Nature Communications - 05 September 2018

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Find out more >>  Journal homepage Recommend to library Web feed     Latest Articles View all Articles     RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation OPEN Berta Casar, Andrew P. Badrock, Iñaki Jiménez, Imanol Arozarena, Paula Colón-Bolea, L. Francisco Lorenzo-Martín, Irene Barinaga-Rementería, Jorge Barriuso, Vincenzo Cappitelli, Daniel J. Donoghue, Xosé R. Bustelo, Adam Hurlstone & Piero Crespo RAS isoforms are associated with the plasma membrane and endomembranes, but how their localization contributes to tumorigenesis is unclear. Here, the authors show that RAS signals from Golgi complex antagonize tumour formation by inducing apoptosis via ERK inhibition. 05 September 2018 | doi: 10.1038/s41467-018-05941-8 Cell signalling  Oncogenes  Anomalous twin boundaries in two dimensional materials OPEN A. P. Rooney, Z. Li, W. Zhao, A. Gholinia, A. Kozikov, G. Auton, F. Ding, R. V. Gorbachev, R. J. Young & S. J. Haigh All materials subjected to mechanical deformation form low energy interfaces known as twin boundaries. Here, the authors investigate a variety of structural features that form upon bending atomically thin 2D-crystals, and predict distinct classes of post deformation microstructure based on their atomic arrangement, bend angle and flake thickness. 05 September 2018 | doi: 10.1038/s41467-018-06074-8 Characterization and analytical techniques  Mechanical and structural properties and devices  Two-dimensional materials  Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene OPEN Satoshi Kojo, Nighat Yasmin, Sawako Muroi, Mari Tenno & Ichiro Taniuchi The commitment of helper and cytotoxic lineages for CD4 and CD8 T cells, respectively, is associated with the regulation of Cd4 gene expression. Here the authors show that an intronic silencer, S4, has differential effects and synergy with the RUNX complex to act on two enhancer elements of the CD4 gene to control T cell lineage commitment in the thymus. 05 September 2018 | doi: 10.1038/s41467-018-05803-3 Clonal selection  Gene regulation in immune cells  T cells  Thymus  Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development OPEN Priya D. Issuree, Kenneth Day, Christy Au, Ramya Raviram, Paul Zappile, Jane A. Skok, Hai-Hui Xue, Richard M. Myers & Dan R. Littman The expression of CD4, a critical co-receptor providing T cell help in adaptive immunity, is finely tuned during development. Here the authors show that two enhancer elements, E4p and the newly-defined E4m, coordinate the expression and heritable demethylation of Cd4 in thymocytes but are dispensable for its sustained expression in peripheral T cells. 05 September 2018 | doi: 10.1038/s41467-018-05834-w Clonal selection  DNA methylation  Epigenetics in immune cells  Thymus  Precipitation thresholds regulate net carbon exchange at the continental scale OPEN Zhihua Liu, Ashley P. Ballantyne, Benjamin Poulter, William R. L. Anderegg, Wei Li, Ana Bastos & Philippe Ciais The sensitivity of terrestrial net ecosystem carbon exchange (NEE) to climate remains a major source of uncertainty. Here, the authors identify a precipitation threshold of between 750-950 mm yr−1 for the contiguous United States, beyond which NEE is regulated by respiration rather than production. 05 September 2018 | doi: 10.1038/s41467-018-05948-1 Carbon cycle  Climate change  Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer OPEN Carolina Moretto Carnielli, Carolina Carneiro Soares Macedo, Tatiane De Rossi, Daniela Campos Granato, César Rivera, Romênia Ramos Domingues, Bianca Alves Pauletti, Sami Yokoo, Henry Heberle, Ariane Fidelis Busso-Lopes, Nilva Karla Cervigne, Iris Sawazaki-Calone, Gabriela Vaz Meirelles, Fábio Albuquerque Marchi, Guilherme Pimentel Telles, Rosane Minghim, Ana Carolina Prado Ribeiro, Thaís Bianca Brandão, Gilberto de Castro Jr, Wilfredo Alejandro González-Arriagada et al. Oral cancer has region-specific histopathological and molecular characteristics, complicating its classification by the standard tumor-node-metastasis system. Here, the authors combine discovery and targeted proteomics with IHC to identify region-specific and saliva biomarkers for oral cancer prognosis. 05 September 2018 | doi: 10.1038/s41467-018-05696-2 Immunohistochemistry  Oral cancer  Proteomic analysis  Tumour biomarkers  Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens OPEN Zihua Lin, Xiaobo Xu, Sheng Zhao, Xiaohong Yang, Jian Guo, Qun Zhang, Chunmei Jing, Shawn Chen & Yun He Albomycins are promising drug candidates for the treatment of bacterial infections. Here, the authors describe the total syntheses of albomycins δ1, δ2, and ε, and evaluate their antimicrobial activity, identifying albomycin δ2 as a strong agent against S. pneumoniae and S. aureus infections. 04 September 2018 | doi: 10.1038/s41467-018-05821-1 Drug discovery and development  Natural product synthesis  Deep reefs of the Great Barrier Reef offer limited thermal refuge during mass coral bleaching OPEN Pedro R. Frade, Pim Bongaerts, Norbert Englebert, Alice Rogers, Manuel Gonzalez-Rivero & Ove Hoegh-Guldberg It has been suggested that deep coral reefs offer a refuge against warming and mass bleaching. Here Frade et al. look at the 2016 bleaching event in the northern Great Barrier Reef and found that deep reefs initially acted as thermal refuges, though this effect lessened in the late summer months. 04 September 2018 | doi: 10.1038/s41467-018-05741-0 Community ecology  Marine biology  Optimal dynamic coding by mixed-dimensionality neurons in the head-direction system of bats OPEN Arseny Finkelstein, Nachum Ulanovsky, Misha Tsodyks & Johnatan Aljadeff Multidimensional stimuli are often represented by neurons encoding only a single dimension and those encoding multiple dimensions. Here, the authors present theoretical and experimental analyses to show that mixed representations are optimal to efficiently encode such stimuli under different behavioral modes. 