nadejda M. Tsankova The intrinsic drivers of glioblastoma (GBM) migration are still poorly understood. Here the authors purify GBM stem cells (GSCs) from patients and profile chromatin accessibility in these cells, identifying TEAD1 as a regulator of migration in human glioblastoma. 01 October 2018 | doi: 10.1038/s41467-018-06258-2 Cancer stem cells  Cell migration  Chromatin structure  Transcriptional regulatory elements  Digital coding of mechanical stress in a dynamic covalent shape memory polymer network OPEN Guogao Zhang, Wenjun Peng, Jingjun Wu, Qian Zhao & Tao Xie Stresses are often detrimental to the mechanical properties of materials but when well controlled can lead to unusual opportunities in various technological areas. Here the authors report a digital photothermal mechanism enabled laser printing that allows freedom in stress manipulation in dynamic covalent shape memory polymers. 01 October 2018 | doi: 10.1038/s41467-018-06420-w Polymer chemistry  Polymers  Pastoralism may have delayed the end of the green Sahara OPEN Chris Brierley, Katie Manning & Mark Maslin Climate deterioration towards desertification in North Africa following the African Humid Period has previously been associated with the emergence of pastoralism. Here, using a climate-vegetation model, the authors show that pastoralism in fact likely slowed the deterioration of orbitally-driven climate change. 01 October 2018 | doi: 10.1038/s41467-018-06321-y Climate-change adaptation  Palaeoclimate  Sustainability  Carrier density and disorder tuned superconductor-metal transition in a two-dimensional electron system OPEN Zhuoyu Chen, Adrian G. Swartz, Hyeok Yoon, Hisashi Inoue, Tyler A. Merz, Di Lu, Yanwu Xie, Hongtao Yuan, Yasuyuki Hikita, Srinivas Raghu & Harold Y. Hwang Studying quantum phase transitions at oxide interfaces provide a key to understand emergent two-dimensional (2D) superconductivity. Here, Chen et al. report comprehensive electronic phase diagram of the 2D electron system at the superconducting LaAlO3/SrTiO3 interface with independent control of carrier density and disorder. 01 October 2018 | doi: 10.1038/s41467-018-06444-2 Superconducting devices  Superconducting properties and materials  Surfaces, interfaces and thin films  Coupled microbial bloom and oxygenation decline recorded by magnetofossils during the Palaeocene–Eocene Thermal Maximum OPEN Liao Chang, Richard J. Harrison, Fan Zeng, Thomas A. Berndt, Andrew P. Roberts, David Heslop & Xiang Zhao Understanding the response of marine productivity and CO2 drawdown to past warming events can provide important insights into the future. Here, the authors use bacterial magnetite nanoparticle fossils to reconstruct nutrient supply and marine deoxygenation during the Palaeocene–Eocene Thermal Maximum. 01 October 2018 | doi: 10.1038/s41467-018-06472-y Palaeoceanography  Palaeomagnetism  Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity OPEN Lulu Yao, Teddy Grand, Jesse Hanson, Pierre Paoletti & Qiang Zhou Inhibitory interneurons play important roles in brain circuits and in several neuropsychiatric disorders. Here, the authors show that excitatory synapses onto interneurons vs. excitatory neurons differ in their ambient synaptic glutamate level, a finding with important implications for selective pharmacological targeting of inhibitory neuron NMDA receptors. 01 October 2018 | doi: 10.1038/s41467-018-06512-7 Neuroscience  Physiology  Femtosecond photoexcitation dynamics inside a quantum solvent OPEN Bernhard Thaler, Sascha Ranftl, Pascal Heim, Stefan Cesnik, Leonhard Treiber, Ralf Meyer, Andreas W. Hauser, Wolfgang E. Ernst & Markus Koch Femtosecond laser spectroscopy has contributed to our understanding of structure and function of matter. Here, the authors explore the applicability of superfluid helium nanodroplets as a sample preparation method that allows investigation of previously inaccessible classes of tailor-made or fragile molecular systems. 01 October 2018 | doi: 10.1038/s41467-018-06413-9 Atomic and molecular interactions with photons  Photochemistry  Engineered mRNA-expressed antibodies prevent respiratory syncytial virus infection OPEN Pooja Munnilal Tiwari, Daryll Vanover, Kevin E. Lindsay, Swapnil Subhash Bawage, Jonathan L. Kirschman, Sushma Bhosle, Aaron W. Lifland, Chiara Zurla & Philip J. Santangelo Engineered neutralizing antibodies are potential therapeutics for numerous viruses, such as respiratory syncytial virus (RSV). Here, the authors develop an mRNA-based approach to express membrane-anchored neutralizing antibodies in the lung and demonstrate that it inhibits RSV infections in mice. 01 October 2018 | doi: 10.1038/s41467-018-06508-3 Antibodies  RNA vaccines  Viral infection  Efficient photocatalytic hydrogen evolution with ligand engineered all-inorganic InP and InP/ZnS colloidal quantum dots OPEN Shan Yu, Xiang-Bing Fan, Xian Wang, Jingguo Li, Qian Zhang, Andong Xia, Shiqian Wei, Li-Zhu Wu, Ying Zhou & Greta R. Patzke While quantum dots show high efficiency solar-to-fuel conversion for renewable energy, the frequently toxic elements employed present severe safety concerns. Here, authors demonstrate indium phosphide quantum dots as low-toxicity alternatives alongside efficient hydrogen evolution photocatalysis. 