Nature Structural & Molecular Biology Contents: 2018 Volume #25 pp 547 - 640

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Advertisement Submit your abstract for the RNA at the Bench and Bedside conference by July 30. This conference will cover the numerous roles of RNAs and the efforts to translate advances in the basic science into new therapies. It will address the opportunities, current status, and the future of this exciting field. View the draft program for more details. Remember to register before submitting your abstract.   TABLE OF CONTENTS July 2018 Volume 25, Issue 7 Obituary Articles Resources       Obituary   Elisa Izaurralde 1959–2018    p547 Matthias W. Hentze & Juan Valcárcel doi:10.1038/s41594-018-0081-1 Articles   Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states    pp548 - 556 Ahmed-Noor A. Agip, James N. Blaza, Hannah R. Bridges, Carlo Viscomi, Shaun Rawson et al. doi:10.1038/s41594-018-0073-1 Cryo-EM analyses of mitochondrial complex I (NADH:ubiquinone oxidoreductase) isolated from mouse heart allow comparisons between the active and deactive states and provide new mechanistic insights into this important complex.   Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly    pp557 - 569 James M. Dunce, Orla M. Dunne, Matthew Ratcliff, Claudia Millán, Suzanne Madgwick et al. doi:10.1038/s41594-018-0078-9 The structural basis for self-assembly of human SYCP1, the core architectural element of the meiotic synaptonemal complex, reveals an obligate tetrameric structure that assembles into a zipper-like supramolecular lattice.   Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog    pp570 - 576 Hidetsugu Asada, Shoichiro Horita, Kunio Hirata, Mitsunori Shiroishi, Yuki Shiimura et al. doi:10.1038/s41594-018-0079-8 The crystal structure of human AT2R binding an angiotensin II analog reveals ‘core’ and ‘extended’ domains within the binding pocket. A signature positively charged motif orients the C terminus of the peptide ligand at the bottom of the binding pocket.   Structural & Molecular Biology JOBS of the week Post-doctoral fellow University of Hawaii, College of Pharmacy Tenure Track or Tenured Position in Molecular and Cellular Biology of Alzheimer’s Disease and Neurodegeneration Brown University Postdoc position for computational genomics, bioinformatics, or molecular cancer biology University of Pittsburgh Cancer Institute (UPCI) Postdoctoral Fellow - Translational Cancer Research University of Pennsylvania Postdoctoral position in Chemistry (NMR-based structural biology) Umeå University - Department of Chemistry More Science jobs from Structural & Molecular Biology EVENT World Structural and Molecular Biology Conference 28.11.18 Rome, Italy More science events from Accurate design of translational output by a neural network model of ribosome distribution    pp577 - 582 Robert Tunney, Nicholas J. McGlincy, Monica E. Graham, Nicki Naddaf, Lior Pachter et al. doi:10.1038/s41594-018-0080-2 Neural network analyses of ribosome profiling data reveal sequence features that affect translation elongation, which can be manipulated to control protein expression levels in yeast.   Structure of the core of the type III secretion system export apparatus    pp583 - 590 Lucas Kuhlen, Patrizia Abrusci, Steven Johnson, Joseph Gault, Justin Deme et al. doi:10.1038/s41594-018-0086-9 Cryo-EM structure of the Salmonella Typhimurium FliP–FliQ–FliR complex identifies this export gate as a core component of the periplasmic portion of the type III secretion system.   Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein    pp591 - 600 Maria Victoria Botuyan, Gaofeng Cui, Pascal Drané, Catarina Oliveira, Alexandre Detappe et al. doi:10.1038/s41594-018-0083-z Structural and functional dissection of the TIRR–53BP1 complex shows that TIRR acts as a regulatory switch that blocks 53BP1 binding to chromatin to direct DNA repair, and it releases 53BP1 in response to DNA damage by binding RNA.   A CLC-type F-/H+ antiporter in ion-swapped conformations    pp601 - 606 Nicholas B. Last, Randy B. Stockbridge, Ashley E. Wilson, Tania Shane, Ludmila Kolmakova-Partensky et al. doi:10.1038/s41594-018-0082-0 Crystal structures of the CLCF proton-coupled fluoride antiporter Eca in two conformations capture two rotamers of the gating glutamate and reveal simultaneous accessibility of F– and H+ ions via separate pathways on opposite sides of the membrane.   The role of tubulin–tubulin lattice contacts in the mechanism of microtubule dynamic instability    pp607 - 615 Szymon W. Manka & Carolyn A. Moores doi:10.1038/s41594-018-0087-8 Cryo-EM analyses of microtubules in different nucleotide-bound states reveal differences in lateral and longitudinal contacts within the lattice, indicating the structural basis for microtubule catastrophe.   Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4    pp616 - 622 Nicholas O. Bodnar, Kelly H. Kim, Zhejian Ji, Thomas E. Wales, Vladimir Svetlov et al. doi:10.1038/s41594-018-0085-x Structures of Cdc48 with heterodimeric cofactor Ufd1–Npl4 reveal the location of Npl4's MPN domain above Cdc48’s central pore, thus suggesting how Npl4 engages with polyubiquitinated substrates and promotes their translocation into the ATPase.   Mechanism of parkin activation by phosphorylation    pp623 - 630 Véronique Sauvé, George Sung, Naoto Soya, Guennadi Kozlov, Nina Blaimschein et al. doi:10.1038/s41594-018-0088-7 Crystal structures of activated, phosphorylated fly parkin in complex with phosphorylated ubiquitin and human UbcH7 reveal large domain movements enabled by the parkin’s internal linkers. Results also explain some Parkinson’s disease mutations.   Resources   UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites    pp631 - 640 Vyacheslav Akimov, Inigo Barrio-Hernandez, Sten V. F. Hansen, Philip Hallenborg, Anna-Kathrine Pedersen et al. doi:10.1038/s41594-018-0084-y Using UbiSite, an antibody-based approach that specifically detects protein lysine and N-terminal ubiquitination, Blagoev and colleagues uncover lack of correlation between changes in protein ubiquitination and abundance upon proteasome inhibition.   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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