04 September 2018 | doi: 10.1038/s41467-018-05562-1 Navigation  Neural decoding  Neural encoding  Sensory processing  Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation OPEN Rachel K. Zwick, Michael C. Rudolph, Brett A. Shook, Brandon Holtrup, Eve Roth, Vivian Lei, Alexandra Van Keymeulen, Victoria Seewaldt, Stephanie Kwei, John Wysolmerski, Matthew S. Rodeheffer & Valerie Horsley During mammary gland involution, the organ undergoes extensive remodeling. Here, the authors explore the role of mammary gland adipose tissue (mgWAT) in this process and demonstrate that adipocyte hypertrophy and lipid trafficking underlie mgWAT expansion and epithelial regression. 04 September 2018 | doi: 10.1038/s41467-018-05911-0 Cell growth  Cell proliferation  Developmental biology  Stem cells  Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection OPEN Tracy T. Chow, Xiaoyu Shi, Jen-Hsuan Wei, Juan Guan, Guido Stadler, Bo Huang & Elizabeth H. Blackburn Chromatin dynamics is thought to play an important role in the maintenance of telomeres, yet how has remained poorly understood. Here the authors locally enrich heterochromatin protein 1α (HP1α) at human telomeres to provide insights into the crosstalk between epigenetic regulations and structural dynamics at the telomeres. 04 September 2018 | doi: 10.1038/s41467-018-05840-y Chromatin  Telomeres  H-bonded reusable template assisted para-selective ketonisation using soft electrophilic vinyl ethers OPEN Arun Maji, Amit Dahiya, Gang Lu, Trisha Bhattacharya, Massimo Brochetta, Giuseppe Zanoni, Peng Liu & Debabrata Maiti Electrophilic acylation of arenes is largely limited to electron rich systems, non-polar medium and often displays moderate selectivity. Here, the authors show a directed para-selective ketonisation of arenes, overriding electronic bias and structural congestion, and apply it to the synthesis of bioactive compounds. 04 September 2018 | doi: 10.1038/s41467-018-06018-2 Homogeneous catalysis  Synthetic chemistry methodology  Reaction mechanisms  Bioinspired ultra-stretchable and anti-freezing conductive hydrogel fibers with ordered and reversible polymer chain alignment OPEN Xue Zhao, Fang Chen, Yuanheng Li, Han Lu, Ning Zhang & Mingming Ma High-performance stretchable conductive fibers are desired for the development of stretchable electronic devices but preparation of conductive hydrogel fibers is challenging. Inspired by spider silk the authors demonstrate here a spinning method to prepare stretchable conductive hydrogel fibers with ordered polymer chain alignment. 04 September 2018 | doi: 10.1038/s41467-018-05904-z Bioinspired materials  Gels and hydrogels  Mechanical properties  Atomic force microscopy methodology and AFMech Suite software for nanomechanics on heterogeneous soft materials OPEN Massimiliano Galluzzi, Guanlin Tang, Chandra S. Biswas, Jinlai Zhao, Shiguo Chen & Florian J. Stadler Atomic force microscopy is an indispensable method in characterizing soft materials but the complexity of biological samples makes reproducible measurements difficult. Here the authors use a 3-step method to investigate biological specimens in which vertical and lateral heterogeneity hinders a precise quantitative characterization. 04 September 2018 | doi: 10.1038/s41467-018-05902-1 Atomic force microscopy  Gels and hydrogels  Software  Exploring Peltier effect in organic thermoelectric films OPEN Wenlong Jin, Liyao Liu, Tao Yang, Hongguang Shen, Jia Zhu, Wei Xu, Shuzhou Li, Qing Li, Lifeng Chi, Chong-an Di & Daoben Zhu Observing the Peltier effect, e.g. cooling/heating at material junctions due to current flow, in organic thermoelectric films remains a challenge due the inherent properties of these materials. Here, the authors use IR imaging to experimentally observe the Peltier effect in poly(Ni-ett)-based films. 04 September 2018 | doi: 10.1038/s41467-018-05999-4 Electronic devices  Thermoelectrics  Structural and biochemical insights into small RNA 3′ end trimming by Arabidopsis SDN1 OPEN Jiayi Chen, Li Liu, Chenjiang You, Jiaqi Gu, Wenjie Ruan, Lu Zhang, Jianhua Gan, Chunyang Cao, Ying Huang, Xuemei Chen & Jinbiao Ma Small RNA degrading nucleases (SDNs) can degrade short RNAs. Here the authors report the crystal structure of Arabidopsis SDN1 in complex with a single-stranded RNA, and provide new insight into 3′ end trimming mechanism of 3′ to 5′ riboexonucleases in the metabolism of various species of small RNAs. 04 September 2018 | doi: 10.1038/s41467-018-05942-7 Plant molecular biology  Small RNAs  X-ray crystallography  The prognostic effects of somatic mutations in ER-positive breast cancer OPEN Obi L. Griffith, Nicholas C. Spies, Meenakshi Anurag, Malachi Griffith, Jingqin Luo, Dongsheng Tu, Belinda Yeo, Jason Kunisaki, Christopher A Miller, Kilannin Krysiak, Jasreet Hundal, Benjamin J Ainscough, Zachary L. Skidmore, Katie Campbell, Runjun Kumar, Catrina Fronick, Lisa Cook, Jacqueline E. Snider, Sherri Davies, Shyam M. Kavuri et al. Unravelling the link between somatic mutation and prognosis in estrogen positive (ER+) breast cancer requires the use of long-term follow-up data. Here, combining archival formalin-fixed paraffin embedded tissue and targeted sequencing in three cohorts of ER+ breast cancer, the authors find associations with clinical outcome for NF1 frame-shift nonsense mutations, PIK3R1 mutation, and DDR1 mutations. 