| | A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes
Integrated analyses of multiple cohorts are used to obtain a better understanding of the immune state of latent infection with Mycobacterium tuberculosis, and factors that mediate and/or predict transitions from latent infection to active disease.
Roshni Roy Chowdhury, Francesco Vallania, Qiantian Yang et al. | Fitness benefits and emergent division of labour at the onset of group living
Experimental data from, and mathematical modelling of, colonies of the clonal raider ant Ooceraea biroi demonstrate that increases in group size generate division of labour among similar individuals, increased homeostasis and higher colony fitness.
Y. Ulrich, J. Saragosti, C. K. Tokita et al. | RAP2 mediates mechanoresponses of the Hippo pathway
The Ras-related GTPase RAP2 is a key intracellular signal transducer by which extracellular matrix rigidity controls mechanosensitive cellular activities through YAP and TAZ.
Zhipeng Meng, Yunjiang Qiu, Kimberly C. Lin et al. | SIRT6 deficiency results in developmental retardation in cynomolgus monkeys
A cynomolgus monkey model deficient in SIRT6 protein exhibits severe retardation in prenatal development, in which neuronal differentiation is delayed by activation of the H19 long non-coding RNA.
Weiqi Zhang, Haifeng Wan, Guihai Feng et al. | Observation of the 1S–2P Lyman-α transition in antihydrogen
The observation of the 1S–2P Lyman-α transition in the antihydrogen atom, the antimatter counterpart of hydrogen, is reported.
M. Ahmadi, B. X. R. Alves, C. J. Baker et al. | Structure of paused transcription complex Pol II–DSIF–NELF
The cryo-electron microscopy structure of a paused transcription elongation complex of RNA polymerase II bound to DRB sensitivity-inducing factor and negative elongation factor is reported at 3.2 Å resolution.
Seychelle M. Vos, Lucas Farnung, Henning Urlaub et al. | Role for the longevity protein SIRT6 in primate development
Monkeys genetically engineered to lack the gene SIRT6 die a few hours after birth, displaying severe growth defects. This finding reveals a previously unknown role for the SIRT6 protein in primate development.
Shoshana Naiman, Haim Y. Cohen | Parkin and PINK1 mitigate STING-induced inflammation
Acute and chronic mitochondrial stress in mice require PINK1 and parkin to restrain STING-mediated innate immunity.
Danielle A. Sliter, Jennifer Martinez, Ling Hao et al. | Crystal structure of the Frizzled 4 receptor in a ligand-free state
The crystal structure of the Frizzled 4 receptor transmembrane domain is reported to a resolution of 2.4 Å in a ligand-free state.
Shifan Yang, Yiran Wu, Ting-Hai Xu et al. | Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
The cryo-electron microscopy structure of an activated transcription elongation complex of RNA polymerase II bound to DRB sensitivity-inducing factor and the elongation factors PAF1 complex and SPT6 is reported at 3.1 Å resolution.
Seychelle M. Vos, Lucas Farnung, Marc Boehning et al. | Stepwise and independent origins of roots among land plants
Meristems of the rooting axes of Asteroxylon mackiei preserved in 407-million-year-old Rhynie chert lack root caps, which demonstrates that the evolution of the root systems of modern vascular plants occurred in a stepwise fashion.
Alexander J. Hetherington, Liam Dolan | Elusive mitochondrial connection to inflammation uncovered
PINK1 and parkin proteins help to degrade damaged mitochondrial organelles, and abnormalities in these proteins are linked to Parkinson’s disease. Mouse studies reveal that the proteins act to prevent inflammation.
Alexandra Stolz, Ivan Dikic | Transcriptional speed bumps revealed in high resolution
The enzyme RNA polymerase II, which transcribes DNA, pauses early in transcription and awaits signals to continue. High-resolution structures reveal how it is stopped and efficiently restarted.
Karen Adelman, Telmo Henriques | Allergic inflammatory memory in human respiratory epithelial progenitor cells
Single-cell RNA sequencing is used to characterize cell types in nasal tissues from human patients with chronic rhinosinusitis, revealing a role for tissue stem cells in allergic inflammatory memory.
Jose Ordovas-Montanes, Daniel F. Dwyer, Sarah K. Nyquist et al. | The genome of the offspring of a Neanderthal mother and a Denisovan father
Genomic evidence of the offspring of a Neanderthal mother and a Denisovan father suggests that mixing among different hominin groups may have more been frequent than previously appreciated.
Viviane Slon, Fabrizio Mafessoni, Benjamin Vernot et al. | From the archive
What Nature was saying 50 and 100 years ago.
| Resonant domain-wall-enhanced tunable microwave ferroelectrics
The domain-wall structure and dynamics are found to enhance, rather than inhibit, the high-frequency performance of an intrinsically tunable material, obtaining ultralow loss and exceptional frequency selectivity.
Zongquan Gu, Shishir Pandya, Atanu Samanta et al. | | | | | |  Register for the latest nature.com webcast Sponsored by ACD | | | | | | Cryo-EM structure of the insect olfactory receptor Orco
A cryo-electron microscopy structure of the insect Orco subunit, which forms ion channels with diverse olfactory receptors, reveals a tetrameric cation channel and sheds light on insect olfaction.
Joel A. Butterwick, Josefina del Mármol, Kelly H. Kim et al. | | | Atomic iron and titanium in the atmosphere of the exoplanet KELT-9b
Cross-correlation analysis of high-resolution spectra obtained as the exoplanet KELT-9b transited its host star reveals neutral and singly ionized atomic iron and singly ionized atomic titanium in the exoplanet’s atmosphere.
H. Jens Hoeijmakers, David Ehrenreich, Kevin Heng et al. | | Photonic topological Anderson insulators
A counter-intuitive state—known as a topological Anderson insulator—in which strong disorder leads to the formation of topologically protected rather than trivial states is realized in a photonic system.
Simon Stützer, Yonatan Plotnik, Yaakov Lumer et al. | | Magnetoelectric inversion of domain patterns
The magnetization or polarization of domain states in multiferroics can be reversed while retaining the overall domain pattern, owing to the inherent versatility in coupling the large number of multiferroic order parameters.
N. Leo, V. Carolus, J. S. White et al. | | A Triassic stem turtle with an edentulous beak
A Triassic stem turtle from China has a mixture of derived characters and plesiomorphic features, including an edentulous beak and a rigid puboischiadic plate.
Chun Li, Nicholas C. Fraser, Olivier Rieppel et al. | | RNA velocity of single cells
RNA velocity, estimated in single cells by comparison of spliced and unspliced mRNA, is a good indicator of transcriptome dynamics and will provide a useful tool for analysis of developmental lineage.
Gioele La Manno, Ruslan Soldatov, Amit Zeisel et al. | | Inositol phosphates are assembly co-factors for HIV-1
Inositol hexakisphosphate, which is found in all mammalian cells, binds to two separate sites to promote the assembly and maturation of HIV-1 virus particles.
Robert A. Dick, Kaneil K. Zadrozny, Chaoyi Xu et al. | | | | | |
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