| | Advertisement | | | | | | | | | Advertisement | | nature.com webcasts Nature Research Custom presents a webcast on: Molecular imaging reveals ONC201 antitumor efficacy and immune stimulation in cancer models Date: Wednesday, August 15, 2018 Join our live webcast to learn about the benefits of cell culture, xenograft tissue sections and mouse models coupled with imaging in preclinical immuno-oncology trials. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content Register for FREE Sponsored by: Perkin Elmer | | | | | | | | Latest Perspectives | | | | A framework for enhancing ethical genomic research with Indigenous communities OPEN | | Katrina G. Claw, Matthew Z. Anderson, Rene L. Begay, Krystal S. Tsosie, Keolu Fox, Nanibaa’ A. Garrison, Alyssa C. Bader, Jessica Bardill, Deborah A. Bolnick, Jada Brooks, Anna Cordova, Ripan S. Malhi, Nathan Nakatsuka, Angela Neller, Jennifer A. Raff, Jamie Singson, Kim TallBear, Tada Vargas & Joseph M. Yracheta | | Indigenous peoples are still underrepresented in genetic research. Here, the authors propose an ethical framework consisting of six major principles that encourages researchers and Indigenous communities to build strong and equal partnerships to increase trust, engagement and diversity in genomic studies. | | 27 July 2018 | doi: 10.1038/s41467-018-05188-3 | | Ethics Genetics research Medical genomics Policy | | | | | Latest Articles | View all Articles | | | Linked dimensions of psychopathology and connectivity in functional brain networks OPEN | | Cedric Huchuan Xia, Zongming Ma, Rastko Ciric, Shi Gu, Richard F. Betzel, Antonia N. Kaczkurkin, Monica E. Calkins, Philip A. Cook, Angel García de la Garza, Simon N. Vandekar, Zaixu Cui, Tyler M. Moore, David R. Roalf, Kosha Ruparel, Daniel H. Wolf, Christos Davatzikos, Ruben C. Gur, Raquel E. Gur, Russell T. Shinohara, Danielle S. Bassett et al. | | | Co-morbidity and symptom overlap make it difficult to associate psychiatric disorders with unique neural signatures. Here, the authors use a data-driven approach to show that the symptom dimensions of mood, psychosis, fear and externalizing behavior exhibit unique patterns of functional dysconnectivity. | | 01 August 2018 | doi: 10.1038/s41467-018-05317-y | | Computational neuroscience Network models Psychiatric disorders | Transient marine euxinia at the end of the terminal Cryogenian glaciation OPEN | | Xianguo Lang, Bing Shen, Yongbo Peng, Shuhai Xiao, Chuanming Zhou, Huiming Bao, Alan Jay Kaufman, Kangjun Huang, Peter W. Crockford, Yonggang Liu, Wenbo Tang & Haoran Ma | | | The termination of the Marinoan snowball Earth event marks one of the most drastic transitions in Earth history, but the oceanic response remains unclear. Here, the authors’ integrated analysis demonstrates that the ocean experienced transient but widespread euxinia following this Snowball Earth event. | | 01 August 2018 | doi: 10.1038/s41467-018-05423-x | | Geochemistry Marine chemistry Planetary science | Transmissive silicon photonic dichroic filters with spectrally selective waveguides OPEN | | Emir Salih Magden, Nanxi Li, Manan Raval, Christopher V. Poulton, Alfonso Ruocco, Neetesh Singh, Diedrik Vermeulen, Erich P. Ippen, Leslie A. Kolodziejski & Michael R. Watts | | | Optical filters are an integral part of many optical devices and circuits. Here, Magden et al. use a design based on mode evolution to demonstrate CMOS-compatible dichroic filters with more than an octave bandwidth, sharp roll-off and transmissive short- and long-wavelength outputs | | 01 August 2018 | doi: 10.1038/s41467-018-05287-1 | | Integrated optics Silicon photonics | Distinct multiple fermionic states in a single topological metal OPEN | | M. Mofazzel Hosen, Klauss Dimitri, Ashis K. Nandy, Alex Aperis, Raman Sankar, Gyanendra Dhakal, Pablo Maldonado, Firoza Kabir, Christopher Sims, Fangcheng Chou, Dariusz Kaczorowski, Tomasz Durakiewicz, Peter M. Oppeneer & Madhab Neupane | | | The existence of multiple topological phases in a single