04 September 2018 | doi: 10.1038/s41467-018-05914-x Breast cancer  Cancer genomics  Land use driven change in soil pH affects microbial carbon cycling processes OPEN Ashish A. Malik, Jeremy Puissant, Kate M. Buckeridge, Tim Goodall, Nico Jehmlich, Somak Chowdhury, Hyun Soon Gweon, Jodey M. Peyton, Kelly E. Mason, Maaike van Agtmaal, Aimeric Blaud, Ian M. Clark, Jeanette Whitaker, Richard F. Pywell, Nick Ostle, Gerd Gleixner & Robert I. Griffiths Land use intensification could modify microbial activity and thus ecosystem function. Here, Malik et al. sample microbes and carbon-related functions across a land use gradient, demonstrating that microbial biomass and carbon use efficiency are reduced in human-impacted near-neutral pH soils. 04 September 2018 | doi: 10.1038/s41467-018-05980-1 Carbon cycle  Ecosystem ecology  Microbial ecology  Soil microbiology  Non-Abelian adiabatic geometric transformations in a cold strontium gas OPEN F. Leroux, K. Pandey, R. Rehbi, F. Chevy, C. Miniatura, B. Grémaud & D. Wilkowski The symmetry group and geometric phase of a system are responsible for many quantum properties related to non-trivial topology. Here the authors show non-Abelian geometric phase in laser-coupled ultracold strontium atoms by using a tripod scheme. 04 September 2018 | doi: 10.1038/s41467-018-05865-3 Quantum simulation  Ultracold gases  Binder driven self-assembly of metal-organic cubes towards functional hydrogels OPEN Papri Sutar, Venkata M. Suresh, Kolleboyina Jayaramulu, Arpan Hazra & Tapas Kumar Maji A possible route to producing processable soft materials is by assembling metal organic cubes into hydrogels. Here the authors show charge-assisted H-bond driven self-assembly of Ga3+-based anionic metal organic cubes and suitable molecular binders towards multi-functional hydrogels. 04 September 2018 | doi: 10.1038/s41467-018-05818-w Gels and hydrogels  Self-assembly  Consumption-based greenhouse gas emissions accounting with capital stock change highlights dynamics of fast-developing countries OPEN Zhan-Ming Chen, Stephanie Ohshita, Manfred Lenzen, Thomas Wiedmann, Magnus Jiborn, Bin Chen, Leo Lester, Dabo Guan, Jing Meng, Shiyun Xu, Guoqian Chen, Xinye Zheng, JinJun Xue, Ahmed Alsaedi, Tasawar Hayat & Zhu Liu Traditional carbon accounting attributes gap between consumption- and production-based emissions to international trade. The authors develop a dynamic model that incorporates capital stock change and find it improves estimates for fast-developing countries. 04 September 2018 | doi: 10.1038/s41467-018-05905-y Climate sciences  Environmental social sciences  Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq OPEN Mihriban Karaayvaz, Simona Cristea, Shawn M. Gillespie, Anoop P. Patel, Ravindra Mylvaganam, Christina C. Luo, Michelle C. Specht, Bradley E. Bernstein, Franziska Michor & Leif W. Ellisen Triple-negative breast cancer is highly heterogeneous and aggressive. Here, the authors utilise single-cell RNA sequencing to investigate this heterogeneity, and discover a subpopulation of cells associated with metastasis and treatment resistance signatures, and linked to long term survival outcomes. 04 September 2018 | doi: 10.1038/s41467-018-06052-0 Breast cancer  Functional clustering  Tumour heterogeneity  Engineered bidirectional promoters enable rapid multi-gene co-expression optimization OPEN Thomas Vogl, Thomas Kickenweiz, Julia Pitzer, Lukas Sturmberger, Astrid Weninger, Bradley W. Biggs, Eva-Maria Köhler, Armin Baumschlager, Jasmin Elgin Fischer, Patrick Hyden, Marlies Wagner, Martina Baumann, Nicole Borth, Martina Geier, Parayil Kumaran Ajikumar & Anton Glieder Classic monodirectional promoters are of limited use for multiple gene co-expression. Here the authors generate a library of 168 bidirectional promoters for the yeast K. phaffii (syn. P. pastoris) with diverse expression profiles to optimize metabolic pathway design. 04 September 2018 | doi: 10.1038/s41467-018-05915-w Expression systems  Genetic vectors  High-throughput screening  Non-model organisms  Synthetic biology  Synthesis of chiral α-trifluoromethyl alcohols and ethers via enantioselective Hiyama cross-couplings of bisfunctionalized electrophiles OPEN Andrii Varenikov & Mark Gandelman Compounds containing stereocenters bearing -CF3 groups, especially in proximity of heteroatoms, are of great interest for drug and agrochemicals development. Here, the authors report a nickel-catalyzed Hiyama cross-coupling methodology for the asymmetric synthesis of valuable alpha-trifluoromethyl alcohols and ethers. 03 September 2018 | doi: 10.1038/s41467-018-05946-3 Homogeneous catalysis  Synthetic chemistry methodology  Stereochemistry  Imaging soliton dynamics in optical microcavities OPEN Xu Yi, Qi-Fan Yang, Ki Youl Yang & Kerry Vahala In order to study the dynamics of solitons in microresonators, which underlie nonlinear phenomena like Kerr comb generation, both high temporal resolution and long record times are needed. Here, the authors develop a coherent sampling method to directly image the temporal behavior of solitons. 03 September 2018 | doi: 10.1038/s41467-018-06031-5 Frequency combs  Microresonators  Solitons  Dynamic earthquake rupture preserved in a creeping serpentinite shear zone OPEN Matthew S. Tarling, Steven A. F. Smith, Cecilia Viti & James M. Scott Creeping serpentinite shear zones may host large earthquakes, but direct evidence of frictional heating and rupture have been missing. Here, the authors demonstrate via laboratory experiments that earthquake ruptures can propagate through serpentinite shear zones shown by high-temperature reaction products. 03 September 2018 | doi: 10.1038/s41467-018-05965-0 Geodynamics  Natural hazards  Tectonics  Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis OPEN Mingming Sun, Wei Wu, Liang Chen, Wenjing Yang, Xiangsheng Huang, Caiyun Ma, Feidi Chen, Yi Xiao, Ye Zhao, Chunyan Ma, Suxia Yao, Victor H. Carpio, Sara M. Dann, Qihong Zhao, Zhanju Liu & Yingzi Cong T cells play a critical role in intestinal homeostasis, with increasing evidence suggesting a role for the microbiome metabolome in modulating this response. Here the authors show short-chain fatty acids promote IL-10 production in Th1 cells. 