Nature Reviews Neuroscience contents August 2018 Volume 19 Number 8

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Advertisement Nature Reviews Reader Survey At Nature Reviews we are continually looking for ways to ensure we meet our readers' needs. Your responses to this short survey will give us insight into how our content may be improved. Get started here.   TABLE OF CONTENTS August 2018 Volume 19, Issue 8 Research Highlights Progress Reviews   Advertisement Neuro-Immunology: The Impact of Immune Function on Alzheimer's Disease  September 25, 2018, NYC This symposium, featuring Philip De Jager of Columbia University and Bruce Lamb of Indiana University, will discuss the role of the immune system in the human biology of Alzheimer's disease (AD), and evaluate prospects for novel AD therapeutics. Abstracts July 20. Register.   Research Highlights   Converging inputs    p441 Darran Yates doi:10.1038/s41583-018-0040-1 A study in flies shows that projections from some groups of glomerular neurons converge on certain types of lateral horn neurons to process combinations of odours that are salient for certain behaviours.   Losing sleep over lipids    pp442 - 443 Natasha Bray doi:10.1038/s41583-018-0033-0 In genetic fly models of Parkinson disease, disrupted lipid trafficking in neuropeptidergic neurons leads to circadian disruption.   Trading places    pp442 - 443 Sian Lewis doi:10.1038/s41583-018-0032-1 Insights into the molecular and cellular mechanisms by which the APOE4 variant increases risk for Alzheimer disease are gained by comparing transcriptomes of neurons, astrocytes and microglia derived from isogenic APOE3- and APOE4-carrying iPSC cell lines.   Treasure hunt    p443 Sian Lewis doi:10.1038/s41583-018-0042-z A discrete subpopulation of CA1 pyramidal cells is identified, which are distinct from place cells, that encode the location of a reward.   Expanding knowledge    p444 Katherine Whalley doi:10.1038/s41583-018-0034-z A matter of taste    p444 Katherine Whalley doi:10.1038/s41583-018-0035-y Influencing identity    p444 Katherine Whalley doi:10.1038/s41583-018-0036-x Sleep it off    p444 Natasha Bray doi:10.1038/s41583-018-0037-9 A set of 80 (mostly synaptic) proteins show hyperphosphorylation in sleep-deprived mice and genetically 'sleepy' mice, suggesting that increased phosphorylation of such proteins may be associated with sleep need.   Nature Reviews Neuroscience JOBS of the week Open Faculty Positions Okinawa Institute of Science and Technology (OIST) Postdoctoral Fellows and Research Scientist Boston Children�s Hospital / Harvard Medical School Psychology Clinical Jr. Faculty Harvard University Multiple Faculty Positions at ShanghaiTech University ShanghaiTech University Excellence in Science PhD Scholarship Award in Neuroscience UTS - University Of Technology Sydney More Science jobs from Nature Reviews Neuroscience EVENT Neurotechnologies 30.09.18 Leuven, Belgium More science events from Progress   Modelling microglial function with induced pluripotent stem cells: an update    pp445 - 452 Jennifer M. Pocock & Thomas M. Piers doi:10.1038/s41583-018-0030-3 In recent years, several studies have reported the production of microglia-like cells from induced pluripotent stem cells. Pocock and Piers describe the methods used to produce and analyse these cells and their potential to improve our understanding of microglial function.   Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today >>   Reviews   Generation of circadian rhythms in the suprachiasmatic nucleus    pp453 - 469 Michael H. Hastings, Elizabeth S. Maywood & Marco Brancaccio doi:10.1038/s41583-018-0026-z In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus acts as the principal pacemaker for circadian rhythms, which are powerful regulators of physiology and behaviour. In this Review, Hastings, Maywood and Brancaccio examine the molecular, cellular and circuit mechanisms underlying time-keeping in the SCN.   Neuroscience of apathy and anhedonia: a transdiagnostic approach    pp470 - 484 Masud Husain & Jonathan P. Roiser doi:10.1038/s41583-018-0029-9 Anhedonia and apathy are syndromes affecting motivation and have been reported in various neurological and psychiatric disorders. Husain and Roiser examine the neural mechanisms underlying apathy and anhedonia within a transdiagnostic framework of effort-based decision making for reward.   The role of engram cells in the systems consolidation of memory    pp485 - 498 Susumu Tonegawa, Mark D. Morrissey & Takashi Kitamura doi:10.1038/s41583-018-0031-2 Long-term episodic memory storage has been proposed to require a reorganization of neural circuits and networks in a process known as systems consolidation. Tonegawa and colleagues discuss recent advances in our understanding of the contribution of engram cells to this process.   Opioid receptors: drivers to addiction?    pp499 - 514 Emmanuel Darcq & Brigitte Lina Kieffer doi:10.1038/s41583-018-0028-x The opioid system is central to addiction. Darcq and Kieffer review the role of these receptors in the addiction neurocircuitry, ask whether opioid receptors can be targeted to kill pain without addiction and discuss studies that bridge the translational gap in the field.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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