Nature Cell Biology contents: September 2018 Volume 20 Number 9

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Advertisement How will your cell culture needs evolve in the future? Upgradeability | Remote Monitoring | Easy Documentation | User Management | Connected Lab Whatever challenges you will face, the new Eppendorf CellXpert CO2 incubator family arriving in October 2018 will support you to get ready for the Culture of Tomorrow.  TABLE OF CONTENTS September 2018 Volume 20, Issue 9 Editorial News & Views Turning Points Review Articles Letters Articles Amendments & Corrections   Advertisement   Synthetic Biology - Resource Allocation in Natural and Unnatural Systems   This nature conference will address the issue of resource allocation from several perspectives from design to implementation, explore current challenges and examine the approaches that are being taken to overcome these challenges. October 15-17, 2018 | Shanghai, China   REGISTER NOW >>    Advertisement Communications Biology: Open for Submissions Communications Biology is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of biology. The journal is now open for submissions. Find out more >>   Advertisement Register for the latest nature.com webcast Simultaneous gene expression and epitope analysis of immune cells from astronauts - Thursday, 6th September, 2018 Listen to Dr Christopher Mason from Weil Cornell Medical College discuss his plan for the survival of the human species on Earth, in space and on other planets.  Register for FREE today  Sponsored by BD   Editorial   Celebrating women in science    p993 doi:10.1038/s41556-018-0190-4 News & Views   Mechanical signals regulate TORC2 activity    pp994 - 995 Michael Ebner & Volker Haucke doi:10.1038/s41556-018-0181-5 Lysosomal catch-and-release controls mTORC1    pp996 - 997 Aaron M. Hosios & Brendan D. Manning doi:10.1038/s41556-018-0188-y Shaping up with morphogen gradients    pp998 - 999 Laurence Garric & Jeroen Bakkers doi:10.1038/s41556-018-0168-2 Nature Cell Biology JOBS of the week Postdoctoral Position in Cancer Genomics and Precision Oncology Memorial Sloan Kettering Cancer Center (MSKCC) Position in Immunology University of Illinois at Urbana - Champaign Faculty Position in Cancer Biology / Genetics University of Michigan Postdoctoral Position in Medicinal Chemistry for Cancer Drug Discovery, University of Michigan, Ann Arbor University of Michigan (U-M) The Cancer Research Uk Manchester Imstitute Cancer Research Manchester Institute More Science jobs from Nature Cell Biology EVENT Cell and Gene Therapy 2018 10.10.18 London, UK More science events from Turning Points   Finding your way through the science maze    p1000 Asifa Akhtar doi:10.1038/s41556-018-0175-3 Having it all, a scientific career and a family    p1001 Sandrine Etienne-Manneville doi:10.1038/s41556-018-0160-x Seeking and embracing change    p1002 Maho Hamasaki doi:10.1038/s41556-018-0180-6 Finding success by following your heart    p1003 Nancy Y. Ip doi:10.1038/s41556-018-0159-3 Serendipity, luck and hard work    p1004 Kum Kum Khanna doi:10.1038/s41556-018-0170-8 Choosing an easier path or following your passion    p1005 Melissa Little doi:10.1038/s41556-018-0158-4 The duty to speak up    p1006 Serena Nik-Zainal doi:10.1038/s41556-018-0171-7 Taking a confident leap into uncertainty    p1007 Melina Schuh doi:10.1038/s41556-018-0177-1 Perseverance when the going gets tough    p1008 M. Celeste Simon doi:10.1038/s41556-018-0172-6 Confidence to go the way science takes you    p1009 Anne Simonsen doi:10.1038/s41556-018-0156-6 Mentorship comes from many sources    p1010 Shubha Tole doi:10.1038/s41556-018-0189-x The reward of great collaborations    p1011 Fiona M. Watt doi:10.1038/s41556-018-0157-5 Helping our country as women scientists    p1012 Mayana Zatz doi:10.1038/s41556-018-0161-9 Advertisement Nature Conference on Inflammation and Cancer  This meeting will bring together a diverse group of researchers from the many interconnected areas of immunology and cancer to discuss how inflammation affects tumour development and metastasis. Presentations will focus on the most recent findings on the tumour-promoting and -suppressing effects of inflammation, the immune tumour environment, and therapeutic approaches. October 23-25, 2018 | Beijing, China  REGISTER NOW >>   Review Articles   Mechanisms of mitophagy in cellular homeostasis, physiology and pathology    pp1013 - 1022 Konstantinos Palikaras, Eirini Lionaki & Nektarios Tavernarakis doi:10.1038/s41556-018-0176-2 In this Review, Tavernarakis and colleagues describe recent advances in delineating the molecular mechanisms that mediate mitophagy, and discuss the complex roles of this pathway in physiological and pathological contexts.   