03 September 2018 | doi: 10.1038/s41467-018-05901-2 CD4-positive T cells  Cellular immunity  Gastroenterology  Mucosal immunology  A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target OPEN Prashant K. Srivastava, Jonathan van Eyll, Patrice Godard, Manuela Mazzuferi, Andree Delahaye-Duriez, Juliette Van Steenwinckel, Pierre Gressens, Benedicte Danis, Catherine Vandenplas, Patrik Foerch, Karine Leclercq, Georges Mairet-Coello, Alvaro Cardenas, Frederic Vanclef, Liisi Laaniste, Isabelle Niespodziany, James Keaney, Julien Gasser, Gaelle Gillet, Kirill Shkura et al. The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify the microglial membrane receptor Csf1R as a potential therapeutic target for epilepsy. 03 September 2018 | doi: 10.1038/s41467-018-06008-4 Epilepsy  Gene regulatory networks  Target identification  Predicting the evolution of Escherichia coli by a data-driven approach OPEN Xiaokang Wang, Violeta Zorraquino, Minseung Kim, Athanasios Tsoukalas & Ilias Tagkopoulos How reproducible evolutionary processes are remains an important question in evolutionary biology. Here, the authors compile a compendium of more than 15,000 mutation events for Escherichia coli under 178 distinct environmental settings, and develop an ensemble of predictors to predict evolution at a gene level. 03 September 2018 | doi: 10.1038/s41467-018-05807-z Computational biology and bioinformatics  Computational models  Data mining  Evolution  Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells OPEN Stephanie Jaeckel, Markus Kaller, Rene Jackstadt, Ursula Götz, Susanna Müller, Sophie Boos, David Horst, Peter Jung & Heiko Hermeking The c-MYC oncoprotein has many targets whose actions are not fully understood including TFAP4/AP4. Here, the authors show in a mouse model of inherited colorectal cancer that deletion of AP4 decreased the frequency of c-MYC-driven intestinal adenomas, and reveal Ap4 as a mediator of adenoma initiation and regulator of colonic and intestinal stem cell and Paneth cell homeostasis. 03 September 2018 | doi: 10.1038/s41467-018-06001-x Cancer models  Cancer stem cells  Colon cancer  Social environment mediates cancer progression in Drosophila OPEN Erika H. Dawson, Tiphaine P. M. Bailly, Julie Dos Santos, Céline Moreno, Maëlle Devilliers, Brigitte Maroni, Cédric Sueur, Andreu Casali, Beata Ujvari, Frederic Thomas, Jacques Montagne & Frederic Mery There is some evidence that social context can mediate the progression of cancers. Here, the authors show that Drosophila flies housed in social isolation experienced faster cancer tumor progression than flies in groups, and that flies select for social environments that minimize cancer risk. 03 September 2018 | doi: 10.1038/s41467-018-05737-w Behavioural ecology  Cancer  Ecological epidemiology  Social evolution  Carboxysome encapsulation of the CO2-fixing enzyme Rubisco in tobacco chloroplasts OPEN Benedict M. Long, Wei Yih Hee, Robert E. Sharwood, Benjamin D. Rae, Sarah Kaines, Yi-Leen Lim, Nghiem D. Nguyen, Baxter Massey, Soumi Bala, Susanne von Caemmerer, Murray R. Badger & G. Dean Price Previous efforts to assemble Rubisco within a cyanobacterial carboxysome-derived protein shell in plant chloroplasts to concentrate CO2 have been unsuccessful. Here, Long et al. produce carboxysomes in tobacco chloroplasts that encapsulate the introduced Rubisco and enable autotrophic growth at elevated CO2. 03 September 2018 | doi: 10.1038/s41467-018-06044-0 Expression systems  Molecular engineering in plants  Protein design  Rubisco  Super-wide-field two-photon imaging with a micro-optical device moving in post-objective space OPEN Shin-Ichiro Terada, Kenta Kobayashi, Masamichi Ohkura, Junichi Nakai & Masanori Matsuzaki Recording the activity of neurons over large brain regions requires expanding the field of view of the optics without losing on spatial and temporal resolution. Here, the authors report a micro-opto-mechanical device that enables two-photon imaging across distant motor areas around 6 mm apart in the mouse. 03 September 2018 | doi: 10.1038/s41467-018-06058-8 Ca2+ imaging  Motor cortex  Multiphoton microscopy  Neural circuits  Dehydrogenative reagent-free annulation of alkenes with diols for the synthesis of saturated O-heterocycles OPEN Chen-Yan Cai & Hai-Chao Xu Dehydrogenative annulation is a valuable approach to heterocycles, however, stoichiometric oxidants are often required. Here, the authors describe the electrochemical dehydrogenative annulation of diols and alkenes to generate dioxanes and dioxepanes under metal- and oxidant-free conditions. 03 September 2018 | doi: 10.1038/s41467-018-06020-8 Catalysis  Electrochemistry  Green chemistry  Synthetic chemistry methodology  Single reach plans in dorsal premotor cortex during a two-target task OPEN Brian M. Dekleva, Konrad P. Kording & Lee E. Miller It is debated whether motor cortical activity reflects plans for multiple potential actions. Here, the authors report that in a delayed response task with two potential reach targets, population activity in the dorsal premotor cortex at any moment in time represents only one of the targets. 03 September 2018 | doi: 10.1038/s41467-018-05959-y Neural decoding  Premotor cortex  Room-temperature polarized spin-photon interface based on a semiconductor nanodisk-in-nanopillar structure driven by few defects OPEN Shula Chen, Yuqing Huang, Dennis Visser, Srinivasan Anand, Irina A. Buyanova & Weimin M. Chen Room-temperature spin-generation in 1D systems like semiconductor nanopillars is typically inefficient. Here, the authors demonstrate an approach to achieve efficient spin polarization, even in the absence of a magnetic field, by selectively enhancing the radiative efficiency of one spin direction. 