01 October 2018 | doi: 10.1038/s41467-018-06294-y Nanoparticles  Photocatalysis  Solar fuels  A flow platform for degradation-free CuAAC bioconjugation OPEN Marine Z. C. Hatit, Linus F. Reichenbach, John M. Tobin, Filipe Vilela, Glenn A. Burley & Allan J. B. Watson Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a common bioconjugation technique; however oxidative degradation and residual copper may limit its use. Here, the authors show that ppm levels of Cu, generated in situ by solvent-mediated pipe erosion in flow, catalyze the CuAAC reaction with no product degradation. 01 October 2018 | doi: 10.1038/s41467-018-06551-0 Chemical biology  Homogeneous catalysis  Sustainability  Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline OPEN Marco L. Hennrich, Natalie Romanov, Patrick Horn, Samira Jaeger, Volker Eckstein, Violetta Steeples, Fei Ye, Ximing Ding, Laura Poisa-Beiro, Mang Ching Lai, Benjamin Lang, Jacqueline Boultwood, Thomas Luft, Judith B. Zaugg, Andrea Pellagatti, Peer Bork, Patrick Aloy, Anne-Claude Gavin & Anthony D. Ho Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced bone marrow niche function, and enhanced myeloid differentiation. 01 October 2018 | doi: 10.1038/s41467-018-06353-4 Ageing  Haematopoietic stem cells  Mesenchymal stem cells  Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism OPEN Kumar Nagarathinam, Yoshiko Nakada-Nakura, Christoph Parthier, Tohru Terada, Narinobu Juge, Frank Jaenecke, Kehong Liu, Yunhon Hotta, Takaaki Miyaji, Hiroshi Omote, So Iwata, Norimichi Nomura, Milton T. Stubbs & Mikio Tanabe The multidrug resistance transporter mediated efflux of antibiotics from the bacterial cytoplasm represents a major challenge to medicine. Here authors solve the X-ray crystallographic structure of the drug/H+ antiporter MdfA from Escherichia coli and shed light on the conformational switching mechanism. 01 October 2018 | doi: 10.1038/s41467-018-06306-x Membrane proteins  X-ray crystallography  Regulatory control of DNA end resection by Sae2 phosphorylation OPEN Elda Cannavo, Dominic Johnson, Sara N. Andres, Vera M. Kissling, Julia K. Reinert, Valerie Garcia, Dorothy A. Erie, Daniel Hess, Nicolas H. Thomä, Radoslav I. Enchev, Matthias Peter, R. Scott Williams, Matt J. Neale & Petr Cejka It has previously been established that DNA end resection in yeast and in humans is under CDK control. Here the authors explain how phosphorylation regulates the capacity of Sae2 — the yeast orthologue of human CtIP — to promote DNA end resection. 01 October 2018 | doi: 10.1038/s41467-018-06417-5 Double-strand DNA breaks  Enzyme mechanisms  Phosphoproteins  Strong coupling and induced transparency at room temperature with single quantum dots and gap plasmons OPEN Haixu Leng, Brian Szychowski, Marie-Christine Daniel & Matthew Pelton The signatures of strong and intermediate plasmon-emitter coupling can be confused if scattering measurements alone are performed. Here, the authors use scattering and photoluminescence to demonstrate weak, intermediate, and strong coupling between single quantum dots and plasmons at room temperature. 01 October 2018 | doi: 10.1038/s41467-018-06450-4 Nanoparticles  Nanophotonics and plasmonics  Optical physics  Quantum dots  LISA improves statistical analysis for fMRI OPEN Gabriele Lohmann, Johannes Stelzer, Eric Lacosse, Vinod J. Kumar, Karsten Mueller, Esther Kuehn, Wolfgang Grodd & Klaus Scheffler Functional magnetic resonance imaging (fMRI) is a powerful technique for measuring human brain activity, but the statistical analysis of fMRI data can be difficult. Here, the authors introduce a new fMRI analysis tool, LISA, which provides increased statistical power compared to existing techniques. 01 October 2018 | doi: 10.1038/s41467-018-06304-z Computational neuroscience  Data processing  Neural circuits  Statistics  Silencing of TGFβ signalling in microglia results in impaired homeostasis OPEN Tanja Zöller, Artur Schneider, Christian Kleimeyer, Takahiro Masuda, Phani Sankar Potru, Dietmar Pfeifer, Thomas Blank, Marco Prinz & Björn Spittau While previous studies had shown the requirement of TGFβ signalling in microglia gene expression, the specificity of the loss-of-function was unclear. Here, Zöller and colleagues generate microglia specific cKO of TGFβ receptor 2, and show dispensable function of Tgfbr2 in microglial survival and the requirement of Tgfbr2 in morphological and transcriptional homeostasis of adult microglia. 01 October 2018 | doi: 10.1038/s41467-018-06224-y Glial biology  Microglia  Neuroimmunology  Neuroscience  Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition OPEN Julien Robert-Paganin, Daniel Auguin & Anne Houdusse Hypertrophic cardiomyopathy (HCM) is caused by point mutations in sarcomeric proteins. Here the authors develop an optimized model of the sequestered state of cardiac myosin and define the features affecting the lever arm compliance, allowing them to group mutations in classes and to elucidate the molecular mechanisms leading to cardiac dysfunction in HCM. 01 October 2018 | doi: 10.1038/s41467-018-06191-4 Cardiac hypertrophy  Myosin  X-ray crystallography  Interface dominated cooperative nanoprecipitation in interstitial alloys OPEN Hongcai Wang, Xie Zhang, Dingshun Yan, Christoph Somsen & Gunther Eggeler The specifics of nanoscale precipitation in steels remain complex. Here the authors combine high-resolution microscopy and atomistic simulations to identify a cooperative growth mechanism leading to the preferential growth of cementite nanoprecipitates along a specific crystallographic direction. 