material, although theoretically possible, has not been verified. Here, the authors observe weak topological insulator surface states and a one-dimensional Dirac-node crossing surface state in a single metallic material Hf2Te2P. | | 01 August 2018 | doi: 10.1038/s41467-018-05233-1 | | Electronic properties and materials Topological insulators | Plk1 overexpression induces chromosomal instability and suppresses tumor development OPEN | | Guillermo de Cárcer, Sharavan Vishaan Venkateswaran, Lorena Salgueiro, Aicha El Bakkali, Kalman Somogyi, Konstantina Rowald, Pablo Montañés, Manuel Sanclemente, Beatriz Escobar, Alba de Martino, Nicholas McGranahan, Marcos Malumbres & Rocío Sotillo | | | PLK1 is a mitotic regulator overexpressed in cancer; however, whether this overexpression causally contributes to tumor development is unclear. Here the authors produce an inducible mouse model to overexpress PLK1 and show that actually this can act as a tumor suppressor by perturbing mitotic progression and cytokinesis. | | 01 August 2018 | doi: 10.1038/s41467-018-05429-5 | | Cancer Cell biology | Block copolymer crystalsomes with an ultrathin shell to extend blood circulation time OPEN | | Hao Qi, Hao Zhou, Qiyun Tang, Jee Young Lee, Zhiyuan Fan, Seyong Kim, Mark C. Staub, Tian Zhou, Shan Mei, Lin Han, Darrin J. Pochan, Hao Cheng, Wenbing Hu & Christopher Y. Li | | | In block copolymer vesicles, crystallization often leads to defects and renders the structures leaky that undermines their potential biomedical application. Here the authors use an emulsion solution method to control the crystallization of an amphiphilic block copolymer at the curved liquid/liquid interface to improve the blood circulation time. | | 01 August 2018 | doi: 10.1038/s41467-018-05396-x | | Nanoscale materials Polymers Soft materials | SUMO-mediated regulation of NLRP3 modulates inflammasome activity OPEN | | Rachael Barry, Sidonie Wicky John, Gianmaria Liccardi, Tencho Tenev, Isabel Jaco, Chih-Hong Chen, Justin Choi, Paulina Kasperkiewicz, Teresa Fernandes-Alnemri, Emad Alnemri, Marcin Drag, Yuan Chen & Pascal Meier | | | The NLRP3 inflammasome is an important component of inflammatory responses, but how it is negatively regulated is still unclear. Here the authors show that post-translational modification of NLRP3 by sumoylation suppresses inflammasome activity, and that desumoylation of NLRP3 by the SENP6 and SENP7 proteases promotes NLRP3 activation. | | 01 August 2018 | doi: 10.1038/s41467-018-05321-2 | | Cell death Inflammation Post-translational modifications Sumoylated proteins | Unravelling the age of fine roots of temperate and boreal forests OPEN | | Emily F. Solly, Ivano Brunner, Heljä-Sisko Helmisaari, Claude Herzog, Jaana Leppälammi-Kujansuu, Ingo Schöning, Marion Schrumpf, Fritz H. Schweingruber, Susan E. Trumbore & Frank Hagedorn | | | Fine-root lifetimes and carbon inputs from roots into soil impact carbon cycle-climate feedbacks yet remain poorly constrained. Here, using annual-growth rings and radiocarbon dating, the authors show that the chronological age of fine roots is substantially younger than that of the carbon used for their growth. | | 01 August 2018 | doi: 10.1038/s41467-018-05460-6 | | Biogeochemistry Environmental sciences | 99TcO4− remediation by a cationic polymeric network OPEN | | Jie Li, Xing Dai, Lin Zhu, Chao Xu, Duo Zhang, Mark A. Silver, Peng Li, Lanhua Chen, Yongzhong Li, Douwen Zuo, Hui Zhang, Chengliang Xiao, Jing Chen, Juan Diwu, Omar K. Farha, Thomas E. Albrecht-Schmitt, Zhifang Chai & Shuao Wang | | | Direct removal of 99TcO4− from highly radioactive and acidic nuclear waste solutions is beneficial for uranium and plutonium recovery and radioactive pollution control but this represents a huge challenge. Here the authors show a cationic polymeric network with high 99TcO4− sorption capability and stability. | | 01 August 2018 | doi: 10.1038/s41467-018-05380-5 | | Coordination polymers Pollution remediation | Spin-induced multiferroicity in the