Wednesday, August 29, 2018

Nature Cell Biology contents: September 2018 Volume 20 Number 9

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Nature Cell Biology

How will your cell culture needs evolve in the future?

Upgradeability | Remote Monitoring | Easy Documentation | User Management | Connected Lab

Whatever challenges you will face, the new Eppendorf CellXpert CO2 incubator family arriving in October 2018 will support you to get ready for the Culture of Tomorrow. 

September 2018 Volume 20, Issue 9

News & Views
Turning Points
Review Articles
Amendments & Corrections


This nature conference will address the issue of resource allocation from several perspectives from design to implementation, explore current challenges and examine the approaches that are being taken to overcome these challenges.
October 15-17, 2018 | Shanghai, China

Communications Biology: Open for Submissions Communications Biology is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of biology. The journal is now open for submissions. Find out more >>

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Celebrating women in science    p993

News & Views


Mechanical signals regulate TORC2 activity    pp994 - 995
Michael Ebner & Volker Haucke

Lysosomal catch-and-release controls mTORC1    pp996 - 997
Aaron M. Hosios & Brendan D. Manning

Shaping up with morphogen gradients    pp998 - 999
Laurence Garric & Jeroen Bakkers

Nature Cell Biology
JOBS of the week
Postdoctoral Position in Cancer Genomics and Precision Oncology
Memorial Sloan Kettering Cancer Center (MSKCC)
Position in Immunology
University of Illinois at Urbana - Champaign
Faculty Position in Cancer Biology / Genetics
University of Michigan
Postdoctoral Position in Medicinal Chemistry for Cancer Drug Discovery, University of Michigan, Ann Arbor
University of Michigan (U-M)
The Cancer Research Uk Manchester Imstitute
Cancer Research Manchester Institute
More Science jobs from
Nature Cell Biology
Cell and Gene Therapy 2018
London, UK
More science events from

Turning Points


Finding your way through the science maze    p1000
Asifa Akhtar

Having it all, a scientific career and a family    p1001
Sandrine Etienne-Manneville

Seeking and embracing change    p1002
Maho Hamasaki

Finding success by following your heart    p1003
Nancy Y. Ip

Serendipity, luck and hard work    p1004
Kum Kum Khanna

Choosing an easier path or following your passion    p1005
Melissa Little

The duty to speak up    p1006
Serena Nik-Zainal

Taking a confident leap into uncertainty    p1007
Melina Schuh

Perseverance when the going gets tough    p1008
M. Celeste Simon

Confidence to go the way science takes you    p1009
Anne Simonsen

Mentorship comes from many sources    p1010
Shubha Tole

The reward of great collaborations    p1011
Fiona M. Watt

Helping our country as women scientists    p1012
Mayana Zatz

Nature Conference on Inflammation and Cancer 

This meeting will bring together a diverse group of researchers from the many interconnected areas of immunology and cancer to discuss how inflammation affects tumour development and metastasis. Presentations will focus on the most recent findings on the tumour-promoting and -suppressing effects of inflammation, the immune tumour environment, and therapeutic approaches.

October 23-25, 2018 | Beijing, China 


Review Articles


Mechanisms of mitophagy in cellular homeostasis, physiology and pathology    pp1013 - 1022
Konstantinos Palikaras, Eirini Lionaki & Nektarios Tavernarakis

In this Review, Tavernarakis and colleagues describe recent advances in delineating the molecular mechanisms that mediate mitophagy, and discuss the complex roles of this pathway in physiological and pathological contexts.




FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis    pp1023 - 1031
Laura Chan Wah Hak, Shaheen Khan, Ilaria Di Meglio, Ah-Lai Law, Safa Lucken-Ardjomande Häsler et al.

Chan Wah Hak et al. show how plasma membrane patches are primed for fast endophilin-mediated endocytosis and disassembly, in the absence of receptor stimulation, through FBP17 and CIP4 binding to SHIP2 and lamellipodin.




Scale-invariant patterning by size-dependent inhibition of Nodal signalling    pp1032 - 1042
María Almuedo-Castillo, Alexander Bläßle, David Mörsdorf, Luciano Marcon, Gary H. Soh et al.

Almuedo-Castillo et al. show that extirpated embryos are reduced in size but exhibit normal proportions. Following a computational screen, the authors identify an increased concentration of the Nodal inhibitor Lefty to be responsible for the size scaling.


Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2    pp1043 - 1051
Margot Riggi, Karolina Niewola-Staszkowska, Nicolas Chiaruttini, Adai Colom, Beata Kusmider et al.

Using a small-molecule modulator of TORC2 signalling and a mechanosensitive probe, Riggi et al. reveal that decreased plasma membrane tension induces distinct PIP2-enriched domains that sequester and inactivate TORC2.


A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase–Ragulator lysosomal scaffold    pp1052 - 1063
Rosalie E. Lawrence, Kelvin F. Cho, Ronja Rappold, Anna Thrun, Marie Tofaute et al.

Lawrence et al. show that mTORC1 capture and activation at the lysosome are regulated by nutrients that destabilize Rag GTPase–Ragulator binding, and delineate how cancer-specific Rag mutants increase mTORC1 signalling.


RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers    pp1064 - 1073
Robert J. Nichols, Franziska Haderk, Carlos Stahlhut, Christopher J. Schulze, Golzar Hemmati et al.

Nichols et al. identify an SHP2 inhibitor that disrupts SOS1-mediated RAS–GTP loading with demonstrated efficacy in various types of tumour driven by mutant BRAF, NF1 or RAS.


m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer    pp1074 - 1083
Jun Liu, Mark A. Eckert, Bryan T. Harada, Song-Mei Liu, Zhike Lu et al.

Liu et al. show that reduced m6A mRNA methylation in endometrial cancer is oncogenic. Mechanistically, the AKT pathway is activated in these tumours due to altered expression of AKT regulators carrying m6A on their transcripts.


IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization    pp1084 - 1097
Zafira Castaño, Beatriz P. San Juan, Asaf Spiegel, Ayush Pant, Molly J. DeCristo et al.

Castaño et al. show that primary breast tumours drive an IL-1β -mediated inflammatory response that inhibits cellular plasticity and metastatic colonization of metastasis-initiating cells.


Amendments & Corrections


Author Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation    p1098
Huilin Huang, Hengyou Weng, Wenju Sun, Xi Qin, Hailing Shi et al.

Author Correction: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation    p1098
Kimberly C. Lin, Toshiro Moroishi, Zhipeng Meng, Han-Sol Jeong, Steven W. Plouffe et al.

Publisher Correction: Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons    p1098
Arnau Hervera, Francesco De Virgiliis, Ilaria Palmisano, Luming Zhou, Elena Tantardini et al.

Publisher Correction: Mechanisms and impact of altered tumour mechanics    p1099
Hamid Mohammadi & Erik Sahai

Publisher Correction: Early lineage segregation of multipotent embryonic mammary gland progenitors    p1099
Aline Wuidart, Alejandro Sifrim, Marco Fioramonti, Shigeru Matsumura, Audrey Brisebarre et al.

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