Thursday, July 26, 2018

Nature Reviews Immunology Contents June 2018 Volume 18 Number 8 pp 479-536

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Nature Reviews Immunology

Focus on Autoimmune Disease from Nature Immunology

A series of Reviews specially commissioned by Nature Immunology discuss the genetic, environmental, microbial and cellular factors underpinning autoimmune disease as well as highlight avenues for therapeutic intervention. 

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August 2018 Volume 18, Issue 8

Research Highlights
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Research Highlights


TH9 cells tackle advanced tumours    p479
Alexandra Flemming

CD4+ TH9 cells show superior activity in adoptive cell transfer approach in melanoma mouse model.


Viperin breaks viral chains    pp480 - 481
Kirsty Minton

The antiviral protein viperin catalyses the production of a small molecule inhibitor of viral RNA polymerization.


Neuroendocrine cells amplify asthma    pp480 - 481
Lucy Bird

Pulmonary neuroendocrine cells communicate with type 2 innate lymphoid cells and goblet cells to promote allergic asthma.


Tumour decides immune cell ins and outs    p481
Grant Otto

Tumour cell-intrinsic factors determine the infiltration of T cells into tumours and their response to immunotherapy.


P2RX7 keeps memory T cells fit    pp482 - 483
Yvonne Bordon

The ATP sensor P2RX7 maintains mitochondrial function in long-lived memory CD8+ T cells.


RFX7 keeps killers quiescent    pp482 - 483
Lucy Bird

The metabolism and maintenance of natural killer (NK) cells is regulated by a previously uncharacterized transcription factor called regulatory factor X7 (RFX7).


The inflammasome starts rolling    p483
Thirumala-Devi Kanneganti

Thirumala-Devi Kanneganti describes a 2002 study by Jürg Tschopp and colleagues that first described the multiprotein, caspase-activating inflammasome complex that drives the maturation and secretion of IL-1β.


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Regulatory mechanisms in T cell receptor signalling    pp485 - 497
Guillaume Gaud, Renaud Lesourne & Paul E. Love

This Review discusses the latest insights into the mechanisms regulating T cell receptor (TCR) signalling responses. In particular, the authors focus on how TCR signalling is regulated during thymocyte selection and during T cell homeostasis.


Integrating oncolytic viruses in combination cancer immunotherapy    pp498 - 513
Praveen K. Bommareddy, Megha Shettigar & Howard L. Kaufman

Oncolytic viruses can target multiple steps in the cancer–immunity cycle and can be engineered to express therapeutic genes and, as a result, can be usefully integrated in combination tumour immunotherapies. Here, the authors discuss features of oncolytic viruses that make them appealing agents for combination approaches in cancer immunotherapy.


Diverse developmental pathways of intestinal intraepithelial lymphocytes    pp514 - 525
Benjamin D. McDonald, Bana Jabri & Albert Bendelac

The intestine harbours a complex array of intraepithelial lymphocytes that patrol the epithelial layer and exert rapid cytolytic function. Here, the authors compare the different cytolytic populations and suggest that this diversity results from evolutionary pressure to protect this important barrier.


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An early history of T cell-mediated cytotoxicity    pp527 - 535
Pierre Golstein & Gillian M. Griffiths

This Timeline looks back at the past 60 years of fundamental research into the mechanisms of T cell-mediated cytotoxicity, which has culminated in recent interest in the therapeutic manipulation of cytotoxic T cell responses for cancer immunotherapy.


Amendments & Corrections


Author Correction: Integrating oncolytic viruses in combination cancer immunotherapy    p536
Praveen K. Bommareddy, Megha Shettigar & Howard L. Kaufman

Publisher Correction: To respond or not to respond — a personal perspective of intestinal tolerance    p536
Allan McI. Mowat

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