01 October 2018 | doi: 10.1038/s41467-018-06474-w Atomistic models  Metals and alloys  Nanoscale materials  Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma OPEN Sarah E. Arthur, Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, Laura K. Hilton, Prince Kumar Lat, Eric Y. Zhao, Luka Culibrk, Daisuke Ennishi, Selin Jessa, Lauren Chong, Nicole Thomas, Prasath Pararajalingam, Barbara Meissner, Merrill Boyle, Jordan Davidson, Kevin R. Bushell et al. The driver mutations for the two main molecular subgroups of diffuse large B-cell lymphoma (DLBCL) are poorly defined. Here, an integrative genomics analysis identifies 3′ UTR NFKBIZ mutations within the activated B-cell DLBCL subgroup and small FCGR2B amplifications in the germinal centre B-cell DLBCL subgroup. 01 October 2018 | doi: 10.1038/s41467-018-06354-3 Cancer genomics  Immunological disorders  Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation OPEN Laura F. Corns, Stuart L. Johnson, Terri Roberts, Kishani M. Ranatunga, Aenea Hendry, Federico Ceriani, Saaid Safieddine, Karen P. Steel, Andy Forge, Christine Petit, David N. Furness, Corné J. Kros & Walter Marcotti Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair cell identity in adult mice. 01 October 2018 | doi: 10.1038/s41467-018-06307-w Hair cell  Sensory processing  Transduction  Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma OPEN Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann et al. Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib while heterozygous methylation of BRCA1 predicts resistance in HGSOC. 28 September 2018 | doi: 10.1038/s41467-018-05564-z DNA methylation  Homologous recombination  Ovarian cancer  Targeted therapies  Structural basis of neurosteroid anesthetic action on GABAA receptors OPEN Qiang Chen, Marta M. Wells, Palaniappa Arjunan, Tommy S. Tillman, Aina E. Cohen, Yan Xu & Pei Tang The anesthetic alphaxalone binds γ-aminobutyric acid type A receptors (GABAARs) that play an important role in regulating sensory processes. Here the authors present the structures of a α1GABAAR chimera in the resting state and in an alphaxalone-bound desensitized state, which might facilitate the development of new GABAAR modulators. 28 September 2018 | doi: 10.1038/s41467-018-06361-4 Biophysics  Neuroscience  Structural biology  Clonal dynamics in osteosarcoma defined by RGB marking OPEN Stefano Gambera, Ander Abarrategi, Fernando González-Camacho, Álvaro Morales-Molina, Josep Roma, Arantzazu Alfranca & Javier García-Castro Osteosarcoma is a heterogeneous bone tumour with a high mutational rate. Here the authors use an RGB-based single-cell tracking system to track clonal dynamics in a mouse model of osteosarcoma, which their findings indicate follows a neutral evolution model in which different clones simultaneously coexist and propagate. 28 September 2018 | doi: 10.1038/s41467-018-06401-z Bone cancer  Bone development  Cancer microenvironment  Cancer models  Paediatric research  USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy OPEN Yi-Chang Wang, Yu-Syuan Wu, Chia-Yang Hung, Shao-An Wang, Ming-Jer Young, Tsung-I Hsu & Jan-Jong Hung USP24 has previously been reported to be involved in cancer progression. Here, the authors demonstrate that USP24 stabilizes p300 and β-TrCP to increase the levels of NF-κB and histone-3 acetylation, and decrease DNMT1 and IκB levels which promotes IL-6 expression in M2 macrophages and lung cancer cells. 28 September 2018 | doi: 10.1038/s41467-018-06178-1 Cancer  Cancer microenvironment  Cell biology  Molecular biology  Atomically precise graphene etch stops for three dimensional integrated systems from two dimensional material heterostructures OPEN Jangyup Son, Junyoung Kwon, SunPhil Kim, Yinchuan Lv, Jaehyung Yu, Jong-Young Lee, Huije Ryu, Kenji Watanabe, Takashi Taniguchi, Rita Garrido-Menacho, Nadya Mason, Elif Ertekin, Pinshane Y. Huang, Gwan-Hyoung Lee & Arend M. van der Zande Fabrication methods to pattern thin materials are a critical tool to build molecular scale devices. Here the authors report a selective etching method using XeF2 gas to pattern graphene based heterostructures with multiple active layers and achieve 1D contacts with low contact resistivity of 80 Ω·µm 28 September 2018 | doi: 10.1038/s41467-018-06524-3 Electronic properties and devices  Molecular electronics  NEMS  Two-dimensional materials  Cooperative supramolecular polymers with anthracene‒endoperoxide photo-switching for fluorescent anti-counterfeiting OPEN Zhao Gao, Yifei Han & Feng Wang There is a continual pursuit for different ways to detect counterfeiting in today's society. Here the authors show photo-responsive supramolecular polymers can be used in fluorescent anti-counterfeit applications, by taking advantage of multicycle anthracene‒endoperoxide switching properties. 