Nature Reviews Immunology Contents June 2018 Volume 18 Number 8 pp 479-536

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Advertisement Focus on Autoimmune Disease from Nature Immunology A series of Reviews specially commissioned by Nature Immunology discuss the genetic, environmental, microbial and cellular factors underpinning autoimmune disease as well as highlight avenues for therapeutic intervention.  Access free online Produced with support from Janssen Research & Development TABLE OF CONTENTS August 2018 Volume 18, Issue 8 Research Highlights Reviews Perspectives Amendments & Corrections   Advertisement AstraZeneca is in search of highly talented scientists to join the company's postdoc industrial programme. This is an excellent opportunity for early career scientists to make a significant impact in the world of science.  Read more. *ad feature   Advertisement Nature Reviews Reader Survey At Nature Reviews we are continually looking for ways to ensure we meet our readers' needs. Your responses to this short survey will give us insight into how our content may be improved. Get started here.     Research Highlights   TH9 cells tackle advanced tumours    p479 Alexandra Flemming doi:10.1038/s41577-018-0032-4 CD4+ TH9 cells show superior activity in adoptive cell transfer approach in melanoma mouse model.   Viperin breaks viral chains    pp480 - 481 Kirsty Minton doi:10.1038/s41577-018-0035-1 The antiviral protein viperin catalyses the production of a small molecule inhibitor of viral RNA polymerization.   Neuroendocrine cells amplify asthma    pp480 - 481 Lucy Bird doi:10.1038/s41577-018-0036-0 Pulmonary neuroendocrine cells communicate with type 2 innate lymphoid cells and goblet cells to promote allergic asthma.   Tumour decides immune cell ins and outs    p481 Grant Otto doi:10.1038/s41577-018-0038-y Tumour cell-intrinsic factors determine the infiltration of T cells into tumours and their response to immunotherapy.   P2RX7 keeps memory T cells fit    pp482 - 483 Yvonne Bordon doi:10.1038/s41577-018-0041-3 The ATP sensor P2RX7 maintains mitochondrial function in long-lived memory CD8+ T cells.   RFX7 keeps killers quiescent    pp482 - 483 Lucy Bird doi:10.1038/s41577-018-0039-x The metabolism and maintenance of natural killer (NK) cells is regulated by a previously uncharacterized transcription factor called regulatory factor X7 (RFX7).   The inflammasome starts rolling    p483 Thirumala-Devi Kanneganti doi:10.1038/s41577-018-0027-1 Thirumala-Devi Kanneganti describes a 2002 study by Jürg Tschopp and colleagues that first described the multiprotein, caspase-activating inflammasome complex that drives the maturation and secretion of IL-1β.   Nature Reviews Immunology JOBS of the week Senior Bioinformatics Scientist Armauer Hansen Research Institute Postdoctoral Fellow University of California - San Francisco Faculty Positions at Institut Pasteur of Shanghai, Chinese Academy of Sciences, China Institute Pasteur of Shanghai, Chinese Academy of Sciences, China Postdoctoral Fellow (m / f) in the Rinkevich Lab Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Postdoctoral Fellow The University of Texas MD Anderson Cancer Center More Science jobs from Nature Reviews Immunology EVENT Cancer Immunotherapy: Recent Progress and Future Challenges 12.10.18 Palermo, Italy More science events from Reviews   Regulatory mechanisms in T cell receptor signalling    pp485 - 497 Guillaume Gaud, Renaud Lesourne & Paul E. Love doi:10.1038/s41577-018-0020-8 This Review discusses the latest insights into the mechanisms regulating T cell receptor (TCR) signalling responses. In particular, the authors focus on how TCR signalling is regulated during thymocyte selection and during T cell homeostasis.   Integrating oncolytic viruses in combination cancer immunotherapy    pp498 - 513 Praveen K. Bommareddy, Megha Shettigar & Howard L. Kaufman doi:10.1038/s41577-018-0014-6 Oncolytic viruses can target multiple steps in the cancer–immunity cycle and can be engineered to express therapeutic genes and, as a result, can be usefully integrated in combination tumour immunotherapies. Here, the authors discuss features of oncolytic viruses that make them appealing agents for combination approaches in cancer immunotherapy.   Diverse developmental pathways of intestinal intraepithelial lymphocytes    pp514 - 525 Benjamin D. McDonald, Bana Jabri & Albert Bendelac doi:10.1038/s41577-018-0013-7 The intestine harbours a complex array of intraepithelial lymphocytes that patrol the epithelial layer and exert rapid cytolytic function. Here, the authors compare the different cytolytic populations and suggest that this diversity results from evolutionary pressure to protect this important barrier.   Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Perspectives   An early history of T cell-mediated cytotoxicity    pp527 - 535 Pierre Golstein & Gillian M. Griffiths doi:10.1038/s41577-018-0009-3 This Timeline looks back at the past 60 years of fundamental research into the mechanisms of T cell-mediated cytotoxicity, which has culminated in recent interest in the therapeutic manipulation of cytotoxic T cell responses for cancer immunotherapy.   Amendments & Corrections   Author Correction: Integrating oncolytic viruses in combination cancer immunotherapy    p536 Praveen K. Bommareddy, Megha Shettigar & Howard L. Kaufman doi:10.1038/s41577-018-0031-5 Publisher Correction: To respond or not to respond — a personal perspective of intestinal tolerance    p536 Allan McI. Mowat doi:10.1038/s41577-018-0033-3 Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. 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