Letters   FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis    pp1023 - 1031 Laura Chan Wah Hak, Shaheen Khan, Ilaria Di Meglio, Ah-Lai Law, Safa Lucken-Ardjomande Häsler et al. doi:10.1038/s41556-018-0146-8 Chan Wah Hak et al. show how plasma membrane patches are primed for fast endophilin-mediated endocytosis and disassembly, in the absence of receptor stimulation, through FBP17 and CIP4 binding to SHIP2 and lamellipodin.   Articles   Scale-invariant patterning by size-dependent inhibition of Nodal signalling    pp1032 - 1042 María Almuedo-Castillo, Alexander Bläßle, David Mörsdorf, Luciano Marcon, Gary H. Soh et al. doi:10.1038/s41556-018-0155-7 Almuedo-Castillo et al. show that extirpated embryos are reduced in size but exhibit normal proportions. Following a computational screen, the authors identify an increased concentration of the Nodal inhibitor Lefty to be responsible for the size scaling.   Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2    pp1043 - 1051 Margot Riggi, Karolina Niewola-Staszkowska, Nicolas Chiaruttini, Adai Colom, Beata Kusmider et al. doi:10.1038/s41556-018-0150-z Using a small-molecule modulator of TORC2 signalling and a mechanosensitive probe, Riggi et al. reveal that decreased plasma membrane tension induces distinct PIP2-enriched domains that sequester and inactivate TORC2.   A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase–Ragulator lysosomal scaffold    pp1052 - 1063 Rosalie E. Lawrence, Kelvin F. Cho, Ronja Rappold, Anna Thrun, Marie Tofaute et al. doi:10.1038/s41556-018-0148-6 Lawrence et al. show that mTORC1 capture and activation at the lysosome are regulated by nutrients that destabilize Rag GTPase–Ragulator binding, and delineate how cancer-specific Rag mutants increase mTORC1 signalling.   RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers    pp1064 - 1073 Robert J. Nichols, Franziska Haderk, Carlos Stahlhut, Christopher J. Schulze, Golzar Hemmati et al. doi:10.1038/s41556-018-0169-1 Nichols et al. identify an SHP2 inhibitor that disrupts SOS1-mediated RAS–GTP loading with demonstrated efficacy in various types of tumour driven by mutant BRAF, NF1 or RAS.   m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer    pp1074 - 1083 Jun Liu, Mark A. Eckert, Bryan T. Harada, Song-Mei Liu, Zhike Lu et al. doi:10.1038/s41556-018-0174-4 Liu et al. show that reduced m6A mRNA methylation in endometrial cancer is oncogenic. Mechanistically, the AKT pathway is activated in these tumours due to altered expression of AKT regulators carrying m6A on their transcripts.   IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization    pp1084 - 1097 Zafira Castaño, Beatriz P. San Juan, Asaf Spiegel, Ayush Pant, Molly J. DeCristo et al. doi:10.1038/s41556-018-0173-5 Castaño et al. show that primary breast tumours drive an IL-1β -mediated inflammatory response that inhibits cellular plasticity and metastatic colonization of metastasis-initiating cells.   Amendments & Corrections   Author Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation    p1098 Huilin Huang, Hengyou Weng, Wenju Sun, Xi Qin, Hailing Shi et al. doi:10.1038/s41556-018-0102-7 Author Correction: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation    p1098 Kimberly C. Lin, Toshiro Moroishi, Zhipeng Meng, Han-Sol Jeong, Steven W. Plouffe et al. doi:10.1038/s41556-018-0101-8 Publisher Correction: Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons    p1098 Arnau Hervera, Francesco De Virgiliis, Ilaria Palmisano, Luming Zhou, Elena Tantardini et al. doi:10.1038/s41556-018-0063-x Publisher Correction: Mechanisms and impact of altered tumour mechanics    p1099 Hamid Mohammadi & Erik Sahai doi:10.1038/s41556-018-0163-7 Publisher Correction: Early lineage segregation of multipotent embryonic mammary gland progenitors    p1099 Aline Wuidart, Alejandro Sifrim, Marco Fioramonti, Shigeru Matsumura, Audrey Brisebarre et al. doi:10.1038/s41556-018-0164-6 Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. 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