28 September 2018 | doi: 10.1038/s41467-018-06392-x Light harvesting  Self-assembly  Supramolecular polymers  Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus OPEN Allison Sang, Thomas Danhorn, Jacob N. Peterson, Andrew L. Rankin, Brian P. O'Connor, Sonia M. Leach, Raul M. Torres & Roberta Pelanda Conventional B cells express clonally specific antigen receptors, but a small subset of B cells from patients and mice with systematic lupus erythematosus simultaneously expresses two distinct antigen receptors. Here the authors show that these dual-specificity B cells have higher levels of MHC-II, depend on IL-21 for expansion, and mount stronger memory response. 28 September 2018 | doi: 10.1038/s41467-018-06293-z Autoimmunity  B cells  Systemic lupus erythematosus  Translational immunology  A modified serine cycle in Escherichia coli coverts methanol and CO2 to two-carbon compounds OPEN Hong Yu & James C. Liao Assimilating the abundant one-carbon compounds by an industrially-relevant microorganism can broaden the substrate range and achieve reactions that are difficult for chemical process. Here the authors show a modified serine cycle can convert methanol and CO2 to two-carbon compounds in an engineered E. coli strain. 28 September 2018 | doi: 10.1038/s41467-018-06496-4 Applied microbiology  Metabolic engineering  Metabolic pathways  A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation OPEN Mathieu Letellier, Zsófia Szíber, Ingrid Chamma, Camille Saphy, Ioanna Papasideri, Béatrice Tessier, Matthieu Sainlos, Katalin Czöndör & Olivier Thoumine Neuroligins are postsynaptic cell adhesion molecules thought to play roles in synaptic development and function. Here, authors show that phosphorylation of Y782 in neuroligin-1 modulates its role in differentiation and ability to recruit AMPARs including during long-term potentiation. 28 September 2018 | doi: 10.1038/s41467-018-06220-2 Cellular neuroscience  Synaptic development  Predicting wave overtopping thresholds on coral reef-island shorelines with future sea-level rise OPEN E. Beetham & P. S. Kench Sea-level rise will exacerbate wave overtopping on low-lying coral reef islands. Here the authors present a novel method that quantifies wave overtopping thresholds and associated reef-island vulnerability trajectories based on differences in local wave climate, reef morphology and island height. 28 September 2018 | doi: 10.1038/s41467-018-06550-1 Climate-change impacts  Natural hazards  Physical oceanography  Activatable probes for diagnosing and positioning liver injury and metastatic tumors by multispectral optoacoustic tomography OPEN Yinglong Wu, Shuailing Huang, Jun Wang, Lihe Sun, Fang Zeng & Shuizhu Wu Optoacoustic tomography has great potential for medical diagnosis and preclinical research. Here they develop near infrared activatable xanthene-based optoacoustic probes for diagnosing and localizing drug-induced liver injury and metastasis in mouse models. 28 September 2018 | doi: 10.1038/s41467-018-06499-1 Optical imaging  Photoacoustics  Curvotaxis directs cell migration through cell-scale curvature landscapes OPEN Laurent Pieuchot, Julie Marteau, Alain Guignandon, Thomas Dos Santos, Isabelle Brigaud, Pierre-François Chauvy, Thomas Cloatre, Arnaud Ponche, Tatiana Petithory, Pablo Rougerie, Maxime Vassaux, Jean-Louis Milan, Nayana Tusamda Wakhloo, Arnaud Spangenberg, Maxence Bigerelle & Karine Anselme The effect that microscale surface curvature has on cell migration has not been evaluated. Here the authors fabricate sinusoidal 3D surfaces and show that the cell nucleus and cytoskeleton cooperate to guide cells to concave valleys in a process they coin curvotaxis. 28 September 2018 | doi: 10.1038/s41467-018-06494-6 Biomaterials  Cell migration  Spin-momentum locking and spin-orbit torques in magnetic nano-heterojunctions composed of Weyl semimetal WTe2 OPEN Peng Li, Weikang Wu, Yan Wen, Chenhui Zhang, Junwei Zhang, Senfu Zhang, Zhiming Yu, Shengyuan A. Yang, A. Manchon & Xi-xiang Zhang The Fermi arcs, topological surface states of Weyl semimetals can enable the intriguing spin control and facilitate topological spintronics. Here the authors report the spin-orbit torque at the interface of WTe2/Py and attribute it to the enhanced spin accumulation by the spin-momentum locking effect of the Fermi arcs of WTe2. 28 September 2018 | doi: 10.1038/s41467-018-06518-1 Spintronics  Surfaces, interfaces and thin films  A sustained change in the supply of parental care causes adaptive evolution of offspring morphology OPEN Benjamin J. M. Jarrett, Emma Evans, Hannah B. Haynes, Miranda R. Leaf, Darren Rebar, Ana Duarte, Matthew Schrader & Rebecca M. Kilner The amount and predictability of parental care may influence the evolution of offspring traits. Here, the authors experimentally evolve burying beetles at different levels of parental care and find smaller mandibles and lower self-sufficiency in populations with more care. 28 September 2018 | doi: 10.1038/s41467-018-06513-6 Behavioural ecology  Experimental evolution  Social evolution  An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel OPEN Arin Marchesi, Xiaolong Gao, Ricardo Adaixo, Jan Rheinberger, Henning Stahlberg, Crina Nimigean & Simon Scheuring Cyclic nucleotide-gated (CNG) ion channels are non-selective cation channels key to signal transduction, but conformational changes associated with gating remained unknown. Here authors use high-speed atomic force microscopy to visualize SthK channels dynamics in response to cyclic nucleotides. 