binary perovskite manganite Mn2O3 OPEN | | Junzhuang Cong, Kun Zhai, Yisheng Chai, Dashan Shang, Dmitry D. Khalyavin, Roger D. Johnson, Denis P. Kozlenko, Sergey E. Kichanov, Artem M. Abakumov, Alexander A. Tsirlin, Leonid Dubrovinsky, Xueli Xu, Zhigao Sheng, Sergey V. Ovsyannikov & Young Sun | | | Multiferroic binary oxides with the perovskite structure have been very rare. Here, Cong et al. report magnetically-driven ferroelectricity and a large magnetoelectric effect in a binary perovskite compound Mn2O3 at low temperatures. | | 31 July 2018 | doi: 10.1038/s41467-018-05296-0 | | Ferroelectrics and multiferroics Magnetic properties and materials | Biodiversity across trophic levels drives multifunctionality in highly diverse forests OPEN | | Andreas Schuldt, Thorsten Assmann, Matteo Brezzi, François Buscot, David Eichenberg, Jessica Gutknecht, Werner Härdtle, Jin-Sheng He, Alexandra-Maria Klein, Peter Kühn, Xiaojuan Liu, Keping Ma, Pascal A. Niklaus, Katherina A. Pietsch, Witoon Purahong, Michael Scherer-Lorenzen, Bernhard Schmid, Thomas Scholten, Michael Staab, Zhiyao Tang et al. | | | Biodiversity change can impact ecosystem functioning, though this is primarily studied at lower trophic levels. Here, Schuldt et al. find that biodiversity components other than tree species richness are particularly important, and higher trophic level diversity plays a role in multifunctionality. | | 31 July 2018 | doi: 10.1038/s41467-018-05421-z | | Biodiversity Ecology Ecosystem services Forest ecology Tropical ecology | Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity OPEN | | Yuan Liu, Pratap C. Naha, Geelsu Hwang, Dongyeop Kim, Yue Huang, Aurea Simon-Soro, Hoi-In Jung, Zhi Ren, Yong Li, Sarah Gubara, Faizan Alawi, Domenick Zero, Anderson T. Hara, David P. Cormode & Hyun Koo | | | Ferumoxytol is a nanoparticle formulation approved for systemic use to treat iron deficiency. Liu et al. show that topical use of ferumoxytol, in combination with low concentrations of H2O2, disrupts intractable oral biofilms and prevents tooth decay in vitro and in an animal model. | | 31 July 2018 | doi: 10.1038/s41467-018-05342-x | | Biofilms Biomaterials Biomedical materials Dental caries Diseases | Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells OPEN | | Erika López-Arribillaga, Verónica Rodilla, Carlota Colomer, Anna Vert, Amy Shelton, Jason H. Cheng, Bing Yan, Abel Gonzalez-Perez, Melissa R. Junttila, Mar Iglesias, Ferran Torres, Joan Albanell, Alberto Villanueva, Anna Bigas, Christian W. Siebel & LLuís Espinosa | | | In intestinal adenomas carrying active β-catenin, Jagged1 (Jag1) ligand is responsible for Notch1 activation. Here, the authors show the reliance of Notch on Jag1 in cancer, and investigate how Jag1–Notch1 signaling interference may provide therapeutic benefits in some colorectal cancer patients | | 31 July 2018 | doi: 10.1038/s41467-018-05385-0 | | Cancer Gastroenterology | Operando and three-dimensional visualization of anion depletion and lithium growth by stimulated Raman scattering microscopy OPEN | | Qian Cheng, Lu Wei, Zhe Liu, Nan Ni, Zhe Sang, Bin Zhu, Weiheng Xu, Meijie Chen, Yupeng Miao, Long-Qing Chen, Wei Min & Yuan Yang | | | The relationship between Li-ion concentration and Li deposition remains an issue to be addressed. Here the authors show that stimulated Raman scattering microscopy offers insight into the concentration evolution and its impact on the dendrite growth, which is not possible by existing techniques. | | 30 July 2018 | doi: 10.1038/s41467-018-05289-z | | Batteries Raman spectroscopy | The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion OPEN | | Marco Padilla-Rodriguez, Sara S. Parker, Deanna G. Adams, Thomas Westerling, Julieann I. Puleo, Adam W. Watson, Samantha M. Hill, Muhammad Noon, Raphael Gaudin, Jesse Aaron, Daoqin Tong, Denise J. Roe, Beatrice Knudsen & Ghassan Mouneimne | | | Whilst estrogen is known to be tumorigenic in some breast cancer, in some contexts it can be protective against