Nature Biotechnology Contents: Volume 36 pp 775-904

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Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today! TABLE OF CONTENTS September 2018 Volume 36, Issue 9 Editorials News News Feature Correspondence Commentary Feature News and Views Research Careers and Recruitment Errata   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Communications Biology: Open for Submissions Communications Biology is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of biology. The journal is now open for submissions. Find out more >>   Editorials   A triumph of perseverance over interference    p775 doi:10.1038/nbt.4255 Gene-edited plants cross European event horizon    p776 doi:10.1038/nbt.4256 News   Alnylam launches era of RNAi drugs    pp777 - 778 Ken Garber doi:10.1038/nbt0918-777 Roche splashes $2.4 billion on Foundation Medicine's cancer platform    pp779 - 780 Cormac Sheridan doi:10.1038/nbt0918-779 Verily project releases millions of factory-reared mosquitoes    pp781 - 782 Judith A Gilbert & Lisa Melton doi:10.1038/nbt0918-781a Smallpox antiviral ends decades-long search    p781 doi:10.1038/nbt0918-781b In silico farming drives next wave in agriculture    pp783 - 784 Eric Smalley doi:10.1038/nbt0918-783a Sangamo poised for CAR-Treg race    p783 doi:10.1038/nbt0918-783b PODCAST: First rounders: Feng Zhang    p784 doi:10.1038/nbt0918-784 FDA approves first single-dose antimalarial    p785 Mark Ratner doi:10.1038/nbt0918-785a Around the world in a month    p785 doi:10.1038/nbt0918-785b Advertisement Meet the shortlist! The shortlist for this year's Nature Research Awards for Inspiring Science and Innovating Science has been announced. These Awards showcase exceptional achievements of leading women in science and of those who have encouraged girls and women to engage with STEM subjects. See more about our shortlisted nominees > In partnership with The Estée Lauder Companies.         Q218—public flotation jackpot    p786 Laura DeFrancesco doi:10.1038/nbt.4249 Advertisement Scientific Reports Editor's choice collection: Machine Learning in Healthcare There is great scope for machine intelligence to bolster human endeavours to improve health and wellbeing. Here is just a small selection of research published in Scientific Reports that has contributed to the rapid progress of this field in the past few years. Access the collection >>>   News Feature   Small molecules get the message    pp787 - 790 Justin Petrone & Laura DeFrancesco doi:10.1038/nbt.4241       Biocon's target factory    pp791 - 797 Thomas X Neenan, Robert E Burrier & Sunghoon Kim doi:10.1038/nbt.4242 Data Page Top 20 translational researchers of 2017    p798 Brady Huggett & Kathryn Paisner doi:10.1038/nbt.4237 Correspondence   EU court casts new plant breeding techniques into regulatory limbo    pp799 - 800 Kai P Purnhagen, Esther Kok, Gijs Kleter, Hanna Schebesta, Richard G F Visser et al. doi:10.1038/nbt.4251 A call for science-based review of the European court's decision on gene-edited crops    pp800 - 802 Fyodor D Urnov, Pamela C Ronald & Dana Carroll doi:10.1038/nbt.4252 A case of mistaken identity    pp802 - 804 Ruth E Hanna & John G Doench doi:10.1038/nbt.4208 Commentary   Brain leaks and consumer neurotechnology    pp805 - 810 Marcello Ienca, Pim Haselager & Ezekiel J Emanuel doi:10.1038/nbt.4240     Analyzing the protection scope limit for biosequence patent claims in China    pp811 - 813 Wei Li doi:10.1038/nbt.4234 Feature   Patents Recent patents in epigenetics    p814 doi:10.1038/nbt.4254 News and Views   Genomes for all    pp815 - 816 Deanna M Church doi:10.1038/nbt.4244 Live bacterial biotherapeutics in the clinic    pp816 - 818 Luis G Bermúdez-Humarán & Philippe Langella doi:10.1038/nbt.4248 Biotechnology JOBS of the week Postdoctoral Research Associate / Postdoctoral Research Fellow University of Exeter Research Associate / PhD Position in Theoretical Biophysics TU Dresden Postdoctoral Fellow / Research Scientist Icahn School of Medicine at Mount Sinai Postdoctoral fellow / Research Scientist IOR - Institute of Oncology Research - Università della Svizzera italiana Postdoctoral Intramural Research Fellowship Position National Institute of Allergy and Infectious Diseases (NIAID) National Institutes of Health (NIH) More Science jobs from Biotechnology EVENT International Colloquium on Biotechnology & Industrial Revolution 15.11.18 Dubai, UAE More science events from     Research Highlights    p819 doi:10.1038/nbt.4243     EvolvR-ing to targeted mutagenesis    p819 Saheli Sadanand doi:10.1038/nbt.4247 Research   Perspective Deep learning in