28 September 2018 | doi: 10.1038/s41467-018-06414-8 Ion transport  Single-molecule biophysics  Robust quantum valley Hall effect for vortices in an interacting bosonic quantum fluid OPEN O. Bleu, G. Malpuech & D. D. Solnyshkov Topologically protected pseudospin transport is difficult to implement for bosonic systems due to the lack of symmetry-protected pseudospins. Here, Bleu et al. propose robust valley pseudospin transport, truly topologically protected by the winding of a quantum vortex propagating between two staggered honeycomb lattices. 28 September 2018 | doi: 10.1038/s41467-018-06520-7 Bose–Einstein condensates  Quantum Hall  Topological defects  Resonant torsion magnetometry in anisotropic quantum materials OPEN K. A. Modic, Maja D. Bachmann, B. J. Ramshaw, F. Arnold, K. R. Shirer, Amelia Estry, J. B. Betts, Nirmal J. Ghimire, E. D. Bauer, Marcus Schmidt, Michael Baenitz, E. Svanidze, Ross D. McDonald, Arkady Shekhter & Philip J. W. Moll Insights into the behavior of quantum materials are only possible because of the development of suitable experimental probes. Modic et. al. develop the theoretical and experimental basis for resonant torsion magnetometry—a technique to measure anisotropic magnetic responses with high sensitivity. 28 September 2018 | doi: 10.1038/s41467-018-06412-w Magnetic properties and materials  Phase transitions and critical phenomena  Techniques and instrumentation  Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery OPEN Hui-Ju Hsieh, Wei Zhang, Shu-Hong Lin, Wen-Hao Yang, Jun-Zhong Wang, Jianfeng Shen, Yiran Zhang, Yiling Lu, Hua Wang, Jane Yu, Gordon B. Mills & Guang Peng DNA damage induces checkpoints to ensure that damage is not transferred to the next generation, but the molecular pathways responsible for checkpoint recovery are not clear. Here the authors show that the nutrient sensor mTORC1 is a determinant for G2/M checkpoint recovery through regulation of cyclin B1 and PLK1 expression. 28 September 2018 | doi: 10.1038/s41467-018-05639-x DNA damage checkpoints  Regulatory networks  Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis OPEN Ronja Driller, Sophie Janke, Monika Fuchs, Evelyn Warner, Anil R. Mhashal, Dan Thomas Major, Mathias Christmann, Thomas Brück & Bernhard Loll The bacterial diterpene synthase CotB2 catalyses the cyclisation of geranylgeranyl diphosphate to cyclooctat-9-en7-ol. Here the authors present various CotB2 structures including a trapped abrupt reaction product that were used for molecular dynamic simulations and allowed them to model all intermediates along the reaction cascade. 28 September 2018 | doi: 10.1038/s41467-018-06325-8 Biocatalysis  Enzyme mechanisms  Metabolic engineering  Molecular modelling  Natural product synthesis  Remote sensing of geomagnetic fields and atomic collisions in the mesosphere OPEN Felipe Pedreros Bustos, Domenico Bonaccini Calia, Dmitry Budker, Mauro Centrone, Joschua Hellemeier, Paul Hickson, Ronald Holzlöhner & Simon Rochester Remote sensing of geomagnetic fields in mesosphere is both challenging and interesting to explore the magnetic field structures and atomic collision processes. Here the authors demonstrate an atomic magnetometer that utilizes the Larmor frequency in sodium atoms and operates in kilometers range. 28 September 2018 | doi: 10.1038/s41467-018-06396-7 Atomic and molecular collision processes  Atomic and molecular interactions with photons  Imaging and sensing  Magnetospheric physics  Intracellular nucleosomes constrain a DNA linking number difference of −1.26 that reconciles the Lk paradox OPEN Joana Segura, Ricky S. Joshi, Ofelia Díaz-Ingelmo, Antonio Valdés, Silvia Dyson, Belén Martínez-García & Joaquim Roca There had been an enduring discrepancy between theoretical and observed measurement of the DNA linking number (∆Lk) constrained by nucleosomes. Here the authors provide measurements of the ∆Lk constrained by individual nucleosomes in native chromatin that reconcile this discrepancy. 28 September 2018 | doi: 10.1038/s41467-018-06547-w Molecular conformation  Nucleosomes  Superplasticity in an organic crystal OPEN Satoshi Takamizawa, Yuichi Takasaki, Toshiyuki Sasaki & Noriaki Ozaki Superplasticity enables processing on hard-to-work solids but superelastic deformation, especially in a single-crystal-to-single-crystal manner, was not demonstrated for organic crystals so far. Here the authors demonstrate a single-crystal-to-single-crystal superplasticity in a crystal of N,N-dimethyl-4-nitroaniline. 28 September 2018 | doi: 10.1038/s41467-018-06431-7 Mechanical properties  Organic molecules in materials science  Structure elucidation  Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones OPEN Noah Guy Lewis Guiberson, André Pineda, Debra Abramov, Parinati Kharel, Kathryn E. Carnazza, Rachel T. Wragg, Jeremy S. Dittman & Jacqueline Burré Munc18-1 is an evolutionary conserved gene whose mutations are linked to various neurological diseases in human. In order to better understand the exact nature of the mutations, the authors here utilize several model systems to show mutant Munc18-1 can aggregate and deplete functional pool of Wt protein, and that chemical chaperones can reverse the cellular deficits. 