invasion and dissemination. Here, the authors show estrogen can promote generation of Suppressive Cortical Actin Bundles that can inhibit motility dynamics through EVL-mediated actin cytoskeletal remodeling. | | 30 July 2018 | doi: 10.1038/s41467-018-05367-2 | | Breast cancer Cell invasion | Transforming ground mica into high-performance biomimetic polymeric mica film OPEN | | Xiao-Feng Pan, Huai-Ling Gao, Yang Lu, Chun-Yan Wu, Ya-Dong Wu, Xiang-Ying Wang, Zhi-Qiang Pan, Liang Dong, Yong-Hong Song, Huai-Ping Cong & Shu-Hong Yu | | | Biomimetic assembly of nanosheets into nacre-like structures and films is of interest for a range of applications; the abundance of mica makes it a good candidate. Here, the authors report on the large-scale exfoliation of ground mica into nanosheets and the assembly into polymeric mica films. | | 30 July 2018 | doi: 10.1038/s41467-018-05355-6 | | Composites Electronic devices Nanoscale materials | Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer’s disease OPEN | | Qing Yu, Yongfu Wang, Fang Du, Shijun Yan, Gang Hu, Nicola Origlia, Grazia Rutigliano, Qinru Sun, Haiyang Yu, James Ainge, Shi Fang Yan, Frank Gunn-Moore & Shirley ShiDu Yan | | | Endophilin A1 protein is known to be elevated in Alzheimer’s disease (AD). Here the authors show that endophilin A1 overexpression exacerbates synaptic deficits in a mouse model of AD. | | 30 July 2018 | doi: 10.1038/s41467-018-04389-0 | | Alzheimer's disease Long-term potentiation | Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics OPEN | | Xiaodun Li, Hayley E. Francies, Maria Secrier, Juliane Perner, Ahmad Miremadi, Núria Galeano-Dalmau, William J. Barendt, Laura Letchford, Genevieve M. Leyden, Emma K. Goffin, Andrew Barthorpe, Howard Lightfoot, Elisabeth Chen, James Gilbert, Ayesha Noorani, Ginny Devonshire, Lawrence Bower, Amber Grantham, Shona MacRae, Nicola Grehan et al. | | | Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate and lacks robust preclinical models for use in research. Here, the authors show that newly derived organoids recapitulate the transcriptomic, genetic, and morphological landscape of the primary EAC tumors and provide a platform to test drug sensitivity and study tumor clonality. | | 30 July 2018 | doi: 10.1038/s41467-018-05190-9 | | Cancer genetics Cancer models | Evolution of cooperativity in the spin transition of an iron(II) complex on a graphite surface OPEN | | Lalminthang Kipgen, Matthias Bernien, Sascha Ossinger, Fabian Nickel, Andrew J. Britton, Lucas M. Arruda, Holger Naggert, Chen Luo, Christian Lotze, Hanjo Ryll, Florin Radu, Enrico Schierle, Eugen Weschke, Felix Tuczek & Wolfgang Kuch | | | Spin-crossover molecules offer a potential route towards molecular spintronics, but retaining the bistability of the spin state upon surface deposition is challenging. Here, the authors study the spin-crossover behaviours of an Fe(II) complex deposited on graphite, determining the scale limit at which cooperative spin switching becomes effective. | | 30 July 2018 | doi: 10.1038/s41467-018-05399-8 | | Magnetic materials Magnetic properties and materials Molecular electronics Molecular self-assembly | Stabilization of three-dimensional charge order in YBa2Cu3O6+x via epitaxial growth OPEN | | M. Bluschke, A. Frano, E. Schierle, D. Putzky, F. Ghorbani, R. Ortiz, H. Suzuki, G. Christiani, G. Logvenov, E. Weschke, R. J. Birgeneau, E. H. da Silva Neto, M. Minola, S. Blanco-Canosa & B. Keimer | | | In many cuprates the high temperature superconducting state competes with a charge ordered phase that has been difficult to investigate in detail. Here the authors show three-dimensional charge order can be stabilized in YBCO films and studied without using the high magnetic fields that are necessary in the bulk material. | | 30 July 2018 | doi: 10.1038/s41467-018-05434-8 | | Superconducting properties and materials Surfaces, interfaces and thin films | Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function OPEN | | Annah B. Wyss, Tamar