Nature Reviews Microbiology contents October 2018 Volume 16 Number 10

TABLE OF CONTENTS October 2018 Volume 16, Issue 10 Editorial Research Highlights News & Analysis Progress Reviews Analysis Perspectives   Advertisement Building a functional understanding of the microbiome to transform drug-discovery & improve health outcomes  World Class speakers provide key take-aways on how to implement their methods to accelerate research: -Integrating multi-omics analysis -Elucidating mechanisms & microbial networks -Systems biology approaches to study design Join leading academics & biotechs this Nov.   Editorial   Communities at the centre    p579 | doi:10.1038/s41579-018-0079-z Full Text | PDF   Research Highlights   Channeling the vacuole Ashley York p581 | doi:10.1038/s41579-018-0081-5 Two recent studies provide new insights into the architecture, molecular mechanisms and function of the Plasmodium translocon of exported proteins (PTEX) complex and the core PTEX protein EXP2. PDF   Layers of complexity in the ground Andrea Du Toit p582 | doi:10.1038/s41579-018-0072-6 PDF   Defending the niche Andrea Du Toit p582 | doi:10.1038/s41579-018-0073-5 PDF   Taking control over the host Andrea Du Toit p582 | doi:10.1038/s41579-018-0074-4 PDF   Maximizing delivery Andrea Du Toit pp582 - 583 | doi:10.1038/s41579-018-0078-0 This study shows that rotaviruses and noroviruses are transmitted in stool as clusters of viruses within vesicles, and that this mode of transmission provides a replication advantage. PDF   A new timeline of life’s early evolution Ashley York pp582 - 583 | doi:10.1038/s41579-018-0080-6 A recent study integrates genomic, geological and fossil evidence to derive a timeline of life’s early evolution and the origin of eukaryotes. PDF   Pick of the crop microbiome Ashley York p583 | doi:10.1038/s41579-018-0082-4 PDF   Next-generation bacterial taxonomy Ashley York p583 | doi:10.1038/s41579-018-0083-3 PDF   Slipping through the NET Ashley York p583 | doi:10.1038/s41579-018-0084-2 PDF   Nature Reviews Microbiology JOBS of the week Assistant Professor - Microbial Biology Vanderbilt University Department of Biological Sciences Faculty Positions in the Department of Microbiology University of Pennsylvania Research Fellow Dana-Farber Cancer Institute (DFCI) Postdoctoral position in Microbiology Genomics, and Computational Biology Stanford University Faculty Positions at Jiangnan University Wuxi School of Medicine and its Affiliated Hospitals & Clinics Jiangnan University Wuxi School of Medicine More Science jobs from Nature Reviews Microbiology EVENT 2018 International Symposium on Biological Engineering and Microbiology (ISBEM 2018) 02.11.18 Guangzhou, China More science events from Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   News & Analysis   Filming flagella and pili in action    Valentine Lagage & Stephan Uphoff* p584 | doi:10.1038/s41579-018-0077-1 This month’s Under the Lens discusses the utility of live-cell fluorescence labelling to record the dynamics of bacterial surface appendages. Full Text | PDF   Progress   Structural insights into the signalling mechanisms of two-component systems    Françoise Jacob-Dubuisson, Ariel Mechaly, Jean-Michel Betton & Rudy Antoine pp585 - 593 | doi:10.1038/s41579-018-0055-7 Canonical two-component systems catalyse autophosphorylation of the histidine kinase, transfer of the phosphoryl group to the regulator and dephosphorylation of the phosphoregulator. In this Progress article, Jacob-Dubuisson and colleagues highlight recent structural insights into the signalling and catalytic mechanisms of sensor histidine kinases. Full Text | PDF   Zika virus vaccines    Peter Abbink, Kathryn E. Stephenson & Dan H. Barouch pp594 - 600 | doi:10.1038/s41579-018-0039-7 The recent epidemic of Zika virus (ZIKV) in the Americas has revealed the devastating consequences of ZIKV infection, particularly in pregnant women. In this Progress article, Barouch and colleagues discuss recent preclinical studies and lessons learned from first-in-human clinical trials with ZIKV vaccines. Full Text | PDF Collection: Vector-borne diseases   Reviews   RNA-binding proteins in bacteria    Erik Holmqvist & Jörg Vogel pp601 - 615 | doi:10.1038/s41579-018-0049-5 Bacterial RNA-binding proteins (RBPs) directly associate with and influence the fate of virtually all cellular transcripts. In this Review, Holmqvist and Vogel discuss our current understanding of the molecular interactions between specific RBPs and RNA during transcription, protein synthesis and RNA decay. Full Text | PDF   Bacterial adhesion at the single-cell level    Cecile Berne, Courtney K. Ellison, Adrien Ducret & Yves V. Brun pp616 - 627 | doi:10.1038/s41579-018-0057-5 In this Review, Brun and colleagues summarize our understanding of the mechanisms governing bacterial adhesion at the single-cell level, including the physical forces experienced by a cell before reaching the surface, the first contact with a surface and the transition from reversible to permanent adhesion. Full Text | PDF Collection: Microbial biofilms   Analysis   Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations    Cindy J. Castelle, Christopher T. Brown, Karthik Anantharaman, Alexander J. Probst, Raven H. Huang et al. pp629 - 645 | doi:10.1038/s41579-018-0076-2 Candidate phyla radiation (CPR) bacteria and DPANN archaea are massive radiations of organisms recently identified. In this Analysis, Castelle et al. explore the metabolic potential of CPR and DPANN radiation, focusing in particular on metabolic gaps and unexpected biological features that are unusual outside of these groups. Full Text | PDF   Perspectives   Why does the microbiome affect behaviour?    Katerina V.-A. Johnson & Kevin R. Foster pp647 - 655 | doi:10.1038/s41579-018-0014-3 The microbiota can influence host behaviour through the gut–brain axis. In this Opinion, Johnson and Foster explore the evolution of this relationship and propose that adaptations of competing gut microorganisms may affect behaviour as a by‑product, leading to host dependence. Full Text | PDF   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. 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