03 September 2018 | doi: 10.1038/s41467-018-06035-1 Nanocavities  Nanophotonics and plasmonics  Spintronics  Biased sequential sampling underlies the effects of time pressure and delay in social decision making OPEN Fadong Chen & Ian Krajbich It has been proposed that humans make unselfish decisions if constrained to decide quickly, but other research has suggested that time constraint makes us selfish. Here, the authors reconcile these two views showing that pro-social people become more pro-social under time pressure, but selfish subjects do the opposite. 03 September 2018 | doi: 10.1038/s41467-018-05994-9 Cognitive neuroscience  Decision  Decision making  Human behaviour  Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear α5-GABAA receptors OPEN Jan M. Schulz, Frederic Knoflach, Maria-Clemencia Hernandez & Josef Bischofberger Somatostatin+ (SOM+ ) GABAergic interneurons are known to fine-tune synaptic plasticity as they inhibit dendritic spikes and burst firing. Here, the authors show that both SOM+ and NOS+ interneurons preferentially recruit nonlinear outward-rectifying GABA(A)R with alpha5 subunit, and that this inhibition with slow gating kinetics matches voltage and time-dependent activation of synaptic NMDARs, thereby controlling the generation of dendritic NMDA spikes. 03 September 2018 | doi: 10.1038/s41467-018-06004-8 Computational neuroscience  Ion channels in the nervous system  Neurophysiology  Synaptic transmission  Comparing frontal eye field and superior colliculus contributions to covert spatial attention OPEN Anil Bollimunta, Amarender R. Bogadhi & Richard J. Krauzlis Superior colliculus (SC) and frontal eye fields (FEF) contain visuo-motor maps but their contributions to selective attention are not fully understood. Here, the authors perform reversible inactivations of the SC or FEF and report that loss of SC activity has a more devastating effect on attention. 03 September 2018 | doi: 10.1038/s41467-018-06042-2 Attention  Cognitive neuroscience  Neural circuits  Neuroscience  Sensorimotor processing  Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexes OPEN Johannes Schiebel, Roberto Gaspari, Tobias Wulsdorf, Khang Ngo, Christian Sohn, Tobias E. Schrader, Andrea Cavalli, Andreas Ostermann, Andreas Heine & Gerhard Klebe Trypsin is a serine protease. Here the authors present the high resolution X-ray and neutron diffraction structures of uncomplexed and inhibitor bound trypsin that provide insights into the geometry of H-bonds in the active site of the enzyme and molecular dynamics simulations reveal the kinetics of ligand binding induced desolvation. 03 September 2018 | doi: 10.1038/s41467-018-05769-2 Biophysics  Computational biology and bioinformatics  Drug discovery  Proteases  X-ray crystallography  Disentangling astroglial physiology with a realistic cell model in silico OPEN Leonid P. Savtchenko, Lucie Bard, Thomas P. Jensen, James P. Reynolds, Igor Kraev, Nikolay Medvedev, Michael G. Stewart, Christian Henneberger & Dmitri A. Rusakov Astrocytes have gained increasing attention for their roles in regulating neural circuits via neurotransmitter uptake, K + buffering, and ability to signal via Ca2 + transients. Here, the authors develop a computational modelling environment for astrocytes, akin to the NEURON environment, called ASTRO. 03 September 2018 | doi: 10.1038/s41467-018-05896-w Astrocyte  Biophysical models  Cellular neuroscience  Topographic precision in sensory and motor corticostriatal projections varies across cell type and cortical area OPEN Bryan M. Hooks, Andrew E. Papale, Ronald F. Paletzki, Muhammad W. Feroze, Brian S. Eastwood, Jonathan J. Couey, Johan Winnubst, Jayaram Chandrashekar & Charles R. Gerfen How corticostriatal connections of different pyramidal cell types are organized, particularly in convergent circuits, has not been evaluated in detail. Here, cell type-specific Cre-driver mice reveal that pyramidal tract-type corticostriatal projections, though broadly similar to intratelencephalic-type projections from the same cortical region, are generally more restricted and variable in their topographic termination patterns. 03 September 2018 | doi: 10.1038/s41467-018-05780-7 Barrel cortex  Basal ganglia  Motor cortex  Neural circuits  Sensorimotor processing  SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis OPEN Li-Yu Huang, Junjie Zhao, Hao Chen, Lixin Wan, Hiroyuki Inuzuka, Jianping Guo, Xuhong Fu, Yangyang Zhai, Zhaoning Lu, Xuefei Wang, Ze-Guang Han, Yihong Sun & Wenyi Wei Upstream pathways regulating Brg1 stability and their role in carcinogenesis are unknown. Here they show Brg1 to be phosphorylated by CK1δ to promote its ubiquitination by SCFFBW7 (FBW7), Brg1 stabilization to promote gastric cancer metastasis, and suggest targeting Brg1 in FBW7 compromised gastric cancer. 03 September 2018 | doi: 10.1038/s41467-018-06038-y Gastric cancer  Prognostic markers  A terahertz-driven non-equilibrium phase transition in a room temperature atomic vapour OPEN C. G. Wade, M. Marcuzzi, E. Levi, J. M. Kondo, I. Lesanovsky, C. S. Adams & K. J. Weatherill The nonlinear interaction between terahertz frequency electric fields and atoms or molecules can be used to study fundamental and technical problems. Here the authors demonstrate a THz–driven phase transition, with a potential application as a THz sensor, using Rydberg atomic states in a cesium vapor. 03 September 2018 | doi: 10.1038/s41467-018-05597-4 Atomic and molecular interactions with photons  Exotic atoms and molecules  Terahertz optics  A hexagon in Saturn’s northern stratosphere surrounding the emerging summertime polar vortex OPEN L. N. Fletcher, G. S. Orton, J. A. Sinclair, S. Guerlet, P. L. Read, A. Antuñano, R. K. Achterberg, F. M. Flasar, P. G. J. Irwin, G. L. Bjoraker, J. Hurley, B. E. Hesman, M. Segura, N. Gorius, A. Mamoutkine & S. B. Calcutt The Cassini spacecraft has provided an unprecedented characterisation of seasonal changes on Saturn. Here the authors describe the development of a warm polar vortex in Saturn’s northern summer, and show that the hexagon extends hundreds of kilometres from the troposphere into the stratosphere. 