Nature Reviews Molecular Cell Biology contents September 2018 Volume 19 Number 9

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Advertisement 2018 longlist - see the full line up  The nominations for the 2018 Nature Research Awards for Inspiring Science and Innovating Science are in. See who's been long listed here > In partnership with The Estée Lauder Companies.   TABLE OF CONTENTS September 2018 Volume 19, Issue 9 Research Highlights Reviews Amendments & Corrections   Advertisement Nature Reviews Reader Survey At Nature Reviews we are continually looking for ways to ensure we meet our readers' needs. Your responses to this short survey will give us insight into how our content may be improved. Get started here.     Advertisement Register for the latest nature.com webcast Simultaneous gene expression and epitope analysis of immune cells from astronauts - Thursday, 6th September, 2018 Listen to Dr Christopher Mason from Weil Cornell Medical College discuss his plan for the survival of the human species on Earth, in space and on other planets.  Register for FREE today Sponsored by BD   Research Highlights   Rejuvenating senolytics Kim Baumann p543 | doi:10.1038/s41580-018-0047-5 Eliminating senescent cells by administering senolytic drugs can improve healthspan and lifespan in mice. PDF   Concentrating on intrinsic disorder Paulina Strzyz p544 | doi:10.1038/s41580-018-0039-5 Many eukaryotic proteins, including key transcription regulators, contain intrinsically disordered regions (IDRs), which serve as flexible interaction platforms. The molecular understanding of IDR-based interactions is now emerging, providing new insights into how IDRs promote protein compartmentalization and/or phase separation and how these processes regulate gene expression. PDF   Gene dimmer switch Anne Mirabella p545 | doi:10.1038/s41580-018-0038-6 The chromatin remodelling complex NuRD fine-tunes gene expression by modulating nucleosome density at gene regulatory elements. PDF   An elegant UPR discovery Rebecca C. Taylor p545 | doi:10.1038/s41580-018-0043-9 Rebecca Taylor discusses the elegance and importance of early discoveries from the Walter laboratory on the unfolded protein response, and why they have become landmark studies. PDF   Nature Reviews Molecular Cell Biology JOBS of the week Postdoc in tumor biology Fox Chase Cancer Center PhD Positions f / m in life sciences Technical University of Munich (TUM) Postdoctoral Fellowship / Research Scientist Boston University School of Medicine, BUMC Faculty Position in Immunology National University of Singapore, Dept of Microbiology and Immunology Faculty Position in Cancer Biology / Genetics Life Sciences Institute (LSI) - University of Michigan More Science jobs from Nature Reviews Molecular Cell Biology EVENT 84th Harden Conference: Single-molecule bacteriology 09.09.18 Oxford, UK More science events from Reviews   The functions and regulation of the PTEN tumour suppressor: new modes and prospects    Yu-Ru Lee, Ming Chen & Pier Paolo Pandolfi pp547 - 562 | doi:10.1038/s41580-018-0015-0 The tumour suppressor PTEN regulates various cellular processes, including maintenance of genomic stability, cell survival, migration, proliferation and metabolism. Recent studies into the regulation of PTEN levels and activity provide new insights into its anti-oncogenic functions and offer novel opportunities for cancer treatment. Full Text | PDF Collection: Cancer at Nature Research   Regulation of chromatin and gene expression by metabolic enzymes and metabolites    Xinjian Li, Gabor Egervari, Yugang Wang, Shelley L. Berger & Zhimin Lu pp563 - 578 | doi:10.1038/s41580-018-0029-7 Metabolism feeds into gene regulation, allowing adaptation of gene expression to satisfy cellular needs, including in pathological scenarios such as cancer. Metabolism modulates gene expression through metabolites, which serve as cofactors for DNA and histone modifiers, and through metabolic enzymes, which locally regulate chromatin and transcription in the nucleus. Full Text | PDF Collection: Metabolic signalling   Autophagy as a promoter of longevity: insights from model organisms    Malene Hansen, David C. Rubinsztein & David W. Walker pp579 - 593 | doi:10.1038/s41580-018-0033-y Recent studies in model organisms uncovered prominent links between autophagy and ageing, suggesting that by removing superfluous or damaged cellular content through lysosomal degradation, autophagy supports tissue and organismal fitness and promotes longevity. Thus, autophagy induction could be considered a strategy to extend lifespan. Full Text | PDF Collection: Cell death and autophagy   Cellular and epigenetic drivers of stem cell ageing    Maria Ermolaeva, Francesco Neri, Alessandro Ori & K. Lenhard Rudolph pp594 - 610 | doi:10.1038/s41580-018-0020-3 Decline in stem cell function causes loss of tissue homeostasis and increased incidence of age-related diseases. During ageing, adult stem cells accumulate damage and the niche in which they reside malfunctions. These defects are associated with changes in the epigenome that contribute to organ dysfunction and disease. Full Text | PDF Collection: Adult stem cells Stem cells from development to the clinic   Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!    Amendments & Corrections   Publisher Correction: Autophagy as a promoter of longevity: insights from model organisms    Malene Hansen, David C. Rubinsztein & David W. Walker p611 | doi:10.1038/s41580-018-0048-4 Full Text | PDF   Advertisement Searching for a new career?  At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do.   Advertisement Register for the latest nature.com webcast: Discover how fluorescent imaging is providing new insights into immune processes. Dr. Garry Nolan of Stanford University will present evidence of deep internal order in immune functionality demonstrating that differentiation and immune activities have evolved with a definable "shape".  Register for FREE today  Sponsored by Akoya Bio   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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