28 September 2018 | doi: 10.1038/s41467-018-06507-4 Mechanisms of disease  Molecular neuroscience  Proteins  Insights into a dual function amide oxidase/macrocyclase from lankacidin biosynthesis OPEN Jonathan Dorival, Fanny Risser, Christophe Jacob, Sabrina Collin, Gerald Dräger, Cédric Paris, Benjamin Chagot, Andreas Kirschning, Arnaud Gruez & Kira J. Weissman The monoamine oxidase family member LkcE is an enzyme from the lankacidin polyketide biosynthetic pathway, where it catalyzes an amide oxidation followed by an intramolecular Mannich reaction, yielding the polyketide macrocycle. Here the authors characterize LkcE and present several of its crystal structures, which explains the unusual dual activity of LkcE. 28 September 2018 | doi: 10.1038/s41467-018-06323-w Biosynthesis  Enzyme mechanisms  X-ray crystallography  Genus-wide sequencing supports a two-locus model for sex-determination in Phoenix OPEN Maria F. Torres, Lisa S. Mathew, Ikhlak Ahmed, Iman K. Al-Azwani, Robert Krueger, Diego Rivera-Nuñez, Yasmin A. Mohamoud, Andrew G. Clark, Karsten Suhre & Joel A. Malek The origin and evolution of separate sexes in plants are long-standing questions. Here, the authors use genus-wide sequencing to identify sex determining candidate genes in the genus Phoenix and demonstrate the consistence with the previously proposed two-mutation model. 28 September 2018 | doi: 10.1038/s41467-018-06375-y Comparative genomics  Fertilization  Plant evolution  Temporal genetic association and temporal genetic causality methods for dissecting complex networks OPEN Luan Lin, Quan Chen, Jeanne P. Hirsch, Seungyeul Yoo, Kayee Yeung, Roger E. Bumgarner, Zhidong Tu, Eric E. Schadt & Jun Zhu Temporal omics data have the potential to dissect complex biological networks. Here the authors develop methods for detecting temporal genetic loci (teQTLs) of quantitative traits monitored over time and inferring causal relationships between traits linked to the locus. 28 September 2018 | doi: 10.1038/s41467-018-06203-3 Data integration  Regulatory networks  High-resolution NMR studies of antibiotics in cellular membranes OPEN João Medeiros-Silva, Shehrazade Jekhmane, Alessandra Lucini Paioni, Katarzyna Gawarecka, Marc Baldus, Ewa Swiezewska, Eefjan Breukink & Markus Weingarth Antibiotics that target the peptidoglycan precursor lipid II are promising templates for next-generation antibiotics. Here authors use solid-state NMR and monitor lipid II-binding antibiotics, such as nisin, directly in cell membranes. 27 September 2018 | doi: 10.1038/s41467-018-06314-x Antibiotics  Antimicrobial resistance  Molecular medicine  NMR spectroscopy  Structure-based drug design  Regulatory mechanisms of incomplete huntingtin mRNA splicing OPEN Andreas Neueder, Anaelle A. Dumas, Agnesska C. Benjamin & Gillian P. Bates Incomplete splicing of HTT results in the production of the highly pathogenic exon 1 HTT protein. Here the authors identify the necessary intronic regions and the underlying mechanisms that contribute to this process. 27 September 2018 | doi: 10.1038/s41467-018-06281-3 Huntington's disease  RNA splicing  Transcription  Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction OPEN Atsushi Yamagata, Sakurako Goto-Ito, Yusuke Sato, Tomoko Shiroshima, Asami Maeda, Masahiko Watanabe, Takashi Saitoh, Katsumi Maenaka, Tohru Terada, Tomoyuki Yoshida, Takeshi Uemura & Shuya Fukai Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Here authors solve the crystal structure of LRRTM2 in complex with its ligand Nrxn1β and shed light on how selective binding of ligands to LRRTM1/2 is achieved. 27 September 2018 | doi: 10.1038/s41467-018-06333-8 Molecular neuroscience  X-ray crystallography  Uniform doping of graphene close to the Dirac point by polymer-assisted assembly of molecular dopants OPEN Hans He, Kyung Ho Kim, Andrey Danilov, Domenico Montemurro, Liyang Yu, Yung Woo Park, Floriana Lombardi, Thilo Bauch, Kasper Moth-Poulsen, Tihomir Iakimov, Rositsa Yakimova, Per Malmberg, Christian Müller, Sergey Kubatkin & Samuel Lara-Avila Incorporating dopants in the graphene lattice to tune its electronic properties is a challenging task. Here, the authors report a strategy to dope epitaxial large-area graphene on SiC by means of spin-coating deposition of F4TCNQ polymers in ambient conditions. 27 September 2018 | doi: 10.1038/s41467-018-06352-5 Electronic devices  Electronic properties and devices  Polymer characterization  Surfaces, interfaces and thin films  Nuclear lamina dysfunction triggers a germline stem cell checkpoint OPEN Lacy J. Barton, Tingting Duan, Wenfan Ke, Amy Luttinger, Kaylee E. Lovander, Alexey A. Soshnev & Pamela K. Geyer Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that healthy gametes are passed on to the next generation. 