03 September 2018 | doi: 10.1038/s41467-018-06017-3 Astronomy and planetary science  Atmospheric dynamics  Giant planets  Planetary science  Crystalline TiO2 protective layer with graded oxygen defects for efficient and stable silicon-based photocathode OPEN Jianyun Zheng, Yanhong Lyu, Ruilun Wang, Chao Xie, Huaijuan Zhou, San Ping Jiang & Shuangyin Wang While silicon-based materials can convert sunlight directly to fuel and electricity, balancing their stability and efficiency constrains usage. Here, authors protect silicon photocathodes with crystalline titanium dioxide layers with graded oxygen defects to improve both durability and efficiency. 03 September 2018 | doi: 10.1038/s41467-018-05580-z Materials chemistry  Photocatalysis  Solar fuels  The mitotic spindle is chiral due to torques within microtubule bundles OPEN Maja Novak, Bruno Polak, Juraj Simunić, Zvonimir Boban, Barbara Kuzmić, Andreas W. Thomae, Iva M. Tolić & Nenad Pavin Forces are required for congression of chromosomes by microtubule spindles. Here, using super-resolution microscopy and computational modelling, the authors find that in addition to forces, torques caused by the microtubule motor protein kinesin-5 induce chirality and curves into the spindle. 03 September 2018 | doi: 10.1038/s41467-018-06005-7 Computational biophysics  Microtubules  Mitotic spindle  Single crystal toroidal diamond anvils for high pressure experiments beyond 5 megabar OPEN Zs. Jenei, E. F. O’Bannon, S. T. Weir, H. Cynn, M. J. Lipp & W. J. Evans Static pressures exceeding 4 million atmospheres are extremely challenging to achieve, but are necessary for the study of matter that exists under these conditions in natural environments. Here, diamonds anvils with a toroidal design are demonstrated to sustain over 6 million atmospheres in a diamond anvil cell. 03 September 2018 | doi: 10.1038/s41467-018-06071-x Characterization and analytical techniques  Design, synthesis and processing  Structure of solids and liquids  Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction OPEN Ilkka Paatero, Loïc Sauteur, Minkyoung Lee, Anne K. Lagendijk, Daniel Heutschi, Cora Wiesner, Camilo Guzmán, Dimitri Bieli, Benjamin M. Hogan, Markus Affolter & Heinz-Georg Belting During the formation of the zebrafish dorsal longitudinal anastomotic vessel, blood vessels connect in a process called anastomosis. Using live imaging, the authors here show that endothelial cell movements during blood vessel anastomosis are associated with oscillating lamellipodia-like structures, oriented in the direction of the movements and emerging at endothelial cell junctions. 31 August 2018 | doi: 10.1038/s41467-018-05851-9 Adherens junctions  Angiogenesis  Ethanol facilitates socially evoked memory recall in mice by recruiting pain-sensitive anterior cingulate cortical neurons OPEN Tetsuya Sakaguchi, Satoshi Iwasaki, Mami Okada, Kazuki Okamoto & Yuji Ikegaya Mice have been shown to display a fear response upon observing another mouse undergo fear conditioning. Here, the authors show that ethanol facilitates socially evoked fear memory recall, via pain-responsive neurons in the anterior cingulate cortex. 30 August 2018 | doi: 10.1038/s41467-018-05894-y Emotion  Social behaviour  Density-functional fluctuation theory of crowds OPEN J. Felipe Méndez-Valderrama, Yunus A. Kinkhabwala, Jeffrey Silver, Itai Cohen & T. A. Arias Tools from statistical physics can be used to investigate a large variety of fields ranging from economics to biology. Here the authors first adapt density-functional theory to predict the distributions of crowds in new environments and then validate their approach using groups of fruit flies. 30 August 2018 | doi: 10.1038/s41467-018-05750-z Biological physics  Computational biophysics  Computer modelling  Population dynamics  Statistical physics  Quantitative mappings between symmetry and topology in solids OPEN Zhida Song, Tiantian Zhang, Zhong Fang & Chen Fang The defining quantities of topological materials—the topological invariants—are often difficult to calculate. Here, Song et al. report a simplified method to calculate both the symmetry data and the topological invariants for arbitrary gapped band structure with time-reversal symmetry. 30 August 2018 | doi: 10.1038/s41467-018-06010-w Electronic properties and materials  Topological insulators  Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains OPEN Wei Huang, Yi Peng, Janna Kiselar, Xuan Zhao, Aljawharah Albaqami, Daniel Mendez, Yinghua Chen, Srinivas Chakravarthy, Sayan Gupta, Corie Ralston, Hung-Ying Kao, Mark R. Chance & Sichun Yang The human estrogen receptor alpha (hERα) is a hormone-responsive transcription factor. Here the authors combine small-angle X-ray scattering, hydroxyl radical protein footprinting and computational modeling and show that multidomain hERα adopts an L-shaped boot-like architecture revealing a cross-talk between its DNA-binding domain and Ligand-binding domain. 30 August 2018 | doi: 10.1038/s41467-018-06034-2 Computational biophysics  Nuclear receptors  SAXS  Back to full interseismic plate locking decades after the giant 1960 Chile earthquake OPEN Daniel Melnick, Shaoyang Li, Marcos Moreno, Marco Cisternas, Julius Jara-Muñoz, Robert Wesson, Alan Nelson, Juan Carlos Báez & Zhiguo Deng Great megathrust earthquakes arise from the sudden release of strain accumulated during centuries of interseismic plate convergence. Here, the authors reconstruct interseismic strain accumulation since the 1960 Chile earthquake, finding a transient evolution at decadal scale with implications for estimating the probability of future events. 