Sofer, Mi Kyeong Lee, Natalie Terzikhan, Jennifer N. Nguyen, Lies Lahousse, Jeanne C. Latourelle, Albert Vernon Smith, Traci M. Bartz, Mary F. Feitosa, Wei Gao, Tarunveer S. Ahluwalia, Wenbo Tang, Christopher Oldmeadow, Qing Duan, Kim de Jong, Mary K. Wojczynski, Xin-Qun Wang, Raymond Noordam, Fernando Pires Hartwig et al. | | | Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for European, African, Asian, or Hispanic/Latino ancestry. | | 30 July 2018 | doi: 10.1038/s41467-018-05369-0 | | Epidemiology Genetics research Genome-wide association studies Respiratory tract diseases | A user-friendly herbicide derived from photo-responsive supramolecular vesicles OPEN | | Cheng Gao, Qiaoxian Huang, Qingping Lan, Yu Feng, Fan Tang, Maggie P. M. Hoi, Jianxiang Zhang, Simon M. Y. Lee & Ruibing Wang | | | Paraquat is a widely used herbicide that is highly toxic to humans upon acute ingestion or chronic exposure. Here, the authors generate a photosensitive formulation that releases paraquat upon exposure to UV light or sunlight, which shows an improved safety profile in zebrafish and mouse models, while maintaining substantial herbicidal activity. | | 27 July 2018 | doi: 10.1038/s41467-018-05437-5 | | Agriculture Nanoscale materials Supramolecular chemistry | Scutoids are a geometrical solution to three-dimensional packing of epithelia OPEN | | Pedro Gómez-Gálvez, Pablo Vicente-Munuera, Antonio Tagua, Cristina Forja, Ana M. Castro, Marta Letrán, Andrea Valencia-Expósito, Clara Grima, Marina Bermúdez-Gallardo, Óscar Serrano-Pérez-Higueras, Florencia Cavodeassi, Sol Sotillos, María D. Martín-Bermudo, Alberto Márquez, Javier Buceta & Luis M. Escudero | | | Cell arrangement in the plane of epithelia is well studied, but its three-dimensional packing is largely unknown. Here the authors model curved epithelia and predict that cells adopt a geometrical shape they call “scutoid”, resulting in different apical and basal neighbours, and confirm the presence of scutoids in curved tissues. | | 27 July 2018 | doi: 10.1038/s41467-018-05376-1 | | Computational models Morphogenesis | Persistent CO2 emissions and hydrothermal unrest following the 2015 earthquake in Nepal OPEN | | Frédéric Girault, Lok Bijaya Adhikari, Christian France-Lanord, Pierre Agrinier, Bharat P. Koirala, Mukunda Bhattarai, Sudhan S. Mahat, Chiara Groppo, Franco Rolfo, Laurent Bollinger & Frédéric Perrier | | | Earthquakes rarely affect hydrothermal systems in non-magmatic context. Here the authors report outbursts of CO2 and hydrothermal disturbances triggered by the 2015 Nepal earthquake, revealing high sensitivity of Himalayan hydrothermal systems to co-, post- and possibly pre- seismic deformation. | | 27 July 2018 | doi: 10.1038/s41467-018-05138-z | | Hydrology Natural hazards Solid Earth sciences | Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes OPEN | | Angli Xue, Yang Wu, Zhihong Zhu, Futao Zhang, Kathryn E. Kemper, Zhili Zheng, Loic Yengo, Luke R. Lloyd-Jones, Julia Sidorenko, Yeda Wu, Mawussé Agbessi, Habibul Ahsan, Isabel Alves, Anand Andiappan, Philip Awadalla, Alexis Battle, Frank Beutner, Marc Jan Bonder, Dorret Boomsma, Mark Christiansen et al. | | | GWAS have so far identified 129 loci associated with type 2 diabetes (T2D). Here, the authors meta-analyse three large T2D GWA studies which uncovers 42 additional loci, further prioritize 33 functional genes using eQTL and mQTL data and propose regulatory mechanisms for three putative T2D genes. | | 27 July 2018 | doi: 10.1038/s41467-018-04951-w | | Gene regulation Genome-wide association studies Quantitative trait loci Type 2 diabetes | Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis OPEN | | Mariana Pavel, Maurizio Renna, So Jung Park, Fiona M. Menzies, Thomas Ricketts, Jens Füllgrabe, Avraham Ashkenazi, Rebecca A. Frake, Alejandro Carnicer Lombarte, Carla F. Bento, Kristian Franze & David C. Rubinsztein | | | At high cell density or when plated on soft matrix, YAP/TAZ are redistributed from the nucleus to the