The EMBO Journal Table of Contents for 01 August 2018; Vol. 37, No. 15

01 August 2018 | Volume 37, Number 15 Submit Table of Contents News & Views Review Articles Volume 37, Number 15 News & Views Growing a gasdermin pore in membranes of pyroptotic cells High‐resolution atomic force microscopy reveals the dynamic pore formation process of Gasdermin. Jingjin Ding and Feng Shao Published online 11.07.2018 A wobbly road to drug resistance in melanoma: tRNA‐modifying enzymes in translation reprogramming A new study shows that codon‐dependent translation regulation of HIF1α couples glycolytic metabolism to drug resistance in skin cancer. Mary McMahon and Davide Ruggero Published online 02.07.2018 Review Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments This review gives an operational definition of shedding as a fundamental cell biological and (patho)physiological process, and summarizes our current understanding of sheddases and their substrates, mechanisms and roles. Stefan F Lichtenthaler, Marius K Lemberg and Regina Fluhrer Published online 05.07.2018 Articles Shelterin promotes tethering of late replication origins to telomeres for replication‐timing control Timing control of late‐firing chromosome arm origins in fission yeast involves Taz1‐mediated origin tethering to the proximity of telomeres, where replication initiation is inhibited independent of subnuclear localization. Shiho Ogawa, Sayuri Kido, Tetsuya Handa, Hidesato Ogawa, Haruhiko Asakawa, Tatsuro S Takahashi, Takuro Nakagawa, Yasushi Hiraoka and Hisao Masukata Published online 11.07.2018 The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion Recruitment of cohesin acetyltransferase ESCO2 by the MCM2‐7 replication complex to chromatin is required for cohesin acetylation around replication forks to maintain centromeric cohesion. Miroslav P Ivanov, Rene Ladurner, Ina Poser, Rebecca Beveridge, Evelyn Rampler, Otto Hudecz, Maria Novatchkova, Jean‐Karim Hériché, Gordana Wutz, Petra van der Lelij, Emanuel Kreidl, James RA Hutchins, Heinz Axelsson‐Ekker, Jan Ellenberg, Anthony A Hyman, Karl Mechtler and Jan‐Michael Peters Published online 21.06.2018 MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B Transient transcriptional shutdown via ATM‐dependent chromatin regulation ensures genome integrity upon DNA breaks in the nucleolus. Dafni Eleftheria Pefani, Maria Laura Tognoli, Deniz Pirincci Ercan, Vassilis Gorgoulis and Eric O'Neill Published online 22.05.2018 Reorganization of inter‐chromosomal interactions in the 2q37‐deletion syndrome DNA‐FISH and Hi‐C reveal the formation and dynamics of inter‐chromosomal contacts in human cells and show that disease‐linked chromosome aberrations can alter the configuration of such contacts. Philipp G Maass, Anja Weise, Katharina Rittscher, Julia Lichtenwald, A Rasim Barutcu, Thomas Liehr, Atakan Aydin, Yvette Wefeld‐Neuenfeld, Laura Pölsler, Sigrid Tinschert, John L Rinn, Friedrich C Luft and Sylvia Bähring Published online 19.06.2018 RNase H2, mutated in Aicardi‐Goutières syndrome, promotes LINE‐1 retrotransposition In contrast to other Aicardi‐Goutières associated proteins that act to restrict LINE‐1 retrotranspostion, RNase H2 activity facilitates LINE‐1 mobilisation. Maria Benitez‐Guijarro, Cesar Lopez‐Ruiz, Žygimantė Tarnauskaitė, Olga Murina, Mahwish Mian Mohammad, Thomas C Williams, Adeline Fluteau, Laura Sanchez, Raquel Vilar‐Astasio, Marta Garcia‐Canadas, David Cano, Marie‐Jeanne HC Kempen, Antonio Sanchez‐Pozo, Sara R Heras, Andrew P Jackson, Martin AM Reijns and Jose L Garcia‐Perez Published online 29.06.2018 Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE‐1 repression The transcription factor Engrailed protects mesencephalic dopaminergic neurons by repressing the expression of the retrotransposon element LINE‐1. François‐Xavier Blaudin de Thé, Hocine Rekaik, Eugenie Peze‐Heidsieck, Olivia Massiani‐Beaudoin, Rajiv L Joshi, Julia Fuchs and Alain Prochiantz Published online 25.06.2018 Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission Live‐cell immunolabeling and metabolic imaging of cultured neurons shows that synaptic vesicles remain in use for about 24 h and become fusion‐incompetent only after some 200 rounds of exo‐ and endocytosis. Sven Truckenbrodt, Abhiyan Viplav, Sebastian Jähne, Angela Vogts, Annette Denker, Hanna Wildhagen, Eugenio F Fornasiero and Silvio O Rizzoli Published online 27.06.2018 Cilia‐localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney A kidney‐specific inactivation of metabolic sensor LKB1 complex reveals a functional crosstalk between primary cilia signaling and aberrant immune cell activation in vivo. Amandine Viau, Frank Bienaimé, Kamile Lukas, Abhijeet P Todkar, Manuel Knoll, Toma A Yakulov, Alexis Hofherr, Oliver Kretz, Martin Helmstädter, Wilfried Reichardt, Simone Braeg, Tom Aschman, Annette Merkle, Dietmar Pfeifer, Verónica I Dumit, Marie‐Claire Gubler, Roland Nitschke, Tobias B Huber, Fabiola Terzi, Jörn Dengjel, Florian Grahammer, Michael Köttgen, Hauke Busch, Melanie Boerries, Gerd Walz, Antigoni Triantafyllopoulou and E Wolfgang Kuehn Published online 19.06.2018 Feeding state regulates pheromone‐mediated avoidance behavior via the insulin signaling pathway in Caenorhabditis elegans Starvation increases ascr#3 pheromone avoidance as a result of communication between ascr#3 sensory neurons and intestinal cells. Leesun Ryu, YongJin Cheon, Yang Hoon Huh, Seondong Pyo, Satya Chinta, Hongsoo Choi, Rebecca A Butcher and Kyuhyung Kim Published online 19.06.2018 Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles Melanoma cell subclones adopt increased migratory behavior in vivo by extracellular vesicle uptake, amplifying signaling nodes involved in cell motility. Sander C Steenbeek, Thang V Pham, Joep de Ligt, Anoek Zomer, Jaco C Knol, Sander R Piersma, Tim Schelfhorst, Rick Huisjes, Raymond M Schiffelers, Edwin Cuppen, Connie R Jimenez and Jacco van Rheenen Published online 14.06.2018 Zeb1 potentiates genome‐wide gene transcription with Lef1 to promote glioblastoma cell invasion Genome‐wide binding reveals that the EMT‐inducer Zeb1, best‐known as a transcriptional repressor, can team up with a transcriptional activator to indirectly enhance gene expression. Pedro Rosmaninho, Susanne Mükusch, Valerio Piscopo, Vera Teixeira, Alexandre ASF Raposo, Rolf Warta, Romina Bennewitz, Yeman Tang, Christel Herold‐Mende, Stefano Stifani, Stefan Momma and Diogo S Castro Published online 14.06.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.