30 August 2018 | doi: 10.1038/s41467-018-05989-6 Geology  Geomorphology  Geophysics  Natural hazards  Tectonics  Reconciling glacial Antarctic water stable isotopes with ice sheet topography and the isotopic paleothermometer OPEN Martin Werner, Jean Jouzel, Valérie Masson-Delmotte & Gerrit Lohmann Despite their importance, the accuracy of the quantitative interpretation of Antarctic ice core stable water isotope records remains a matter of debate. Here, the authors use an isotope-enabled atmospheric general circulation model to test and validate the isotopic paleothermometer approach. 30 August 2018 | doi: 10.1038/s41467-018-05430-y Cryospheric science  Palaeoclimate  Color-stable highly luminescent sky-blue perovskite light-emitting diodes OPEN Jun Xing, Yongbiao Zhao, Mikhail Askerka, Li Na Quan, Xiwen Gong, Weijie Zhao, Jiaxin Zhao, Hairen Tan, Guankui Long, Liang Gao, Zhenyu Yang, Oleksandr Voznyy, Jiang Tang, Zheng-Hong Lu, Qihua Xiong & Edward H. Sargent Perovskite light-emitting diodes show promising color tunability and device performance but suffer from emission color shift at higher driving voltages. Here Xing et al. report color stable blue light-emitting diodes by drastically increasing the phase purity of the quasi-2D perovskite thin films. 30 August 2018 | doi: 10.1038/s41467-018-05909-8 Inorganic LEDs  Organic LEDs  Luciferase-induced photoreductive uncaging of small-molecule effectors OPEN Eric Lindberg, Simona Angerani, Marcello Anzola & Nicolas Winssinger Bioluminescence resonance energy transfer (BRET) has been mostly employed in imaging applications. Here the authors use BRET to activate a ruthenium-based photocatalyst and perform a bioorthogonal chemical reaction, which can be used to uncage small molecule drugs in a cellular context. 30 August 2018 | doi: 10.1038/s41467-018-05916-9 Chemical biology  Photochemistry  Long-lived polarization memory in the electronic states of lead-halide perovskites from local structural dynamics OPEN Jasmine P. H. Rivett, Liang Z. Tan, Michael B. Price, Sean A. Bourelle, Nathaniel J. L. K. Davis, James Xiao, Yatao Zou, Rox Middleton, Baoquan Sun, Andrew M. Rappe, Dan Credgington & Felix Deschler Anharmonic ultrafast structural dynamics are expected in lead halide perovskites due to their soft nature. Here Rivett et al. show that these dynamics lead to picosecond-long polarization anisotropy of photo-carriers in several halide perovskites, orders of magnitude slower than in conventional semiconductors. 30 August 2018 | doi: 10.1038/s41467-018-06009-3 Condensed-matter physics  Electronic properties and materials  Semiconductors  Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin OPEN Florian Haun, Simon Neumann, Lukas Peintner, Katrin Wieland, Jüri Habicht, Carsten Schwan, Kristine Østevold, Maria Magdalena Koczorowska, Martin Biniossek, Matthias Kist, Hauke Busch, Melanie Boerries, Roger J. Davis, Ulrich Maurer, Oliver Schilling, Klaus Aktories & Christoph Borner Gliotoxin (GT), produced by the pulmonary pathogen A. fumigatus, induces detachment-induced apoptosis (anoikis) of lung epithelial cells and likely promotes invasion. Here, the authors show that GT covalently modifies integrins at the RGD binding site followed by activation of RhoA-ROCK-MKK4/7-JNK signalling leading to Bim-mediated anoikis. 30 August 2018 | doi: 10.1038/s41467-018-05850-w Apoptosis  RHO signalling  A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers OPEN Jonathan D. Mosley, QiPing Feng, Quinn S. Wells, Sara L. Van Driest, Christian M. Shaffer, Todd L. Edwards, Lisa Bastarache, Wei-Qi Wei, Lea K. Davis, Catherine A. McCarty, Will Thompson, Christopher G. Chute, Gail P. Jarvik, Adam S. Gordon, Melody R. Palmer, David R. Crosslin, Eric B. Larson, David S. Carrell, Iftikhar J. Kullo, Jennifer A. Pacheco et al. Biomarker identification requires prohibitively large cohorts with gene expression and phenotype data. The approach introduced here learns polygenic predictors of expression from genetic and expression data, used to infer biomarker levels in patients with genetic and disease information. 30 August 2018 | doi: 10.1038/s41467-018-05624-4 Biomarkers  Genetic markers  Genomics  Risk factors  Evidence of a turbulent ExB mixing avalanche mechanism of gas breakdown in strongly magnetized systems OPEN Min-Gu Yoo, Jeongwon Lee, Young-Gi Kim, Jayhyun Kim, Francesco Maviglia, Adrianus C. C. Sips, Hyun-Tae Kim, Taik Soo Hahm, Yong-Seok Hwang, Hae June Lee & Yong-Su Na Gas breakdown mechanism in plasma under the influence of complex electromagnetic field topology is still debatable. Here the authors present the evidence of the E×B mixing avalanche for gas breakdown in magnetized plasmas in fusion devices as tokamak. 30 August 2018 | doi: 10.1038/s41467-018-05839-5 Atomic and molecular collision processes  Computational science  Magnetically confined plasmas  Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors OPEN Fresia Pareja, Alissa H. Brandes, Thais Basili, Pier Selenica, Felipe C. Geyer, Dan Fan, Arnaud Da Cruz Paula, Rahul Kumar, David N. Brown, Rodrigo Gularte-Mérida, Barbara Alemar, Rui Bi, Raymond S. Lim, Ino de Bruijn, Sho Fujisawa, Rui Gardner, Elvin Feng, Anqi Li, Edaise M. da Silva, John R. Lozada et al. Granular cell tumors (GCTs) are rare tumors that arise in multiple anatomical locations. Here, the authors investigate the genomics of GCTs, finding inactivating somatic mutations in ATP6AP1 or ATP6AP2 in 72% of the 82 GCTs analyzed. In vitro manipulation of these genes recapitulated GCT phenotypes in cellular models. 30 August 2018 | doi: 10.1038/s41467-018-05886-y Genetics  Sarcoma  Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution OPEN Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu & Ikuro Abe Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity. Here the authors use evolutionary alignments of NRPS/PKS gene clusters to guide rational design of complexes that can produce novel lactones. 