cytosol, becoming transcriptionally inactive. Here the authors show that at high cell density, autophagosome formation is impaired due to reduced YAP/TAZ-dependent transcription of actomyosin genes | | 27 July 2018 | doi: 10.1038/s41467-018-05388-x | | Cell proliferation Cell signalling Macroautophagy | Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis OPEN | | Tamara Muliaditan, Jonathan Caron, Mary Okesola, James W. Opzoomer, Paris Kosti, Mirella Georgouli, Peter Gordon, Sharanpreet Lall, Desislava M. Kuzeva, Luisa Pedro, Jacqueline D. Shields, Cheryl E. Gillett, Sandra S. Diebold, Victoria Sanz-Moreno, Tony Ng, Esther Hoste & James N. Arnold | | | The relationship between wound healing and cancer is intricate and complex. Here, the authors show that in breast cancer models an IL-6 driven co-expression of FAP and HO-1 in tumour-associated macrophages, similar to the wound healing response, facilitates migration and metastatic spread. | | 27 July 2018 | doi: 10.1038/s41467-018-05346-7 | | Cancer Cancer microenvironment Metastasis | Real-space imaging with pattern recognition of a ligand-protected Ag374 nanocluster at sub-molecular resolution OPEN | | Qin Zhou, Sami Kaappa, Sami Malola, Hui Lu, Dawei Guan, Yajuan Li, Haochen Wang, Zhaoxiong Xie, Zhibo Ma, Hannu Häkkinen, Nanfeng Zheng, Xueming Yang & Lansun Zheng | | | Translating high-resolution imaging methods to the curved organic surface of a nanoparticle has been challenging. Here, the authors are able to spatially resolve the sub-molecular surface details of a silver nanocluster by comparing scanning tunneling microscopy images and simulated topography data through a pattern recognition algorithm. | | 27 July 2018 | doi: 10.1038/s41467-018-05372-5 | | Electronic structure Nanoparticles Scanning probe microscopy | Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production OPEN | | Poorya Amini, Darko Stojkov, Andrea Felser, Christopher B. Jackson, Carolina Courage, André Schaller, Laurent Gelman, Maria Eugenia Soriano, Jean-Marc Nuoffer, Luca Scorrano, Charaf Benarafa, Shida Yousefi & Hans-Uwe Simon | | | Optic atrophy 1 (OPA1) is known to be important for mitochondrial fusion and structural integrity. Here, using OPA1 knockout mice, the authors show a detrimental effect on host defense capabilities against pathogen infections. This study reports a critical role for OPA1 in innate immunity. | | 27 July 2018 | doi: 10.1038/s41467-018-05387-y | | Cell biology Innate immunity | Lighting up silicon nanoparticles with Mie resonances OPEN | | Chengyun Zhang, Yi Xu, Jin Liu, Juntao Li, Jin Xiang, Hui Li, Jinxiang Li, Qiaofeng Dai, Sheng Lan & Andrey E. Miroshnichenko | | | As an indirect semiconductor, silicon shows notoriously inefficient luminescence. Here, the authors utilize the Mie resonances in silicon nanoparticles to demonstrate visible white-light emission, both from free-standing spheres and particles etched on a silicon-on-insulator substrate. | | 27 July 2018 | doi: 10.1038/s41467-018-05394-z | | Nonlinear optics Silicon photonics Supercontinuum generation | A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma OPEN | | Xiaoyue Chen, Minjie Zhang, Haiyun Gan, Heping Wang, Jeong-Heon Lee, Dong Fang, Gaspar J. Kitange, Lihong He, Zeng Hu, Ian F. Parney, Fredric B. Meyer, Caterina Giannini, Jann N. Sarkaria & Zhiguo Zhang | | | Temozolomide (TMZ) resistance in glioblastomas (GBM) is associated with increased MGMT expression. Here, the authors identify an enhancer between the promoters of MKI67 and MGMT, that when activated drives MGMT expression despite MGMT promoter methylation to confer TMZ resistance in GBM. | | 27 July 2018 | doi: 10.1038/s41467-018-05373-4 | | Biochemistry CNS cancer | Two-dimensional multibit optoelectronic memory with broadband spectrum distinction OPEN | | Du Xiang, Tao Liu, Jilian Xu, Jun Y. Tan, Zehua Hu, Bo Lei, Yue Zheng, Jing Wu, A. H. Castro Neto, Lei Liu & Wei Chen | | | Continued device miniaturization and feasibility of integrating two-dimensional