27 September 2018 | doi: 10.1038/s41467-018-06277-z DNA damage response  Oogenesis  Nitrogen availability regulates topsoil carbon dynamics after permafrost thaw by altering microbial metabolic efficiency OPEN Leiyi Chen, Li Liu, Chao Mao, Shuqi Qin, Jun Wang, Futing Liu, Sergey Blagodatsky, Guibiao Yang, Qiwen Zhang, Dianye Zhang, Jianchun Yu & Yuanhe Yang Soil nitrogen availability may alter carbon dynamics after permafrost thaw, but experimental evidence for this carbon-nitrogen interaction is still lacking. Here the authors show that elevated post-thaw nitrogen availability inhibits soil carbon release through its enhancement in microbial metabolic efficiency. 27 September 2018 | doi: 10.1038/s41467-018-06232-y Carbon cycle  Element cycles  Metal-organic framework patterns and membranes with heterogeneous pores for flow-assisted switchable separations OPEN Guan-Young Jeong, Ajay K. Singh, Min-Gyu Kim, Ki-Won Gyak, UnJin Ryu, Kyung Min Choi & Dong-Pyo Kim Tailoring MOFs to allow access of complex and large molecules is a challenging task due to their inherent microporous nature. Here the authors engineer meso- and macroporous MOF patterns and membranes via a mild decarboxylation applicable to different substrates, demonstrating their potential in macromolecule separations. 27 September 2018 | doi: 10.1038/s41467-018-06438-0 Metal–organic frameworks  Organic chemistry  Porous materials  Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells OPEN Joseph C. Mudd, Kathleen Busman-Sahay, Sarah R. DiNapoli, Stephen Lai, Virginia Sheik, Andrea Lisco, Claire Deleage, Brian Richardson, David J. Palesch, Mirko Paiardini, Mark Cameron, Irini Sereti, R. Keith Reeves, Jacob D. Estes & Jason M. Brenchley Innate lymphoid cells (ILCs) have been shown to be depleted during HIV-1 infection. Here the authors show that ILC loss is associated with CD4 depletion and gastrointestinal damage in a primate model of SIV infection. 27 September 2018 | doi: 10.1038/s41467-018-05528-3 HIV infections  Innate lymphoid cells  Mucosal immunology  Viral host response  Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome OPEN Michael Rusch, Joy Nakitandwe, Sheila Shurtleff, Scott Newman, Zhaojie Zhang, Michael N. Edmonson, Matthew Parker, Yuannian Jiao, Xiaotu Ma, Yanling Liu, Jiali Gu, Michael F. Walsh, Jared Becksfort, Andrew Thrasher, Yongjin Li, James McMurry, Erin Hedlund, Aman Patel, John Easton, Donald Yergeau et al. Clinical oncology is rapidly adopting next-generation sequencing technology for nucleotide variant and indel detection. Here the authors present a three-platform approach (whole-genome, whole-exome, and whole-transcriptome) in pediatric patients for the detection of diverse types of germline and somatic variants. 27 September 2018 | doi: 10.1038/s41467-018-06485-7 Cancer genomics  Genome informatics  RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis OPEN Uwe Richter, Molly E. Evans, Wesley C. Clark, Paula Marttinen, Eric A. Shoubridge, Anu Suomalainen, Anna Wredenberg, Anna Wedell, Tao Pan & Brendan J. Battersby Mutations in mitochondrially-encoded tRNA genes can lead to mitochondrial disorders. Here the authors use next generation RNA sequencing to reveal the role of a N1 -methyladenosine modification in tRNALys MERR patients for translation elongation and the stability of selected nascent chains. 27 September 2018 | doi: 10.1038/s41467-018-06471-z Mitochondria  RNA modification  Translation  Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases OPEN Yun Zhang, Shunbin Xiong, Bin Liu, Vinod Pant, Francis Celii, Gilda Chau, Ana C. Elizondo-Fraire, Peirong Yang, Mingjian James You, Adel K. El-Naggar, Nicholas E. Navin & Guillermina Lozano Mutations in TP53 gene are very common in cancer development. Here the authors take advantage of murine models to show that somatic Trp53 mutations differentially drive breast cancer and evolution of metastases. 27 September 2018 | doi: 10.1038/s41467-018-06146-9 Breast cancer  Cancer models  Spatial heterogeneity as the structure feature for structure–property relationship of metallic glasses OPEN Fan Zhu, Shuangxi Song, Kolan Madhav Reddy, Akihiko Hirata & Mingwei Chen Directly relating the mechanical properties of metallic glasses to their atomic structure remains a challenge. Here, the authors use high resolution microscopy to show many mechanical properties of metallic glasses depend on a single structural parameter, the characteristic length of spatial heterogeneity. 27 September 2018 | doi: 10.1038/s41467-018-06476-8 Glasses  Mechanical properties  Metals and alloys  Structure of solids and liquids  Nordic Seas polynyas and their role in preconditioning marine productivity during the Last Glacial Maximum OPEN Jochen Knies, Denizcan Köseoğlu, Leif Rise, Nicole Baeten, Valérie K. Bellec, Reidulv Bøe, Martin Klug, Giuliana Panieri, Patrycja E. Jernas & Simon T. Belt Polynyas potentially played a role in sustaining marine life during the last glacial, yet their presence and importance remains equivocal. This multi-proxy study reconstructs a corridor of polynyas in the Nordic Seas during the last glacial maximum, and reveals a strong association with biological productivity. 