30 August 2018 | doi: 10.1038/s41467-018-05877-z Biocatalysis  Metabolic engineering  Multienzyme complexes  Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells OPEN Cedric S. Tremblay, Jesslyn Saw, Sung Kai Chiu, Nicholas C. Wong, Kirill Tsyganov, Sarah Ghotb, Alison N. Graham, Feng Yan, Andrew A. Guirguis, Stefan E. Sonderegger, Nicole Lee, Paul Kalitsis, John Reynolds, Stephen B. Ting, David R. Powell, Stephen M. Jane & David J. Curtis Cell cycle kinetics of pre-leukemic stem cells (pre-LSCs) may be an important determinant of clonal evolution and therapeutic resistance. Here, the AUs use a transgenic T-ALL mouse model that allows non-dividing cells to be tracked and identify a subset of non-dividing pre-LSCs maintained by p21. 30 August 2018 | doi: 10.1038/s41467-018-06021-7 Cancer  Cell biology  Stem cells  A myosin II nanomachine mimicking the striated muscle OPEN Irene Pertici, Lorenzo Bongini, Luca Melli, Giulio Bianchi, Luca Salvi, Giulia Falorsi, Caterina Squarci, Tamás Bozó, Dan Cojoc, Miklós S. Z. Kellermayer, Vincenzo Lombardi & Pasquale Bianco There is interest in mimicking striated muscle for a range of applications including nanomachines. Here, the authors report on synthetic 1D nanomachines which are used to study an ensemble of myosin motors interacting with an actin filament with potential to create assays of muscle related diseases 30 August 2018 | doi: 10.1038/s41467-018-06073-9 Biophysics  Physiology  Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function OPEN A. Laustsen, R. O. Bak, C. Krapp, L. Kjær, J. H. Egedahl, C. C. Petersen, S. Pillai, H. Q. Tang, N. Uldbjerg, M. Porteus, N. R. Roan, M. Nyegaard, P. W. Denton & M. R. Jakobsen Plasmacytoid dendritic cells (pDC) are an important regulator of immune responses. Here the authors show that pDC precursors, similar to peripheral blood-derived pDCs, can be differentiated from human CD34+ hematopoietic stem and progenitor cells, with type I/II IFN priming being required for their functional maturation and differentiation. 30 August 2018 | doi: 10.1038/s41467-018-05816-y Antigen-presenting cells  Cytokines  Innate immunity  Plasmacytoid dendritic cells  Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation OPEN Dirk Benzinger & Mustafa Khammash Natural transcription factors are often regulated in a pulsatile fashion unlike many synthetic systems. Here the authors show that dynamic pulsatile signals reduce cell-to-cell gene expression variability in an optogenetic construct. 30 August 2018 | doi: 10.1038/s41467-018-05882-2 Cellular noise  Gene expression  Optogenetics  Synthetic biology    Nature Communications JOBS of the week Tenure Track Assistant Professorship in Physiology University of Zurich (UZH) Faculty Position In Theoretical And Computational Molecular Science Dartmouth College Postdoctoral - Spatiotemporal regulation of autophagy in yeast Oslo University Hospital Research Associate / Postdoctoral position Hamburg University of Technology Research Assistant / Associate - ubiquitylation in innate immunity Newcastle University Research Software Engineer Diamond Light Source Ltd Postdoc position on CRISPR / Cas9 functional screens German Cancer Research Center (DKFZ). Postdoc German Cancer Research Center (DKFZ). More Science jobs from Nature Communications EVENT 19th International Conference on Alzheimer’s Drug Discovery 17.09.18 Jersey City, USA More science events from     Latest Correspondence       Reply to ‘Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects’ OPEN David A. Sykes, J. Robert Lane, Monika Szabo, Ben Capuano, Jonathan A. Javitch & Steven J. Charlton 03 September 2018 | doi: 10.1038/s41467-018-05678-4 Neurotransmitters  Receptor pharmacology  Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects OPEN Hugo Zeberg & Kristoffer Sahlholm 03 September 2018 | doi: 10.1038/s41467-018-04489-x Neurotransmitters  Receptor pharmacology      Latest Addendum       Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways OPEN David M. Howard , Mark J. Adams, Masoud Shirali, Toni-Kim Clarke, Riccardo E. Marioni, Gail Davies, Jonathan R. I. Coleman, Clara Alloza, Xueyi Shen, Miruna C. Barbu, Eleanor M. Wigmore, Jude Gibson, Saskia P. Hagenaars, Cathryn M. Lewis, Joey Ward, Daniel J. Smith, Patrick F. Sullivan, Chris S. Haley, Gerome Breen, Ian J. Deary et al. 30 August 2018 | doi: 10.1038/s41467-018-05310-5 Depression  Genome-wide association studies      Latest Author Correction       Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer OPEN Myoung-Hee Kang, Hyunji Choi, Masanobu Oshima, Jae-Ho Cheong, Seokho Kim, Jung Hoon Lee, Young Soo Park, Hueng-Sik Choi, Mi-Na Kweon, Chan-Gi Pack, Ju-Seog Lee, Gordon B. Mills, Seung-Jae Myung & Yun-Yong Park 31 August 2018 | doi: 10.1038/s41467-018-06061-z Gastric cancer  Transcription  Transcriptional regulatory elements      Latest Publisher Corrections       Publisher Correction: Strongly-coupled quantum critical point in an all-in-all-out antiferromagnet OPEN Yishu Wang, T. F. Rosenbaum, A. Palmer, Y. Ren, J.-W. Kim, D. Mandrus & Yejun Feng 05 September 2018 | doi: 10.1038/s41467-018-05881-3 Magnetic properties and materials  Phase transitions and critical phenomena  Publisher Correction: Electrically driven three-dimensional solitary waves as director bullets in nematic liquid crystals OPEN Bing-Xiang Li, Volodymyr Borshch, Rui-Lin Xiao, Sathyanarayana Paladugu, Taras Turiv, Sergij V. Shiyanovskii & Oleg D. Lavrentovich 30 August 2018 | doi: 10.1038/s41467-018-06028-0 Fluid dynamics  Liquid crystals      Advertisement Register for the latest nature.com webcast Tissue-based profiling for confident decisions in immuno-oncology Learn how standardizing tissue profiling in drug development and trial designs in immuno-oncology will improve decision making.  Thursday 12th September 2018 Sponsored by Definiens     Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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