materials into circuits have enabled flexible and transparent optoelectronic memories. Here, the authors show a WSe2–hBN-based heterostructure memory with switching ratio of ~1.1 × 106, ensuring over 128 distinct storage states and retention time of ~4.5 × 104 s. | | 27 July 2018 | doi: 10.1038/s41467-018-05397-w | | Electronic devices Information storage Optical data storage Two-dimensional materials | A facile strategy for realizing room temperature phosphorescence and single molecule white light emission OPEN | | Jianguo Wang, Xinggui Gu, Huili Ma, Qian Peng, Xiaobo Huang, Xiaoyan Zheng, Simon H. P. Sung, Guogang Shan, Jacky W. Y. Lam, Zhigang Shuai & Ben Zhong Tang | | | The demonstration of pure organic room temperature phosphorescence (RTP) luminogens with complementary emission is a key requirement for developing low-cost white light emitters. Here, the authors construct RTP-active organic salt compounds by exchanging the counterion with a heavy halide ion. | | 27 July 2018 | doi: 10.1038/s41467-018-05298-y | | Chemical physics Optical materials | Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation OPEN | | Eva Maria Wenzel, Sebastian Wolfgang Schultz, Kay Oliver Schink, Nina Marie Pedersen, Viola Nähse, Andreas Carlson, Andreas Brech, Harald Stenmark & Camilla Raiborg | | | Intraluminal vesicles are formed by the endosomal sorting complex required for transport (ESCRT) machinery. Here, the authors unravel the timing of vesicle budding, and that endosomal clathrin regulates concerted recruitment of ESCRT subcomplexes, required for efficient membrane remodeling. | | 26 July 2018 | doi: 10.1038/s41467-018-05345-8 | | Cellular imaging ESCRT | Bottom-up growth of n-type monolayer molecular crystals on polymeric substrate for optoelectronic device applications OPEN | | Yanjun Shi, Lang Jiang, Jie Liu, Zeyi Tu, Yuanyuan Hu, Qinghe Wu, Yuanping Yi, Eliot Gann, Christopher R. McNeill, Hongxiang Li, Wenping Hu, Daoben Zhu & Henning Sirringhaus | | | New methods for obtaining large-area monolayer molecular crystals (MMCs) on hydrophobic surfaces are needed to realize the full potential of MMCs for organic electronics. Here, the authors demonstrate bottom-up growth of high-grade n-type MMCs, which show superior performance in device applications. | | 26 July 2018 | doi: 10.1038/s41467-018-05390-3 | | Electronic devices | FABP4 as a key determinant of metastatic potential of ovarian cancer OPEN | | Kshipra M. Gharpure, Sunila Pradeep, Marta Sans, Rajesha Rupaimoole, Cristina Ivan, Sherry Y. Wu, Emine Bayraktar, Archana S. Nagaraja, Lingegowda S. Mangala, Xinna Zhang, Monika Haemmerle, Wei Hu, Cristian Rodriguez-Aguayo, Michael McGuire, Celia Sze Ling Mak, Xiuhui Chen, Michelle A. Tran, Alejandro Villar-Prados, Guillermo Armaiz Pena, Ragini Kondetimmanahalli et al. | | | In ovarian cancer, metastatic phenotype may impact surgical outcomes. Here, the authors show miR-409-3p regulates FABP4 which can increase metastatic potential of ovarian cancer, and treatment with DOPC nanoliposomes containing either miR-409--3p mimic or FABP4 siRNA inhibits tumor progression in mice. | | 26 July 2018 | doi: 10.1038/s41467-018-04987-y | | Cancer therapy Metastasis Ovarian cancer | Glucose promotes cell growth by suppressing branched-chain amino acid degradation OPEN | | Dan Shao, Outi Villet, Zhen Zhang, Sung Won Choi, Jie Yan, Julia Ritterhoff, Haiwei Gu, Danijel Djukovic, Danos Christodoulou, Stephen C. Kolwicz Jr, Daniel Raftery & Rong Tian | | | Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids, which is required for the activation of pro-growth mTOR signaling. | | 26 July 2018 | doi: 10.1038/s41467-018-05362-7 | | Cardiac hypertrophy Metabolism TOR signalling | High sensitivity organic inorganic hybrid X-ray detectors with direct transduction and broadband response OPEN | | H. M. Thirimanne, K. D. G. I. Jayawardena, A. J. Parnell, R. M. I. Bandara, A. Karalasingam, S. Pani, J. E. Huerdler, D. G. Lidzey, S. F. Tedde, A. Nisbet, C. A. Mills & S. R. P. Silva | | | X-ray detectors based on low-cost organic semiconductors have inherently low detector sensitivity due to poor X-ray to charge conversion and charge collection. Here, the authors demonstrate a flexible, high-sensitivity X-ray detector based on an organic bulk heterojunction-nanoparticle composite. | | 26 July 2018 | doi: 10.1038/s41467-018-05301-6 | | Nanoparticles Organic–inorganic nanostructures | Mechanical mismatch-driven rippling in carbon-coated silicon sheets for stress-resilient battery anodes OPEN | | Jaegeon Ryu, Tianwu Chen, Taesoo Bok, Gyujin Song, Jiyoung Ma, Chihyun Hwang, Langli Luo, Hyun-Kon Song, Jaephil Cho, Chongmin Wang, Sulin Zhang & Soojin Park | | | Maintaining the structural stability during electrochemical cycling remains a big challenge facing the silicon anode material. Here, the authors have developed 2D silicon nanosheets coated with carbon layers, which show a unique mechanism in releasing internal stress by forming ripple structures. | | 26 July 2018 | doi: 10.1038/s41467-018-05398-9 | | Energy science and technology Materials science | Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1 OPEN | | Axel Weber, Sigrid C. Schwarz, Jörg Tost, Dietrich Trümbach, Pia Winter, Florence Busato, Pawel Tacik, Anita C. Windhorst, Maud Fagny, Thomas Arzberger, Catriona McLean, John C. van Swieten, Johannes Schwarz, Daniela Vogt Weisenhorn, Wolfgang Wurst, Till Adhikary, Dennis W. Dickson, Günter U. Höglinger & Ulrich Müller | | | Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by aggregation of Tau, encoded by MAPT. Here, the authors perform an EWAS for PSP in prefrontal lobe tissue and find hypermethylation of DLX1 and its antisense transcript DLX1AS to associate with MAPT expression. | | 26 July 2018 | doi: 10.1038/s41467-018-05325-y | | DNA methylation Epigenetics in the nervous system Epigenomics Neurodegenerative diseases | Digital acoustofluidics enables contactless and programmable liquid handling OPEN | | Steven Peiran Zhang, James Lata, Chuyi Chen, John Mai, Feng Guo, Zhenhua Tian, Liqiang Ren, Zhangming Mao, Po-Hsun Huang, Peng Li, Shujie Yang & Tony Jun Huang | | | Contamination is an obstacle to the functioning of microfluidic devices. Here the authors exploit acoustic streaming to manipulate droplets which float on a layer of immiscible oil. This prevents contamination and enables rewritability by which different fluids can be used on the same substrate. | | 26 July 2018 | doi: 10.1038/s41467-018-05297-z | | Acoustics Fluid dynamics Lab-on-a-chip | | | | | | | | | Latest Author Corrections | | | | Author Correction: TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons OPEN | | Layal Maatouk, Anne-Claire Compagnion, Maria-Angeles Carrillo-de Sauvage, Alexis-Pierre Bemelmans, Sabrina Leclere-Turbant, Vincent Cirotteau, Mira Tohme, Allen Beke, Michaël Trichet, Virginie Bazin, Bobby N. Trawick, Richard M. Ransohoff, François Tronche, Bénédicte Manoury & Sheela Vyas | | 01 August 2018 | doi: 10.1038/s41467-018-05680-w | | Neuroimmunology Parkinson's disease | Author Correction: The nature of spin excitations in the one-third magnetization plateau phase of Ba3CoSb2O9 OPEN | | Y. Kamiya, L. Ge, Tao Hong, Y. Qiu, D. L. Quintero-Castro, Z. Lu, H. B. Cao, M. Matsuda, E. S. Choi, C. D. Batista, M. Mourigal, H. D. Zhou & J. Ma | | 01 August 2018 | doi: 10.1038/s41467-018-05679-3 | | Magnetic properties and materials | Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex OPEN | | Fabrizio Martino, Mohinder Pal, Hugo Muñoz-Hernández, Carlos F. Rodríguez, Rafael Núñez-Ramírez, David Gil-Carton, Gianluca Degliesposti, J. Mark Skehel, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl & Oscar Llorca | | 31 July 2018 | doi: 10.1038/s41467-018-05546-1 | | Biochemistry Cryoelectron microscopy Structural biology | | | | | Latest Publisher Corrections | | | | | | | | Advertisement | | Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. 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