27 September 2018 | doi: 10.1038/s41467-018-06252-8 Carbon cycle  Palaeoclimate  AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A OPEN Alexandra K. Davies, Daniel N. Itzhak, James R. Edgar, Tara L. Archuleta, Jennifer Hirst, Lauren P. Jackson, Margaret S. Robinson & Georg H. H. Borner Adaptor protein complex 4 (AP-4) deficiency causes a severe neurological disorder via an unknown mechanism. Here, the authors reveal cargo and machinery of the AP-4 transport pathway, and propose that AP-4 mediates spatial regulation of autophagy through peripheral delivery of ATG9A. 27 September 2018 | doi: 10.1038/s41467-018-06172-7 Autophagy  Mechanisms of disease  Membrane trafficking  Proteomics  Systems biology  Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy OPEN Fabio A. Iannotti, Ester Pagano, Ombretta Guardiola, Simone Adinolfi, Valentina Saccone, Silvia Consalvi, Fabiana Piscitelli, Elisabetta Gazzerro, Giuseppe Busetto, Diego Carrella, Raffaele Capasso, Pier Lorenzo Puri, Gabriella Minchiotti & Vincenzo Di Marzo The regenerative capacity of muscle stem cells is impaired in Duchenne muscular dystrophy (DMD). Here, the authors show that the endocannabinoid receptor CB1 is activated by PAX7 in muscle stem cells, and that pharmacological inhibition of CB1 promotes stem cell activation and ameliorates symptoms in DMD mouse models. 27 September 2018 | doi: 10.1038/s41467-018-06267-1 Lipid signalling  Neuromuscular disease  A Mendelian randomization study of the effects of blood lipids on breast cancer risk OPEN Christoph Nowak & Johan Ärnlöv The link between circulating lipids and breast cancer risk is complex. Here, the authors utilise data from more than 400,000 participants in two-sample Mendelian randomization to assess the link between blood lipids and breast cancer risk, and they find risk-promoting effects of raised LDL-cholesterol and CETP-mediated raised HDL-cholesterol. 27 September 2018 | doi: 10.1038/s41467-018-06467-9 Breast cancer  Cancer epidemiology  Cancer prevention  Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine OPEN Yaoqiu Zhu, Elkin L. Romero, Xiaodong Ren, Angel J. Sanca, Congkuo Du, Cai Liu, Zubair A. Karim, Fatima Z. Alshbool, Fadi T. Khasawneh, Jiang Zhou, Dafang Zhong & Bing Geng Hydrogen sulphide (H2S) is a gaseous signalling molecule, which has shown therapeutic value. Here, the authors show that a thioenol metabolite of the antithrombotic drug clopidogrel is an efficient H2S donor and masked thioenols can be linked to existing compounds to develop H2S-releasing agents. 27 September 2018 | doi: 10.1038/s41467-018-06373-0 Drug discovery and development  Small molecules    Nature Communications EVENT AHIMA World Congress (AWC) Healthcare Information Summit 25.10.18 Abdu Dhabi, UAE More science events from     Latest Correspondence     Premature alarm on the impacts of climate change on Arctic Char in Lake Hazen OPEN Jean-Sébastien Moore, Jacqueline M. Chapman, Marc J. Mazerolle, Les N. Harris & Eric B. Taylor 28 September 2018 | doi: 10.1038/s41467-018-06479-5 Community ecology  Ecosystem ecology  Freshwater ecology  Population dynamics      Latest Author Corrections     Author Correction: The identification of carbon dioxide mediated protein post-translational modifications OPEN Victoria L. Linthwaite, Joanna M. Janus, Adrian P. Brown, David Wong-Pascua, AnnMarie C. O'Donoghue, Andrew Porter, Achim Treumann, David R. W. Hodgson & Martin J. Cann 03 October 2018 | doi: 10.1038/s41467-018-06711-2 Chemical modification  Post-translational modifications  Proteomic analysis  Author Correction: Multilayer networks reveal the spatial structure of seed-dispersal interactions across the Great Rift landscapes OPEN Sérgio Timóteo, Marta Correia, Susana Rodríguez-Echeverría, Helena Freitas & Ruben Heleno 02 October 2018 | doi: 10.1038/s41467-018-06669-1 Community ecology  Ecological networks  Tropical ecology  Author Correction: Dynamically induced cascading failures in power grids OPEN Benjamin Schäfer, Dirk Witthaut, Marc Timme & Vito Latora 27 September 2018 | doi: 10.1038/s41467-018-06483-9 Complex networks  Energy modelling      Latest Publisher Corrections     Publisher Correction: Necroptosis mediates myofibre death in dystrophin-deficient mice OPEN Jennifer E. Morgan, Alexandre Prola, Virginie Mariot, Veronica Pini, Jinhong Meng, Christophe Hourde, Julie Dumonceaux, Francesco Conti, Frederic Relaix, Francois-Jerôme Authier, Laurent Tiret, Francesco Muntoni & Maximilien Bencze 02 October 2018 | doi: 10.1038/s41467-018-06636-w Necroptosis  Skeletal muscle  Publisher Correction: Critical Southern Ocean climate model biases traced to atmospheric model cloud errors OPEN Patrick Hyder , John M. Edwards, Richard P. Allan, Helene T. Hewitt, Thomas J. Bracegirdle, Jonathan M. Gregory, Richard A. Wood, Andrew J. S. Meijers, Jane Mulcahy, Paul Field, Kalli Furtado, Alejandro Bodas-Salcedo, Keith D. Williams, Dan Copsey, Simon A. Josey, Chunlei Liu, Chris D. Roberts, Claudio Sanchez, Jeff Ridley, Livia Thorpe et al. 02 October 2018 | doi: 10.1038/s41467-018-06662-8 Atmospheric dynamics  Physical oceanography  Projection and prediction      Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events You have been sent this Table of Contents Alert because you have opted in to receive it. 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