biomedicine    pp829 - 838 Michael Wainberg, Daniele Merico, Andrew Delong & Brendan J Frey doi:10.1038/nbt.4233 Brendan Frey and colleagues provide a personal overview of the machine learning field and in particular deep learning. They outline the technical challenges in applying machine learning to different types of biological and biomedical data and go on to discuss the challenges in implementing these approaches in the clinical realm, in drug discovery programs and within regulatory agencies. Analysis Deep learning is combined with massive-scale citizen science to improve large-scale image classification    pp820 - 828 Devin P Sullivan, Casper F Winsnes, Lovisa Åkesson, Martin Hjelmare, Mikaela Wiking et al. doi:10.1038/nbt.4225 Pattern recognition in imaging data by >300,000 players of a global, online, commercial computer game is combined with deep learning to improve the accuracy of annotation of subcellular protein localization. Brief Communications Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice    pp839 - 842 Dan Wang, Jia Li, Chun-Qing Song, Karen Tran, Haiwei Mou et al. doi:10.1038/nbt.4219 Diseases caused by different mutations in the two alleles of a gene are treated in mice by Cas-9-induced allelic exchange. Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction    pp843 - 846 Luke W Koblan, Jordan L Doman, Christopher Wilson, Jonathan M Levy, Tristan Tay et al. doi:10.1038/nbt.4172 Optimization of cytidine and adenine base editors increases editing efficiency. Articles Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo    pp847 - 856 Sarwish Rafiq, Oladapo O Yeku, Hollie J Jackson, Terence J Purdon, Dayenne G van Leeuwen et al. doi:10.1038/nbt.4195 Anti-PD-1 secreted by CAR-T cells remains localized to the tumor and improves therapeutic outcome in mice. Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria    pp857 - 864 Vincent M Isabella, Binh N Ha, Mary Joan Castillo, David J Lubkowicz, Sarah E Rowe et al. doi:10.1038/nbt.4222 Synthetic probiotic for a human metabolic disease is taken through a drug development pathway to enable translation into clinic trials. A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells    pp865 - 874 Ben M Maoz, Anna Herland, Edward A FitzGerald, Thomas Grevesse, Charles Vidoudez et al. doi:10.1038/nbt.4226 Three linked microfluidic chips model transport across the blood–brain barrier. Letters Variation graph toolkit improves read mapping by representing genetic variation in the reference    pp875 - 879 Erik Garrison, Jouni Sirén, Adam M Novak, Glenn Hickey, Jordan M Eizenga et al. doi:10.1038/nbt.4227 Reducing read mapping bias and improving complex variant detection with a highly scalable computational toolkit that implements variation graphs. Efficient proximity labeling in living cells and organisms with TurboID    pp880 - 887 Tess C Branon, Justin A Bosch, Ariana D Sanchez, Namrata D Udeshi, Tanya Svinkina et al. doi:10.1038/nbt.4201 Protein–protein interactions in cells are rapidly identified with improved proximity labeling methods. Optimized base editors enable efficient editing in cells, organoids and mice    pp888 - 893 Maria Paz Zafra, Emma M Schatoff, Alyna Katti, Miguel Foronda, Marco Breinig et al. doi:10.1038/nbt.4194 The efficiency of base editing is substantially increased by optimizing expression and nuclear localization of the editing enzymes. Genome editing of upstream open reading frames enables translational control in plants    pp894 - 898 Huawei Zhang, Xiaomin Si, Xiang Ji, Rong Fan, Jinxing Liu et al. doi:10.1038/nbt.4202 CRISPR/Cas9 editing of upstream open reading frames (uORFs) in Arabidopsis thaliana and lettuce enables upregulation of translation of plant genes. Careers and Recruitment   Personalized postdoctoral fellowship care    pp900 - 902 Mindy Kim Graham, Ben Ho Park & Nicolas Wyhs doi:10.1038/nbt.4228 People People    p904 doi:10.1038/nbt.4253 Errata   Erratum: Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates    p899 Yen-Wen Liu, Billy Chen, Xiulan Yang, James A Fugate, Faith A Kalucki et al. doi:10.1038/nbt0918-899a Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling    p899 Maria D Giraldez, Ryan M Spengler, Alton Etheridge, Paula M Godoy, Andrea J Barczak et al. doi:10.1038/nbt0918-899b Erratum: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements    p899 Michael Kosicki, Kärt Tomberg & Allan Bradley doi:10.1038/nbt0918-899c Erratum: Strength in numbers from integrated single-cell neuroscience    p899 Rahul Satija doi:10.1038/nbt0918-899d Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. 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